CN110201136A

CN110201136A - Composition, the preparation method and application for treating heart disease and vascular sclerosis class disease

Info

Publication number: CN110201136A
Application number: CN201910590855.7A
Authority: CN
Inventors: 伍永刚
Original assignee: Guangzhou Wushishen Health Industry Co Ltd
Current assignee: Guangzhou Wushishen Health Industry Co Ltd
Priority date: 2019-07-02
Filing date: 2019-07-02
Publication date: 2019-09-06

Abstract

The invention discloses a kind of compositions for treating heart disease and vascular sclerosis class disease, preparation method and application；The composition includes following components by weight: 1~20 part of the dried immature fruit of citron orange, 1~20 part of Cortex Magnoliae Officinalis, 1~50 part of red halloysite, 0.5~10 part of gun additioner, 0.1~2 part of monkshood, 0.5~20 part of Radix Glycyrrhizae, 0.5~30 part of rhizoma zingiberis, 0.5~30 part of ramulus cinnamomi, 0.5~25 part of cortex cinnamomi, it is 0.5~25 part real to include beach wormwood, 0.5~25 part of Rhizoma Chuanxiong, 0.1~5 part of cinnabar, 0.1~10 part of another name for Sichuan Province green pepper, 0.5~30 part of Radix Angelicae Sinensis, 0.5~25 part of dark plum.Its formula science of composition provided by the invention, the effect of having and promote heart-yang, quickly get through blood vessel blockage, remove thrombus, soften vascular wall, eliminate ponding under the heart, eliminate chest and back pain, restore heart side film, curative effect is fast and obvious；Safety simultaneously is good, and few side effects, crude drug source is extensive, is easy to volume production.

Description

Composition, the preparation method and application for treating heart disease and vascular sclerosis class disease

Technical field

The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of combinations for treating heart disease and vascular sclerosis class disease Object, preparation method and application.

Background technique

The drug majority for being currently used for heart disease and vascular sclerosis class disease is based on chemicals, and western medicine exists Many worthless factors and disadvantage, mainly have the following:

1, Western medicine cannot be completely with blood phased soln, and in the blood vessels, it is more and more narrower that long-time service will cause blood vessel to deposition；

2, vascular wall is thinning；

3, easily rupturable；

4, heart burden increases, and be easy to cause cerebral hemorrhage at any time；

5, it takes for a long time, the damage to the vital organs of the human body is quite big.

Chinese medicinal formulae is particular about monarch, just records in Shennong's Herbal: " 120 kinds of medicine-feeding are monarch, main to support life； 120 kinds of Chinese medicine are minister, and master nourishs one's nature；Putting in poison 120 kinds makes for assistant, cures mainly disease；Medication must close monarch." " clear Will is clever " paraphrase: 120 kinds of top grade are monarch, and main life of supporting is nontoxic with Ying Tian, take long term usage more and do not hurt sb.'s feelings, are intended to QI invigorating macrobiosis and make light of one's life by commiting suicide Angle person, this top grade；120 kinds of middle product are minister, and master nourishs one's nature to answer people, toxic, nontoxic, consider it preferably, qi-restoratives to be cured the disease is thin Person, it is main in product；Made with 120 kinds of low-grades for assistant, it is mostly malicious to answer ground, can not long term usage, fever and chills perverse trend remove, break accumulation remove it is chronic Disease person, this low-grade.As it can be seen that being especially particular about the compatibility combination of each medicinal material in the research of Chinese medicine composition, passing through medicine between each medicinal material The coordinated of effect and pharmacological property, has the function that the toxicity that heightens the effect of a treatment or mitigate.However there are many existing similar Chinese patent drug Prescription is not scientific, and curative effect is slow and single.

Therefore there is an urgent need to a kind of prescription science, clinical efficacy is fast and apparent new medicine composition.

Summary of the invention

In view of this, the main object of the present invention is to provide a kind of prescription science, curative effect is fast and apparent new medicine group Close object.

