CN103976933B - Compositions and manufacturing process thereof containing Limax pituitary extract - Google Patents
Compositions and manufacturing process thereof containing Limax pituitary extract Download PDFInfo
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- CN103976933B CN103976933B CN201410229287.5A CN201410229287A CN103976933B CN 103976933 B CN103976933 B CN 103976933B CN 201410229287 A CN201410229287 A CN 201410229287A CN 103976933 B CN103976933 B CN 103976933B
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- 239000000284 extract Substances 0.000 title claims abstract description 64
- 239000000203 mixture Substances 0.000 title claims abstract description 61
- 241001523405 Limax Species 0.000 title claims abstract description 51
- 230000001817 pituitary effect Effects 0.000 title claims abstract description 41
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 24
- 241000219226 Acer truncatum Species 0.000 claims abstract description 16
- 229920001817 Agar Polymers 0.000 claims abstract description 16
- 239000008272 agar Substances 0.000 claims abstract description 16
- 239000000679 carrageenan Substances 0.000 claims abstract description 16
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 16
- 229920001525 carrageenan Polymers 0.000 claims abstract description 16
- 229940113118 carrageenan Drugs 0.000 claims abstract description 16
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 16
- 230000001815 facial effect Effects 0.000 claims abstract description 13
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 12
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 12
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 12
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 12
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 12
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 12
- 239000011718 vitamin C Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000011230 binding agent Substances 0.000 claims abstract description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
- 238000002156 mixing Methods 0.000 claims description 25
- 150000001875 compounds Chemical class 0.000 claims description 22
- 229920002774 Maltodextrin Polymers 0.000 claims description 13
- 239000005913 Maltodextrin Substances 0.000 claims description 13
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 13
- 229940035034 maltodextrin Drugs 0.000 claims description 13
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 13
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 13
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 13
- 239000002994 raw material Substances 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 7
- 238000001704 evaporation Methods 0.000 claims description 6
- 230000008020 evaporation Effects 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 238000005119 centrifugation Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000005286 illumination Methods 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000013049 sediment Substances 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 3
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 2
- 238000004132 cross linking Methods 0.000 claims description 2
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- 235000014380 magnesium carbonate Nutrition 0.000 claims description 2
- 239000001630 malic acid Substances 0.000 claims description 2
- 235000011090 malic acid Nutrition 0.000 claims description 2
- 239000011736 potassium bicarbonate Substances 0.000 claims description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 2
- 239000011734 sodium Substances 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 239000003826 tablet Substances 0.000 abstract description 33
- 235000013361 beverage Nutrition 0.000 abstract description 5
- 239000007938 effervescent tablet Substances 0.000 abstract description 3
- 230000000052 comparative effect Effects 0.000 description 19
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 14
- 230000000694 effects Effects 0.000 description 8
- 230000028327 secretion Effects 0.000 description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 7
- 235000017557 sodium bicarbonate Nutrition 0.000 description 7
- 206010000496 acne Diseases 0.000 description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 6
- 108010014258 Elastin Proteins 0.000 description 5
- 102000016942 Elastin Human genes 0.000 description 5
- 241000218628 Ginkgo Species 0.000 description 5
- 235000011201 Ginkgo Nutrition 0.000 description 5
- 235000008100 Ginkgo biloba Nutrition 0.000 description 5
- 229920002549 elastin Polymers 0.000 description 5
- 210000000582 semen Anatomy 0.000 description 5
- 230000003064 anti-oxidating effect Effects 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 150000003254 radicals Chemical class 0.000 description 4
- 230000037303 wrinkles Effects 0.000 description 4
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 3
- -1 DPPH free radical Chemical class 0.000 description 3
- 229960000458 allantoin Drugs 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- 241000219095 Vitis Species 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003026 anti-oxygenic effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
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- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 150000005846 sugar alcohols Chemical class 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000237858 Gastropoda Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
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- 235000021355 Stearic acid Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
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- 239000004745 nonwoven fabric Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
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- 239000000600 sorbitol Substances 0.000 description 1
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- 239000013589 supplement Substances 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of compositions containing Limax pituitary extract, comprise following components: the Limax pituitary extract of 0.1-1.0wt%, the Acer Truncatum Buge pollen extract of 0.1-1.0wt%, the vitamin C of 0.1-1.0wt%, the potassium sorbate of 0.1-1.0wt%, the gelatinous mass of 45-70wt%, the disintegrating agent of 5-30wt%, the binding agent of 5-25wt%；Wherein said gelatinous mass is carrageenan and agar, and the mass ratio of carrageenan and agar is 5: 5-6: 4.Compositions containing Limax pituitary extract of the present invention acts not only as fruit-vegetable facial mask machine automatization film forming, and its soluble, good film-forming property；And be dissolved in water can drink as beverage as tablet or effervescent tablet.
