CN206970584U - A kind of unicellular 3D printing system - Google Patents
A kind of unicellular 3D printing system Download PDFInfo
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- CN206970584U CN206970584U CN201720740605.3U CN201720740605U CN206970584U CN 206970584 U CN206970584 U CN 206970584U CN 201720740605 U CN201720740605 U CN 201720740605U CN 206970584 U CN206970584 U CN 206970584U
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Abstract
The utility model provides a kind of unicellular 3D printing system.A kind of unicellular 3D printing system, wherein, including barrel and the nozzle system that is connected with the barrel, the nozzle system, which is provided with, to be used to extrude the drive device for including single celled droplet；The nozzle system includes inner nozzle, and the internal diameter of the inner nozzle is more than the diameter of individual cells, and less than 150 μm；The drive device includes being located at the driving diaphragm of the inner nozzle rear end, the push rod that front end is close to the driving diaphragm and the piezoelectric ceramics for being connected to the putting back-end.The utility model is simple in construction, easy to use, it is possible to achieve unicellular 3D printing.
Description
Technical field
Bioengineered tissue technical field is the utility model is related to, more particularly, to a kind of unicellular 3D printing system.
Background technology
Organizational project is the subjects such as fusion engineering science, life science and material science, by imitating human tissue organ's shape
Into process build and cultivate in vitro the structure with bioactivity.Among these, 3D printing technique is because it is usable more
Kind material is molded any complicated three-dimensional structure, turns into the most strong research meanses of field of tissue engineering technology.The original of 3D printing technique
Reason is exactly Layered manufacturing, is accumulated layer by layer.Traditional cell printing shower nozzle is exactly after cell is mixed with biomaterial and extruded shape
Into a silk thread shape, in multiple reciprocal forming face, the accumulation in face then forms corresponding three-dimensional structure.Typical shower nozzle among these
It is exactly electric motor boosted formula shower nozzle.
Fig. 1 is traditional electric motor boosted formula shower nozzle three-dimensional structure subdivision schematic diagram, and linear stepping motor is fixed on sportswear
Put on support, screw rod can apply certain pressure under the drive of linear stepping motor to the moulding material in shower nozzle, shape material
Material is extruded from nozzle immediately, and heating rod and insulated sheath are arranged on the temperature that shower nozzle hypomere makes the moulding material in shower nozzle keep setting
Degree.
Fig. 2 is conventional motors assisted shower nozzle extrusion effect, and Fig. 3 is traditional sprinkler heads extruded material cross-sectional view, from
It can be seen that cell is included in biomaterial and extruded in figure, multiple cells are extruded simultaneously, and cell is wherein
Position is random uncontrollable.Cell is not protected in extrusion, is influenceed by shearing force caused by nozzle inside diameter, meeting
Phenomena such as causing membranolysis death, produces, and greatly reduces the activity of cell.
Therefore, although such a design is simple and reliable, also there is following weak point：1) formed precision is not high to realize
For single celled injection, the minimum internal diameter of traditional prints shower nozzle is 150 μm or so, is far longer than the chi of 10 μm of cell dia
It is very little, multiple cells can be extruded simultaneously, position of the cell in formed body is random uncontrollable；2) in extrusion, cell can be by
To the influence of shearing force caused by nozzle interior so that cytoactive sustains damage；3) speed of extrusion is relatively low, the efficiency of shaping
It is not high.
Utility model content
The utility model is to overcome at least one defect described in above-mentioned prior art, there is provided a kind of unicellular 3D printing system
System.The 3D printing system is simple in construction, easy to use, it is possible to achieve unicellular 3D printing.
In order to solve the above technical problems, the technical solution adopted in the utility model is：A kind of unicellular 3D printing system, its
In, including barrel and the nozzle system that is connected with the barrel, the nozzle system, which is provided with, to be used to extrude comprising single celled
The drive device of droplet；The nozzle system includes inner nozzle, and the internal diameter of the inner nozzle is more than the diameter of individual cells, and small
In 150 μm；The drive device is including being located at the driving diaphragm of the inner nozzle rear end, front end is close to the driving diaphragm
Push rod and the piezoelectric ceramics for being connected to the putting back-end.Cell suspending liquid is contained in barrel, and the small part in barrel is thin
Born of the same parents' suspension enters nozzle system, and piezoelectric ceramics deforms under the stimulation of pulse voltage, promotes the push rod of lower section, and then promote
Diaphragm deformation is driven, driving diaphragm deforms downwards, and the pressure that diminishes of the volume inside inner nozzle increases and then extrudes one comprising single
The droplet of cell；When piezoelectric ceramics back shrinkage drives driving diaphragm upwardly-deformed, inner nozzle internal pressure reduces, and is stored in
Cell suspension in barrel enters inner nozzle along pipeline, completes a circulation.Piezoelectric ceramics can under the control of pulse voltage
The deformation and then the ejection of promotion droplet one by one of control.
