CN110582483A - 含邻氨基杂芳环炔基的化合物及其制备方法和用途 - Google Patents
含邻氨基杂芳环炔基的化合物及其制备方法和用途 Download PDFInfo
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
Description
Claims (10)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
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CN2017100902428 | 2017-02-20 | ||
CN201710090242.8A CN108456163A (zh) | 2017-02-20 | 2017-02-20 | 含邻氨基杂芳环炔基的化合物及其制备方法和用途 |
PCT/CN2018/076423 WO2018149382A1 (zh) | 2017-02-20 | 2018-02-12 | 含邻氨基杂芳环炔基的化合物及其制备方法和用途 |
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CN110582483A true CN110582483A (zh) | 2019-12-17 |
CN110582483B CN110582483B (zh) | 2022-05-13 |
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CN201710090242.8A Pending CN108456163A (zh) | 2017-02-20 | 2017-02-20 | 含邻氨基杂芳环炔基的化合物及其制备方法和用途 |
CN201880012699.XA Active CN110582483B (zh) | 2017-02-20 | 2018-02-12 | 含邻氨基杂芳环炔基的化合物及其制备方法和用途 |
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US (1) | US10988456B2 (zh) |
EP (1) | EP3584239A4 (zh) |
JP (1) | JP6965360B2 (zh) |
KR (2) | KR102366670B1 (zh) |
CN (2) | CN108456163A (zh) |
AU (1) | AU2018222073B2 (zh) |
CA (1) | CA3053983C (zh) |
WO (1) | WO2018149382A1 (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108456163A (zh) * | 2017-02-20 | 2018-08-28 | 中国科学院上海药物研究所 | 含邻氨基杂芳环炔基的化合物及其制备方法和用途 |
CN114075135A (zh) * | 2020-08-10 | 2022-02-22 | 上海润石医药科技有限公司 | 含邻氨基吡啶炔基的化合物的盐及其制备方法和应用 |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2918588T3 (pl) | 2010-05-20 | 2017-10-31 | Array Biopharma Inc | Związki makrocykliczne jako inhibitory kinazy TRK |
EP3571203B1 (en) | 2017-01-18 | 2023-06-07 | Array BioPharma Inc. | Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
TWI802635B (zh) | 2018-01-18 | 2023-05-21 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡咯并[2,3-d]嘧啶化合物 |
JP6997876B2 (ja) | 2018-01-18 | 2022-02-04 | アレイ バイオファーマ インコーポレイテッド | Retキナーゼ阻害剤としての置換ピラゾリル[4,3-c]ピリジン化合物 |
US11524963B2 (en) | 2018-01-18 | 2022-12-13 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors |
WO2020131674A1 (en) | 2018-12-19 | 2020-06-25 | Array Biopharma Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
CN111662227B (zh) * | 2019-03-06 | 2022-07-05 | 中国科学院上海药物研究所 | 邻氨基吡啶炔类化合物及其制备方法和用途 |
CN112341437A (zh) * | 2020-12-21 | 2021-02-09 | 李寒 | 一种取代的吡嗪衍生物及其应用 |
CN114853739B (zh) * | 2021-02-03 | 2023-09-22 | 药雅科技(上海)有限公司 | 一种炔代吡嗪类fgfr抑制剂及其制备方法和用途 |
CN116730978A (zh) * | 2022-03-11 | 2023-09-12 | 中国科学院上海药物研究所 | 一类含杂芳环炔基化合物及其制备方法和用途 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006044823A2 (en) * | 2004-10-18 | 2006-04-27 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
CN101389338A (zh) * | 2005-12-23 | 2009-03-18 | 阿里亚德医药股份有限公司 | 双环杂芳基化合物 |
CN101490053A (zh) * | 2006-05-08 | 2009-07-22 | 阿里亚德医药股份有限公司 | 单环杂芳基化合物 |
CN103998431A (zh) * | 2011-10-20 | 2014-08-20 | 阿勒根公司 | 作为酪氨酸激酶抑制剂的吡啶-亚砜亚胺 |
WO2015108490A2 (en) * | 2014-01-17 | 2015-07-23 | Agency For Science, Technology And Research | Heteroaryl alkyne derivatives and uses thereof |
CN104870446A (zh) * | 2012-11-07 | 2015-08-26 | 内尔维阿诺医学科学有限公司 | 取代的嘧啶基和吡啶基吡咯并吡啶酮类、其制备方法及其作为激酶抑制剂的用途 |
WO2016029776A1 (en) * | 2014-08-26 | 2016-03-03 | Astar Biotech Llc | Protein kinase inhibitors |
CN108456163A (zh) * | 2017-02-20 | 2018-08-28 | 中国科学院上海药物研究所 | 含邻氨基杂芳环炔基的化合物及其制备方法和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2006077901A1 (ja) * | 2005-01-20 | 2008-06-19 | 塩野義製薬株式会社 | Ctgf発現阻害剤 |