Description
Technical field
The present invention relates to the technical field of food for health care, it is more particularly related to a kind of compositions containing Limax pituitary extract and manufacturing process thereof.
Background technology
Limax pituitary extract mainly contains the components such as collagen protein, elastin, allantoin and Portugal (grape) alduronic acid.Collagen protein therein is the important connective tissue elements of skin, and elastin co-architecture intact skin, has the effect keeping moisture；And elastin is the elastin laminin keeping skin histology, when the age increases, skin follows the string generation wrinkle, suitably supplements elastin and can prevent wrinkle appearance ahead of time, and reduces the ultraviolet injury to skin.Allantoin therein can help free radical resisting, Hydrolyzed Protein, wound healing, anti-inflammatory, stimulation cell regeneration and the effect releived；And Portugal (grape) alduronic acid can speed up cell regeneration, reduces wrinkle of skin and cicatrix, moreover it is possible to remove the colour of skin obscure, the destruction of desalination mottle and opposing radical pair skin.The mucus of Limax secretion makes the requisite material of cosmetics containing natural allantoin, calcium, glycolic acid, ossein, protein and vitamin etc..Limax pituitary extract also has the effect of antioxidation and antiinflammatory, is the antioxidant of a kind of natural green, it is possible to kill some antibacterial on skin.Limax pituitary extract can apply in the field such as cosmetics or health food Just because of this.Additionally, prior art also discloses that many health cares relevant containing Limax extract and cosmetic product, for instance CN101999658A discloses a kind of Fructus Fortunellae Margaritae snail nutrition pellet, is used for increasing energy, recovers blood glucose.CN102793655A discloses a kind of Regeneration and Repair facial mask liquid applying Limax pituitary extract and preparation method thereof, and it can improve sensitive skin, gentle can effectively suppress acne and obscure etc. appearance, it is possible to whitening effect skin moistening, the aging of delaying skin；But it needs to be immersed in non-woven fabrics and uses, and it is cumbersome that the automatic film forming of domestic fruit-vegetable facial mask machine can not be utilized to use；And wherein contain component such as 1,3 butylene glycol and the EDETATE SODIUM etc. of non-green material, additionally the antioxidation of described facial film, antiinflammatory performance also have much room for improvement.CN103126909A discloses a kind of sheet-type packs and manufacturing process thereof, and facial film is made effervescent tablet by it, can be applied directly in liquid, solves viscous wall and dissolves slow problem, and the viscosity after dissolving is low, it is achieved that Self-leveling film forming；Applicant have discovered that salinity therein is higher, time composite with Limax pituitary extract, film property is poor, and it is found by the applicant that the non-oxidizability of Limax mucus also is difficult to play in this system, effect of its strong anti-oxidation and despeckle is not notable；And owing to mouthfeel is poor, antioxygenic property is limited, it is also unsuitable for eating as health food.
Summary of the invention
In order to solve above-mentioned technical problem existing in prior art, it is an object of the invention to provide a kind of compositions containing Limax pituitary extract and manufacturing process thereof.Compositions containing Limax pituitary extract of the present invention acts not only as fruit-vegetable facial mask machine automatization film forming, and its soluble, good film-forming property；And be dissolved in water can drink as beverage as tablet or effervescent tablet.
