CN107158076A - A kind of Chinese medicine composition of prevention and treatment visual fatigue - Google Patents
A kind of Chinese medicine composition of prevention and treatment visual fatigue Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine composition of prevention and treatment visual fatigue, including, honeysuckle, cassia seed, climbing groundsel, the seed of feather cockscomb, butterflybush flower, peppermint and borneol.Using pure Chinese medicine low-temperature extraction technology, the caused gasification of the reason for active ingredient is because of temperature is prevented, the active ingredient of Chinese medicine draft is remained to greatest extent.In encapsulation process, whole sterile working is disposable after sealing, without any preservative, effectively infringement of the prevention by preservative to eyes tear film and cornea.The product is sprayed on user's eyelid, and eye is directly acted on by Transdermal absorption, it is to avoid because effect decline caused by liver detoxification function and systemic circulation metabolism, usage amount is few, and targeting, absorption efficiency high.
Description
Technical field
The present invention relates to technical field of Chinese medicine, more particularly to a kind of Chinese medicine composition of prevention and treatment visual fatigue.
Background technology
Visual fatigue is a kind of common disease of current ophthalmology, and the symptom of patient is varied, common are close eye
Can not be lasting, pain, blurred vision, eyes are dry and astringent around eye and eye socket, shed tears, severe patient headache, dizziness.It is not independent
Disease, and be due to one group of fatigue syndrome caused by a variety of causes.Its occurrence cause be also it is diversified, it is common
Have：(l) the reason for eyes itself, such as myopia, long sight, astigmatism diopter not just, heterophoria, regulation factor, eye muscle factor, knot
Film inflammation, keratitis etc.；(2) systemic factor, such as neurasthenia, body overwork；(3) environmental factor, such as illumination are not enough or too strong, light
Source distribution is uneven or glimpses, and the target watched attentively is too small, meticulous or unstable etc..
The symptom of visual fatigue has dry and astringent kopiopia, eye, foreign body sensation, eyelid sense of heaviness, blurred vision, photophobia to shed tears, eyeball
Dry and astringent, eye distending pain and eye hyperemia etc., severe patient are it may also occur that dizzy, One's spirits are drooping, absent minded, and small number of patients can go out
Myopia (pseudo-myopia and very can also occur in existing diplopia, stereoscopic vision dysfunction, intraocular pressure rise, corneal injury etc., teenager
Property myopia) or deepen original myopic degree.There are glaucoma, eye surface or anterior ocular segment disease patient also to draw because of the fatigue of eye
Send out or aggravate original illness in eye.
The alleviation of current visual fatigue mainly has following several：1. external application eye drops：Sodium chloride eye drops, ZHENSHIMING DIYANYE
Deng the treatment of 2. extract orals, 3. point massage therapies.
Eyedrops on sale all contains preservative more than ninety percent on the market at present, and preservative can cause cornea, conjunctival epithelium
Coming off and being denatured for cell, causes damage.Extract oral therapy, medicine need to pass through liver detoxification, and adjoint systemic circulation, finally
Part tissue of eye is acted on, is acted, most drug effect is absorbed by other histoorgans in the process.
The content of the invention
In view of this, the invention provides a kind of Chinese medicine composition of prevention and treatment visual fatigue.
The technical scheme that it is used is as follows：A kind of Chinese medicine composition of prevention and treatment visual fatigue, including, honeysuckle, certainly
Pine torch, climbing groundsel, the seed of feather cockscomb, butterflybush flower, peppermint and borneol.
It is preferred that, include in parts by weight：4~6 parts of honeysuckle, 3.5~5 parts of cassia seed, 2~4 parts of climbing groundsel, the seed of feather cockscomb
2.5~4 parts, 1.5~4 parts of butterflybush flower, 0.4~1 part of peppermint, 0.3~1 part of borneol.
It is preferred that, include in parts by weight：4.5~6 parts of honeysuckle, 4~5 parts of cassia seed, 2.5~4 parts of climbing groundsel, feather cockscomb
2.8~4 parts of son, 2~4 parts of butterflybush flower, 0.6~1 part of peppermint, 0.5~1 part of borneol.
