CN110141609A - It is a kind of for treating the ointment and preparation method thereof that children canthus is split - Google Patents
It is a kind of for treating the ointment and preparation method thereof that children canthus is split Download PDFInfo
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- CN110141609A CN110141609A CN201810138382.2A CN201810138382A CN110141609A CN 110141609 A CN110141609 A CN 110141609A CN 201810138382 A CN201810138382 A CN 201810138382A CN 110141609 A CN110141609 A CN 110141609A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The ointment that the present invention provides a kind of to split for treating children canthus is made of, Roselle, procyanidine > 0.2% insect wax 6g, Roselle 2g, pheretima 3g, borneol 2g and coptis 4g, and sulfur content is lower than 5ppm, total plate count≤100cfu/g；The present invention also provides a kind of preparation methods, and sterilization, grinding, mixing is mixed well and cream processed, are sterilized using 400nm UV treatment 10min；After pulverizing, 20ml yellow rice wine is added into powder, is heated to 40 DEG C；3% hydroxypropyl methylcellulose powder, mild and heavy respiration alternately tanning 2-3 times, each 8-10min, until at paste is added；A kind of ointment split for treating children canthus of the invention, can cooperate with and dispel cold-evil, clearing heat and detoxicating, toxin expelling sterilization, treating both manifestation and root cause of disease, while achieve the effect that rapid healing, and cure rate is high, and short treating period, no detoxifying function is uneasy to recur, does not develop drug resistance.
Description
Technical field
The invention belongs to pharmaceutical technology fields, are related to a kind of ointment split for treating children canthus, and in particular to a kind of
The ointment split for treating children canthus.
Background technique
Children, which are split at canthus, is called blear-eye, and blear-eye is subacute, the chronic inflammation of skin of palpebral margins, Eyelash follicle and its body of gland
Disease.Margo palpebrae position is imbued with gland tissue and fatty sexual secretion, is easily infected with dust and dirt and germ causes infection.Clinically divide three types: squama
Bits property, exedens, angular blepharitis.Scaling person is margo palpebrae eczema, is caused by the excessive secondary infection of glandular secretion, ulcer
Caused by property person is Eyelash follicle and skin of palpebral margins infected by bacterium.Angular blepharitis is an Ah (MorAx-Axenfeld) family name's double rod of rubbing
Caused by bacterium.In addition, also related with riboflavin deficiency, chronic systemic disease.The general course of disease of blear-eye is longer, adheres to medication curative effect still
Good, the predisposing factors of blear-eye is chemical factors, ametropia, bad health habit etc..
There are following major defects for the ointment that existing treatment canthus is split: the medicinal ointment therapy canthus that existing treatment canthus is split
It is slow to split curative effect, the course for the treatment of is more, need to adhere to that treatment can just take effect, and general effect is undesirable, and for young child, suffer from
The normal unconscious wiping eye of small hand channel after being ill causes ointment to be lost or the problems such as other antihygienic germs are infected in wound, makes
Canthus splits that effect is poor, it is bad to cure for a long time, or even cause other ophthalmic inflammations.
Summary of the invention
Against the above deficiency, technical problem to be solved by the invention is to provide one kind for treating children canthus by the present invention
Ointment split and preparation method thereof.Following goal of the invention may be implemented in the present invention:
(1) ointment split using treatment canthus of the invention, can cooperate with and dispel cold-evil, clearing heat and detoxicating, toxin expelling sterilization, and sample is simultaneous
It controls, while achieving the effect that rapid healing.
(2) ointment split using treatment canthus of the invention, cure rate is high, and short treating period, no detoxifying function is uneasy to recur,
It does not develop drug resistance.
In order to solve the above technical problems, using following technical scheme:
A kind of ointment split for treating children canthus, which is characterized in that it is described for treating the ointment that children canthus is split, by with
The raw material of lower weight forms: insect wax, Roselle, pheretima, borneol and the coptis.
It is described for treating the ointment that children canthus is split as currently preferred technical solution, by the original of following weight
Material composition: insect wax 6g, Roselle 2g, pheretima 3g, borneol 2g and coptis 4g.
