CN109010572A - A kind of Chinese medicine composition and its preparation method and application with sun-proof synergy and anti-aging effects - Google Patents
A kind of Chinese medicine composition and its preparation method and application with sun-proof synergy and anti-aging effects Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The present invention relates to a kind of Chinese medicine composition and its preparation method and application, the raw material for preparing of the Chinese medicine composition is composed of the following parts by weight: 20-30 parts of sunflower, 15-25 parts of chamomile, 15-25 parts of aloe, 5-15 parts of rosemary, 5-10 parts of peppermint, 5-10 parts of sweet mary.Chinese medicine composition reasonable component formula of the invention, can be synergistic, can not only delay scytitis problem caused by being irradiated by ultraviolet light, has apparent anti-sunlight function, while energy scavenging hydroxyl, has significant senile-resistant efficacy.The Chinese medicine composition is applied in cosmetics, the product property being prepared is stablized, and has higher SPF and PFA value relative to traditional sunscreen product, and mildness is more preferable.
Description
Technical field
The invention belongs to the field of Chinese medicines, it is related to a kind of Chinese medicine composition and its preparation method and application, more particularly to a kind of
Chinese medicine composition and its preparation method and application with sun-proof synergy and anti-aging effects.
Background technique
Skin aging is the irreversible natural phenomena of human body, and there are many external and inherent influence factors, wherein ultraviolet light
It is that the obscure aging of skin and skin surface is caused to form one of the principal element of spot, only carries out ultraviolet protection, it is effectively pre-
The excessive generation of anti-melanin could retain youth moist at the moment.Ultraviolet spectrogram in daylight is in 200-400nm wavelength model
It encloses, 3 wave bands can be divided into, is i.e. wavelength is the short wave ultraviolet (UVC) of 200-290nm, and wavelength is that the medium wave of 290-320nm is ultraviolet
The long wave ultraviolet (UVA) that line (UVB) and wavelength are 320-400nm.The ultraviolet light of different wave length, the depth for penetrating skin is not
With, UVC penetration capacity is poor, and the UVC in daylight is almost fully absorbed by ozone layer, ground cannot be reached, it can be said that
Human body is not injured；And UVA have very strong penetration power, daily skin contact to 95% or more ultraviolet light be UVA,
UVA can penetrate epidermis " attack " skin corium, and ossein and elastin laminin in skin is enabled to be inflicted heavy losses on, and dermal cell is protected self
Shield ability is poor, and minimal amount of UVA just can cause great damage to it, and over time, skin generates loose, wrinkle, color spot etc.
Problem；The lipid layer that UVB can then have epidermis protective effect aoxidizes, and so that skin is dried out, further then makes the core in epidermal cell
Acid and protein denaturation generate the symptoms such as erythrosis, sore, acute dermatitis (tanning severely), when serious, are also easy to lead to skin
Canceration.Therefore, antitan agent has attracted extensive attention.
In addition to ultraviolet light factor, the free radical generated in cell normal metabolic processes be also accelerate skin aging factor it
One.The aging course of organism is the accumulation that the histocyte of body constantly generates free radicals as a result, free radical is eubolism
Intermediate product, respond is very strong, many kinds of substance in cell can be made to aoxidize, damage biomembrane, additionally it is possible to make egg
The macromolecules cross-linkings such as white matter, nucleic acid influence its normal function, and most active and toxicity is maximum for hydroxyl freedom in body free radical
Base.For skin anti-aging, removes free radical and ultraviolet protection is of equal importance.
The ultraviolet protection of sunscreen cosmetic on the market is based primarily upon physical protection, chemical protection or physico at present
Protection is learned to combine.The principle of physical protection is reflection, scatters ultraviolet, its advantage is that light is stable, protective range is wide, molecular weight
Greatly, it and is not absorbed by the skin, it is comparatively safe for sensitive skin, the disadvantage is that general quality is more thick and heavy, it is easy after smearing general
It is white, and protective capacities is relatively weak；Chemical protection then passes through absorption ultraviolet light, converts light energy into thermal energy, fluorescence or phosphorescence,
Advantage be it is strong to the UV protection ability of a certain wave-length coverage, quality is frivolous, be partially soluble in water, the disadvantage is that molecular weight is small,
Skin can be penetrated into, is potentially dangerous to skin, free radical, photosensitization, contact atopic dermatitis, cancer cell hyperplasia etc. may be caused and permitted
More skin problems, while light degradation easily occurs, chemical sun is reduced to the assimilation effect of ultraviolet light.In addition to above-mentioned deficiency, mesh
The also less injury for considering free radical to skin of preceding sunscreen product on the market, and anti-aging product is often ignored to ultraviolet
The protection of line.
CN102973471B discloses a kind of anti-aging suncream containing natural plant active component, natural plant active at
Divide includes Ampelopsis grossedentata extrat, licorice and camellia seed oil.This suncream has wide spectrum, stable strong absorption to imitate ultraviolet light
Fruit especially has strong assimilation effect to ultraviolet (UV) A.