To achieve the above object, technical scheme is as follows:

A kind of composition for treating heart disease and vascular sclerosis class disease, the composition include with the following group by weight Point:

It is 1~20 part of the dried immature fruit of citron orange, 1~20 part of Cortex Magnoliae Officinalis, 1~50 part of red halloysite, 0.5~10 part of gun additioner, 0.1~2 part of monkshood, sweet 0.5~20 part of grass, 0.5~30 part of ramulus cinnamomi, 0.5~25 part of cortex cinnamomi, includes 0.5~25 part in fact of beach wormwood, Rhizoma Chuanxiong 0.5 by 0.5~30 part of rhizoma zingiberis ~25 parts, 0.1~5 part of cinnabar, 0.1~10 part of another name for Sichuan Province green pepper, 0.5~30 part of Radix Angelicae Sinensis, 0.5~25 part of dark plum.

Preferably, the composition includes following components by weight:

It is 5~15 parts of the dried immature fruit of citron orange, 5~15 parts of Cortex Magnoliae Officinalis, 10~40 parts of red halloysite, 2~6 parts of gun additioner, 0.5~1.5 part of monkshood, sweet 5~15 parts of grass, 10~20 parts of ramulus cinnamomi, 6~18 parts of cortex cinnamomi, includes real 5~20 parts of beach wormwood by 10~20 parts of rhizoma zingiberis, and 6~18 parts of Rhizoma Chuanxiong, Zhu 0.5~2.5 part of sand, 2~8 parts of another name for Sichuan Province green pepper, 10~25 parts of Radix Angelicae Sinensis, 10~20 parts of dark plum.

Preferably, the composition includes following components by weight:

10 parts of the dried immature fruit of citron orange, 10 parts of Cortex Magnoliae Officinalis, 25 parts of red halloysite, 3 parts of gun additioner, 0.8 part of monkshood, 9 parts of Radix Glycyrrhizae, 12 parts of rhizoma zingiberis, osmanthus 10 parts of cortex cinnamomi, it is 12 parts, 15 parts of Rhizoma Chuanxiong, 1 part of cinnabar, 3 parts of another name for Sichuan Province green pepper, 20 parts of Radix Angelicae Sinensis, 18 parts of dark plum real to include beach wormwood for 15 parts of branch.

Preferably, the Radix Glycyrrhizae is radix glycyrrhizae preparata；The another name for Sichuan Province another name for Sichuan Province Jiao Weichao green pepper.Specifically, in honey set being smelt in pot Honey uses mild fire instead and licorice piece is added to stir uniformly, and 3~5min takes the dish out of the pot, and sets barn or taking-up when 60 DEG C of baking oven are dried to tack-free, puts It is cool, so that relatively tonifying Qi, drug effect are milder；Another name for Sichuan Province green pepper is open descending through frying, fries out oil content.

The second object of the present invention, which also resides in, provides a kind of system of composition for treating heart disease and vascular sclerosis class disease Preparation Method, comprising the following steps:

(1) according to the raw material progress ingredient of following parts by weight: 1~20 part of the dried immature fruit of citron orange, 1~20 part of Cortex Magnoliae Officinalis, red halloysite 1~50 Part, 0.5~10 part of gun additioner, 0.1~2 part of monkshood, 0.5~20 part of Radix Glycyrrhizae, 0.5~30 part of rhizoma zingiberis, 0.5~30 part of ramulus cinnamomi, meat 0.5~25 part of osmanthus, includes real 0.5~25 part of beach wormwood, and 0.5~25 part of Rhizoma Chuanxiong, 0.1~5 part of cinnabar, 0.1~10 part of another name for Sichuan Province green pepper, Radix Angelicae Sinensis 0.5 ~30 parts, 0.5~25 part of dark plum；

(2) drying and processing is carried out after cleaning up all medicinal materials in ingredient；

(3) it after the medicinal material after drying being carried out sterilization processing, crushes, obtains fine powder；

(4) auxiliary material is added in gained fine powder, mix, be made pill or be packed into capsule to get.

