CN110253881A - A kind of more spray head 3D biometric print devices and Method of printing - Google Patents
A kind of more spray head 3D biometric print devices and Method of printing Download PDFInfo
- Publication number
- CN110253881A CN110253881A CN201910563558.3A CN201910563558A CN110253881A CN 110253881 A CN110253881 A CN 110253881A CN 201910563558 A CN201910563558 A CN 201910563558A CN 110253881 A CN110253881 A CN 110253881A
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- Prior art keywords
- runner
- nozzle
- storehouse
- spray head
- printing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000007639 printing Methods 0.000 title claims abstract description 28
- 239000007921 spray Substances 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 title claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 170
- 230000000694 effects Effects 0.000 claims abstract description 7
- 210000000056 organ Anatomy 0.000 claims description 17
- 238000005192 partition Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000004113 cell culture Methods 0.000 claims description 3
- 208000002925 dental caries Diseases 0.000 claims description 3
- 230000001360 synchronised effect Effects 0.000 claims description 3
- 238000010146 3D printing Methods 0.000 abstract description 3
- 239000002131 composite material Substances 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 12
- 239000012620 biological material Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 3
- 235000009854 Cucurbita moschata Nutrition 0.000 description 1
- 240000001980 Cucurbita pepo Species 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000013178 mathematical model Methods 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 235000020354 squash Nutrition 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Optics & Photonics (AREA)
- Materials For Medical Uses (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
A kind of more spray head 3D biometric print devices of the present invention and Method of printing, belong to medical instruments field；It is a kind of by way of extruding the technical problem to be solved is that providing, the biometric print machine of 3D printing is carried out while cultivating cell；Solve the technical solution of technical problem use are as follows: a kind of more spray head 3D biometric print devices, including be sequentially arranged from top to bottom material storehouse, material runner, nozzle runner, print platform, material runner is flexibly connected with nozzle runner, activity setting material storehouse in material runner, 6 chambers are divided into inside material runner and nozzle runner, material runner and nozzle runner connecting place are provided with electromagnetism wire coil, rise-withdraw fram is provided with below print platform, material storehouse is moved in nozzle runner, is then printed by way of extruding；It the composite can be widely applied to medical instruments field.
Description
Technical field
A kind of more spray head 3D biometric print devices of the present invention and Method of printing, belong to the field of medical instrument technology.
Background technique
Organ transplant can save the patient vitals of many human organ functional failure or damage, but this technology is also deposited
In the drawbacks such as organ origin is insufficient, rejection is difficult to avoid that, but, with the appearance of 3D biometric print machine, these problems have
Substantive progress, 3D biometric print machine are that one kind can be fixed according to increasing material manufacturing principle under digital three-dimensional mode activated
Position assembly biomaterial or cell factory, manufacture medical instrument, organizational project directly and the equipment of organizer official rank product, simultaneously
The plastics of 3D biometric print machine not instead of not in layer go to manufacture using biomaterial or cell structure block in layer
Real living tissue, however, being limited by cell printing technique, existing cell three-dimensional printing technique is mostly that operation is single
Cell or the material of ingredient are planted to construct simple structural body, is only confined in certain simple tissues, such as soft tissue, skin
Tissue and tendon tissue etc. cannot print complicated tissue, and the controlled assembling of cell three-dimensional at present is the anatomy in histoorgan
Mathematical model directly drives down, and positioning assembly living cells or material cell manufacture the new technology of tissue or organ precursor, be external
Component complicated tissue organ provides completely new possibility, but organ is made of different cells and has complicated microstructure
Three-dimensional structure, therefore many cells package technique becomes the key for developing cell assembling technology.
