CN110522842A - 利于药浴防治体外寄生虫的药剂制备方法 - Google Patents
利于药浴防治体外寄生虫的药剂制备方法 Download PDFInfo
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Abstract
本发明公开了利于药浴防治体外寄生虫的药剂制备方法,具体步骤为:取鹤草芽、雷丸、榛子分别采用乙醇进行浸提获得鹤草芽、雷丸、榛子各自的提取液;取白屈菜、红血柳、老虎姜、酸藤木、马齿笕、竹叶蕉、百里香、油渣果、细叶桉、油柑木皮、独活加水煮沸,获得混合提取液;取辛夷花、野菊花、金银花、甘松进行超微粉碎获得混合粉末;将鹤草芽、雷丸、榛子各自的提取液、混合提取液、柠檬精油、硬脂酸和混合粉末进行快速搅拌,获得最终乳化产品制剂。本发明通过改进制备方法、优化各组分配伍关系,提供的药物具有良好的防治狗狗体外寄生虫感染,对狗狗皮肤无毒副作用,味道清香,无异味、难闻气味,可制成喷雾剂喷涂于宠物狗狗体表,操作方便。
Description
技术领域
本发明涉及医药化学领域,具体涉及一种利于药浴防治体外寄生虫的药剂制备方法。
背景技术
宠物狗狗的寄生虫分为体内寄生虫和体外寄生虫,体内寄生虫分为吸虫、绦虫、线虫、棘头虫等;体外寄生虫为节肢动物类;还要特别提到的是血液寄生虫,多为原虫类。寄生虫对宿主的危害:掠夺宿主营养;对局部甚至全身造成机械性损伤如炎症、出血、阻塞等;寄生虫生活期间排出的代谢物及机体崩解后的物质对机体都是有毒害的,造成局部或全身的中毒,同时会引起机体的免疫损伤,携带其他细菌病毒进入体内引发疾病,特别是皮肤病。
已经发现了防治在狗狗的体表或毛发或其邻近生存的寄生虫(体外寄生虫)的各种化合物,并且已知包括下述步骤的方法:向动物的体表施用包含所述化合物的药剂或给动物口服施用所述药剂。然后,大多数给狗狗体外驱虫的药物都存在较大的异味,口服过程中狗狗的服从性较差,不易完成口服操作;而体表喷涂药物驱虫时,由于存在较大异味,不易让人接近。
发明内容
本发明所要解决的技术问题是:大多数给狗狗体外驱虫的药物都存在较大的异味,口服过程中狗狗的服从性较差,不易完成口服操作;而体表喷涂药物驱虫时,由于存在较大异味,不易让人接近,本发明提供了解决上述问题的利于药浴防治体外寄生虫的药剂制备方法。
本发明通过下述技术方案实现:
利于药浴防治体外寄生虫的药剂制备方法,所述制备方法的具体步骤为:
步骤1,按重量份称取鹤草芽、雷丸、榛子,经洗净晾干后,分别采用乙醇进行浸提获得鹤草芽、雷丸、榛子各自的提取液;
步骤2,按重量份称取白屈菜、红血柳、老虎姜、酸藤木、马齿笕、竹叶蕉、百里香、油渣果、细叶桉、油柑木皮、独活,经洗净、晾干、粉碎后,加入同一容器中进行浸泡,加水煮沸,获得混合提取液;
步骤3,按重量份称取辛夷花、野菊花、金银花、甘松经洗净后进行干燥,最后进行超微粉碎,获得混合粉末;
步骤4,将所述鹤草芽、雷丸、榛子各自的提取液、混合提取液、柠檬精油、硬脂酸和混合粉末进行快速搅拌,获得最终乳化产品制剂。
优选地,所述药剂的原料组成按重量份配比为:鹤草芽,23~35份,雷丸,3~12份,榛子,8~16份,白屈菜,5~15份,红血柳,2~12份,老虎姜,2~10份,酸藤木,5~17份,马齿笕,10~21份,竹叶蕉,12~22份,百里香,15~25份,油渣果,5~15份,细叶桉,3~13份,油柑木皮,2~13份,辛夷花,6~15份,野菊花,5~15份,独活,10~19份,金银花,12~25份,甘松,8~18份。