In step (3), the mode of sterilization processing can be far infrared sterilization, ultraviolet sterilization, high temperature sterilization and smelly Any sterilization method in oxygen sterilization.For example, being sterilized according to far infrared, concrete mode are as follows: select wavelength 100~ 300 microns of far infrared carries out processing 3~8 minutes to fine powder after crushing.According to ozone sterilization, concrete mode Are as follows: selecting concentration is the smashed fine powder of ozone treatment 5~10 minutes of 6~10mg/L.According to high temperature sterilization, tool Body mode are as follows: after smashed fine powder is warming up to 120~140 DEG C, thermostatic control 3~7 seconds, then be quickly cooled to 20~35 DEG C Between.According to ultraviolet sterilization, concrete mode are as follows: select wavelength after 200~280 nanometers of ultraviolet light is to crushing Fine powder carry out processing 5~10 minutes.

Certainly, sterilization processing mode can also select two ways Combined Treatment, such as first be handled 1~2 minute with far infrared, It uses ozone treatment 1~2 minute again.Far infrared and ultraviolet light Combined Treatment similarly also can be selected；High temperature combines place with ozone Reason etc..Two kinds of sterilization combination processings, compared to the sterilization effect of method for disinfection processing a kind of is used alone more preferably, to improve The holding time of finished product and safety, and the processing time can also be greatly shortened.

Preferably, the concrete operations of step (3) are as follows: after the medicinal material after drying is carried out sterilization processing by ultraviolet light, powder It is broken to 400-600, obtains fine powder.

Preferably, auxiliary material described in step (4) includes one in corrigent, preservative, adhesive, lubricant and disintegrating agent Kind is a variety of, and the additional amount of the auxiliary material is 0.2~0.5 times of fine powder total weight.

It should be noted that corrigent includes but is not limited to honey, mannitol, sucrose, syrupus aromaticus etc. in the present invention Natural sweetener or saccharin or other artificial sweeteners；Preservative include but is not limited to benzoic acid, sodium benzoate, sorbic acid, Potassium sorbate, calcium propionate etc.；Adhesive includes but is not limited to carboxymethyl cellulose, alginates, gelatin or polyvinylpyrrolidine Ketone etc.；Lubricant such as colloidal silicon dioxide, talcum powder, magnesium stearate, calcium stearate or solid polyethylene glycol etc.；Disintegrating agent is as formed sediment Powder, methylcellulose, agar, bentonite, xanthan gum etc..Can be added in right amount according to specific preparation demand it is one such or It is a variety of.

The object of the invention is also to provide a kind of compositions for treating heart disease and vascular sclerosis class disease in preparation Application in medicine preparation or health care product.

Preferably, the dosage form of the Chinese materia medica preparation includes pill, powder, tablet, capsule or granule.

The beneficial effects of the present invention are:

(1) the present invention provides a kind of composition for treating heart disease and vascular sclerosis class disease, made from the composition Its formula science of drug, has and promotes heart-yang, quickly get through blood vessel blockage, remove thrombus, soften vascular wall, eliminate product under the heart The effect of water eliminates chest and back pain, restores heart side film, curative effect are fast and obvious；Safety simultaneously is good, few side effects, and medicinal material comes Source is extensive, is easy to volume production；

(2) the composition can treat heart disease caused by vascular sclerosis and many reasons, and therapeutic domain is wide, reduce medication The learning cost of personnel, while improving the drug safety coefficient of patient；

(3) preparation method provided by the invention obtains pill or capsule, and process is simple, easily operated, product storage And it takes easily.

Specific embodiment

The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation Example is only a part of the embodiments of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is general Logical technical staff every other embodiment obtained without creative efforts belongs to what the present invention protected Range.

It in addition, the technical solution between each embodiment of the present invention can be combined with each other, but must be general with this field Based on logical technical staff can be realized, it will be understood that when the combination of technical solution appearance is conflicting or cannot achieve this The combination of technical solution is not present, also not the present invention claims protection scope within.