CN105581955A discloses that a kind of food grade is crease-resistant, anti-aging suncream, and ingredient includes pure natural natural ox
Milk, pure natural olive oil, glycerol, monoglyceride, fresh cacumen biotae, fresh purslane, fresh-rose, fresh Fructus Forsythiae, pearl powder, peppermint, chicken
Blood rattan, Radix Astragali, radix pseudostellariae etc., Radix Astragali, radix pseudostellariae, Caulis Spatholobi three cooperate, can sun-proof, anti-color spot, solar control
Dermatitis, Radix Astragali are green blood tonifying Qi in Chinese medicine, and effect has good sun-proof result on the skin, and compatibility other drugs reach sun-proof
The effect of anti-aging.
CN108125861A discloses a kind of whitening anti-aging composition, including sun-screening agent, antioxidant, moisturizer at
Point, wherein moisturizer can lock skin moisture, supplement skin collagen, the aging of delaying skin, sun-screening agent can be resisted ultraviolet
Line, antioxidant can remove free radical, reduce oxidative damage, and reduce pigment deposition, this composition can be sent out to a certain extent
Wave the effect of whitening anti-aging.
To sum up, it for Related product in the market and the deficiencies in the prior art, develops a kind of while there is sun-proof synergy and resist
The Chinese medicine composition of aging effect, and it is necessary for being applied to cosmetic field.
Summary of the invention
In view of the problems of the existing technology, the purpose of the present invention is to provide a kind of Chinese medicine compositions and preparation method thereof
And application, a kind of Chinese medicine composition and its preparation method and application with sun-proof synergy and anti-aging effects is especially provided.
In order to achieve that object of the invention, the invention adopts the following technical scheme:
On the one hand, the present invention provides a kind of Chinese medicine composition, and the Chinese medicine composition prepares raw material by following parts by weight
Several groups are grouped as: 20-30 parts of sunflower, 15-25 parts of chamomile, 15-25 parts of aloe, 5-15 parts of rosemary, 5-10 parts of peppermint,
5-10 parts of sweet mary.
Wherein, sunflower is monarch drug in a prescription, i.e. main ingredient, is most important part in prescription, is embodied in dosage also as maximum.To
Ingredients, the Chinese medicines such as day certain herbaceous plants with big flowers active material rich in such as polysaccharide, pectin, chlorogenic acid and flavonoids think sunflower nature and flavor
It is sweet, flat, it is nontoxic, there is the effect of calming the liver wind-dispelling, clearing away damp-heat, the stagnant gas that disappears.Modern Dermatology test result shows that sunflower is living
Property ingredient be used for human skin, have the function of skin barrier maintenance.Sun-proof most important as maintenance ultraviolet light irradiation causes
Skin barrier destruction, skin barrier system is established, could exciting human most original resilience.Therefore, sunflower
Content in each component content highest, the maintenance effect of skin barrier is adversely affected less than 20 parts.
Chamomile, aloe are ministerial drug.Ultraviolet light irradiation can also cause scytitis reaction, dehydration and response to oxidative stress
(free radical generation), therefore also need anti-inflammatory, moisturizing moisturizing and chamomile and the aloe ingredient of removing free radical.Chamomile is rich
Active component containing flavones, Chinese medicine think chamomile nature and flavor slight bitter, Gan Xiang, and irascibility is moved back in energy improving eyesight, and treatment insomnia reduces blood pressure,
It can invigorate, refresh oneself.Modern Dermatology test result shows that chamomile active constituent has good Shu Min, maintenance quick
Feel skin, anti-inflammatory and anti-oxidation efficacy；The principle active component of aloe is the substances such as aloin, polysaccharide, and Chinese medicine thinks aloe property
It is bitter, cold, there is the effect of removing heat from the liver, defaecation." book on Chinese herbal medicine is new again " thinks that aloe controls irascibility, and town liver wind, clear away heart-fire heat, and solution is vexed, only
It promotes the production of body fluid yearningly, hearing-improing and eyesight improving, the tooth that disappears is swollen, solves fire toxin.Modern Dermatology test result shows that there is aloe anti-aging, calmness to relax
Effect that is slow, anti-inflammatory, promoting healing and moisten.Therefore, play the second efficacy effect chamomile and aloe dosage be lower than to
Day certain herbaceous plants with big flowers, but it is higher than rosemary, peppermint and sweet mary.
Rosemary is adjutant, and main component is rosmanol and Flavonoid substances, supplement to the Herbal think its property it is pungent,
It is warm, nontoxic, have the function of tranquilizing and allaying excitement, restoring consciouness, promote blood circulation.
Peppermint, sweet mary are to make medicine, and the main component of peppermint is menthol, and the main component of sweet mary is citral, sinks
The effect of ingredients such as aromatic, geraniol, class flavine and triterpene, having makes product flavouring, anti-inflammatory, antibacterial.
Chinese medicine composition of the invention contains there are many sun-proof synergy and aging ingredient, and reasonable component formula can cooperate with increasing
Effect.The cosmetic property being prepared is mild, and sun-proof synergy and anti-aging effects are significant.