As currently preferred technical solution, the Roselle, procyanidine > 0.2%, sulfur content is lower than 5ppm, bacterium
Fall sum≤100cfu/g.
As currently preferred technical solution, the insect wax, effective percentage of 26 carbon alcohol ester of Hexacosendioic acid
Content be 85% or more, 80-85 DEG C of fusing point.
As currently preferred technical solution, the coptis, sulfur content is lower than 3ppm.
It is a kind of for treating the preparation method for the ointment that children canthus is split characterized by comprising sterilization, grinding, mixing
It mixes well and cream processed.
As currently preferred technical solution, the sterilization, ultraviolet wavelength handles 10min using 400nm.
As currently preferred technical solution, the mixing is mixed well, and 20ml yellow rice wine is added into powder, is heated to 40
℃。
As currently preferred technical solution, the grinding is ground to 100 mesh.
As currently preferred technical solution, 3% hydroxypropyl methylcellulose powder is added in the cream processed, and mild and heavy respiration is alternately endured
It is 2-3 times processed, each 8-10min.
The invention adopts the above technical scheme, compared with prior art, has the advantage that
(1) ointment split using treatment canthus of the invention, can cooperate with and dispel cold-evil, clearing heat and detoxicating, toxin expelling sterilization, and sample is simultaneous
It controls, while achieving the effect that rapid healing.
(2) ointment split using treatment canthus of the invention, cure rate height, cure rate is up to 100%, short treating period, and 2-4 days
It can cure, no detoxifying function is uneasy to recur, does not develop drug resistance.
Specific embodiment
Embodiment 1 is a kind of for treating the ointment and preparation method thereof that children canthus is split
A kind of ointment split for treating children canthus, is made of the raw material of following weight: insect wax 6g, Roselle 2g, pheretima
3g, borneol 2g and coptis 4g；
Roselle, procyanidine > 0.2%, sulfur content are lower than 5ppm, total plate count≤100cfu/g；
Insect wax, effective percentage composition of 26 carbon alcohol ester of Hexacosendioic acid are 85% or more, 80-85 DEG C of fusing point；
The coptis, sulfur content are lower than 3ppm.
Of the invention is a kind of for treating the preparation method for the ointment that children canthus is split, comprising:
1, it sterilizes: above-mentioned raw material is removed into surface impurity, put sterilization processing 10min under ultraviolet light, ultraviolet wavelength uses
400nm；Insect wax, Roselle, pheretima, borneol and the coptis of corresponding weight are weighed according to formula.
2, it grinds: above-mentioned insect wax, Roselle, pheretima, borneol and the coptis being mixed, 100 mesh is ground to, obtains powder.
3, mixing is mixed well: 20ml yellow rice wine being added into powder, is heated to 40 DEG C, stirs evenly.
4,3% hydroxypropyl methylcellulose powder, mild and heavy respiration alternately tanning 2-3 times, each 8-10min, mild fire 115 cream processed: is added
± 5 DEG C, 175 ± 5 DEG C of intense fire, when naturally cooling to 40 DEG C, 15% vaseline is added, continues to boil, until at paste.
Comparative example 1: insect-taking Chinese wax 6g, Roselle 2g, pheretima 3g, borneol 2g and coptis 4g；It is miscellaneous that raw material are removed into surface
Matter, puts sterilization processing 10min under ultraviolet light, and ultraviolet wavelength uses 400nm；Mixed grinding obtains powder to 100 mesh；To
20ml water is added in powder, is heated to 40 DEG C, stirs evenly；3% hydroxypropyl methylcellulose powder is added, mild and heavy respiration alternately boils 2-3
Secondary, 115 ± 5 DEG C of mild fire, 175 ± 5 DEG C of intense fire, when naturally cooling to 40 DEG C, 15% vaseline is added in each 8-10min, after
Continuous tanning, until at paste.
Comparative example 2: insect-taking Chinese wax 6g, Roselle 2g, pheretima 3g, borneol 2g and coptis 4g；It is miscellaneous that raw material are removed into surface
Matter, puts sterilization processing 10min under ultraviolet light, and ultraviolet wavelength uses 400nm；Mixed grinding obtains powder to 100 mesh；To
20ml vinegar is added in powder, is heated to 40 DEG C, stirs evenly；3% hydroxypropyl methylcellulose powder is added, mild and heavy respiration alternately boils 2-3
Secondary, 115 ± 5 DEG C of mild fire, 175 ± 5 DEG C of intense fire, when naturally cooling to 40 DEG C, 15% vaseline is added in each 8-10min, after
Continuous tanning, until at paste.