Composition, system below by way of specific embodiment to treatment heart disease proposed by the present invention and vascular sclerosis class disease Preparation Method and application are specifically described:

Embodiment one

A kind of composition for treating heart disease and vascular sclerosis class disease includes following components: the dried immature fruit of citron orange 10 by weight Part, 10 parts of Cortex Magnoliae Officinalis, 25 parts of red halloysite, 3 parts of gun additioner, 0.8 part of monkshood, 9 parts of radix glycyrrhizae preparata, 12 parts of rhizoma zingiberis, 15 parts of ramulus cinnamomi, cortex cinnamomi 10 Part, 12 parts in fact of beach wormwood are included, 15 parts of Rhizoma Chuanxiong, 1 part of cinnabar, fries 3 parts of another name for Sichuan Province green pepper, 20 parts of Radix Angelicae Sinensis, 18 parts of dark plum.

The preparation method of the composition of the treatment heart disease and vascular sclerosis class disease, comprising the following steps:

(1) according to the raw material progress ingredient of following parts by weight: 10 parts of the dried immature fruit of citron orange, 10 parts of Cortex Magnoliae Officinalis, 25 parts of red halloysite, gun additioner 3 Part, 0.8 part of monkshood, 9 parts of radix glycyrrhizae preparata, 12 parts of rhizoma zingiberis, 15 parts of ramulus cinnamomi, 10 parts of cortex cinnamomi, include real 12 parts of beach wormwood, 15 parts of Rhizoma Chuanxiong, cinnabar 1 Part, fry 3 parts of another name for Sichuan Province green pepper, 20 parts of Radix Angelicae Sinensis, 18 parts of dark plum；

(3) after the medicinal material after drying being carried out sterilization processing by ultraviolet light, 500 mesh is ground into, fine powder is obtained；

(4) it is mixed in gained fine powder according to 0.3 times of addition honey of fine powder weight, is added in pellet processing machine and carries out pill, Most afterwards through drying, screening, the pill that partial size is 3.5~4.1mm is obtained.

Embodiment two

A kind of composition for treating heart disease and vascular sclerosis class disease includes following components: the dried immature fruit of citron orange 20 by weight Part, 5 parts of Cortex Magnoliae Officinalis, 40 parts of red halloysite, 6 parts of gun additioner, 1.5 parts of monkshood, 15 parts of radix glycyrrhizae preparata, 10 parts of rhizoma zingiberis, 20 parts of ramulus cinnamomi, cortex cinnamomi 5 Part, 20 parts in fact of beach wormwood are included, 6 parts of Rhizoma Chuanxiong, 0.5 part of cinnabar, fries 8 parts of another name for Sichuan Province green pepper, 10 parts of Radix Angelicae Sinensis, 20 parts of dark plum.

(1) according to the raw material progress ingredient of following parts by weight: 20 parts of the dried immature fruit of citron orange, 5 parts of Cortex Magnoliae Officinalis, 40 parts of red halloysite, gun additioner 6 Part, 1.5 parts of monkshood, 15 parts of radix glycyrrhizae preparata, 10 parts of rhizoma zingiberis, 20 parts of ramulus cinnamomi, 5 parts of cortex cinnamomi, include real 20 parts of beach wormwood, 6 parts of Rhizoma Chuanxiong, cinnabar 0.5 Part, fry 8 parts of another name for Sichuan Province green pepper, 10 parts of Radix Angelicae Sinensis, 20 parts of dark plum；

(4) it is mixed in gained fine powder according to 0.2 times of addition honey of fine powder weight, is added in pellet processing machine and carries out pill, Most afterwards through drying, screening, the pill that partial size is 3.5~4.1mm is obtained.

Embodiment three

A kind of composition for treating heart disease and vascular sclerosis class disease includes following components: the dried immature fruit of citron orange 5 by weight Part, 15 parts of Cortex Magnoliae Officinalis, 10 parts of red halloysite, 0.5 part of gun additioner, 0.1 part of monkshood, 5 parts of Radix Glycyrrhizae, 20 parts of rhizoma zingiberis, 10 parts of ramulus cinnamomi, cortex cinnamomi 18 Part, it is 5 parts, 18 parts of Rhizoma Chuanxiong, 1 part of cinnabar, 2 parts of another name for Sichuan Province green pepper, 25 parts of Radix Angelicae Sinensis, 10 parts of dark plum real to include beach wormwood.