In the present invention, the raw material for preparing of the Chinese medicine composition is composed of the following parts by weight: sunflower 25-
30 parts, 20-25 parts of chamomile, 20-25 parts of aloe, 10-15 parts of rosemary, 5-10 parts of peppermint, 5-10 parts of sweet mary.
Preferably, the raw material for preparing of the Chinese medicine composition is composed of the following parts by weight: 30 parts of sunflower, ocean
25 parts of camomile, 25 parts of aloe, 10 parts of rosemary, 5 parts of peppermint, 5 parts of sweet mary.
Preferably, the raw material for preparing of the Chinese medicine composition is composed of the following parts by weight: 30 parts of sunflower, ocean
20 parts of camomile, 20 parts of aloe, 10 parts of rosemary, 10 parts of peppermint, 10 parts of sweet mary.
Preferably, the raw material for preparing of the Chinese medicine composition is composed of the following parts by weight: 25 parts of sunflower, ocean
25 parts of camomile, 20 parts of aloe, 15 parts of rosemary, 10 parts of peppermint, 5 parts of sweet mary.
Preferably, the raw material for preparing of the Chinese medicine composition is composed of the following parts by weight: 25 parts of sunflower, ocean
20 parts of camomile, 25 parts of aloe, 15 parts of rosemary, 5 parts of peppermint, 10 parts of sweet mary.
On the other hand, the present invention also provides a kind of preparation methods of Chinese medicine composition as described above, comprising the following steps:
(1) medicinal material pre-processes: the raw material for preparing of Chinese medicine composition being broken into powder respectively, is then mixed
Powder；
(2) homogeneous extracts: the mixed-powder that step (1) obtains being placed in high pressure homogenizer, Extraction solvent is added, is carried out
It is high-pressure homogeneous, obtain extracting solution；
(3) it concentrates and purifies: by extracting solution filtering with microporous membrane that step (2) obtains and being concentrated, obtain concentrate,
Macroporous resin column on the concentrate is eluted, eluent is collected, decoloration and miillpore filter mistake are carried out to the eluent
Filter, obtains medical fluid；
(4) it is concentrated and dried: the medical fluid that step (3) obtains being concentrated and is dried in vacuo, the Chinese medicine composition is obtained.
In the present invention, the size of step (1) described powder is 100-200 mesh, such as 100 mesh, 120 mesh, 140 mesh, 150
Mesh, 160 mesh, 180 mesh or 200 mesh etc..
Step (2) Extraction solvent is the ethanol water of water or/and 30-95%, for example, 30%, 35%, 40%,
45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90% or 95% etc..
Preferably, the dosage of the Extraction solvent is 10-40 times of the mixed-powder weight, such as 10 times, 12 times, 15
Again, 20 times, 25 times, 30 times, 35 times or 40 times etc..
Preferably, step (2) the high-pressure homogeneous time be 5-30min, such as 5min, 10min, 15min, 20min,
25min or 30min etc..
Preferably, step (2) the high-pressure homogeneous pressure be 10-30MPa, such as 10MPa, 15MPa, 20MPa,
25MPa or 30MPa etc..
In the present invention, the specific steps of step (3) described concentrating and purifying are as follows: by extracting solution miillpore filter mistake
Filter, filtrate is concentrated through reverse osmosis membrane, obtains concentrate, by macroporous resin column on the concentrate, be washed to it is colourless after, then use second
It is colourless that alcoholic solution be eluted to eluent, collects eluent, the active carbon decoloring of the eluent, then with miillpore filter mistake
Filter, obtains medical fluid.
Preferably, the aperture of the miillpore filter is 0.2-0.5 μm, such as 0.2 μm, 0.3 μm, 0.4 μm or 0.5 μm etc..
Preferably, the pressure of reverse osmosis membrane concentration is 5-30bar, for example, 5bar, 10bar, 15bar, 20bar,
25bar or 30bar etc..
Preferably, step (3) it is described concentration for be concentrated into be concentrated before filtrate volume 10-30%, such as 10%, 15%,
20%, 25% or 30% etc..
Preferably, the model D101 or AB-8 of the macroporous resin column.
Preferably, the concentration of step (3) described ethanol solution be 30-85%, such as 30%, 35%, 40%, 45%,
50%, 55%, 60%, 65%, 70%, 75%, 80% or 85% etc..
Preferably, mass-volume concentration of the active carbon in eluent be 1-10% (W/V), such as 1%, 2%,
5%, 8% or 10% etc..
In the present invention, step (4) is described medical fluid is concentrated after weight and step (1) described mixed-powder weight
Amount is than being 1:2-1:5, such as 1:2,1:2.5,1:3,1:3.5,1:4,1:4.5 or 1:5 etc..
Preferably, step (4) the vacuum drying temperature is 45-65 DEG C, such as 45 DEG C, 50 DEG C, 55 DEG C, 60 or 65 DEG C
Deng.