Further, unicellular 3D printing system provided by the utility model also includes constant temperature cabin, and the barrel is located at institute
State in constant temperature cabin, the nozzle system is located at the constant temperature bilge portion.The cell suspending liquid that constant temperature cabin can be given in barrel provides
One isoperibol, avoid because outside environmental elements change and caused by cytoactive damage.
Further, the nozzle system also includes outer nozzle, and the outer nozzle is set in the front end of the inner nozzle, outside
It is spaced apart between nozzle inner walls and inner nozzle outer wall.Preferably, the internal diameter of the inner nozzle is 20 ~ 90 μm, described outer
The internal diameter of nozzle is 100 ~ 200 μm.The internal diameter of inner nozzle is slightly larger than single celled 10 μm of diameter, to ensure what is sprayed from inner nozzle
Only individual cells are included in cell suspending liquid droplet.
Further, the outer wall of the outer nozzle rear end is provided with air inlet pipe, relative on the outer wall of the outer nozzle front end
Airway tube is provided with, the inside of the air inlet pipe and airway tube with the outer nozzle connects, and the airway tube is towards described outer
The front end of nozzle tilts.Angle between the central axis of the central axis of the airway tube and the outer nozzle is 30 ~ 60 °,
Preferably, the angle between the central axis of the airway tube and the central axis of outer nozzle is 45 °.Inner nozzle, which ejects, to be included
During single celled droplet, gases at high pressure are passed through in the air inlet pipe of outer nozzle, and apply on the airway tube of outer nozzle
Suction force, the stable air-flow sprayed downwards is formed among such inner nozzle and outer nozzle, when including the spray of single celled droplet
When being mapped to outer nozzle, comprising just there is one layer of air cushion between single celled droplet and outer nozzle inwall, protective effect is served, is reduced
Comprising the shearing force between single celled droplet and outer nozzle inwall, cell survival rate is improved, gas is in outer nozzle
When wall is ejected into the front end of outer nozzle, most air-flows will be avoided influenceing by the airway tube discharge positioned at outer nozzle front end
The direction of motion for including single celled droplet ejected from outer nozzle.Airway tube tilts towards the front end of the outer nozzle can
Discharged with ensureing that most air-flows are aspirated by airway tube.
Further, the barrel is connected with the nozzle system by pipeline, between barrel and the nozzle system
Pipeline is provided with check valve.Cell suspending liquid in barrel, small part drive via inner nozzle, drive device is entered after check valve
When dynamic inner nozzle extrusion includes single celled droplet, closed check valve, the cell suspending liquid in inner nozzle can be prevented to be back to
In barrel so that droplet is extruded from inner nozzle, and when drive device bounces back so that inner nozzle internal pressure reduces, check valve is opened,
The cell suspension being stored in barrel enters inner nozzle along pipeline.
Further, it is sequentially provided with below the outer nozzle for making to take electricity from the unicellular of outer nozzle ejection
The polarized electric field of lotus, and take the unicellular deflecting electric field that respective shapes are arranged out on bottom plate of electric charge for controlling.Spray
The unicellular of mouth system ejection takes electric charge in the presence of polarized electric field, and the then control through deflecting electric field arranges on bottom plate
Go out corresponding shape.
Compared with prior art, the utility model has the advantages that：
The inner nozzle of cell 3D printing system provided by the utility model and the internal diameter of outer nozzle are all smaller, improve cell
Formed precision, drive injection unicellular with the use of piezoelectric ceramics, realize for single celled 3D printing, along with electric field
To control the arrangement for including single celled droplet, all electronic control, shaping efficiency height.Traditional prints shower nozzle is because nozzle inside diameter
It is larger, it is multiple cells being extruded simultaneously, and position of the cell in extruded material is random uncontrollable.Meanwhile this
The cell 3D printing system of utility model adds air-flow protection on nozzle system so that wraps in celliferous droplet and nozzle
One layer of air cushion is formed between wall, weakens and is even a cancellation adversely affecting for the shearing force that cell is subject to, substantially increase cell
Survival rate.