(1) according to the raw material progress ingredient of following parts by weight: 5 parts of the dried immature fruit of citron orange, 15 parts of Cortex Magnoliae Officinalis, 10 parts of red halloysite, gun additioner 0.5 Part, 0.1 part of monkshood, 5 parts of Radix Glycyrrhizae, 20 parts of rhizoma zingiberis, 10 parts of ramulus cinnamomi, 18 parts of cortex cinnamomi, include real 5 parts of beach wormwood, 18 parts of Rhizoma Chuanxiong, 1 part of cinnabar, another name for Sichuan Province 2 parts of green pepper, 25 parts of Radix Angelicae Sinensis, 10 parts of dark plum；

Example IV

A kind of composition for treating heart disease and vascular sclerosis class disease includes following components: the dried immature fruit of citron orange 2 by weight Part, 20 parts of Cortex Magnoliae Officinalis, 20 parts of red halloysite, 10 parts of gun additioner, 0.1 part of monkshood, 20 parts of radix glycyrrhizae preparata, 2 parts of rhizoma zingiberis, 30 parts of ramulus cinnamomi, cortex cinnamomi 3 Part, 25 parts in fact of beach wormwood are included, 2 parts of Rhizoma Chuanxiong, 3 parts of cinnabar, fries 0.5 part of another name for Sichuan Province green pepper, 30 parts of Radix Angelicae Sinensis, 3 parts of dark plum.

(1) according to the raw material progress ingredient of following parts by weight: 10 parts of the dried immature fruit of citron orange, 2 parts of the dried immature fruit of citron orange, 20 parts of Cortex Magnoliae Officinalis, 20 parts of red halloysite, 10 parts of gun additioner, 0.1 part of monkshood, 20 parts of radix glycyrrhizae preparata, 2 parts of rhizoma zingiberis, 30 parts of ramulus cinnamomi, 3 parts of cortex cinnamomi, include real 25 parts of beach wormwood, 2 parts of Rhizoma Chuanxiong, 3 parts of cinnabar, fry 0.5 part of another name for Sichuan Province green pepper, 30 parts of Radix Angelicae Sinensis, 3 parts of dark plum；

(3) after the medicinal material after drying being carried out sterilization processing by ultraviolet light, 600 mesh is ground into, fine powder is obtained；

(4) suitable xanthan gum and agar are added in gained fine powder, mixes, is directly loadable into capsule.

Embodiment five

A kind of composition for treating heart disease and vascular sclerosis class disease includes following components: the dried immature fruit of citron orange 12 by weight Part, 15 parts of Cortex Magnoliae Officinalis, 35 parts of red halloysite, 6 parts of gun additioner, 0.1 part of monkshood, 8 parts of radix glycyrrhizae preparata, 13 parts of rhizoma zingiberis, 10 parts of ramulus cinnamomi, cortex cinnamomi 5 Part, 10 parts in fact of beach wormwood are included, 15 parts of Rhizoma Chuanxiong, 3 parts of cinnabar, fries 4 parts of another name for Sichuan Province green pepper, 25 parts of Radix Angelicae Sinensis, 20 parts of dark plum.

(1) according to the raw material progress ingredient of following parts by weight: 12 parts of the dried immature fruit of citron orange, 15 parts of Cortex Magnoliae Officinalis, 35 parts of red halloysite, gun additioner 6 Part, 0.1 part of monkshood, 8 parts of radix glycyrrhizae preparata, 13 parts of rhizoma zingiberis, 10 parts of ramulus cinnamomi, 5 parts of cortex cinnamomi, include real 10 parts of beach wormwood, 15 parts of Rhizoma Chuanxiong, 3 parts of cinnabar, Fry 4 parts of another name for Sichuan Province green pepper, 25 parts of Radix Angelicae Sinensis, 20 parts of dark plum；

(4) suitable starch and agar are added in gained fine powder, mixes, is directly loadable into capsule.