It is preferred that, include in parts by weight：5.5~6 parts of honeysuckle, 4.5~5 parts of cassia seed, 3.5~4 parts of climbing groundsel is blue or green
3.8~4 parts of feather cockscomb, 3.6~4 parts of butterflybush flower, 0.8~1 part of peppermint, 0.9~1 part of borneol.
It is preferred that, include in parts by weight：6 parts of honeysuckle, 5 parts of cassia seed, 4 parts of climbing groundsel, 4 parts of the seed of feather cockscomb, butterflybush flower 4
Part, 1 part of peppermint, 1 part of borneol.
The invention provides a kind of eye refreshing drop for including above-mentioned Chinese medicine composition.
The invention provides a kind of preparation method for the Chinese medicine composition eye refreshing drop for preventing and treating visual fatigue, comprising following
Step：
Step 1) prepare honeysuckle, butterflybush flower extract solution：
A. distill：By weight, high-quality, fresh honeysuckle, butterflybush flower are chosen, cleans after stalk, is placed in boiler
It is interior, vapor is injected, distillation handles to obtain honeysuckle, butterflybush flower distillate；
B. microwave abstracting：Extracting honeysuckle, butterflybush flower distillate are placed in Microwave Extraction Apparatus, 10~15min of microwave treatment, mistake
Filter to obtain honeysuckle, butterflybush flower extract solution；
Step 2) prepare Chinese medicine extract
A. ultrasonic extraction：5 parts of cassia seed, 4 parts of climbing groundsel, 4 parts of the seed of feather cockscomb, 1 part of peppermint takes cleaning, impurity elimination, cooked
Medicinal material, add 300~500 parts of distilled water, immersion 3~5h after, be placed in ultrasonic extraction instrument, add 100~200 parts distillation
Water, 20~40min of ultrasonication filters to obtain Chinese medicine extract, and add 1 part of borneol；
B. concentrate：Chinese medicine extract is taken, moisture is concentrated in vacuo to below 15%, obtains Chinese medicine extract；
Step 3) mix, sterilize：
By weight, 50 parts of Chinese medicine extract, 1 part of borneol, Sodium Hyaluronate 10000ppm, vitamin B6 are taken
1000ppm, 900 parts of distilled water is placed in after being well mixed in mixer, after sterilization processing, and packaging is got product.
It is preferred that, prepared by the step (1) distills the temperature of processing for 85~100 DEG C in honeysuckle, butterflybush flower extract solution,
The time of distillation processing is 2~3h；The temperature of microwave treatment is 60~70 DEG C, and the microwave power of microwave treatment is 300~450W.
It is preferred that, the temperature that the step (2) prepares ultrasonication in Chinese medicine extract is 40~65 DEG C, at ultrasonic wave
The ultrasonic power of reason is 300~800W.
It is preferred that, the sterilization mode that sterilization processing is used in step (3) mixing, sterilizing can be ultraviolet disinfection, bar
Family name's sterilizing, any one in high-temperature short-time sterilization.
The present invention uses selected medicinal material, and the eye refreshing drop that the method being combined using tradition and modernity technique is made is sprayed on eye
Epidermis face, using transdermal drag delivery, allows pure natural draft extract component uniformly to discharge, into circumference of eyes blood vessel and tissue,
The purpose for alleviating visual fatigue is reached, the product formula technique is unique, and the effect of having one's ideas straightened out with removing nebula for improving eyesight, inducing resuscitation can be alleviated
Fatigability intraocular pressure is raised, and periocular muscle and ciliary muscular fatigue, eyes are dry and astringent, the symptom such as blurred vision, is tried through 8 to 50 years old patients
With evident in efficacy.