Brief description of the drawings
Fig. 1 is conventional motors assisted shower nozzle three-dimensional structure subdivision schematic diagram.
Fig. 2 is conventional motors assisted shower nozzle extruded material design sketch.
Fig. 3 is conventional motors assisted shower nozzle extruded material cross-sectional view.
Fig. 4 is overall structure diagram of the present utility model.
In figure：201-screw rod；202-linear stepping motor；203-heating rod；204-insulated sheath；205-nozzle；
401-cell；402-biomaterial；1-constant temperature cabin；2-barrel；3-inner nozzle；4-outer nozzle；5-air inlet pipe；6-lead
Tracheae；7-check valve；8-driving diaphragm；9-push rod；10-piezoelectric ceramics；11-polarized electric field；12-deflecting electric field.
Embodiment
Accompanying drawing being given for example only property explanation, it is impossible to be interpreted as the limitation to this patent；It is attached in order to more preferably illustrate the present embodiment
Scheme some parts to have omission, zoom in or out, do not represent the size of actual product；To those skilled in the art,
Some known features and its explanation may be omitted and will be understood by accompanying drawing.Being given for example only property of position relationship described in accompanying drawing
Explanation, it is impossible to be interpreted as the limitation to this patent.
As shown in figure 4, a kind of unicellular 3D printing system, wherein, including barrel 2 and the nozzle that is connected with the barrel 2
System, the nozzle system, which is provided with, to be used to extrude the drive device for including single celled droplet；The nozzle system includes interior
Nozzle 3, the internal diameter of the inner nozzle 3 are more than the diameter of individual cells, and less than 150 μm；The drive device includes being located at institute
After stating the driving diaphragm 8 of the rear end of inner nozzle 3, the push rod 9 that front end is close to the driving diaphragm 8 and being connected to the push rod 9
The piezoelectric ceramics 10 at end.Cell suspending liquid is contained in barrel 2, and the small part cell suspending liquid in barrel 2 enters nozzle system
System, piezoelectric ceramics 10 deform under the stimulation of pulse voltage, promote the push rod 9 of lower section, and then promote driving diaphragm 8 to deform, and drive
Dynamic diaphragm 8 deforms downwards, the volume inside inner nozzle 3 diminish pressure increase so that extrude one include single celled droplet；When
When the back shrinkage of piezoelectric ceramics 10 drives driving diaphragm 8 upwardly-deformed, the internal pressure of inner nozzle 3 reduces, and is stored in barrel 2
Cell suspension enters inner nozzle 3 along pipeline, completes a circulation.The change controllable under the control of pulse voltage of piezoelectric ceramics 10
Shape and then the ejection of promotion droplet one by one.
As shown in figure 4, unicellular 3D printing system provided by the utility model also includes constant temperature cabin 1, the barrel 2 is located at
In the constant temperature cabin 1, the nozzle system is located at the bottom of constant temperature cabin 1.The cell that constant temperature cabin 1 can be given in barrel 2 suspends
Liquid provide an isoperibol, avoid because outside environmental elements change and caused by cytoactive damage.
As shown in figure 4, the nozzle system also includes outer nozzle 4, before the outer nozzle 4 is set in the inner nozzle 3
End, it is spaced apart between the inwall of outer nozzle 4 and the outer wall of inner nozzle 3.Preferably, the internal diameter of the inner nozzle 3 is 20 ~ 90 μ
M, the internal diameter of the outer nozzle 4 is 100 ~ 200 μm.The internal diameter of inner nozzle 3 is slightly larger than single celled 10 μm of diameter, to ensure from interior
Only individual cells are included in the cell suspending liquid droplet that nozzle 3 sprays.