Embodiment six

A kind of composition for treating heart disease and vascular sclerosis class disease includes following components: the dried immature fruit of citron orange 20 by weight Part, 5 parts of Cortex Magnoliae Officinalis, 40 parts of red halloysite, 1 part of gun additioner, 0.2 part of monkshood, 20 parts of radix glycyrrhizae preparata, 5 parts of rhizoma zingiberis, 20 parts of ramulus cinnamomi, cortex cinnamomi 6 Part, 20 parts in fact of beach wormwood are included, 8 parts of Rhizoma Chuanxiong, 2 parts of cinnabar, fries 7 parts of another name for Sichuan Province green pepper, 20 parts of Radix Angelicae Sinensis, 10 parts of dark plum.

(1) according to the raw material progress ingredient of following parts by weight: 20 parts of the dried immature fruit of citron orange, 5 parts of Cortex Magnoliae Officinalis, 40 parts of red halloysite, gun additioner 1 Part, 0.2 part of monkshood, 20 parts of radix glycyrrhizae preparata, 5 parts of rhizoma zingiberis, 20 parts of ramulus cinnamomi, 6 parts of cortex cinnamomi, include real 20 parts of beach wormwood, 8 parts of Rhizoma Chuanxiong, 2 parts of cinnabar, Fry 7 parts of another name for Sichuan Province green pepper, 20 parts of Radix Angelicae Sinensis, 10 parts of dark plum；

(3) after the medicinal material after drying being carried out sterilization processing by ultraviolet light, 400 mesh is ground into, fine powder is obtained；

(4) it is mixed in gained fine powder according to 0.5 times of addition honey of fine powder weight, is added in pellet processing machine and carries out pill, Most afterwards through drying, screening, the pill that partial size is 3.5~4.1mm is obtained.

Typical case/clinical test results:

Clinical test is carried out to the composition for the treatment of heart disease provided by the invention and vascular sclerosis class disease below:

1, case selection

Select the age between 40~79 years old, cardiopathic patient 280 not waited between the course of disease 1~30 year, wherein suffering from There are hypertensive cardiopathy patient 80, coronary atherosclerotic heart disease patient 120, cor pulmonale patient 80 Example, is randomly divided into 4 groups, hypertensive cardiopathy patient 20 in every group, and coronary atherosclerotic heart disease patient 30, Cor pulmonale patient 20；The embodiment of the present invention 1, embodiment 3, embodiment 5 and embodiment 6 are taken respectively for every group prepare institute The Chinese medicine composition obtained, is successively recorded as experimental group 1 to experimental group 4；I.e. experimental group 1 takes the preparation gained of the embodiment of the present invention one Chinese medicine composition；Experimental group 2 takes the embodiment of the present invention three and prepares resulting Chinese medicine composition；Experimental group 3 takes the present invention Embodiment five prepares resulting Chinese medicine composition；Experimental group 4 takes the embodiment of the present invention six and prepares resulting Chinese medicine composition.

2, instructions of taking

One dosage is respectively taken sooner or later daily, if composition is pill, one dosage is 4, when being capsule, then One dosage is 3；It is observed after continuously taking 1 month.

3, criterion of therapeutical effect

Clinical cure: angina pectoris, cough and asthma, uncomfortable in chest, shortness of breath, cardio palmus shape mitigate or disappear completely；It is effective: symptom part Mitigate or is improved；Invalid: symptom is without substantially changeing.

4, test result

According to above-mentioned standard, the symptomatic condition of patient is investigated, result is investigated and please refers to table 1.

The symptom of 1 patient of table, which improves, investigates result

5, typical treatment case

Patient one: Zhang, male, and 52 years old.Symptoms are to occur precordial fullness pain when tired or nervous, often Feel uncomfortable in chest, palpitaition, shortness of breath, is alleviated later and voluntarily, coronary atherosclerotic is once diagnosed as in local hospital Heart disease, using western medicine, effect is unobvious；After take and prepare resulting pharmaceutical composition according to the embodiment of the present invention one, Sooner or later each 4, the phenomenon that after continuously taking one month, patient's private prosecution is uncomfortable in chest, palpitaition, shortness of breath, disappears, and precordial fullness pain phenomenon is bright It is aobvious to improve, continue the above symptom after taking one month and completely disappears.Follow-up is without recurrence after half a year.

