CN107875365A

CN107875365A - A kind of Chinese medicine composition for treating chronic cor pulmonale and preparation method thereof

Info

Publication number: CN107875365A
Application number: CN201711259044.6A
Authority: CN
Inventors: 代立新; 代哲尘
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-12-02
Filing date: 2017-12-02
Publication date: 2018-04-06

Abstract

The invention discloses a kind of Chinese medicine composition for treating chronic cor pulmonale and preparation method thereof, wherein, the Chinese medicine composition, it is made up of the Chinese medicine material of following weight：69 parts of Chinese ephedra, 36 parts of asarum, 10 15 parts of schizonepeta, windproof 10 20 parts, 10 20 parts of rhizoma zingiberis, 10 25 parts of the fruit of Chinese magnoliavine, 20 30 parts of honeysuckle, 10 15 parts of the capsule of weeping forsythia, 20 30 parts of gypsum, 10 15 parts of radix scutellariae, 10 15 parts of the root bark of white mulberry, 10 20 parts of reed rhizome, 10 15 parts of coix seed, 8 15 parts of Semen Benincasae, 10 20 parts of almond, 15 20 parts of radix scrophulariae, 10 15 parts of caulis bambusae in taenian, 6 10 parts of radix glycyrrhizae.Chinese medicine composition compatibility disclosed by the invention is reasonable, has no toxic side effect, and moistens the lung and relieve the cough, dispersing swelling and dissipating binds, clearing heat-fire, dredges cardiopulmonary, and for chronic cor pulmonale, good effect is quick, cures short treating period, uneasy to recur.

Description

A kind of Chinese medicine composition for treating chronic cor pulmonale and preparation method thereof

Technical field

Patent of the present invention is related to, especially a kind of Chinese medicine composition for treating chronic cor pulmonale and its preparation side Method, belong to the field of Chinese medicines.

Background technology

Chronic cor pulmonale (chronic pulmonary heart disease), abbreviation chronic cardiopulmonary disease (chroniccorpulmonale) it is, that lung tissue structure and (or) work(are caused by the chronic disease of lung tissue, Pulmonary Vascular or thorax Can be abnormal, produce pulmonary vascular resistance increase, pulmonary artery pressure increases, make right ventricle expansion (and) plump, companion or without the right heart The heart disease of MSOF, and exclude congenital heart disease and left worry change causer.This sick slower development, clinically except original Lung, chest disease various symptoms and sign outside, mainly progressively there is the sign of lung, heart failure and other organ injuries As.Division is carried out by the compensatory phase and Decompensated stage of its function.

(1) lung, cardiac functional compensatory period：

1st, symptom：Can had palpitation, expiratory dyspnea, the decline of weak and work tolerance after cough, expectoration, shortness of breath, activity.

2nd, sign：Can there are different degrees of cyanosis and pulmonary emphysema sign.Occasionally there is dry, moist rales, heart sound is remote, P2>A2, There is systolic murmur or xiphoid-process heartbeat shown below in tricuspid valve area, prompts have right ventricle plump.Some patientss make because of pulmonary emphysema Intrathoracic pressure raises, and hinders Vena cava return, can have jugular vein to fill.It is that diaphragm declines institute extremely that this Qi Gan circle, which is moved down,.

(2) lung, cardiac functional decompensatory period：

1st, respiratory failure

(1) symptom：Expiratory dyspnea aggravates, and night is very, often to have headache, insomnia, loss of appetite, but daytime drowsiness, even There is the performance of the pulmonary encephalopathies such as apathy, wandering, delirium.

(2) sign：Obvious cyanosis, bulbar conjunctiva is congested, oedema, can there is retinal blood enlargement of pipe, papilloedema when serious Etc. the elevated performance of intracranial pressure.Tendon reflex weakens or disappeared, and pathologic reflex occurs.Because hypercapnia may occur in which that peripheral vessels expands The performance opened, such as flush, hidrosis.

2nd, right heart failure

(1) symptom：Shortness of breath becomes apparent from, palpitaition, poor appetite, abdominal distension, nausea etc..