优选地,所述药剂的原料组成按重量份配比为:鹤草芽,29份,雷丸,7份,榛子,12份,白屈菜,10份,红血柳,7份,老虎姜,8份,酸藤木,12份,马齿笕,15份,竹叶蕉,18份,百里香,20份,油渣果,10份,细叶桉,8份,油柑木皮,6份,辛夷花,11份,野菊花,10份,独活,15份,金银花,19份,甘松,14份。
优选地,所述柠檬精油和硬脂酸的加入量分别为上述原料总质量的10%和5.5%。
优选地,所述步骤1中,采用65~70%的乙醇浸溶,回流2~3h,且经过滤和减压蒸馏获得最终提取液。
优选地,所述步骤2中,粉碎后物料的粒径为40~60目。
优选地,所述步骤3中,超微粉碎后混合粉末的粒径为270~325目。
优选地,所述步骤4中,先将鹤草芽、雷丸、榛子各自的提取液、混合提取液和混合粉末混合均匀后,加热至50~55℃,不断搅拌条件下,分别加入温度均为80~85℃的柠檬精油和硬脂酸。
本发明具有如下的优点和有益效果:
本发明通过改进制备方法、优化各组分配伍关系,提供的药物具有良好的防治狗狗体外寄生虫感染,作用温和,对狗狗皮肤无毒副作用,味道清香,无异味、难闻气味,可制成喷雾剂喷涂于宠物狗狗体表,操作方便。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚明白,下面结合实施例,对本发明作进一步的详细说明,本发明的示意性实施方式及其说明仅用于解释本发明,并不作为对本发明的限定。
实施例1
本实施例提供了一种利于药浴防治体外寄生虫的药剂制备方法,所述制备方法的具体步骤为:
步骤1,按重量份称取鹤草芽、雷丸、榛子,经洗净晾干后,分别采用乙醇进行浸提获得鹤草芽、雷丸、榛子各自的提取液;采用65~70%的乙醇浸溶,回流2~3h,且经过滤和减压蒸馏获得最终提取液;
步骤2,按重量份称取白屈菜、红血柳、老虎姜、酸藤木、马齿笕、竹叶蕉、百里香、油渣果、细叶桉、油柑木皮、独活,经洗净、晾干、粉碎后,粉碎后物料的粒径为40~60目,加入同一容器中进行浸泡,加水煮沸,获得混合提取液;
步骤3,按重量份称取辛夷花、野菊花、金银花、甘松经洗净后进行干燥,最后进行超微粉碎,获得混合粉末,超微粉碎后混合粉末的粒径为270~325目;
步骤4,将所述鹤草芽、雷丸、榛子各自的提取液、混合提取液、柠檬精油、硬脂酸和混合粉末进行快速搅拌;先将鹤草芽、雷丸、榛子各自的提取液、混合提取液和混合粉末混合均匀后,加热至50~55℃,不断搅拌条件下,分别加入温度均为80~85℃的柠檬精油和硬脂酸;获得最终乳化产品制剂。
所述药剂的原料组成按重量份配比为:鹤草芽,23份,雷丸,3份,榛子,8份,白屈菜,5份,红血柳,2份,老虎姜,2份,酸藤木,5份,马齿笕,10份,竹叶蕉,12份,百里香,15份,油渣果,5份,细叶桉,3份,油柑木皮,2份,辛夷花,6份,野菊花,5份,独活,10份,金银花,12份,甘松,8份;所述柠檬精油和硬脂酸的加入量分别为上述原料总质量的10%和5.5%。
实施例2
采用实施例1提供的方法制备一种利于药浴防治体外寄生虫的药剂,区别在于所述药剂的原料组成按重量份配比为:鹤草芽,35份,雷丸,12份,榛子,16份,白屈菜,15份,红血柳,12份,老虎姜,10份,酸藤木,17份,马齿笕,21份,竹叶蕉,22份,百里香,25份,油渣果,15份,细叶桉,13份,油柑木皮,13份,辛夷花,15份,野菊花,15份,独活,19份,金银花,25份,甘松,18份。
实施例3