In order to solve above-mentioned technical problem, present invention employs techniques below scheme:
A kind of compositions containing Limax pituitary extract, it is characterized in that: comprise following components: the Limax pituitary extract of 0.1-1.0wt%, the Acer Truncatum Buge pollen extract of 0.1-1.0wt%, the vitamin C of 0.1-1.0wt%, the potassium sorbate of 0.1-1.0wt%, the gelatinous mass of 45-70wt%, the disintegrating agent of 5-30wt%, the binding agent of 5-25wt%；Wherein said gelatinous mass is carrageenan and agar, and the mass ratio of carrageenan and agar is 5: 5-6: 4.
Wherein, described disintegrating agent is selected from dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose or boiling disintegrating agent.Wherein said boiling disintegrating agent includes a kind of composition being selected from sodium bicarbonate, potassium bicarbonate, calcium carbonate, magnesium carbonate and sodium carbonate, and selected from citric acid, malic acid and tartaric a kind of component.
Wherein, described binding agent is the mixture of microcrystalline Cellulose and maltodextrin, and the content of microcrystalline Cellulose is 5-15wt%, and the content of maltodextrin is 5-10wt%.
Wherein, described compositions can also contain other conventional ingredient, such as, when using as solid beverage, can be selected from dextrose, sucrose, mannitol, sorbitol, lactose, maltose alcohol etc. containing a kind of sugar or sugar alcohol, described sugar or sugar alcohol to improve mouthfeel.Such as use as facial film and can also contain slipping agent, for instance magnesium stearate, stearic acid, and preservative etc..
The preparation method that a second aspect of the present invention further relates to the above-mentioned compositions containing Limax pituitary extract, it is characterised in that comprise the following steps:
(1) above-mentioned each component raw material being added in mixing machine according to proportioning, mixing and stirring also refines, and obtains the granularity compound less than 200 μm；
(2) then in a mold, described compound is carried out tabletting when pressure is 10～60KN and obtain composition tablet.
Compared with prior art, the compositions containing Limax pituitary extract of the present invention has following useful technique effect:
Compositions containing Limax pituitary extract of the present invention passes through the composition to component and proportion design so that it can use simultaneously as solid beverage and facial film.And by Limax pituitary extract, Acer Truncatum Buge pollen extract and ascorbic synergism, it is possible to better play the effect of free radical resisting oxidation, despeckle and wrinkle removing.
Detailed description of the invention
Below in conjunction with specific embodiments the compositions containing Limax pituitary extract of the present invention and manufacturing process thereof are described in detail, but specific embodiment is not as the restriction to patent of the present invention.
Compositions containing Limax pituitary extract of the present invention, comprise following components: the Limax pituitary extract of 0.1-1.0wt%, the Acer Truncatum Buge pollen extract of 0.1-1.0wt%, the vitamin C of 0.1-1.0wt%, the potassium sorbate of 0.1-1.0wt%, the carrageenan of 25-35wt%, the agar of 20-25wt%, the microcrystalline Cellulose of 8-15wt%, the maltodextrin of 5-10wt%, the disintegrating agent of 5-30wt%；Wherein said gelatinous mass is the mass ratio of carrageenan and agar is 5: 5-6: 4.The tablet of the described compositions containing Limax pituitary extract is prepared by the method comprised the following steps: first, above-mentioned each component raw material is added in mixing machine according to proportioning, and mixing and stirring also refines, and obtains the granularity compound less than 100 μm；Then in a mold, described compound is carried out tabletting when pressure is 10～60KN and obtain composition tablet.The weight of described composition tablet is generally 1.0～1.2g, and hardness is 2.5～3.5kg/mm, and brittle degree is less than 0.01%.Prior art generally carries out batch mixing refinement and pressing process at normal temperatures.Described composition tablet needs when using as solid beverage to carry out sterilization treatment, but applicants have unexpectedly found that, described mixing refinement and pressing process are all when carrying