As shown in figure 4, the outer wall of the rear end of outer nozzle 4 is provided with air inlet pipe 5, on the outer wall of the front end of outer nozzle 4
Be relatively set with airway tube 6, the inside of the air inlet pipe 5 and airway tube 6 with the outer nozzle 4 connects, the airway tube 6 to
The front end for the outer nozzle 4 tilts.Folder between the central axis of the airway tube 6 and the central axis of the outer nozzle 4
Angle is 30 ~ 60 °, it is preferred that the angle between the central axis of the airway tube 6 and the central axis of outer nozzle 4 is 45 °.It is interior
During nozzle 3 is ejected comprising single celled droplet, gases at high pressure are passed through in the air inlet pipe 5 of outer nozzle 4, and spray outside
Apply suction force on the airway tube 6 of mouth 4, the stable air-flow sprayed downwards be formed among such inner nozzle 3 and outer nozzle 4,
When comprising single celled droplet ejection to outer nozzle 4, comprising just there is one layer of gas between single celled droplet and the inwall of outer nozzle 4
Pad, protective effect is served, reduce comprising the shearing force between single celled droplet and the inwall of outer nozzle 4, improve cell and deposit
Motility rate, when gas is ejected into the front end of outer nozzle 4 along the inwall of outer nozzle 4, most air-flows will be by positioned at outer nozzle 4
The airway tube 6 of front end is discharged, and avoids influenceing the direction of motion for including single celled droplet ejected from outer nozzle 4.Air guide
Pipe 6 tilts towards the front end of the outer nozzle 4 can ensure that most air-flows aspirate discharge by airway tube 6.
As shown in figure 4, the barrel 2 is connected with the nozzle system by pipeline, between barrel 2 and the nozzle system
Pipeline be provided with check valve 7.Cell suspending liquid in barrel 2, small part drive via inner nozzle 3 is entered after check valve 7
When the device driving extrusion of inner nozzle 3 includes single celled droplet, check valve 7 is closed, and can prevent the cell in inner nozzle 3 from suspending
Liquid is back in barrel 2 so that and droplet is extruded from inner nozzle 3, when drive device bounces back so that the internal pressure of inner nozzle 3 reduces,
Check valve 7 is opened, and the cell suspension being stored in barrel 2 enters inner nozzle 3 along pipeline.
As shown in figure 4, the lower section of the outer nozzle 4 is sequentially provided with the unicellular band for making to spray from the outer nozzle 4
The polarized electric field 11 of upper electric charge, and for controlling the unicellular deflection for arranging out respective shapes on bottom plate for taking electric charge electric
Field 12.The unicellular of nozzle system ejection takes electric charge in the presence of polarized electric field 11, the control then through deflecting electric field 12
Corresponding shape is arranged out on bottom plate.
Obviously, above-described embodiment of the present utility model is used for the purpose of clearly demonstrating the utility model example,
And it is not the restriction to embodiment of the present utility model.For those of ordinary skill in the field, stated upper
It can also be made other changes in different forms on the basis of bright.There is no need and unable to give all embodiments
With exhaustion.All made within spirit of the present utility model and principle all any modification, equivalent and improvement etc., all should be included
Within the protection domain of the utility model claims.
Claims (9)
1. a kind of unicellular 3D printing system, it is characterised in that including barrel（2）With with the barrel（2）The nozzle system of connection
System, the nozzle system, which is provided with, to be used to extrude the drive device for including single celled droplet；The nozzle system includes interior spray
Mouth（3）, the inner nozzle（3）Internal diameter be more than the diameters of individual cells, and less than 150 μm；The drive device includes being located at
The inner nozzle（3）The driving diaphragm of rear end（8）, front end and the driving diaphragm（8）The push rod being close to（9）And it is connected to institute
State push rod（9）The piezoelectric ceramics of rear end（10）.
2. a kind of unicellular 3D printing system according to claim 1, it is characterised in that also including constant temperature cabin（1）, it is described
Barrel（2）It is located at the constant temperature cabin（1）Interior, the nozzle system is located at the constant temperature cabin（1）Bottom.
3. a kind of unicellular 3D printing system according to claim 1, it is characterised in that the nozzle system also includes outer
Nozzle（4）, the outer nozzle（4）It is set in the inner nozzle（3）Front end, outer nozzle（4）Inwall and inner nozzle（3）Outer wall it
Between it is spaced apart.
A kind of 4. unicellular 3D printing system according to claim 3, it is characterised in that the inner nozzle（3）Internal diameter
For 20 ~ 90 μm, the outer nozzle（4）Internal diameter be 100 ~ 200 μm.