Patient two: Cao, female, and 45 years old.Symptoms are long-term chronic cough, and expectoration is had difficulty in breathing, and tcm diagnosis is The dificiency of the lung due to protracted disease, weakened defensive QI, heart arteries and veins stasis blocking.It takes the embodiment of the present invention one and prepares resulting pill, it is each 4 sooner or later, continuous to take After two weeks, breathe it is smooth, cough it is obvious weaken, continue after taking two weeks, no longer cough, expectoration, be after treatment, again Medication two weeks.Follow-up after 1 year: recovery from illness, no recurrence.

Patient three: Zou, male, and 48 years old.Patient suffers from hypertension all the year round, occurs within 2 months dyspneic disease before the treatment Shape, mostly in night-time attack, oneself is suppressed for several times it is awake, through hospital diagnosis be hypertensive cardiopathy.It uses western medicine one month It is effect improved unobvious；After take the embodiment of the present invention five and prepare resulting pill, it is sooner or later each 4 daily, bright using after a week It is aobvious to feel that breathing is smooth, without feeling uncomfortable in chest；After two weeks, during which only there is 1 dyspnea symptom in night；After Continuous to use one month, breathing is smooth, and the phenomenon that expiratory dyspnea did not occurred again in night；For after treatment, continue medication one week.One Follow-up after year, dyspnea symptom do not occur again.

Patient four: certain is cared for, male, and 63 years old.Symptoms are the intermittent colic pain of pareordia, before the treatment two weeks, pain Gradually aggravation, frequency conversion, duration extension is half an hour, and with symptoms such as Nausea and vomiting, perspiration, fevers, is diagnosed as being preced with Shape atherosclerotic heart disease；It takes the embodiment of the present invention six and prepares resulting composition capsule, sooner or later twice daily, often Secondary 3, using after a week, panic attacks frequency is reduced, and degree is also mitigated；Continue after taking two weeks, panic attacks frequency Rate is substantially reduced, 2 pareordia colic pain of during which only breaking out, and the time, only within 5 minutes, the symptoms such as vomiting, fever disappear completely It loses；Continue after taking two weeks, colic pain symptom also completely disappears；For after treatment, continue medication one week.Follow-up after 1 year, disease Shape does not occur again.

The above case shows that pharmaceutical composition prescription science provided by the invention, curative effect are fast and obvious；And clinic is not found Adverse reaction, safety is good, few side effects, while crude drug source is extensive, is easy to volume production；It can be clinically used for various heart class diseases And the treatment of arterial blood tubing disease.

In the description of this specification, reference term " embodiment ", " another embodiment ", " other embodiments " or " The description of one embodiment~X embodiment " etc. mean specific features described in conjunction with this embodiment or example, structure, material or Person's feature is included at least one embodiment or example of the invention.In the present specification, to the schematic table of above-mentioned term Stating may not refer to the same embodiment or example.Moreover, specific features, structure, material, method and step or the spy of description Point can be combined in any suitable manner in any one or more of the embodiments or examples.

It should be noted that, in this document, the terms "include", "comprise" or its any other variant are intended to non-row His property includes, so that the process, method, article or the device that include a series of elements not only include those elements, and And further include other elements that are not explicitly listed, or further include for this process, method, article or device institute it is intrinsic Element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that including being somebody's turn to do There is also other identical elements in the process, method of element, article or device.

The serial number of the above embodiments of the invention is only for description, does not represent the advantages or disadvantages of the embodiments.

The above examples are only used to illustrate the technical scheme of the present invention and are not limiting, although referring to preferred embodiment to this hair It is bright to be described in detail, those skilled in the art should understand that, it can modify to technical solution of the present invention Or equivalent replacement should all cover without departing from the objective and range of technical solution of the present invention in claim of the invention In range.

Claims

1. a kind of composition for treating heart disease and vascular sclerosis class disease, which is characterized in that the composition is by weight Including following components:

1~20 part of the dried immature fruit of citron orange, 1~20 part of Cortex Magnoliae Officinalis, 1~50 part of red halloysite, 0.5~10 part of gun additioner, 0.1~2 part of monkshood, Radix Glycyrrhizae 0.5~20 part, 0.5~30 part of rhizoma zingiberis, 0.5~30 part of ramulus cinnamomi, 0.5~25 part of cortex cinnamomi, include real 0.5~25 part of beach wormwood, Rhizoma Chuanxiong 0.5~ 25 parts, 0.1~5 part of cinnabar, 0.1~10 part of another name for Sichuan Province green pepper, 0.5~30 part of Radix Angelicae Sinensis, 0.5~25 part of dark plum.