out for-5～-10 DEG C, (needing when the ultraviolet that 120～150nm wavelength is shorter, illumination only needs 0.5～1.0mWcm only need to take the ultraviolet radiation of low-light (level)-2), can make the worm's ovum in mixture tablet and bacteria inactivation, and the content of microorganisms of product is controlled in safety range (less than 1000 total plate counts/gram).And if (5-40 DEG C) carries out batch mixing refinement and compacting at normal temperatures, during radiothermy ultraviolet sterilization, illumination needs to reach 50～75mWcm-2Irradiation just can make the content of microorganisms in described composition tablet control less than 1000 total plate counts/gram scope in, but so irradiation, it will cause that the activity of composition tablet described herein and function significantly reduce (such as the antioxygenic property of DPPH free radical at least being reduced by 50%).In the present invention, Limax pituitary extract belongs to product known in the art, and described Acer Truncatum Buge pollen extract is prepared by following methods: the Acer Truncatum Buge pollen of collection is dried by (1) under vacuum；(2) dried pollen is put into supersonic jet mill to pulverize, when 0～-10 DEG C, utilize CO2Pollen is carried out broken wall treatment by supersonic airstream；(3) pollen after broken wall treatment, with pure water for Extraction solvent, the feed liquid mass ratio carrying out supersound extraction, pollen and pure water is 1: 10, and ultrasonic power is 30-50W, and ultrasonic time is 30-60min, and temperature is 10-20 DEG C, is then centrifuged for obtaining extracting solution；Sediment fraction extracts 1 time again, centrifugal, merges supernatant, and evaporation obtains concentrated solution；(4) described concentrated solution being carried out precipitate with ethanol, standing, centrifugation, evaporation and concentration, drying and crushing obtains above-mentioned Acer Truncatum Buge pollen extract.
Embodiment 1
The present embodiment relates to a kind of composition tablet containing Limax pituitary extract, it includes following components: carrageenan: 30wt%, agar: 25wt%, sodium bicarbonate: 24wt%, citric acid: 8wt%, microcrystalline Cellulose: 8wt%, maltodextrin: 4wt%, potassium sorbate: 0.5wt%, vitamin C: 0.2wt%, Acer Truncatum Buge pollen extract: 0.2wt%, Limax secretions: 0.1wt%.First, above-mentioned each component raw material being added in mixing machine according to proportioning, mixing and stirring also refines, and obtains the granularity compound less than 100 μm；Then in a mold, described compound is carried out tabletting when pressure is 30KN and obtain composition tablet.The weight of described composition tablet is generally 1.0～1.2g, and hardness is 2.5～3.5kg/mm, and brittle degree is less than 0.01%.
Comparative example 1
This comparative example relates to a kind of composition tablet containing Limax pituitary extract, it includes following components: carrageenan: 30wt%, agar: 25wt%, sodium bicarbonate: 24wt%, citric acid: 8wt%, microcrystalline Cellulose: 8wt%, maltodextrin: 4wt%, potassium sorbate 0.5wt%, Acer Truncatum Buge pollen extract: 0.2wt%, Limax secretions: 0.3wt%.First, above-mentioned each component raw material being added in mixing machine according to proportioning, mixing and stirring also refines, and obtains the granularity compound less than 100 μm；Then in a mold, described compound is carried out tabletting when pressure is 30KN and obtain composition tablet.The weight of described composition tablet is generally 1.0～1.2g, and hardness is 2.5～3.5kg/mm, and brittle degree is less than 0.01%.
Comparative example 2
This comparative example relates to a kind of composition tablet containing Limax pituitary extract, it includes following components: carrageenan: 30wt%, agar: 25wt%, sodium bicarbonate: 24wt%, citric acid: 8wt%, microcrystalline Cellulose: 8wt%, maltodextrin: 4wt%, potassium sorbate 0.5wt%, vitamin C: 0.2wt%, Limax secretions: 0.3wt%.First, above-mentioned each component raw material being added in mixing machine according to proportioning, mixing and stirring also refines, and obtains the granularity compound less than 100tm；Then in a mold, described compound is carried out tabletting when pressure is 30KN and obtain composition tablet.The weight of described composition tablet is generally 1.0～1.2g, and hardness is 2.5～3.5kg/mm, and brittle degree is less than 0.01%.