GB0502418D0 (en) * | 2005-02-05 | 2005-03-16 | Astrazeneca Ab | Compounds |
US8859553B2 (en) * | 2012-07-30 | 2014-10-14 | Astar Biotech Llc | Protein kinase inhibitors |
CN104211639A (zh) | 2013-06-05 | 2014-12-17 | 中国科学院上海药物研究所 | 一类炔基杂环类化合物及其应用 |
BR112016013539A2 (pt) | 2013-12-12 | 2020-10-27 | Allergan, Inc. | derivados de nicotinamida substituídos como inibidores de quinase e seu uso |
MX2016007719A (es) | 2013-12-12 | 2017-01-18 | Allergan Inc | Derivados de nicotinamida dialquil(oxido)-?4-sulfanilideno como inhibidores de cinasa. |
US9359336B2 (en) | 2014-10-09 | 2016-06-07 | Allergan, Inc. | Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors |
CN106146391A (zh) * | 2015-04-15 | 2016-11-23 | 中国科学院上海药物研究所 | 5-芳香炔基取代的苯甲酰胺类化合物及其制备方法、药物组合物和用途 |
CN109843294A (zh) * | 2016-08-15 | 2019-06-04 | 普渡研究基金会 | 4-取代的氨基异喹啉衍生物 |
-
2017
- 2017-02-20 CN CN201710090242.8A patent/CN108456163A/zh active Pending
-
2018
- 2018-02-12 AU AU2018222073A patent/AU2018222073B2/en active Active
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- 2018-02-12 KR KR1020197025924A patent/KR20190120766A/ko not_active Application Discontinuation
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Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006044823A2 (en) * | 2004-10-18 | 2006-04-27 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
CN101389338A (zh) * | 2005-12-23 | 2009-03-18 | 阿里亚德医药股份有限公司 | 双环杂芳基化合物 |
CN101490053A (zh) * | 2006-05-08 | 2009-07-22 | 阿里亚德医药股份有限公司 | 单环杂芳基化合物 |
CN103998431A (zh) * | 2011-10-20 | 2014-08-20 | 阿勒根公司 | 作为酪氨酸激酶抑制剂的吡啶-亚砜亚胺 |
CN104870446A (zh) * | 2012-11-07 | 2015-08-26 | 内尔维阿诺医学科学有限公司 | 取代的嘧啶基和吡啶基吡咯并吡啶酮类、其制备方法及其作为激酶抑制剂的用途 |
WO2015108490A2 (en) * | 2014-01-17 | 2015-07-23 | Agency For Science, Technology And Research | Heteroaryl alkyne derivatives and uses thereof |
WO2016029776A1 (en) * | 2014-08-26 | 2016-03-03 | Astar Biotech Llc | Protein kinase inhibitors |
CN108456163A (zh) * | 2017-02-20 | 2018-08-28 | 中国科学院上海药物研究所 | 含邻氨基杂芳环炔基的化合物及其制备方法和用途 |
Non-Patent Citations (4)
Title |
---|
DENG XIANMING等: "Broad spectrum alkynyl inhibitors of T315I Bcr-Abl", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
LIU YANG等: "Discovery of novel Ponatinib analogues for reducing KDR activity as potent FGFRs inhibitors", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 * |
MOCCIA MARIALUISA: "Identification of novel small molecule inhibitors of oncogenic RET kinase", 《PLOS ONE》 * |
THOMAS MATHEW等: "Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108456163A (zh) * | 2017-02-20 | 2018-08-28 | 中国科学院上海药物研究所 | 含邻氨基杂芳环炔基的化合物及其制备方法和用途 |
CN114075135A (zh) * | 2020-08-10 | 2022-02-22 | 上海润石医药科技有限公司 | 含邻氨基吡啶炔基的化合物的盐及其制备方法和应用 |
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CA3053983A1 (en) | 2018-08-23 |
WO2018149382A1 (zh) | 2018-08-23 |
JP6965360B2 (ja) | 2021-11-10 |
CN110582483B (zh) | 2022-05-13 |
EP3584239A4 (en) | 2020-08-26 |
US20200055838A1 (en) | 2020-02-20 |
AU2018222073B2 (en) | 2021-02-04 |
CA3053983C (en) | 2024-01-09 |
KR20190120766A (ko) | 2019-10-24 |
EP3584239A1 (en) | 2019-12-25 |
AU2018222073A1 (en) | 2019-10-10 |
RU2019129336A3 (zh) | 2021-03-22 |
JP2020510642A (ja) | 2020-04-09 |
KR102366670B1 (ko) | 2022-02-23 |
US10988456B2 (en) | 2021-04-27 |
RU2019129336A (ru) | 2021-03-22 |
CN108456163A (zh) | 2018-08-28 |
KR20200130868A (ko) | 2020-11-20 |
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