Summary of the invention
The invention overcomes the deficiencies of the prior art, and provides a kind of by way of extruding, cultivates cell on one side
The biometric print machine of 3D printing is carried out on one side.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention are as follows: a kind of more spray head 3D biometric print devices,
Including be sequentially arranged from top to bottom material storehouse, material runner, nozzle runner, print platform, material runner and nozzle runner are living
It is dynamic to connect, activity setting material storehouse in material runner；
Material runner includes material shaft, material envelope, and material shaft is connected with material envelope by material separates plate；
Nozzle runner includes nozzle shaft, nozzle housing, and nozzle shaft is connected with nozzle housing by nozzle demarcation plate；
Lower arrangement, material envelope are identical as nozzle housing structure on the same axis for material shaft and nozzle shaft；
Material storehouse includes material storage tube, and material storage tube lower part is provided with conical discharge port, and top is provided with piston, and side is set
It is equipped with lifter plate.
The material envelope and nozzle housing is cylindrical shell.
Material envelope inner cavity even partition is 6 chambers by the material separates plate, and the nozzle demarcation plate will spray
Mouth shell even partition is 6 chambers.
The material runner and nozzle runner connecting place is provided with electromagnetism wire coil.
Rise-withdraw fram is provided with below the print platform.
The material storehouse is the material storehouse of included heating mantle.
A kind of more spray head 3D biometric print methods, include the following steps:
1) the 3D model for the living tissue or organ to be printed, while synchronous progress cell culture, are established by mathematical modeling,
By cultured loading cells in the thermal control material storehouse with heating mantle；
2) living tissue or organ model frame, are established, six parts are divided into, the correspondence of print platform is arranged according to 3D model
Region, in order to organize to be formed with the early period of organ；
3) it, in sequence by material storehouse, is successively loaded in six cavitys of material runner, while controlling material shaft rotation, really
Six cavity bodies in the six material storehouses and nozzle runner of protecting material runner correspond, and material runner is moved to nozzle runner
Surface；
4) material runner, is slowly put down, material runner is docked with nozzle runner；
5), material storage tube is moved in nozzle runner by the lifter plate of the material storehouse side in material runner, and material is stored
Pipe is transported in nozzle runner；
6), material runner is separated with nozzle runner, carries out secondary material transhipment；
7) pneumatic control valve, is connected above the material storehouse on nozzle runner, connects o controller at the nozzle of lower section；
8), print platform is moved to immediately below nozzle runner, is sprayed by the rotation of print platform, stretching, lifting and printing
The opening and closing of head realize that the fixed point of printed material is placed, realize the accurate forming of printing target, complete print out task；
9) after the completion of, printing, the pneumatic control valve on separating nozzle runner top and the o controller of lower part, then by material storehouse
It is taken out from nozzle runner, the corresponding cavity of nozzle runner is idle out, it is convenient for printing next time；
10), circulation step 3 arrives step 9, until printing is completed.
Mechanical arm can be used in the movement of the step 3 material runner, and taking out material storehouse in the step 9 can also
To use mechanical arm.
Compared with the prior art, the invention has the following beneficial effects: having multiple skies inside material runner and nozzle runner
Chamber may be implemented more spray head switchings, realize printing of the squash type 3D biometric print for complex organ and polymorphic type cell, be
Future really prints widely applied histoorgan and provides technical support, may be implemented to carry out 3D while cultivating cell to beat
The mode of print, guarantee printing rapidity and real-time, and can guarantee print cell activity, improve printed material at
Power has bright prospects in terms of tissue defect, replacement, emergency rescue in time.
Detailed description of the invention
Following further describes the present invention with reference to the drawings.
Fig. 1 is the structural diagram of the present invention.
Specific embodiment
As shown in Figure 1, a kind of more spray head 3D biometric print devices of the present invention, including the material being sequentially arranged from top to bottom
Storehouse, material runner, nozzle runner, print platform, material runner are flexibly connected with nozzle runner, activity setting material in material runner
Feed bin；Material runner includes material shaft, material envelope, and material shaft is connected with material envelope by material separates plate；Nozzle
Runner includes nozzle shaft, nozzle housing, and nozzle shaft is connected with nozzle housing by nozzle demarcation plate；Material shaft and nozzle
Lower arrangement, material envelope are identical as nozzle housing structure on the same axis for shaft；Material storehouse includes material storage tube, and material is deposited
Storage pipe lower part is provided with conical discharge port, and top is provided with piston, and side is provided with lifter plate, the material envelope and nozzle
Shell is cylindrical shell, and material envelope inner cavity even partition is 6 chambers, the nozzle point by the material separates plate
Nozzle housing even partition is 6 chambers by partition, and material runner and nozzle runner connecting place are provided with electromagnetism wire coil, beat
Rise-withdraw fram is provided with below print platform, material storehouse is the material storehouse of included heating mantle.