(2) sign：Cyanosis becomes apparent from, distension of jugular vein, increased heart rate, may occur in which arrhythmia cordis, audible and receipts under xiphoid-process Contracting time limit noise, or even there is diastolic murmur.Hepatomegaly and there is tenderness, hepatojugular reflux piece is positive, and edema of lower extremity, severe one can There is ascites.Small number of patients may occur in which pulmonary edema and the sign of whole heart failure.

The method of current treatment chronic cor pulmonale, is usually controlled treatment for diseases, but medicine using medicine Thing toxic side effect is big；What is be in a bad way takes operative treatment, and still, operation risk is big.Based on this, how to realize safety and stability, Treating chronic cor pulmonale with having no toxic side effect is the current technical issues that need to address of those skilled in the art.

The content of the invention

For the problems of the prior art, the invention aims to provide a kind of safety and stability, controlling of having no toxic side effect Treat Chinese medicine composition of chronic cor pulmonale and preparation method thereof.

In order to achieve the above object, the technical scheme is that：

A kind of Chinese medicine composition for treating chronic cor pulmonale, is made up of the Chinese medicine material of following weight： Chinese ephedra 6-9 parts, asarum 3-6 parts, schizonepeta 10-15 parts, windproof 10-20 parts, rhizoma zingiberis 10-20 parts, fruit of Chinese magnoliavine 10-25 parts, honeysuckle 20-30 parts, capsule of weeping forsythia 10-15 parts, gypsum 20-30 parts, radix scutellariae 10-15 parts, root bark of white mulberry 10-15 parts, reed rhizome 10-20 parts, coix seed 10-15 parts, Semen Benincasae 8-15 parts, almond 10-20 parts, radix scrophulariae 15-20 parts, caulis bambusae in taenian 10-15 parts, radix glycyrrhizae 6-10 parts.

As preferable, the Chinese medicine composition for the treatment of chronic cor pulmonale of the present invention, by following parts by weight The Chinese medicine material composition of proportioning：Chinese ephedra 6-8 parts, asarum 3-4 parts, schizonepeta 12-15 parts, windproof 12-18 parts, rhizoma zingiberis 12-18 parts, five Taste 12-25 parts, honeysuckle 22-28 parts, capsule of weeping forsythia 12-15 parts, gypsum 22-30 parts, radix scutellariae 12-15 parts, root bark of white mulberry 12-15 parts, Reed rhizome 12-18 parts, coix seed 12-15 parts, Semen Benincasae 10-15 parts, almond 12-18 parts, radix scrophulariae 18-20 parts, caulis bambusae in taenian 12-15 parts, Radix glycyrrhizae 6-8 parts.

As preferable, the Chinese medicine composition for the treatment of chronic cor pulmonale of the present invention, by following parts by weight The Chinese medicine material composition of proportioning：7 parts of Chinese ephedra, 5 parts of asarum, 13 parts of schizonepeta, windproof 15 parts, 15 parts of rhizoma zingiberis, 20 parts of the fruit of Chinese magnoliavine, gold and silver Spend 25 parts, 13 parts of the capsule of weeping forsythia, 25 parts of gypsum, 13 parts of radix scutellariae, 13 parts of the root bark of white mulberry, 15 parts of reed rhizome, 14 parts of coix seed, 13 parts of Semen Benincasae, 15 parts of almond, 17 parts of radix scrophulariae, 13 parts of caulis bambusae in taenian, 7 parts of radix glycyrrhizae.