The selected pharmaceutical formulation of the eye refreshing drop, using pure Chinese medicine low-temperature extraction technology, prevents active ingredient because the original of temperature
Gasify caused by, the active ingredient of Chinese medicine draft is remained to greatest extent.In encapsulation process, whole sterile working, after sealing
To be disposable, without any preservative, effectively infringement of the prevention by preservative to eyes tear film and cornea.The product is sprayed on
User's eyelid, eye is directly acted on by Transdermal absorption, it is to avoid because liver detoxification function and systemic circulation metabolism cause
Effect decline, usage amount is few, and targeting, absorption efficiency high.
The product have promote circulate, Green Tea Extract, activate lachrymal gland, the effect of inducing resuscitation is sensible, thus reach improvement metabolism,
Improving eyesight, swollen, dry and astringent, tired effect of eyes acid of releiving.The product is applicable 8--50 Sui visual fatigue crowd, wide with applicable crowd,
Effect is fast, and the cycle is short (effect can be shown by spraying 9 seconds, be sprayed within every 30 minutes for height eye crowd suggestion), generation
Thank fast, effect is notable, the features such as without any side effects.
The successful exploitation of the product and application, have filled up the domestic blank for alleviating visual fatigue crowd using the formula technique.
The product is applicable crowd extensively, is particularly suitable for teenager, and to alleviating visual fatigue, pre- myopia prevention is significant；
The product uses safety, without any side effects, devoid of risk and sequelae；
The product operation is simple and easy to apply, easily popularizes, and more visual fatigue crowds can be made to be benefited；
The product clinical tests prove that, determined curative effect, total effective rate is up to more than 92%.
Embodiment
With reference to specific embodiment, the present invention is described in further detail.
Embodiment 1：A kind of Chinese medicine composition of prevention and treatment visual fatigue, 4~6 parts of honeysuckle, 3.5~5 parts of cassia seed,
2~4 parts of climbing groundsel, 2.5~4 parts of the seed of feather cockscomb, 1.5~4 parts of butterflybush flower, 0.4~1 part of peppermint, 0.3~1 part of borneol.
Embodiment 2：A kind of Chinese medicine composition of prevention and treatment visual fatigue, is included in parts by weight：Honeysuckle 4.5~6
Part, 4~5 parts of cassia seed, 2.5~4 parts of climbing groundsel, 2.8~4 parts of the seed of feather cockscomb, butterflybush flower 2~4,0.6~1 part of peppermint, borneol 0.5
~1 part.
Embodiment 3：A kind of Chinese medicine composition of prevention and treatment visual fatigue, is included in parts by weight：Honeysuckle 5.5~6
Part, 4.5~5 parts of cassia seed, 3.5~4 parts of climbing groundsel, 3.8~4 parts of the seed of feather cockscomb, butterflybush flower 3.6~4,0.8~1 part of peppermint, ice
0.9~1 part of piece.
Embodiment 4：A kind of Chinese medicine composition of prevention and treatment visual fatigue, is included in parts by weight：6 parts of honeysuckle, certainly
5 parts of pine torch, 4 parts of climbing groundsel, 4 parts of the seed of feather cockscomb, 4 parts of butterflybush flower, 1 part of peppermint, 1 part of borneol.
Embodiment 5：A kind of preparation method for the Chinese medicine composition eye refreshing drop for preventing and treating visual fatigue, includes following step
Suddenly：
Step 1) prepare honeysuckle, butterflybush flower extract solution：
A. distill：By weight, high-quality, fresh honeysuckle, butterflybush flower are chosen, cleans after stalk, is placed in boiler
It is interior, vapor is injected, distillation handles to obtain honeysuckle, butterflybush flower distillate；
B. microwave abstracting：Extracting honeysuckle, butterflybush flower distillate are placed in Microwave Extraction Apparatus, 10~15min of microwave treatment, mistake
Filter to obtain honeysuckle, butterflybush flower extract solution；
Step 2) prepare Chinese medicine extract
A. ultrasonic extraction：5 parts of cassia seed, 4 parts of climbing groundsel, 4 parts of the seed of feather cockscomb, 1 part of peppermint takes cleaning, impurity elimination, cooked
Medicinal material, add 300~500 parts of distilled water, immersion 3~5h after, be placed in ultrasonic extraction instrument, add 100~200 parts distillation
Water, 20~40min of ultrasonication filters to obtain Chinese medicine extract, and add 1 part of borneol；
B. concentrate：Chinese medicine extract is taken, moisture is concentrated in vacuo to below 15%, obtains Chinese medicine extract；
Step 3) mix, sterilize：
By weight, 50 parts of Chinese medicine extract, 1 part of borneol, Sodium Hyaluronate 10000ppm, vitamin B6 are taken
1000ppm, 900 parts of distilled water is placed in after being well mixed in mixer, after sterilization processing, and packaging is got product.