A kind of more spray head 3D biometric print methods, include the following steps:
1) the 3D model for the living tissue or organ to be printed, while synchronous progress cell culture, are established by mathematical modeling,
By cultured loading cells in the thermal control material storehouse with heating mantle；
2) living tissue or organ model frame, are established, six parts are divided into, the correspondence of print platform is arranged according to 3D model
Region, in order to organize to be formed with the early period of organ；
3) it, in sequence by material storehouse, is successively loaded in six cavitys of material runner, while controlling material shaft rotation, really
Six cavity bodies in the six material storehouses and nozzle runner of protecting material runner correspond, and material runner is moved to nozzle runner
Surface；
4) material runner, is slowly put down, material runner is docked with nozzle runner；
5), material storage tube is moved in nozzle runner by the lifter plate of the material storehouse side in material runner, and material is stored
Pipe is transported in nozzle runner；
6), material runner is separated with nozzle runner, carries out secondary material transhipment；
7) pneumatic control valve, is connected above the material storehouse on nozzle runner, connects o controller at the nozzle of lower section；
8), print platform is moved to immediately below nozzle runner, is sprayed by the rotation of print platform, stretching, lifting and printing
The opening and closing of head realize that the fixed point of printed material is placed, realize the accurate forming of printing target, complete print out task；
9) after the completion of, printing, the pneumatic control valve on separating nozzle runner top and the o controller of lower part, then by material storehouse
It is taken out from nozzle runner, the corresponding cavity of nozzle runner is idle out, it is convenient for printing next time；
10), circulation step 3 arrives step 9, until printing is completed.
Mechanical arm can be used in the movement of the step 3 material runner, and taking out material storehouse in the step 9 can also
To use mechanical arm.
Print platform is a disk, is the fan-shaped region for being divided into six pieces of interior angles and being 60 °, the mould for the object that need to be printed
Type can also be divided into six parts, and one fan-shaped region of each nozzle face is mainly responsible for the printing in the region, and every piece of region printed
All be in journey it is independently operable, after all six pieces of print areas all form, combine, formed one complete group
It knits or organ, nozzle runner is by hexahedron as external frame, be uniformly cut into six regular triangular prisms, each triangular prism
Inside can accommodate the material storehouse of a carrying printing nozzle, and material storehouse side has one piece for going up and down the lifting groove in material storehouse, sprays
The outer rib of mouth runner upper surface metal material makes (the outer rib of material runner lower surface also makes of method of the same race), works as material
Runner lower surface and nozzle runner upper surface spacing (can add a rangefinder in material runner lower surface) when being less than given value, and two
Kind metal inside leads to same direction current, under the magnetic fields that electric current generates, so that nozzle runner is tightly adsorbed with material runner, from
And realize the purpose in lifting material storehouse, and after material storehouse is smoothly placed on nozzle runner designated position, the logical reversed electricity of the outer rib of metal
Stream generates repulsive force, pilot jet runner and the separation of material runner.After the two compartment is away from certain certain value is more than or equal to,
Electric current output stops, using the effect of mechanical arm, so that material runner realizes that perfection separates with nozzle runner, right above material storehouse
There is the air-breather of a connection controllable pressure, this through-hole connects gas control valve, by regulating gas control valve, realizes gas
The controllable adjustment of pressure further controls print speed, coats one layer of heat preservation material around material storehouse, and require temperature adjustable
Section meets different printed materials to the difference of temperature requirement, and material runner is external frame, size and spray by a hexahedron
Mouth runner is consistent, and central axis controls the position in six material storehouses, and six material storehouses can be around center axis rotation, to realize material
Storehouse can reach any nozzle runner, and material runner and nozzle runner one-to-one relationship up and down, hexahedron side is can
The metal plate of folding, coats one layer of thermal control material around material storehouse, and material storehouse can use mechanical arm by opening the metal plate of side
Ready material storehouse is put into a cavity of specified material runner, completes the loading in material storehouse, material storehouse is primary
Property product, only carry out primary printing process, so material selection biocompatible material, pass through o controller at printing head
The time and progress, this o controller for controlling printing are impulse generators, when printing, can be beaten on one side completely
Print, cultivates cell on one side, and the biomaterial that needs are printed is loaded in material storehouse after culture is good, waits last handling
After, the material runner being available is loaded cultured material storehouse, to guarantee the activity of biomaterial.