As the preferred technical solution of the present invention, the preparation method specifically includes the following steps:
(1) medicinal material pre-processes: the raw material for preparing of Chinese medicine composition being broken into 100-200 mesh powder respectively, is then mixed
Uniformly obtain mixed-powder；
(2) homogeneous extracts: the mixed-powder that step (1) obtains being placed in high pressure homogenizer, it is described mixed that dosage, which is added,
The Extraction solvent for closing 10-40 times of powder weight, carries out high-pressure homogeneous 5-30min, pressure 10-30MPa obtains extracting solution；
(3) it concentrates and purifies: 0.2-0.5 μm of filtering with microporous membrane of the extracting solution that step (2) is obtained, by filtrate through reverse osmosis
Permeable membrane concentration, pressure 5-30bar are concentrated into the 10-30% of filtrate volume before being concentrated, concentrate are obtained, by the concentrate
The macroporous resin column of upper model D101 or AB-8, be washed to it is colourless after, then with the ethanol solution of 30-85% be eluted to
De- liquid is colourless, collects eluent, the active carbon decoloring of the eluent, then with 0.2-0.5 μm of filtering with microporous membrane, obtains medicine
Liquid；
(4) it is concentrated and dried: carrying out the medical fluid that step (3) obtains to be concentrated into weight and the weight ratio of the mixed-powder is
1:2-1:5, then be dried in vacuo at 45-65 DEG C, obtain the Chinese medicine composition.
On the other hand, the present invention also provides a kind of cosmetics, comprising as described above in the raw material composition of the cosmetics
Chinese medicine composition.
In the present invention, additive amount of the Chinese medicine composition in cosmetics be 0.1-20%, such as 0.1%,
0.5%, 1%, 2%, 5%, 8%, 10%, 15% or 20% etc., preferably 0.1-5%.
The cosmetics can also add usually as suitably desired other than comprising Chinese medicine composition as described above
The ingredient used in cosmetics, for example, the matrix components such as moisturizer, surfactant, emollient, preservative, water.
Compared with the existing technology, the invention has the following advantages:
Chinese medicine composition reasonable component formula of the invention, can be synergistic, can not only delay to be caused by ultraviolet light irradiation
Scytitis problem, have apparent anti-sunlight function, while can scavenging hydroxyl, have significant senile-resistant efficacy.It will
The Chinese medicine composition is applied in cosmetics, and the product property being prepared is stablized, and has relative to traditional sunscreen product higher
SPF and PFA value, and mildness is more preferable.
Detailed description of the invention
Fig. 1 be sun-proof result evaluation test result statistical chart, wherein the number marked in each cylindricality represent its spf value or
PFA value；
Fig. 2 be consumer sensory's evaluation test result statistical chart, wherein the number marked in each cylindricality represent it is corresponding
Number.
Specific embodiment
The technical scheme of the invention is further explained by means of specific implementation.Those skilled in the art should be bright
, the described embodiments are merely helpful in understanding the present invention, should not be regarded as a specific limitation of the invention.
Embodiment 1
The present embodiment provides a kind of Chinese medicine composition with sun-proof synergy and anti-aging effects, the Chinese medicine composition
Prepare raw material to be composed of the following parts by weight: 30 parts of sunflower, 25 parts of chamomile, 25 parts of aloe, 10 parts of peppermint, fan change
It is 5 parts, 5 parts of sweet mary fragrant.
Preparation method includes the following steps:
The raw material for preparing of above-mentioned Chinese medicine composition is broken into 100 mesh powder, is then uniformly mixed and obtains mixed-powder, will mix
It closes powder to be placed in high pressure homogenizer, the pure water that dosage is 10 times of the mixed-powder weight is added, carries out high-pressure homogeneous
30min, pressure 20MPa, obtains extracting solution.By 0.3 μm of filtering with microporous membrane of obtained extracting solution, by filtrate through RO reverse osmosis
Permeable membrane concentration, pressure 10bar are concentrated into 10% of filtrate volume before being concentrated, by model D101 on obtained concentrate
Macroporous resin column, be washed to it is colourless after, then with 30% ethanol solution be eluted to eluent colourless, collects eluent, institute
It states the eluent active carbon decoloring of 5% (W/V), then with 0.3 μm of filtering with microporous membrane, obtains medical fluid, medical fluid is concentrated into
Weight and the weight ratio of the mixed-powder are 1:2, are finally dried in vacuo at 65 DEG C, obtain the Chinese medicine composition.
Embodiment 2
The present embodiment provides a kind of Chinese medicine composition with sun-proof synergy and anti-aging effects, the Chinese medicine composition
Prepare raw material to be composed of the following parts by weight: 30 parts of sunflower, 20 parts of chamomile, 20 parts of aloe, 10 parts of peppermint, fan change
It is 10 parts, 10 parts of sweet mary fragrant.
Preparation method includes the following steps:
The raw material for preparing of above-mentioned Chinese medicine composition is broken into 150 mesh powder, is then uniformly mixed and obtains mixed-powder, will mix
It closes powder to be placed in high pressure homogenizer, 30% ethanol water that dosage is 12 times of the mixed-powder weight is added, carry out high
Homogeneous 15min, pressure 30MPa is pressed to obtain extracting solution.By 0.2 μm of filtering with microporous membrane of obtained extracting solution, filtrate is passed through
The concentration of RO reverse osmosis membrane, pressure 20bar are concentrated into 15% of filtrate volume before being concentrated, by model on obtained concentrate
The macroporous resin column of AB-8, be washed to it is colourless after, then with 40% ethanol solution be eluted to eluent colourless, collects elution
Liquid, the eluent active carbon decoloring of 8% (W/V), then with 0.2 μm of filtering with microporous membrane, obtain medical fluid, medical fluid is carried out dense
The weight ratio for being reduced to weight and the mixed-powder is 1:4, is finally dried in vacuo at 60 DEG C, obtains the Chinese medicine composition.