It is preferred that, prepared by the step (1) distills the temperature of processing for 85~100 DEG C in honeysuckle, butterflybush flower extract solution,
The time of distillation processing is 2~3h；The temperature of microwave treatment is 60~70 DEG C, and the microwave power of microwave treatment is 300~450W.
It is preferred that, the temperature that the step (2) prepares ultrasonication in Chinese medicine extract is 40~65 DEG C, at ultrasonic wave
The ultrasonic power of reason is 300~800W.
It is preferred that, the sterilization mode that sterilization processing is used in step (3) mixing, sterilizing can be ultraviolet disinfection, bar
Family name's sterilizing, any one in high-temperature short-time sterilization.
Embodiment 6：Therapeutic treatment is verified
Adolescent myopia patient and with typical visual fatigue symptom totally 120 240, wherein male 58 116, female
Property 62 124, age 6-14 Sui, average 10.12 ± 2.42 years old.All patients eliminate typical keratoconjunctivitis sicca, green light
The eye diseases such as eye, uveitis.
Method one：The therapy is that, to be atomized jet based on the eyelid, auxiliary integrates alleviation in Bates visual training method and regarded
Fatigue.
Method two：Using sitting, the sleeping, posture stood, close after eyes and to be atomized eye refreshing drop by Dey-Dose, be sprayed on
Eyelid surface.For alleviating swollen, dry and astringent eyes acid caused by visual fatigue, red blood silk, periocular muscle and ciliary muscular fatigue.
Method three：Using the posture sat, crouch, stood, first get into the frame of mind for work and compose oneself, loosen body, then firmly close eyes tightly, one
Close one to open, be repeated.Eye socket power during eye closing, and thought will utterly focus on the position of eye；On the contrary, to make when opening
Eye loosens as best one can, there is a kind of very comfortable sensation.It is 5 minutes or so the time taken exercise every time, daily minimum three or four times.
Therapeutic evaluation is as follows：Two groups of therapeutic effects are contrasted after treatment：
Fill in visual fatigue questionnaire table, to eye symptom (foreign body sensation, burn feeling is dry and astringent, photophobia, shed tears, eye distending pain
Deng) registered, with without (0), light (1), in (2), weight (3) is classified, statistics integrated value, visual fatigue symptom index (n)=
Integration × 100%, n >=70% is effective before integration/treatment after integration-treatment before treatment；30%≤n<70% is effective；n<
30% is invalid, effective+effective=improvement.
Above-mentioned all data are handled through SPSS17.0 statistical analyses.
The result：
Take " visual training of aerosol therapy combination Bates " method to alleviate visual fatigue clinical efficacy significantly, may be current state
A kind of inside and outside most effective method for alleviating visual fatigue.This group of patients with dry eye treatment backsight fatigue symptom has clear improvement, wherein
Effective 99, effective 12, total improvement rate is up to 92.5%.