A kind of 5. unicellular 3D printing system according to claim 3, it is characterised in that the outer nozzle（4）Rear end
Outer wall is provided with air inlet pipe（5）, the air inlet pipe（5）With the outer nozzle（4）Inside connection；The outer nozzle（4）Front end
Outer wall on be relatively set with airway tube（6）, the airway tube（6）With the outer nozzle（4）Inside connection, the airway tube
（6）Towards the outer nozzle（4）Front end tilt.
A kind of 6. unicellular 3D printing system according to claim 5, it is characterised in that the airway tube（6）Center
Axis and the outer nozzle（4）Central axis between angle be 30 ~ 60 °.
A kind of 7. unicellular 3D printing system according to claim 6, it is characterised in that the airway tube（6）Center
Axis and outer nozzle（4）Central axis between angle be 45 °.
A kind of 8. unicellular 3D printing system according to claim any one of 1-7, it is characterised in that the barrel（2）
It is connected with the nozzle system by pipeline, barrel（2）Pipeline between the nozzle system is provided with check valve（7）.
A kind of 9. unicellular 3D printing system according to claim any one of 3-7, it is characterised in that the nozzle system
Lower section be sequentially provided with for making from the outer nozzle（4）The unicellular polarized electric field for taking electric charge sprayed（11）, Yi Jiyong
The unicellular deflecting electric field that respective shapes are arranged out on bottom plate of electric charge is taken in control（12）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720740605.3U CN206970584U (en) | 2017-06-23 | 2017-06-23 | A kind of unicellular 3D printing system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720740605.3U CN206970584U (en) | 2017-06-23 | 2017-06-23 | A kind of unicellular 3D printing system |
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| Publication Number | Publication Date |
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| CN206970584U true CN206970584U (en) | 2018-02-06 |
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| CN201720740605.3U Active CN206970584U (en) | 2017-06-23 | 2017-06-23 | A kind of unicellular 3D printing system |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108515175A (en) * | 2018-05-08 | 2018-09-11 | 东南大学 | A kind of magnesium alloy slurry and its Method of printing |
| CN109822889A (en) * | 2019-03-22 | 2019-05-31 | 河北雄安大洲智造科技有限公司 | A kind of multichannel 3D printing spray head and preparation method thereof, cell/bio-ink transportation system |
| CN110539480A (en) * | 2019-09-25 | 2019-12-06 | 李筱穗 | FDM shower nozzle extrusion pressure stable structure |
| CN111331845A (en) * | 2020-03-23 | 2020-06-26 | 尤宝旺 | Biological 3D prints shower nozzle |
| EP4147850A1 (en) * | 2021-09-14 | 2023-03-15 | CIC nanoGUNE - Asociación Centro de Investigación Cooperativa en Nanociencias | Additive manufacturing system |
-
2017
- 2017-06-23 CN CN201720740605.3U patent/CN206970584U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108515175A (en) * | 2018-05-08 | 2018-09-11 | 东南大学 | A kind of magnesium alloy slurry and its Method of printing |
| CN109822889A (en) * | 2019-03-22 | 2019-05-31 | 河北雄安大洲智造科技有限公司 | A kind of multichannel 3D printing spray head and preparation method thereof, cell/bio-ink transportation system |
| CN109822889B (en) * | 2019-03-22 | 2024-03-26 | 深圳大洲医学科技有限公司 | Multichannel 3D printing spray head, preparation method thereof and cell/biological ink conveying system |
| CN110539480A (en) * | 2019-09-25 | 2019-12-06 | 李筱穗 | FDM shower nozzle extrusion pressure stable structure |
| CN111331845A (en) * | 2020-03-23 | 2020-06-26 | 尤宝旺 | Biological 3D prints shower nozzle |
| EP4147850A1 (en) * | 2021-09-14 | 2023-03-15 | CIC nanoGUNE - Asociación Centro de Investigación Cooperativa en Nanociencias | Additive manufacturing system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 510663 Guangzhou, Guangdong, Guangzhou hi tech Industrial Development Zone, Science City, 80 E third district. Patentee after: Guangzhou Maple regenerative medicine Polytron Technologies Inc Address before: 510670 Guangzhou District, Guangdong, new high tech Industrial Development Zone, Science City, 80 E third district. Patentee before: Medprin Regenerative Medical Technologies Co., Ltd. |
|
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Liu Libiao Inventor after: Yuan Yuyu Inventor before: Li Sihua Inventor before: Yuan Yuyu |