Embodiment 3
The present embodiment provides a kind of Chinese medicine composition with sun-proof synergy and anti-aging effects, the Chinese medicine composition
Prepare raw material to be composed of the following parts by weight: 25 parts of sunflower, 25 parts of chamomile, 20 parts of aloe, 15 parts of peppermint, fan change
It is 10 parts, 5 parts of sweet mary fragrant.
Preparation method includes the following steps:
The raw material for preparing of above-mentioned Chinese medicine composition is broken into 200 mesh powder, is then uniformly mixed and obtains mixed-powder, will mix
It closes powder to be placed in high pressure homogenizer, 70% ethanol water that dosage is 20 times of the mixed-powder weight is added, carry out high
Homogeneous 10min, pressure 30MPa is pressed to obtain extracting solution.By 0.5 μm of filtering with microporous membrane of obtained extracting solution, filtrate is passed through
The concentration of RO reverse osmosis membrane, pressure 30bar are concentrated into 30% of filtrate volume before being concentrated, by model on obtained concentrate
The macroporous resin column of D101, be washed to it is colourless after, then with 70% ethanol solution be eluted to eluent colourless, collects elution
Liquid, the eluent active carbon decoloring of 10% (W/V), then with 0.5 μm of filtering with microporous membrane, obtain medical fluid, medical fluid is carried out
The weight ratio for being concentrated into weight and the mixed-powder is 1:5, is finally dried in vacuo at 60 DEG C, obtains the Chinese traditional medicine composition
Object.
Embodiment 4
The present embodiment provides a kind of Chinese medicine composition with sun-proof synergy and anti-aging effects, the Chinese medicine composition
It prepares raw material to be composed of the following parts by weight: 25 parts of sunflower, 20 parts of chamomile, 25 parts of aloe, 15 parts of rosemary, thin
5 parts of lotus, 10 parts of sweet mary.
Preparation method includes the following steps:
The raw material for preparing of above-mentioned Chinese medicine composition is broken into 200 mesh powder, is then uniformly mixed and obtains mixed-powder, will mix
It closes powder to be placed in high pressure homogenizer, 50% ethanol water that dosage is 40 times of the mixed-powder weight is added, carry out high
Homogeneous 30min, pressure 10MPa is pressed to obtain extracting solution.By 0.4 μm of filtering with microporous membrane of obtained extracting solution, filtrate is passed through
The concentration of RO reverse osmosis membrane, pressure 5bar are concentrated into 20% of filtrate volume before being concentrated, by model on obtained concentrate
The macroporous resin column of AB-8, be washed to it is colourless after, then with 50% ethanol solution be eluted to eluent colourless, collects elution
Liquid, the eluent active carbon decoloring of 7% (W/V), then with 0.4 μm of filtering with microporous membrane, obtain medical fluid, medical fluid is carried out dense
The weight ratio for being reduced to weight and the mixed-powder is 1:3, is finally dried in vacuo at 65 DEG C, obtains the Chinese medicine composition.
Comparative example 1-6
Comparative example 1-6 provides the Chinese medical extract of 6 kinds of one-components, respectively comparative example 1 (Helianthi extract), right
Ratio 2 (camomile extract), comparative example 3 (aloe extract), comparative example 4 (mint extract), (rosemary mentions comparative example 5
Take object), comparative example 6 (sweet mary extract).Preparation method is same as Example 1.
Embodiment 5-8
The present embodiment provides 4 kinds suncream with sun-proof synergy and anti-aging effects, the constituent of the suncream
As shown in table 1.
Preparation method includes the following steps:
A phase raw material and water are mixed and heated to 80 DEG C, are dispersed with stirring uniformly, for use；B phase raw material is mixed and heated to 80
DEG C, stirring and dissolving is uniform, for use；Pumping A phase raw material enters B phase and carries out emulsifying, cools down after emulsification；Add after being cooled to 45 DEG C
Enter C phase raw material, is dispersed with stirring uniformly, vacuumizing and defoaming obtains the suncream.Wherein the Chinese medicine composition in C phase raw material is
Embodiment 1-4 Chinese medicine composition, respectively corresponds
Embodiment 5-8.
Table 1
Comparative example 7-13
Comparative example 7-13 provides 7 kinds of suncreams with sun-proof synergy and anti-aging effects, with the composition of embodiment 5 at
Chinese medicine composition is only replaced with the Chinese medical extract of one-component made from comparative example 1-6 or not added any by split-phase ratio
(aloe is extracted for traditional Chinese medicinal components, respectively comparative example 1 (Helianthi extract), comparative example 2 (camomile extract), comparative example 3
Object), comparative example 4 (mint extract), comparative example 5 (Rosmarinus officinalis extract), comparative example 6 (sweet mary extract), comparative example 7
(not adding any traditional Chinese medicinal components).Preparation method is same as Example 5.