The embodiment of the present invention is explained in detail above in conjunction with attached drawing, but the present invention is not limited to above-mentioned implementations
Example, within the knowledge of a person skilled in the art, can also make without departing from the purpose of the present invention
Various change out.
Claims (8)
1. a kind of more spray head 3D biometric print devices, it is characterised in that: including be sequentially arranged from top to bottom material storehouse, material turn
Wheel, nozzle runner, print platform, material runner are flexibly connected with nozzle runner, activity setting material storehouse in material runner；
Material runner includes material shaft, material envelope, and material shaft is connected with material envelope by material separates plate；
Nozzle runner includes nozzle shaft, nozzle housing, and nozzle shaft is connected with nozzle housing by nozzle demarcation plate；
Lower arrangement, material envelope are identical as nozzle housing structure on the same axis for material shaft and nozzle shaft；
Material storehouse includes material storage tube, and material storage tube lower part is provided with conical discharge port, and top is provided with piston, and side is set
It is equipped with lifter plate.
2. a kind of more spray head 3D biometric print devices according to claim 1, it is characterised in that: the material envelope with
Nozzle housing is cylindrical shell.
3. a kind of more spray head 3D biometric print devices according to claim 1, it is characterised in that: the material separates plate
It is 6 chambers by material envelope inner cavity even partition, nozzle housing even partition is 6 chambers by the nozzle demarcation plate.
4. a kind of more spray head 3D biometric print devices according to claim 1, it is characterised in that: the material runner with
Nozzle runner connecting place is provided with electromagnetism wire coil.
5. a kind of more spray head 3D biometric print devices according to claim 1, it is characterised in that: under the print platform
Side is provided with rise-withdraw fram.
6. a kind of more spray head 3D biometric print devices according to claim 1, it is characterised in that: the material storehouse is certainly
Material storehouse with heating mantle.
7. a kind of more spray head 3D biometric print methods, which comprises the steps of:
1) the 3D model for the living tissue or organ to be printed, while synchronous progress cell culture, are established by mathematical modeling,
By cultured loading cells in the thermal control material storehouse with heating mantle；
2) living tissue or organ model frame, are established, six parts are divided into, the correspondence of print platform is arranged according to 3D model
Region, in order to organize to be formed with the early period of organ；
3) it, in sequence by material storehouse, is successively loaded in six cavitys of material runner, while controlling material shaft rotation, really
Six cavity bodies in the six material storehouses and nozzle runner of protecting material runner correspond, and material runner is moved to nozzle runner
Surface；
4) material runner, is slowly put down, material runner is docked with nozzle runner；
5), material storage tube is moved in nozzle runner by the lifter plate of the material storehouse side in material runner, and material is stored
Pipe is transported in nozzle runner；
6), material runner is separated with nozzle runner, carries out secondary material transhipment；
7) pneumatic control valve, is connected above the material storehouse on nozzle runner, connects o controller at the nozzle of lower section；
8), print platform is moved to immediately below nozzle runner, is sprayed by the rotation of print platform, stretching, lifting and printing
The opening and closing of head realize that the fixed point of printed material is placed, realize the accurate forming of printing target, complete print out task；
9) after the completion of, printing, the pneumatic control valve on separating nozzle runner top and the o controller of lower part, then by material storehouse
It is taken out from nozzle runner, the corresponding cavity of nozzle runner is idle out, it is convenient for printing next time；
10), circulation step 3 arrives step 9, until printing is completed.