Present invention simultaneously provides a kind of preparation side of the Chinese medicine composition for the treatment of chronic cor pulmonale as described above Method, comprise the following steps：

1) weigh by weight Chinese ephedra, asarum, schizonepeta, windproof, rhizoma zingiberis, the fruit of Chinese magnoliavine, honeysuckle, the capsule of weeping forsythia, gypsum, radix scutellariae, The root bark of white mulberry, reed rhizome, coix seed, Semen Benincasae, almond, radix scrophulariae, caulis bambusae in taenian, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into soya bean size Fritter, be well mixed after under ultraviolet germicidal lamp sterilization treatment 1 hour, be subsequently placed in container with normal-temperature water soak 40- 60 minutes；

2) Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow fire heats 30 minutes, Dry in the air after being down to 40-70 DEG C to temperature, take filtrate, the dregs of a decoction in marmite are standby, and filtrate is poured into container, obtain a medicine Liquid；

3) hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire 30 Minute, dry in the air after being down to 40-70 DEG C to temperature, filter to obtain secondary decoction；

4) the secondary decoction obtained in obtained in step 2) decoction and step 3) is merged, and be well mixed, dried in the air Bottle or pack after to room temperature, obtain Traditional Chinese medicine composition liquid medicine.

The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction：Take in three times within 1 day.Also can be 1 time Property decoct the dose of 2 days, filling and sealing after obtained decoction is sterilized, refrigeration, first pico- heating when taking.This Chinese medicine group Compound can also be prepared into powder capsule, specifically comprise the following steps：

1) weigh by weight Chinese ephedra, asarum, schizonepeta, windproof, rhizoma zingiberis, the fruit of Chinese magnoliavine, honeysuckle, the capsule of weeping forsythia, gypsum, radix scutellariae, The root bark of white mulberry, reed rhizome, coix seed, Semen Benincasae, almond, radix scrophulariae, caulis bambusae in taenian, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into soya bean size Fritter, be well mixed after under ultraviolet germicidal lamp sterilization treatment 1 hour；

2) powder is then ground to, after crossing 500-800 mesh sieves point, obtains Chinese medicine composition powder；

3) the Chinese medicine composition powder that step 2) obtains is fitted into capsule skin and Chinese medicinal capsule is made, obtain Chinese medicine composition Capsule.

Chinese medicinal composition capsules prepared by the above method, instructions of taking are：Take at twice within 1 day, 15 grams every time (2).

Further, the preparation method of the Chinese medicine composition for the treatment of chronic cor pulmonale of the present invention, step 2) granularity of the Chinese medicine composition powder obtained in is 650 mesh.

The Chinese medicine composition of the treatment chronic cor pulmonale of the present invention, can be prepared into Chinese medicinal tablet, particle, Chinese medicine The diversified forms such as ball, are not limited to decoction and capsule, suitable for a variety of therapeutic modalities, application method.

Each component pharmacology is as follows in the Chinese medicine composition of the treatment chronic cor pulmonale of the present invention：

Chinese ephedra：Meridian distribution of property and flavor：Pungent, slight bitter, temperature.Return lung, bladder warp.Sweating cold dispelling, freeings lung and relieving asthma, inducing diuresis for removing edema.For Anemofrigid cold, uncomfortable in chest to breath with cough, geomantic omen edema；Bronchial astehma.Herba ephedrae moistens the lung and relieve the cough.It is used for table disease to have solved, asthma and cough.

Asarum：Meridian distribution of property and flavor：It is pungent, temperature.Enter lung, kidney channel.Major function：Relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, warm lung Drink.Anemofrigid cold, have a headache, toothache, arthralgia pain due to rheumatism, nasosinusitis, lung cold cough.

Schizonepeta：Meridian distribution of property and flavor：Tepor；It is pungent；Return lung, Liver Channel.Inducing diaphoresis dissipates wind, promoting eruption.For catching a cold, headache, measles, wind Rash, sore from the beginning of.Fry charcoal treating hematochezia, uterine bleeding, postpartum anemic fainting.1. diseases caused by external factors exterior syndrome.The pungent scattered gas of this product is fragrant, is longer than and delivers scattered wind, and Tepor is not strong, and the property of medicine relaxes, and is that wind-cold-dispersing medicinal property of traditional Chinese is the most gentle.For diseases caused by external factors exterior syndrome, no matter chill, wind-heat or fever and chills Unobvious person, it can widely use.2. measles without adequate eruption, rubella itch.3. sore is from the beginning of having exterior syndrome concurrently.4. haematemesis, bleeding from five sense organs or subcutaneous tissue, just Blood, uterine bleeding etc. it is a variety of go out blood trouble.Flu fever and chills are cured mainly, are had a headache, eye itching, pharyngalgia, cough, measles, rubella, ulcerative carbuncle, brigadier, are told Blood, clot blood, has blood in stool, uterine bleeding, affection by cold after delivery, bruise.