Comparative example 3: insect-taking Chinese wax 6g, Roselle 5g, pheretima 5g, borneol 5g and coptis 5g；It is miscellaneous that raw material are removed into surface
Matter, puts sterilization processing 10min under ultraviolet light, and ultraviolet wavelength uses 400nm；Mixed grinding obtains powder to 100 mesh；To
20ml vinegar is added in powder, is heated to 40 DEG C, stirs evenly；3% hydroxypropyl methylcellulose powder is added, mild and heavy respiration alternately boils 2-3
Secondary, 115 ± 5 DEG C of mild fire, 175 ± 5 DEG C of intense fire, when naturally cooling to 40 DEG C, 15% vaseline is added in each 8-10min, after
Continuous tanning, until at paste.
Comparative example 4: insect-taking Chinese wax 6g, Roselle 5g, pheretima 5g, borneol 5g and coptis 5g；It is miscellaneous that raw material are removed into surface
Matter, puts sterilization processing 10min under ultraviolet light, and ultraviolet wavelength uses 400nm；Mixed grinding obtains powder to 100 mesh；To
20ml yellow rice wine is added in powder, is heated to 40 DEG C, stirs evenly；3% hydroxypropyl methylcellulose powder is added, mild and heavy respiration alternately boils
2-3 times, each 8-10min, 115 ± 5 DEG C of mild fire, 175 ± 5 DEG C of intense fire, when naturally cooling to 40 DEG C, 15% vaseline is added,
Continue to boil, until at paste.
Clinical treatment is carried out to the case split at children canthus is clinically suffered from:
I group and I ' group case are organized case and are used the ointment in comparative example 1, III group using the ointment in embodiment 1, II group and II '
And III ' group case is used using the ointment in comparative example 2, IV group and IV ' group using the ointment in comparative example 3, V group and V ' group
Ointment in comparative example 4；
Case in I group, II group, III group, IV group and V group is suffered from ulcer type canthus and is split, and each group case gender, age, disease
Journey etc. is comparable through statistical analysis；
I ' group, II ' group, III ' group, IV ' group and V ' group are suffered from squama type canthus and are split, and each group case gender, age, the course of disease
Etc. through statistical analysis, be comparable.
In clinical trial, the therapeutic effect of ointment of the present invention and comparative example 1-4 are counted, and statistical result is shown in Table 1.
Table 1:
As shown in Table 1, being split using the embodiment of the present invention 1 to ulcer type canthus has good effect, general treatment 2 days can be antipruritic
Alleviating pain and detumescence can fully recover for 3-4 days, and when treating the 4th day, cure rate reaches 99%, and effective percentage reaches 100%；The present invention is implemented
Example 1 is used to treat the treatment that the ointment that children canthus is split splits squama type canthus, does not have obvious effects on；
The present invention has good curative effect to treatment ulcer type canthus ripper, uneasy to recur, and has no toxic side effect, and does not generate anti-medicine
Property.
The difference of embodiment 1 and comparative example 1- comparative example 2 is only in that comparative example 1 is the water that 20ml is added, and comparative example 2 is
The vinegar of 20ml is added, the yellow rice wine of 20ml is added in embodiment 1；After yellow rice wine is added in embodiment 1, the embodiment of the present invention 1 is used to treat
The drug effect for the ointment that children are split at canthus has great promotion.
Embodiment 1 and the difference of comparative example 3 are: parts by weight are different, and what embodiment 1 was added is 20ml yellow rice wine, comparative example 3
What is be added is 20ml vinegar；The effect of the embodiment of the present invention 1 is promoted much than the effect that comparative example 3 obtains.
The difference of embodiment 1 and comparative example 4 is only in that the parts by weight of comparative example 3 are different, described in the embodiment of the present invention 1
Effect acquired by weight of the weight than comparative example 4 is good, and the embodiment of the present invention 1 is used to treat children's eye
The drug effect of the ointment of chink has great promotion.