8. a kind of more spray head 3D biometric print methods according to claim 7, it is characterised in that: step 3 material
Mechanical arm can be used in the movement of runner, and taking out material storehouse in the step 9 also can be used mechanical arm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910563558.3A CN110253881B (en) | 2019-06-26 | 2019-06-26 | Multi-nozzle 3D biological printing device and printing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910563558.3A CN110253881B (en) | 2019-06-26 | 2019-06-26 | Multi-nozzle 3D biological printing device and printing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110253881A true CN110253881A (en) | 2019-09-20 |
| CN110253881B CN110253881B (en) | 2021-05-28 |
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| CN201910563558.3A Active CN110253881B (en) | 2019-06-26 | 2019-06-26 | Multi-nozzle 3D biological printing device and printing method |
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|---|---|---|---|---|
| CN104924614A (en) * | 2015-06-08 | 2015-09-23 | 浙江大学 | Rotary switching biological 3D printing sprayer for multi-material printing and rotary switching biological 3D printing method |
| CN105796206A (en) * | 2016-05-07 | 2016-07-27 | 浙江大学 | Multi-spray head biological 3D printing equipment capable of batching and mixing materials automatically and control method for multi-spray head biological 3D printing equipment |
| WO2017113186A1 (en) * | 2015-12-30 | 2017-07-06 | 四川蓝光英诺生物科技股份有限公司 | Nozzle assembly of biological printer and biological printer |
| CN107028681A (en) * | 2017-04-11 | 2017-08-11 | 清华大学深圳研究生院 | A kind of 3D printing device and method of tissue engineering bracket |
| CN207758151U (en) * | 2018-01-11 | 2018-08-24 | 刘晓军 | More nozzle switching devices, 3D printing head and 3D printer |
| CN108673891A (en) * | 2018-06-14 | 2018-10-19 | 浙江大学 | The multiple flow passages nozzle structure of portable biometric 3D printer |
-
2019
- 2019-06-26 CN CN201910563558.3A patent/CN110253881B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104924614A (en) * | 2015-06-08 | 2015-09-23 | 浙江大学 | Rotary switching biological 3D printing sprayer for multi-material printing and rotary switching biological 3D printing method |
| WO2017113186A1 (en) * | 2015-12-30 | 2017-07-06 | 四川蓝光英诺生物科技股份有限公司 | Nozzle assembly of biological printer and biological printer |
| CN105796206A (en) * | 2016-05-07 | 2016-07-27 | 浙江大学 | Multi-spray head biological 3D printing equipment capable of batching and mixing materials automatically and control method for multi-spray head biological 3D printing equipment |
| CN107028681A (en) * | 2017-04-11 | 2017-08-11 | 清华大学深圳研究生院 | A kind of 3D printing device and method of tissue engineering bracket |
| CN207758151U (en) * | 2018-01-11 | 2018-08-24 | 刘晓军 | More nozzle switching devices, 3D printing head and 3D printer |
| CN108673891A (en) * | 2018-06-14 | 2018-10-19 | 浙江大学 | The multiple flow passages nozzle structure of portable biometric 3D printer |
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| CN110253881B (en) | 2021-05-28 |
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Effective date of registration: 20240429 Address after: Room 703, Building 1, No. 430 Miaoqiao Road, Pudong New Area, Shanghai, 201315 Patentee after: Lanbaotai (Shanghai) Biopharmaceutical Co.,Ltd. Country or region after: China Address before: 030024 No. 79 West Main Street, Taiyuan, Shanxi, Yingze Patentee before: Taiyuan University of Technology Country or region before: China |