It is windproof：Meridian distribution of property and flavor：Acrid, sweet, warm.Return bladder, liver, the spleen channel.Major function：Inducing diaphoresis to dispel wind, victory is wet, only convulsion.With In cold headache, arthralgia pain due to rheumatism, rubella itch, lockjaw.

Rhizoma zingiberis：Meridian distribution of property and flavor：It is pungent, hot.Returns spleen warp, stomach, kidney channel, the heart channel of Hang-Shaoyin, lung channel.Middle benefit gas is by cold, Back to Yang Tongmai.Control the heart Abdomen crymodynia, vomit and diarrhoea, cold weak pulse of limb is breathed with cough for cold time, and wind-cold-dampness arthralgia, the deficiency of yang is told, is defeated in battle, lower blood.

The fruit of Chinese magnoliavine：Meridian distribution of property and flavor：It is sour, sweet, temperature.Return lung, the heart, kidney channel.Major function：Restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, kidney tonifying Calming heart.For empty asthma of coughing long, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, injury thirst, feeble pulse of losing heart, interior heat Quench one's thirst, palpitation and insomnia.

Honeysuckle：Meridian distribution of property and flavor：It is cold in nature, it is sweet.Return lung, the heart, stomach.It is clearing heat and detoxicating, wind-heat dissipating.For carbuncle swells malignant boil Sore, larynx numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating.

The capsule of weeping forsythia：Meridian distribution of property and flavor：It is slightly cold；It is bitter；Return lung, the heart, small intestinl channel.Major function：It is clearing heat and detoxicating, dispersing swelling and dissipating binds.For Ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of warm is joined the army, hyperpyrexia polydipsia, coma hair spot, heat gonorrhea renal shutdown.

Gypsum：Meridian distribution of property and flavor：It is sweet, pungent, property Great Cold.Attach to the lung and stomach meridians.Major function：It is raw to use：Clearing heat-fire, relieving restlessness stop Yearningly；Forge use：Expelling pus and promoting granulation, hygroscopic, hemostasis.For fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, dyspnea and cough due to lung-heat, the high Sheng of stomach fire, have a headache, toothache.

Radix scutellariae：Meridian distribution of property and flavor：Bitter, it is cold in nature.Return lung, courage, spleen, large intestine, small intestinl channel.Major function：Heat-clearing and damp-drying drug, purging intense heat Removing toxic substances, hemostasis, antiabortive, hypotensive.For damp-warm syndrome, heat temperature evil of vomitting uncomfortable in chest, damp and hot feeling of fullness, rush down dysentery, jaundice, cough with lung heat, high fever Polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability.

The root bark of white mulberry：Meridian distribution of property and flavor：It is sweet, it is cold in nature.Enter lung channel, the spleen channel.Removing heat from lung and relieving asthma, line water detumescence.Dyspnea and cough due to lung-heat is controlled, is told Blood, oedema, tinea pedis, difficult urination.

Reed rhizome：Meridian distribution of property and flavor：It is sweet, tremble with fear.Return lung warp, stomach.Major function：Clearing heat and promoting fluid, relieving restlessness, preventing or arresting vomiting, diuresis.For Pyreticosis polydipsia, gastropyretic vomiting, cough with lung heat, lung carbuncle pyemesis, puckery pain of heat gonorrhea.

Coix seed：Meridian distribution of property and flavor：It is sweet light, it is cool.Enter spleen, lung, kidney channel.Invigorating the spleen excreting dampness, remove numbness antidiarrheal, clearing away heat and eliminating pus.For Oedema, tinea pedis, difficult urination, arthritis with fixed pain caused by dampness contraction, splenasthenic diarrhea, lung carbuncle, acute appendicitis；Flat wart.