Comparative example 3
This comparative example relates to a kind of composition tablet containing Limax pituitary extract, it includes following components: carrageenan: 30wt%, agar: 25wt%, sodium bicarbonate: 24wt%, citric acid: 8wt%, microcrystalline Cellulose: 8wt%, maltodextrin: 4wt%, potassium sorbate 0.5wt%, Limax secretions: 0.5wt%.First, above-mentioned each component raw material being added in mixing machine according to proportioning, mixing and stirring also refines, and obtains the granularity compound less than 100 μm；Then in a mold, described compound is carried out tabletting when pressure is 30KN and obtain composition tablet.The weight of described composition tablet is generally 1.0～1.2g, and hardness is 2.5～3.5kg/mm, and brittle degree is less than 0.01%.
Comparative example 4
This comparative example relates to a kind of composition tablet containing Limax pituitary extract, it includes following components: carrageenan: 30wt%, agar: 25.4wt%, sodium bicarbonate: 24wt%, citric acid: 8wt%, microcrystalline Cellulose: 8wt%, maltodextrin: 4wt%, potassium sorbate 0.5wt%, Limax secretions: 0.1wt%.First, above-mentioned each component raw material being added in mixing machine according to proportioning, mixing and stirring also refines, and obtains the granularity compound less than 100 μm；Then in a mold, described compound is carried out tabletting when pressure is 30KN and obtain composition tablet.The weight of described composition tablet is generally 1.0～1.2g, and hardness is 2.5～3.5kg/mm, and brittle degree is less than 0.01%.
Comparative example 5
This comparative example relates to a kind of composition tablet containing Limax pituitary extract, it includes following components: carrageenan: 30wt%, agar: 25.3wt%, sodium bicarbonate: 24wt%, citric acid: 8wt%, microcrystalline Cellulose: 8wt%, maltodextrin: 4wt%, potassium sorbate 0.5wt%, vitamin C: 0.2wt%, Limax secretions: 0.1wt%.First, above-mentioned each component raw material being added in mixing machine according to proportioning, mixing and stirring also refines, and obtains the granularity compound less than 100 μm；Then in a mold, described compound is carried out tabletting when pressure is 30KN and obtain composition tablet.The weight of described composition tablet is generally 1.0～1.2g, and hardness is 2.5～3.5kg/mm, and brittle degree is less than 0.01%.
Comparative example 6
This comparative example relates to a kind of composition tablet containing Limax pituitary extract, it includes following components: carrageenan: 30wt%, agar: 25wt%, sodium bicarbonate: 24wt%, citric acid: 8wt%, microcrystalline Cellulose: 8wt%, maltodextrin: 4wt%, potassium sorbate: 0.5wt%, vitamin C: 0.2wt%, Semen Ginkgo pollen extract: 0.2wt%, Limax secretions: 0.1wt%.First, above-mentioned each component raw material being added in mixing machine according to proportioning, mixing and stirring also refines, and obtains the granularity compound less than 100 μm；Then in a mold, described compound is carried out tabletting when pressure is 30KN and obtain composition tablet.The weight of described composition tablet is generally 1.0～1.2g, and hardness is 2.5～3.5kg/mm, and brittle degree is less than 0.01%.Described Semen Ginkgo pollen extract is prepared by following methods: the Semen Ginkgo pollen of collection is dried by (1) under vacuum；(2) dried pollen is put into supersonic jet mill to pulverize, when 0～-10 DEG C, utilize CO2Pollen is carried out broken wall treatment by supersonic airstream；(3) pollen after broken wall treatment, with pure water for Extraction solvent, the feed liquid mass ratio carrying out supersound extraction, pollen and pure water is 1: 10, and ultrasonic power is 30-50W, and ultrasonic time is 30-60min, and temperature is 10-20 DEG C, is then centrifuged for obtaining extracting solution；Sediment fraction extracts 1 time again, centrifugal, merges supernatant, and evaporation obtains concentrated solution；(4) described concentrated solution being carried out precipitate with ethanol, standing, centrifugation, evaporation and concentration, drying and crushing obtains above-mentioned Semen Ginkgo pollen extract.
The result of use contrast experiment of embodiment and comparative example facial film
Subjects is the face women population with blackhead and/or skin dark stain, the object on probation investigated is 840 examples, age is 18～45 years old, it is divided into embodiment 1:120 example (A1 group), comparative example 1:120 example (B group), comparative example 2:120 example (C group), comparative example 3:120 example (D group), comparative example 4:120 example (E group), comparative example 5:120 example (F group), comparative example 6:120 example (G group).Age distributing equilibrium in each group, eliminates the impact at age.