Conclusion：In terms of this group of large sample quantifier elimination and visual fatigue and treating effect, this method curative effect is distinguished, and success rate is high,
Have in 120 99 it is effective, total improvement rate is up to 92.5%.This research curative effect has notable statistics to anticipate through statistical analysis
Justice.Men and women, which obtains visual fatigue rate, certain gap, but therapeutic effect no significant difference.This also indicates that spraying eye refreshing drop is used to delay
Solving visual fatigue can raise to effectively improve by improvement metabolism, regulation eye muscle contractility, activation lachrymal gland, reduction fatigability intraocular pressure
Eyesight.By the analysis of statistical data of this research, and contrast other various therapies for alleviating visual fatigue, it is believed that, spraying shield
Ocular fluid can be considered presently the most effective method for alleviating visual fatigue.
Embodiment of above is merely illustrative of the technical solution of the present invention and unrestricted, although with reference to embodiment of above pair
The present invention is described in detail, it will be understood by those within the art that, technical scheme can be carried out
Modification or equivalent substitution should not all depart from the spirit and scope of technical solution of the present invention.
Claims (10)
1. a kind of Chinese medicine composition of prevention and treatment visual fatigue, it is characterised in that including, honeysuckle, cassia seed, climbing groundsel,
The seed of feather cockscomb, butterflybush flower, peppermint and borneol.
2. Chinese medicine composition according to claim 1, it is characterised in that include in parts by weight：4~6 parts of honeysuckle, certainly
3.5~5 parts of pine torch, 2~4 parts of climbing groundsel, 2.5~4 parts of the seed of feather cockscomb, 1.5~4 parts of butterflybush flower, 0.4~1 part of peppermint, borneol 0.3
~1 part.
3. Chinese medicine composition according to claim 1, it is characterised in that include in parts by weight：4.5~6 parts of honeysuckle,
4~5 parts of cassia seed, 2.5~4 parts of climbing groundsel, 2.8~4 parts of the seed of feather cockscomb, 2~4 parts of butterflybush flower, 0.6~1 part of peppermint, borneol 0.5
~1 part.
4. Chinese medicine composition according to claim 1, it is characterised in that include in parts by weight：5.5~6 parts of honeysuckle,
4.5~5 parts of cassia seed, 3.5~4 parts of climbing groundsel, 3.8~4 parts of the seed of feather cockscomb, 3.6~4 parts of butterflybush flower, 0.8~1 part of peppermint, borneol
0.9~1 part.
5. Chinese medicine composition according to claim 1, it is characterised in that include in parts by weight：6 parts of honeysuckle, Cassia
5 parts of son, 4 parts of climbing groundsel, the seed of feather cockscomb 4, butterflybush flower 4,1 part of peppermint, 1 part of borneol.
6. include the eye refreshing drop of any one of the Claims 1 to 5 Chinese medicine composition.
7. a kind of preparation method for the Chinese medicine composition eye refreshing drop for preventing and treating visual fatigue, is comprised the steps of：
Step 1) prepare honeysuckle, butterflybush flower extract solution：
A. distill：By weight, high-quality, fresh honeysuckle, butterflybush flower are chosen, cleans after stalk, is placed in boiler, is noted
Enter vapor, distillation handles to obtain honeysuckle, butterflybush flower distillate；
B. microwave abstracting：Extracting honeysuckle, butterflybush flower distillate are placed in Microwave Extraction Apparatus, and 10~15min of microwave treatment is filtered
Honeysuckle, butterflybush flower extract solution；
Step 2) prepare Chinese medicine extract
A. ultrasonic extraction：5 parts of cassia seed, 4 parts of climbing groundsel, 4 parts of the seed of feather cockscomb, 1 part of peppermint takes cleaning, impurity elimination, the medicine cooked
Material, adds after 300~500 parts of distilled water, 3~5h of immersion, is placed in ultrasonic extraction instrument, adds 100~200 parts of distilled water,
20~40min of ultrasonication, filters to obtain Chinese medicine extract, and add 1 part of borneol；
B. concentrate：Chinese medicine extract is taken, moisture is concentrated in vacuo to below 15%, obtains Chinese medicine extract；
Step 3) mix, sterilize：
By weight, 50 parts of Chinese medicine extract is taken, 1 part of borneol, Sodium Hyaluronate 10000ppm, vitamin B6 1000ppm,
900 parts of distilled water, is placed in after being well mixed in mixer, after sterilization processing, and packaging is got product.