Semen Benincasae：Meridian distribution of property and flavor：Nature and flavor：It is sweet, it is slightly cold.Channel tropism：Enter spleen, small intestinl channel.Major function：Moistening lung, resolving sputum, disappear Carbuncle, Li Shui.Control phlegm-heat cough, lung carbuncle, acute appendicitis, gonorrhoea, oedema, tinea pedis, hemorrhoid, nasal surface wine Zha.

Almond：Meridian distribution of property and flavor：Hardship, temperature are poisonous.Enter lung, large intestine channel.Expelling phlegm and arresting coughing, relieving asthma, ease constipation.Exogenous cough is controlled, is breathed heavily It is full, larynx numbness, dry constipation of intestines.

Radix scrophulariae：Meridian distribution of property and flavor：It is sweet, bitter, salty, it is slightly cold.Returns spleen, stomach, kidney channel.Effect：Clearing heat and cooling blood；Nourishing Yin and falling fire； Detoxicating and resolving a mass.Warm heat disease heat and ying blood；Body heat；Polydipsia；Tongue is deep red；Send out spot；Hectic fever due to yin labor is coughed；Dysphoria not awake；Tianjin hinder constipation；Mesh puckery dusk Flower；Throat larynx swells and ache；Scrofula subcutaneous nodule；Skin sore.

Caulis bambusae in taenian：Meridian distribution of property and flavor：It is sweet, it is cool.Enter stomach, gallbladder channel.Heat-clearing, cool blood, resolving sputum, antiemetic.Control dysphoria with smothery sensation vomiting, hiccup, phlegm Hot cough and asthma, haematemesis, bleeding from five sense organs or subcutaneous tissue, uterine bleeding, vomiting during early pregnancy, a word used in place name move, frightened epilepsy.

Radix glycyrrhizae：Meridian distribution of property and flavor：It is sweet, put down.Enter spleen, stomach, lung channel.Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, Coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, Alleviate drug toxicity, strong.

The Chinese medicine composition of the treatment chronic cor pulmonale of the present invention, according to drug matching mechanism, to freeing lung and relieving asthma Chinese ephedra be monarch drug in a prescription, the schizonepeta of wind is dissipated as ministerial drug using the asarum of Wenfei of drink and inducing diaphoresis, with the windproof of inducing diaphoresis to dispel wind, middle benefit gas by cold Rhizoma zingiberis, the fruit of Chinese magnoliavine of nourishing generate fluid, clearing heat and detoxicating honeysuckle, the capsule of weeping forsythia of dispersing swelling and dissipating binds, the gypsum of clearing heat-fire, heat-clearing it is dry The radix scutellariae of wet purging intense heat and detonicating, the root bark of white mulberry of removing heat from lung and relieving asthma, the reed rhizome of clearing heat and promoting fluid, the coix seed of invigorating the spleen excreting dampness, moistening lung for removing phlegm Semen Benincasae, the almond of expelling phlegm and arresting coughing, the radix scrophulariae of nourishing Yin and falling fire are adjutant, using clearing heat and detoxicating, expelling phlegm and arresting coughing radix glycyrrhizae as medicine is made, are matched somebody with somebody 5 rationally, have no toxic side effect, moisten the lung and relieve the cough, dispersing swelling and dissipating binds, clearing heat-fire, dredge cardiopulmonary, for chronic cor pulmonale, treat Imitate, it is quick, short treating period is cured, it is uneasy to recur.

Embodiment

Technical scheme is clearly and completely described below in conjunction with embodiment.Obviously, described reality It is only part of the embodiment of the present invention to apply example, rather than whole embodiments.It is general based on the embodiment in the present invention, this area The every other embodiment that logical technical staff is obtained under the premise of creative work is not made, belong to what the present invention protected Scope.