Embodiment 9
Hydroxyl radical-scavenging effect test:
By Chinese medicine composition made from embodiment 1-4, the Chinese medical extract of one-component made from comparative example 1-6 is spent
Ionized water is configured to sample solution, is purged hydroxy radical effect test, and test method is as follows:
Sample sets, sample controls group, blank control group are set, and configure each group reaction solution, the group of each group reaction solution
Divide and content is as shown in table 2；It is taken out after being placed in 37 DEG C of heating water bath 15min after reaction solution is shaken up, with ultraviolet-visible point
Absorbance value of the light photometric determination solution at 510nm.
Table 2
The calculation formula of Scavenging action to hydroxyl free radical is as follows:
In formula, ABlank control group、ASample sets、ASample controls groupThe respectively absorbance of blank control group, sample sets and sample controls group
Value.
Test result is as shown in table 3:
Table 3
| Sample ID | Clearance rate/% of hydroxy radical |
| Embodiment 1 | 98.61 |
| Embodiment 2 | 97.69 |
| Embodiment 3 | 98.47 |
| Embodiment 4 | 96.57 |
| Comparative example 1 | 95.96 |
| Comparative example 2 | 97.64 |
| Comparative example 3 | 91.67 |
| Comparative example 4 | 94.97 |
| Comparative example 5 | 94.99 |
| Comparative example 6 | 86.41 |
According to above-mentioned test result it is found that Chinese medicine composition made from embodiment 1-4 is bright to the elimination effect of hydroxy radical
It is aobvious, illustrate to produce unexpected synergistic function by compounding.
Embodiment 10
Sun-proof result evaluation test:
Suncream made from embodiment 5-8, comparative example 7-13 is chosen to carry out sun-proof result evaluation test, according to " makeup
Product technical specification of security " (2015 editions) sunscreen cosmetic SPF test method (human body method) test product sun-proof result, with
SPF (SPF) and sunscreen cosmetic long wave ultraviolet protection index (PFA value) are used as evaluation index.
SPF (SPF): also referred to as sun protection coefficient shows the height for the sun-proof efficiency that sun-proof articles can play
It is low.Spf value is bigger, better to the protection effect of UVB.It is according to the minimum Erythema Dose (MED) of skin come what is determined.It uses
After sun-proof articles, the minimum Erythema Dose of skin can increase, then the sun protection factor SPF of the sun-proof articles is then are as follows:
Sunscreen cosmetic long wave ultraviolet protection index (PFA value): also referred to as UVA protection index.UVA is irradiated to skin in daylight
Skin, the main physiological effect for generating skin melanism, the effect are measured with minimal persistent pigment dose (MPPD), and MPPD is spoke
According to rear 2-4h when generating minimum ultraviolet irradiation dosage needed for slight melanism or most short irradiation on entire irradiated site skin
Between, the PFA of sun-proof articles is then are as follows:
Test result is as shown in Figure 1.
According to Fig. 1 result it is found that being added to the embodiment 5-8 of the Chinese medicine composition of 1-4 of the embodiment of the present invention, compared to not adding
Add the comparative example 13 of any traditional Chinese medicinal components, SPF and PFA value has preferable promotion；It is added to one-component Chinese medicine extract
Comparative example 7-12, SPF and PFA value all have promotion, but both less than embodiment 5-8 compared with comparative example 13.Illustrate by science compounding
The traditional chinese medicine composition of the invention, produce significant sun-proof synergistic effect, and tradition chemical sun excitatory can be reduced
Dosage.
Embodiment 11
Skin irritation evaluation test:
Suncream made from embodiment 5-8, comparative example 13 is chosen to carry out skin irritation evaluation test, test method is such as
Under:
Using 20 women and 10 males as subjects, 0.03mL sample is taken to be placed in the coyote hole that spot tries adhesive tape with syringe
It is interior, the spot for being equipped with sample examination adhesive tape longitudinal direction since lower part is affixed on the normal skin of subject's left forearm immediately, while by
A light pressing room keeps sample distribution uniform to drive away air.Experiment position marks, to observe.It was pasted every 24 hours
Skin is primary, opens half an hour after patch, is checked according to the term of CTFA guide, has carried out 6 patch experiments altogether.Paste skin
After the 6th day, in order to observe delayed response, carried out additional inspection, data then utilize last time inspection result, carry out
Compare.