As it can be seen that a kind of ointment split for treating children canthus of the embodiment of the present invention 1, using insect wax 6g, Roselle
2g, pheretima 3g, borneol 2g and coptis 4g, can cooperate with and dispel cold-evil, clearing heat and detoxicating, toxin expelling sterilization, treating both manifestation and root cause of disease, while reach fast
The effect that speed is cured.
In use, the ointment that treatment children canthus is split to be applied to the Jingming acupoint of eye, rub clockwise 10 times, obtains slightly pain
Sense is degree, is washed one's face with warm water before smearing, can be relieved pain for general 1 time, can be fully recovered within 2-3 days, daytime is usable at night.
It abstains from rich food in use, spicy food or marine product.
It is of the present invention it is a kind of treat the ointment that children canthus is split be configured to be suitble to use in practical applications it is any
Dosage formulation can be suspending agent, microemulsion, missible oil and ointment.
Unless otherwise indicated, percentage of the present invention is weight percent, and ratio of the present invention is
Mass ratio.
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention,
It, for those skilled in the art, still can be with although describing the invention in detail with reference to the foregoing embodiments
It modifies the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features.It is all
Within the spirit and principles in the present invention, any modification, equivalent replacement, improvement and so on should be included in guarantor of the invention
Within the scope of shield.
Claims (10)
1. a kind of ointment split for treating children canthus, which is characterized in that it is described for treating the ointment that children canthus is split, by
The raw material of following weight forms: insect wax, Roselle, pheretima, borneol and the coptis.
2. a kind of ointment split for treating children canthus according to claim 1, which is characterized in that described for treating
The ointment that children are split at canthus is made of the raw material of following weight: insect wax 6g, Roselle 2g, pheretima 3g, borneol 2g and the coptis
4g。
3. a kind of ointment split for treating children canthus according to claim 1, which is characterized in that the Roselle,
Procyanidine > 0.2%, sulfur content are lower than 5ppm, total plate count≤100cfu/g.
4. a kind of ointment split for treating children canthus according to claim 1, which is characterized in that the insect wax,
Effective percentage composition of 26 carbon alcohol ester of Hexacosendioic acid be 85% or more, 80-85 DEG C of fusing point.
5. a kind of ointment split for treating children canthus according to claim 1, which is characterized in that the coptis, sulphur
Content is lower than 3ppm.
6. a kind of for treating the preparation method for the ointment that children canthus is split characterized by comprising sterilization, grinding, mixing are adjusted
Uniform cream processed.
7. according to claim 6 a kind of for treating the preparation method for the ointment that children canthus is split, which is characterized in that institute
Sterilization is stated, ultraviolet wavelength handles 10min using 400nm.
8. according to claim 6 a kind of for treating the preparation method for the ointment that children canthus is split, which is characterized in that institute
It states mixing to mix well, 20ml yellow rice wine is added into powder, is heated to 40 DEG C.
9. according to claim 6 a kind of for treating the preparation method for the ointment that children canthus is split, which is characterized in that institute
Grinding is stated, 100 mesh are ground to.
10. according to claim 6 a kind of for treating the preparation method for the ointment that children canthus is split, which is characterized in that
3% hydroxypropyl methylcellulose powder, mild and heavy respiration alternately tanning 2-3 times, each 8-10min is added in the cream processed.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810138382.2A CN110141609A (en) | 2018-02-10 | 2018-02-10 | It is a kind of for treating the ointment and preparation method thereof that children canthus is split |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810138382.2A CN110141609A (en) | 2018-02-10 | 2018-02-10 | It is a kind of for treating the ointment and preparation method thereof that children canthus is split |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946928A (en) * | 2019-12-26 | 2020-04-03 | 广东暨晴生物医药科技有限公司 | Natural plant eye spray and preparation method thereof |
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2018
- 2018-02-10 CN CN201810138382.2A patent/CN110141609A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946928A (en) * | 2019-12-26 | 2020-04-03 | 广东暨晴生物医药科技有限公司 | Natural plant eye spray and preparation method thereof |
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Application publication date: 20190820 |