采用实施例1提供的方法制备一种利于药浴防治体外寄生虫的药剂,区别在于所述药剂的原料组成按重量份配比为:鹤草芽,29份,雷丸,7份,榛子,12份,白屈菜,10份,红血柳,7份,老虎姜,8份,酸藤木,12份,马齿笕,15份,竹叶蕉,18份,百里香,20份,油渣果,10份,细叶桉,8份,油柑木皮,6份,辛夷花,11份,野菊花,10份,独活,15份,金银花,19份,甘松,14份。
以上所述的具体实施方式,对本发明的目的、技术方案和有益效果进行了进一步详细说明,所应理解的是,以上所述仅为本发明的具体实施方式而已,并不用于限定本发明的保护范围,凡在本发明的精神和原则之内,所做的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (8)
1.利于药浴防治体外寄生虫的药剂制备方法,其特征在于,所述制备方法的具体步骤为:
步骤1,按重量份称取鹤草芽、雷丸、榛子,经洗净晾干后,分别采用乙醇进行浸提获得鹤草芽、雷丸、榛子各自的提取液;
步骤2,按重量份称取白屈菜、红血柳、老虎姜、酸藤木、马齿笕、竹叶蕉、百里香、油渣果、细叶桉、油柑木皮、独活,经洗净、晾干、粉碎后,加入同一容器中进行浸泡,加水煮沸,获得混合提取液;
步骤3,按重量份称取辛夷花、野菊花、金银花、甘松经洗净后进行干燥,最后进行超微粉碎,获得混合粉末;
步骤4,将所述鹤草芽、雷丸、榛子各自的提取液、混合提取液、柠檬精油、硬脂酸和混合粉末进行快速搅拌,获得最终乳化产品制剂。
2.根据权利要求1所述的利于药浴防治体外寄生虫的药剂制备方法,其特征在于,所述药剂的原料组成按重量份配比为:鹤草芽,23~35份,雷丸,3~12份,榛子,8~16份,白屈菜,5~15份,红血柳,2~12份,老虎姜,2~10份,酸藤木,5~17份,马齿笕,10~21份,竹叶蕉,12~22份,百里香,15~25份,油渣果,5~15份,细叶桉,3~13份,油柑木皮,2~13份,辛夷花,6~15份,野菊花,5~15份,独活,10~19份,金银花,12~25份,甘松,8~18份。
3.根据权利要求2所述的利于药浴防治体外寄生虫的药剂制备方法,其特征在于,所述药剂的原料组成按重量份配比为:鹤草芽,29份,雷丸,7份,榛子,12份,白屈菜,10份,红血柳,7份,老虎姜,8份,酸藤木,12份,马齿笕,15份,竹叶蕉,18份,百里香,20份,油渣果,10份,细叶桉,8份,油柑木皮,6份,辛夷花,11份,野菊花,10份,独活,15份,金银花,19份,甘松,14份。
4.根据权利要求1所述的利于药浴防治体外寄生虫的药剂制备方法,其特征在于,所述柠檬精油和硬脂酸的加入量分别为上述原料总质量的10%和5.5%。
5.根据权利要求1所述的利于药浴防治体外寄生虫的药剂制备方法,其特征在于,所述步骤1中,采用65~70%的乙醇浸溶,回流2~3h,且经过滤和减压蒸馏获得最终提取液。
6.根据权利要求1所述的利于药浴防治体外寄生虫的药剂制备方法,其特征在于,所述步骤2中,粉碎后物料的粒径为40~60目。
7.根据权利要求1所述的利于药浴防治体外寄生虫的药剂制备方法,其特征在于,所述步骤3中,超微粉碎后混合粉末的粒径为270~325目。
8.根据权利要求1所述的利于药浴防治体外寄生虫的药剂制备方法,其特征在于,所述步骤4中,先将鹤草芽、雷丸、榛子各自的提取液、混合提取液和混合粉末混合均匀后,加热至50~55℃,不断搅拌条件下,分别加入温度均为80~85℃的柠檬精油和硬脂酸。
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