8. method according to claim 7, it is characterised in that the step (1) is prepared in honeysuckle, butterflybush flower extract solution
The temperature of distillation processing is 85~100 DEG C, and the time of distillation processing is 2~3h；The temperature of microwave treatment is 60~70 DEG C, microwave
The microwave power of processing is 300~450W.
9. method according to claim 7, it is characterised in that the step (2) is prepared in Chinese medicine extract at ultrasonic wave
The temperature of reason is 40~65 DEG C, and the ultrasonic power of ultrasonication is 300~800W.
10. method according to claim 7, it is characterised in that sterilization processing is used in step (3) mixing, sterilizing
Sterilization mode can be ultraviolet disinfection, pasteurization, high-temperature short-time sterilization in any one.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108904593A (en) * | 2018-07-12 | 2018-11-30 | 云南大理瑞鹤药业有限公司 | Bear gall health mesh eye drops and preparation method thereof |
| CN109467998A (en) * | 2018-11-20 | 2019-03-15 | 四川德程建设有限公司 | A kind of furniture paint to refresh the mind |
| CN110478383A (en) * | 2019-09-27 | 2019-11-22 | 王琪烨 | A kind of shield pupil liquid, preparation method and application |
| CN110898159A (en) * | 2019-12-31 | 2020-03-24 | 马云 | External eye-protecting traditional Chinese medicine extract paste |
| CN110946928A (en) * | 2019-12-26 | 2020-04-03 | 广东暨晴生物医药科技有限公司 | Natural plant eye spray and preparation method thereof |
| CN111265587A (en) * | 2019-12-23 | 2020-06-12 | 北京椿生宇生物科技有限公司 | A Chinese medicinal composition with eyesight improving and tonic effects |
| CN113491734A (en) * | 2021-07-13 | 2021-10-12 | 昆山市中医医院 | Traditional Chinese medicine formula for relieving eye fatigue |
| CN113713052A (en) * | 2021-09-16 | 2021-11-30 | 天津儒益康中医药科技有限公司 | Eyeball bright eye conditioning nutrient solution cream and preparation method thereof |
| CN116832108A (en) * | 2023-02-23 | 2023-10-03 | 合壹视力 (湖北) 实业股份有限公司 | Traditional Chinese medicine composition for preventing and treating eye diseases, eye drops and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108904593A (en) * | 2018-07-12 | 2018-11-30 | 云南大理瑞鹤药业有限公司 | Bear gall health mesh eye drops and preparation method thereof |
| CN109467998A (en) * | 2018-11-20 | 2019-03-15 | 四川德程建设有限公司 | A kind of furniture paint to refresh the mind |
| CN110478383A (en) * | 2019-09-27 | 2019-11-22 | 王琪烨 | A kind of shield pupil liquid, preparation method and application |
| CN111265587A (en) * | 2019-12-23 | 2020-06-12 | 北京椿生宇生物科技有限公司 | A Chinese medicinal composition with eyesight improving and tonic effects |
| CN110946928A (en) * | 2019-12-26 | 2020-04-03 | 广东暨晴生物医药科技有限公司 | Natural plant eye spray and preparation method thereof |
| CN110898159A (en) * | 2019-12-31 | 2020-03-24 | 马云 | External eye-protecting traditional Chinese medicine extract paste |
| CN113491734A (en) * | 2021-07-13 | 2021-10-12 | 昆山市中医医院 | Traditional Chinese medicine formula for relieving eye fatigue |
| CN113713052A (en) * | 2021-09-16 | 2021-11-30 | 天津儒益康中医药科技有限公司 | Eyeball bright eye conditioning nutrient solution cream and preparation method thereof |
| CN116832108A (en) * | 2023-02-23 | 2023-10-03 | 合壹视力 (湖北) 实业股份有限公司 | Traditional Chinese medicine composition for preventing and treating eye diseases, eye drops and preparation method |
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