Using method: adopt above-mentioned composition tablet to utilize domestic fruit-vegetable facial mask machine to make sheet-type packs (every time using composition tablet a piece of, weight is 1.0～1.2g).Clean face, facial film is spread on the face, after 30 minutes, take facial film off, clean, apply once before sleep every night, use two weeks continuously.
Effect standard:
(1) effective: skin is fine and smooth, and blackhead or skin dark stain substantially reduce (needing minimizing amount more than 10%), and color thin out (more than 30% color of the visible number of naked eyes is thin out).
(2) effective: macroscopic blackhead or skin dark stain quantity reduce (needing minimizing amount more than 10%) to some extent；Though or macroscopic blackhead or skin dark stain do not reduce, but integral color thin out (needs more than 30% color is thin out)；Only meet one of them.
(3) invalid: macroscopic blackhead or skin dark stain quantity minimizing amount inconspicuous (minimizing amount is less than 10%), and integral color has no thin out (the thin out quantity of color is less than 30%).
Result of use is as shown in table 1:
Table 1 result of use
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
| A1 group | 120 | 23 | 51 | 46 | 61.7% |
| B group | 120 | 10 | 36 | 74 | 38.3% |
| C group | 120 | 6 | 38 | 76 | 36.7% |
| D group | 120 | 13 | 60 | 47 | 60.8% |
| E group | 120 | 3 | 20 | 97 | 19.2% |
| F group | 120 | 2 | 15 | 103 | 14.2% |
| G group | 120 | 4 | 19 | 97 | 19.2% |
It addition, each and the Oxidation Resistance Test of DPPH free radical is also indicated that when combination uses by Limax pituitary extract, Acer Truncatum Buge pollen extract and vitamin C, when three is used in conjunction with, could effectively play the Oxidation of free radical resisting oxidation；And combine both vitamin C and Limax pituitary extract when being used in combination, even reduce the antioxidation of its DPPH free radical；When combination uses both Acer Truncatum Buge pollen extract and Limax pituitary extract to be used in combination, also almost without synergism；And use the pollen extract such as Semen Ginkgo pollen extract that other is conventional, even if triple combination uses also substantially does not produce synergism.Visible, in the present invention, only by the synergism of Limax pituitary extract, Acer Truncatum Buge pollen extract and vitamin C three, it is possible to significantly reduce the addition of Limax pituitary extract.
The foregoing is only the preferred embodiments of the present invention; can not being construed to limit the scope of the present invention with this, equivalent deformation made in the scope that all claims in the present invention claim and the embodiment of change are all in present invention scope required for protection.
Claims (7)
1. the compositions containing Limax pituitary extract being used for preparing facial film, it is characterized in that: composed of the following components: the Limax pituitary extract of 0.1-1.0wt%, the Acer Truncatum Buge pollen extract of 0.1-1.0wt%, the vitamin C of 0.1-1.0wt%, the potassium sorbate of 0.1-1.0wt%, the gelatinous mass of 45-70wt%, the disintegrating agent of 5-30wt%, and the binding agent of 5-25wt%；Wherein said gelatinous mass is carrageenan and agar, and the mass ratio of carrageenan and agar is 5: 5-6: 4；Wherein, described Acer Truncatum Buge pollen extract is prepared by following methods: the Acer Truncatum Buge pollen of collection is dried by (1) under vacuum；(2) dried pollen is put into supersonic jet mill to pulverize, when 0～-10 DEG C, utilize CO2Pollen is carried out broken wall treatment by supersonic airstream；(3) pollen after broken wall treatment, with pure water for Extraction solvent, the feed liquid mass ratio carrying out supersound extraction, pollen and pure water is 1:10, and ultrasonic power is 30-50W, and ultrasonic time is 30-60min, and temperature is 10-20 DEG C, is then centrifuged for obtaining extracting solution；Sediment fraction extracts 1 time again, centrifugal, merges supernatant, and evaporation obtains concentrated solution；(4) described concentrated solution is carried out precipitate with ethanol, standing, centrifugation, evaporation and concentration, drying and crushing.