Embodiment one：

A kind of Chinese medicine composition for treating chronic cor pulmonale, is made up of the Chinese medicine material of following weight： 6 parts of Chinese ephedra, 3 parts of asarum, 10 parts of schizonepeta, windproof 10 parts, 10 parts of rhizoma zingiberis, 10 parts of the fruit of Chinese magnoliavine, 20 parts of honeysuckle, 10 parts of the capsule of weeping forsythia, stone 20 parts of cream, 10 parts of radix scutellariae, 10 parts of the root bark of white mulberry, 10 parts of reed rhizome, 10 parts of coix seed, 8 parts of Semen Benincasae, 10 parts of almond, 15 parts of radix scrophulariae, bamboo 10 parts are eaten, 6 parts of radix glycyrrhizae.

The present embodiment provides a kind of system of the Chinese medicine composition for the treatment of chronic cor pulmonale as described above simultaneously Preparation Method, comprise the following steps：

1) weigh by weight Chinese ephedra, asarum, schizonepeta, windproof, rhizoma zingiberis, the fruit of Chinese magnoliavine, honeysuckle, the capsule of weeping forsythia, gypsum, radix scutellariae, The root bark of white mulberry, reed rhizome, coix seed, Semen Benincasae, almond, radix scrophulariae, caulis bambusae in taenian, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into soya bean size Fritter, be well mixed after under ultraviolet germicidal lamp sterilization treatment 1 hour, be subsequently placed in container with normal-temperature water soak 40 points Clock；

2) Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow fire heats 30 minutes, Dry in the air after being down to 60 DEG C to temperature, take filtrate, the dregs of a decoction in marmite are standby, and filtrate is poured into container, obtain a decoction；

3) hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire 30 Minute, dry in the air after being down to 60 DEG C to temperature, filter to obtain secondary decoction；

The above method prepare be for traditional Chinese herbal decoction, the instructions of taking of this traditional Chinese herbal decoction：Take in three times within 1 day.Also can be 1 time Property decoct the dose of 2 days, filling and sealing after obtained decoction is sterilized, refrigeration, first pico- heating when taking.

Embodiment two：

A kind of Chinese medicine composition for treating chronic cor pulmonale, is made up of the Chinese medicine material of following weight： 7 parts of Chinese ephedra, 5 parts of asarum, 13 parts of schizonepeta, windproof 15 parts, 15 parts of rhizoma zingiberis, 20 parts of the fruit of Chinese magnoliavine, 25 parts of honeysuckle, 13 parts of the capsule of weeping forsythia, stone 25 parts of cream, 13 parts of radix scutellariae, 13 parts of the root bark of white mulberry, 15 parts of reed rhizome, 14 parts of coix seed, 13 parts of Semen Benincasae, 15 parts of almond, 17 parts of radix scrophulariae, 13 parts of caulis bambusae in taenian, 7 parts of radix glycyrrhizae.

2) powder is then ground to, after crossing 600 mesh sieves point, obtains Chinese medicine composition powder.

Chinese medicinal composition capsules prepared by the above method, instructions of taking are：Take in three times within 1 day, 15 grams every time (3).

Embodiment three：

A kind of Chinese medicine composition for treating chronic cor pulmonale, is made up of the Chinese medicine material of following weight： 8 parts of Chinese ephedra, 4 parts of asarum, 14 parts of schizonepeta, windproof 16 parts, 16 parts of rhizoma zingiberis, 23 parts of the fruit of Chinese magnoliavine, 26 parts of honeysuckle, 14 parts of the capsule of weeping forsythia, stone 26 parts of cream, 14 parts of radix scutellariae, 14 parts of the root bark of white mulberry, 17 parts of reed rhizome, 14 parts of coix seed, 14 parts of Semen Benincasae, 16 parts of almond, 18 parts of radix scrophulariae, 14 parts of caulis bambusae in taenian, 8 parts of radix glycyrrhizae.