The standard of perfection of skin irritation test is as shown in table 4:
Table 4
Test result is as shown in table 5:
Table 5
| Lagging number | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Comparative example 13 |
| 1 | 0 | 0 | 0 | 0 | 0 |
| 2 | 0 | 0 | 0 | 0 | 0 |
| 3 | 0 | 0 | 0 | 0 | 0 |
| 4 | 0 | 0 | 0 | 0 | 0 |
| 5 | 0 | 0 | 0 | 0 | 0 |
| 6 | 0 | 0 | 0 | 0 | 1 time+ |
| After the 6th day | 0 | 0 | 0 | 0 | 0 |
| It is total | 0 | 0 | 0 | 0 | 1 time+ |
According to above-mentioned test result it is found that the suncream of embodiment 5-8 is non-stimulated to skin, no positive reaction, and compare
There is a positive reaction in example 13.Illustrate that the product containing the traditional chinese medicine composition of the invention is safer, mildness is higher, and can be effective
Reduce the irritation of chemical sun.Reach identical SPF, the usage amount of traditional sun-screening agent can be reduced.
Embodiment 12
Consumer sensory's evaluation test:
Suncream made from embodiment 6, comparative example 13 is chosen to carry out consumer sensory's evaluation test, test method is such as
Under:
Choosing 30 usually has the female consumer being accustomed to using suncream product in 18-50 years old, it is desirable that subject carries out half
Face comparative experiments, subject choose the suncream that half face on one side uses embodiment 6, the other half face then uses the sun-proof of comparative example 13
Frost.Subject adheres to using product daily, evaluate after 1 month product effect.Improve from whole skin, skin light
Damp degree and microgroove improve three aspects and carry out effective evaluation.
Subject is using carrying out fed back statistics according to the method described above after sample one month, number represent more approve product this
The number of effect.
Test result is as shown in Figure 2.
After result is it is found that there is 29 suncreams for thinking to have used embodiment 6 according to fig. 2 in 30 subjects, skin is whole
Body situation has improvement, and degree of recognition is higher.86% or more subject thinks the sun-proof of the suncream relative contrast example 13 of embodiment 6
Frost has the effect for preferably improving skin shine and sophistication and improvement microgroove.
The traditional chinese medicine composition of the invention and its preparation method and application that the present invention is explained by the above embodiments, but the present invention
It is not limited to above-described embodiment, that is, does not mean that the present invention must rely on above-described embodiment and could implement.Technical field
Technical staff it will be clearly understood that any improvement in the present invention, to the equivalence replacement and auxiliary element of raw material selected by the present invention
Addition, the selection of concrete mode etc., all of which fall within the scope of protection and disclosure of the present invention.
Claims (10)
1. a kind of Chinese medicine composition, which is characterized in that the Chinese medicine composition prepares raw material by the component of following parts by weight
Composition: 20-30 parts of sunflower, 15-25 parts of chamomile, 15-25 parts of aloe, 5-15 parts of rosemary, 5-10 parts of peppermint, sweet mary 5-
10 parts.
2. Chinese medicine composition as described in claim 1, which is characterized in that the Chinese medicine composition prepares raw material by following heavy
The group of amount number is grouped as: 25-30 parts of sunflower, 20-25 parts of chamomile, 20-25 parts of aloe, 10-15 parts of rosemary, peppermint 5-
10 parts, 5-10 parts of sweet mary；
Preferably, the raw material for preparing of the Chinese medicine composition is composed of the following parts by weight: 30 parts of sunflower, chamomile
25 parts, 25 parts of aloe, 10 parts of rosemary, 5 parts of peppermint, 5 parts of sweet mary；
Preferably, the raw material for preparing of the Chinese medicine composition is composed of the following parts by weight: 30 parts of sunflower, chamomile
20 parts, 20 parts of aloe, 10 parts of rosemary, 10 parts of peppermint, 10 parts of sweet mary；
Preferably, the raw material for preparing of the Chinese medicine composition is composed of the following parts by weight: 25 parts of sunflower, chamomile
25 parts, 20 parts of aloe, 15 parts of rosemary, 10 parts of peppermint, 5 parts of sweet mary；
Preferably, the raw material for preparing of the Chinese medicine composition is composed of the following parts by weight: 25 parts of sunflower, chamomile
20 parts, 25 parts of aloe, 15 parts of rosemary, 5 parts of peppermint, 10 parts of sweet mary.
3. the preparation method of Chinese medicine composition as claimed in claim 1 or 2, which comprises the following steps:
(1) medicinal material pre-processes: the raw material for preparing of Chinese medicine composition being broken into powder respectively, is then uniformly mixed and obtains mixed powder
End；
(2) homogeneous extracts: the mixed-powder that step (1) obtains being placed in high pressure homogenizer, Extraction solvent is added, carries out high pressure
Homogeneous obtains extracting solution；
(3) it concentrates and purifies: by extracting solution filtering with microporous membrane that step (2) obtains and being concentrated, concentrate is obtained, by institute
It states macroporous resin column on concentrate to be eluted, collects eluent, decoloration and filtering with microporous membrane are carried out to the eluent, obtained
To medical fluid；
(4) it is concentrated and dried: the medical fluid that step (3) obtains being concentrated and is dried in vacuo, the Chinese medicine composition is obtained.
4. preparation method as claimed in claim 3, which is characterized in that the size of step (1) described powder is 100-200 mesh.