2. compositions according to claim 1, it is characterised in that: described disintegrating agent is selected from dried starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose or boiling disintegrating agent.
3. compositions according to claim 2, it is characterised in that: described boiling disintegrating agent includes a kind of composition being selected from sodium bicarbonate, potassium bicarbonate, calcium carbonate, magnesium carbonate and sodium carbonate, and selected from citric acid, malic acid and tartaric a kind of component.
4. compositions according to claim 1, it is characterised in that: described binding agent is the mixture of microcrystalline Cellulose and maltodextrin, and the content of described microcrystalline Cellulose is 5-15wt%, and the content of maltodextrin is 5-10wt%.
5. compositions according to claim 1, it is characterized in that: containing the compositions of Limax pituitary extract, composed of the following components: the Limax pituitary extract of 0.1-1.0wt%, the Acer Truncatum Buge pollen extract of 0.1-1.0wt%, the vitamin C of 0.1-1.0wt%, the potassium sorbate of 0.1-1.0wt%, the carrageenan of 25-35wt%, the agar of 20-25wt%, the microcrystalline Cellulose of 8-15wt%, the maltodextrin of 5-10wt%, and the disintegrating agent of 5-30wt%.
6. compositions according to claim 1, it is characterized in that: described compositions is obtained by the preparation method comprised the following steps: above-mentioned each component raw material is added in mixing machine according to proportioning, mixing and stirring also refines, and obtains the granularity compound less than 200 μm；Then in a mold, described compound is carried out tabletting when pressure is 10～60KN and obtain composition tablet.
7. the manufacturing process of the compositions containing Limax pituitary extract described in any one of claim 1-5, it is characterised in that: described technique comprises the following steps:
(1) above-mentioned each component raw material being added in mixing machine according to proportioning, mixing and stirring also refines, and obtains the granularity compound less than 200 μm；
(2) then in a mold, described compound is carried out tabletting when pressure is 10～60KN and obtain composition tablet；
Wherein, step (1) and step (2) all carry out at-5～-10 DEG C, and are 120～150nm at wavelength, and illumination is 0.5～1.0mWcm-2When carry out ultraviolet irradiation.
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| CN107865817A (en) * | 2017-12-27 | 2018-04-03 | 长春杭盖生物科技有限公司 | A kind of preparation method of the anti-inflammatory Deacne pack liquid containing snail mucus and sodium hyaluronate |
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| WO2019130227A1 (en) * | 2017-12-29 | 2019-07-04 | Jumpstar10 S.R.L. | Edible film and related uses |
| CN109055954A (en) * | 2018-09-05 | 2018-12-21 | 合肥久新不锈钢厨具有限公司 | A kind of composite environmental-friendly stainless steel cleaner and its application method |
| CN109718140A (en) * | 2019-03-13 | 2019-05-07 | 齐鲁工业大学 | One main laminaria bioactivity facial mask effervescent tablet and preparation method thereof |
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| CN102793655A (en) * | 2012-08-10 | 2012-11-28 | 彭再辉 | Regenerating and repairing mask liquid by applying snail mucus extract and preparation method thereof |
| CN103126909A (en) * | 2013-03-13 | 2013-06-05 | 盖云秀 | Sheet mask and preparation process thereof |
| CN103315289A (en) * | 2013-05-07 | 2013-09-25 | 江苏丹枫神源生物科技有限公司 | Mono maple pollen extract and application of the same as health care product |
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| CN102793655A (en) * | 2012-08-10 | 2012-11-28 | 彭再辉 | Regenerating and repairing mask liquid by applying snail mucus extract and preparation method thereof |
| CN103126909A (en) * | 2013-03-13 | 2013-06-05 | 盖云秀 | Sheet mask and preparation process thereof |
| CN103315289A (en) * | 2013-05-07 | 2013-09-25 | 江苏丹枫神源生物科技有限公司 | Mono maple pollen extract and application of the same as health care product |
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| CN107865817A (en) * | 2017-12-27 | 2018-04-03 | 长春杭盖生物科技有限公司 | A kind of preparation method of the anti-inflammatory Deacne pack liquid containing snail mucus and sodium hyaluronate |
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