2. the composition for the treatment of heart disease and vascular sclerosis class disease according to claim 1, which is characterized in that described group Close object includes following components by weight:

5~15 parts of the dried immature fruit of citron orange, 5~15 parts of Cortex Magnoliae Officinalis, 10~40 parts of red halloysite, 2~6 parts of gun additioner, 0.5~1.5 part of monkshood, Radix Glycyrrhizae 5 ~15 parts, 10~20 parts of rhizoma zingiberis, 10~20 parts of ramulus cinnamomi, 6~18 parts of cortex cinnamomi, include real 5~20 parts of beach wormwood, 6~18 parts of Rhizoma Chuanxiong, cinnabar 0.5~2.5 part, 2~8 parts of another name for Sichuan Province green pepper, 10~25 parts of Radix Angelicae Sinensis, 10~20 parts of dark plum.

3. the composition for the treatment of heart disease and vascular sclerosis class disease according to claim 1, which is characterized in that described group Close object includes following components by weight:

10 parts of the dried immature fruit of citron orange, 10 parts of Cortex Magnoliae Officinalis, 25 parts of red halloysite, 3 parts of gun additioner, 0.8 part of monkshood, 9 parts of Radix Glycyrrhizae, 12 parts of rhizoma zingiberis, ramulus cinnamomi 15 Part, 10 parts of cortex cinnamomi, it is 12 parts, 15 parts of Rhizoma Chuanxiong, 1 part of cinnabar, 3 parts of another name for Sichuan Province green pepper, 20 parts of Radix Angelicae Sinensis, 18 parts of dark plum real to include beach wormwood.

4. the composition for the treatment of heart disease and vascular sclerosis class disease according to claim 1, which is characterized in that described sweet Grass is radix glycyrrhizae preparata；The another name for Sichuan Province another name for Sichuan Province Jiao Weichao green pepper.

5. the preparation method of the composition for the treatment of heart disease according to any one of claims 1 to 4 and vascular sclerosis class disease, Characterized by comprising the following steps:

(1) according to the raw material progress ingredient of following parts by weight: 1~20 part of the dried immature fruit of citron orange, 1~20 part of Cortex Magnoliae Officinalis, 1~50 part of red halloysite, big gun 0.5~10 part of monkshood, 0.1~2 part of monkshood, 0.5~20 part of Radix Glycyrrhizae, 0.5~30 part of rhizoma zingiberis, 0.5~30 part of ramulus cinnamomi, cortex cinnamomi 0.5 ~25 parts, include real 0.5~25 part of beach wormwood, 0.5~25 part of Rhizoma Chuanxiong, 0.1~5 part of cinnabar, 0.1~10 part of another name for Sichuan Province green pepper, Radix Angelicae Sinensis 0.5~30 Part, 0.5~25 part of dark plum；

6. the preparation method of the composition for the treatment of heart disease according to claim 5 and vascular sclerosis class disease, feature It is, the concrete operations of step (2) are as follows: after the medicinal material after drying is carried out sterilization processing by ultraviolet light, be crushed to 400- 600, obtain fine powder.

7. the preparation method of the composition for the treatment of heart disease according to claim 5 and vascular sclerosis class disease, feature It is, auxiliary material described in step (4) includes one of corrigent, preservative, adhesive, lubricant and disintegrating agent or a variety of, The additional amount of the auxiliary material is 0.2~0.5 times of fine powder total weight.

8. the composition for the treatment of heart disease according to any one of claims 1 to 4 and vascular sclerosis class disease is preparing Chinese medicine Application in preparation or health care product.

9. application according to claim 8, which is characterized in that the dosage form of the Chinese materia medica preparation includes pill, powder, piece Agent, capsule or granule.