5. preparation method as described in claim 3 or 4, which is characterized in that step (2) Extraction solvent is water or/and 30-
95% ethanol water；
Preferably, the dosage of the Extraction solvent is 10-40 times of the mixed-powder weight；
Preferably, step (2) the high-pressure homogeneous time is 5-30min；
Preferably, step (2) the high-pressure homogeneous pressure is 10-30MPa.
6. the preparation method as described in any one of claim 3-5, which is characterized in that the tool of step (3) described concentrating and purifying
Body step are as follows: by the extracting solution filtering with microporous membrane, filtrate is concentrated through reverse osmosis membrane, obtains concentrate, by the concentration
Macroporous resin column on liquid, be washed to it is colourless after, then with ethanol solution be eluted to eluent colourless, collects eluent, described
The active carbon decoloring of eluent, then with filtering with microporous membrane, obtain medical fluid；
Preferably, the aperture of the miillpore filter is 0.2-0.5 μm；
Preferably, the pressure of the reverse osmosis membrane concentration is 5-30bar；
Preferably, the concentration is to be concentrated into the 10-30% that preceding filtrate volume is concentrated；
Preferably, the model D101 or AB-8 of the macroporous resin column；
Preferably, the concentration of the ethanol solution is 30-85%；
Preferably, mass-volume concentration of the active carbon in eluent is 1-10%.
7. the preparation method as described in any one of claim 3-6, which is characterized in that step (4) is described medical fluid is carried out it is dense
The weight ratio of weight and step (1) described mixed-powder after contracting is 1:2-1:5；
Preferably, step (4) the vacuum drying temperature is 45-65 DEG C.
8. the preparation method as described in any one of claim 3-7, which comprises the following steps:
(1) medicinal material pre-processes: the raw material for preparing of Chinese medicine composition being broken into 100-200 mesh powder respectively, is then uniformly mixed
Obtain mixed-powder；
(2) homogeneous extracts: the mixed-powder that step (1) obtains being placed in high pressure homogenizer, addition dosage is the mixed powder
The Extraction solvent of 10-40 times of last weight, carries out high-pressure homogeneous 5-30min, and pressure 10-30MPa obtains extracting solution；
(3) it concentrates and purifies: 0.2-0.5 μm of filtering with microporous membrane of the extracting solution that step (2) is obtained, by filtrate through reverse osmosis membrane
Concentration, pressure 5-30bar are concentrated into the 10-30% of filtrate volume before being concentrated, concentrate are obtained, by the concentrate mo(u)ld top half
Number macroporous resin column for being D101 or AB-8, be washed to it is colourless after, then carried out being eluted to eluent with the ethanol solution of 30-85%
It is colourless, collect eluent, the active carbon decoloring of the eluent, then with 0.2-0.5 μm of filtering with microporous membrane, obtain medical fluid；
(4) it is concentrated and dried: the medical fluid that step (3) obtains is carried out being concentrated into the weight ratio of weight and the mixed-powder being 1:2-
1:5, then be dried in vacuo at 45-65 DEG C, obtain the Chinese medicine composition.
9. a kind of cosmetics, which is characterized in that comprising such as any one of claims 1 or 2 in the raw material composition of the cosmetics
The Chinese medicine composition.
10. cosmetics as claimed in claim 9, which is characterized in that additive amount of the Chinese medicine composition in cosmetics be
0.1-20%, preferably 0.1-5%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020105125A (en) * | 2018-12-28 | 2020-07-09 | ポーラ化成工業株式会社 | Anti-aging method and anti-aging agent |
| CN112006955A (en) * | 2020-09-04 | 2020-12-01 | 广东药科大学 | Flower traditional Chinese medicine composite sunscreen agent and application thereof in cosmetics |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006131A (en) * | 2011-09-23 | 2013-04-03 | 张水珍 | Wet tissue |
| CN106852793A (en) * | 2016-12-08 | 2017-06-16 | 长沙协浩吉生物工程有限公司 | A kind of compound method of nti-freckle suncream |
-
2018
- 2018-09-10 CN CN201811052338.6A patent/CN109010572A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006131A (en) * | 2011-09-23 | 2013-04-03 | 张水珍 | Wet tissue |
| CN106852793A (en) * | 2016-12-08 | 2017-06-16 | 长沙协浩吉生物工程有限公司 | A kind of compound method of nti-freckle suncream |
Non-Patent Citations (1)
| Title |
|---|
| 广州环亚化妆品科技有限公司: "美肤宝水感隔离防晒乳SPF30+PA+++", 《国家药品监督管理局国产特殊用途化妆品查询》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020105125A (en) * | 2018-12-28 | 2020-07-09 | ポーラ化成工業株式会社 | Anti-aging method and anti-aging agent |
| JP7232642B2 (en) | 2018-12-28 | 2023-03-03 | ポーラ化成工業株式会社 | Anti-aging method and anti-aging agent |
| CN112006955A (en) * | 2020-09-04 | 2020-12-01 | 广东药科大学 | Flower traditional Chinese medicine composite sunscreen agent and application thereof in cosmetics |
| CN112006955B (en) * | 2020-09-04 | 2021-02-26 | 广东药科大学 | Flower traditional Chinese medicine composite sunscreen agent and application thereof in cosmetics |
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