1) weigh by weight Chinese ephedra, asarum, schizonepeta, windproof, rhizoma zingiberis, the fruit of Chinese magnoliavine, honeysuckle, the capsule of weeping forsythia, gypsum, radix scutellariae, The root bark of white mulberry, reed rhizome, coix seed, Semen Benincasae, almond, radix scrophulariae, caulis bambusae in taenian, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into soya bean size Fritter, be well mixed after under ultraviolet germicidal lamp sterilization treatment 1 hour, be subsequently placed in container with normal-temperature water soak 60 points Clock；

Example IV：

A kind of Chinese medicine composition for treating chronic cor pulmonale, is made up of the Chinese medicine material of following weight： 9 parts of Chinese ephedra, 6 parts of asarum, 15 parts of schizonepeta, windproof 20 parts, 20 parts of rhizoma zingiberis, 25 parts of the fruit of Chinese magnoliavine, 30 parts of honeysuckle, 15 parts of the capsule of weeping forsythia, stone 30 parts of cream, 15 parts of radix scutellariae, 15 parts of the root bark of white mulberry, 20 parts of reed rhizome, 15 parts of coix seed, 15 parts of Semen Benincasae, 20 parts of almond, 20 parts of radix scrophulariae, 15 parts of caulis bambusae in taenian, 10 parts of radix glycyrrhizae.

2) powder is then ground to, after crossing 650 mesh sieves point, obtains Chinese medicine composition powder.

Chinese medicinal composition capsules prepared by the above method, instructions of taking are：Take at twice within 1 day, 10 grams every time (2).

The present invention has carried out clinical efficacy tracking with the data given by embodiment 3 simultaneously, and curative effect is summarized as follows：

1. Chronic Cor Pulmonale 100 is chosen, wherein male 35 female 65, age 28-60 year, average age 45 Year.

2. treatment method, the oral Chinese medicine composition decoction made from optimization formula embodiment 3 of the present invention for the treatment of group, per bu Take three times, each 200ml, the course for the treatment of 30 days.

3. diagnostic criteria

1) there is chronic respiratory disease medical history.Mainly COPD, pulmonary tuberculosis, bronchiectasis and chest The medical histories such as wide disease；

2) there is the corresponding performance of pulmonary hypertension, right ventricle increase or right heart failure；

3) auxiliary examination：Rabat, electrocardiogram or ultrasound electrocardiogram show pulmonary hypertension, right ventricle and/or atrium dextrum Increase performance.1 and 2 or 1 and 3 with more than.

4) tcm diagnosis standard is：Phlegm dampness in lungs, cough and asthma are uncomfortable in chest, and abundant expectoration is easily coughed up, phlegm it is viscous or cough up tell it is not well, it is close in the heart, Greasy, the Anhui ruffian abdominal distension of mouth.Tongue nature is light, white and greasy fur, wiry and rolling pulse.

4. efficacy determination

Recovery from illness：Cough, expectoration, syndrome characterized by dyspnea are disappeared, and related symptoms and tongue, pulse condition are obviously improved, without recurrence in 2 months；

It is effective：Cough, expectoration, syndrome characterized by dyspnea substantially mitigate, and as severe is kept to slightly, related symptoms and tongue vein are as improving, 2 months Interior no exacerbation；

Effectively：Cough, expectoration, syndrome characterized by dyspnea mitigate, and as severe is kept to moderate, moderate is kept to slightly, related symptoms and tongue vein as Make moderate progress, without exacerbation in 2 months；

It is invalid：Cough, expectoration, syndrome characterized by dyspnea are without change or anti-exacerbation.

5. treatment results, clinical recovery rate 48%, effective 13%, effective 18%, invalid 6%, total effective rate 79%.

The Chinese medicine composition of the treatment chronic cor pulmonale of the present invention, compatibility is reasonable, has no toxic side effect, and moistening lung stops Cough, dispersing swelling and dissipating binds, clearing heat-fire, cardiopulmonary are dredged, for chronic cor pulmonale, good effect is quick, cures short treating period, It is uneasy to recur.

Toxicity test is carried out to the Chinese medicine composition of the present invention, test effect is as follows：

To choose that the suitable adult of body weight is female, male each 20 of small white mouse, be divided into control group and administration group, rearing conditions are consistent, Control group not medicine feed, the daily medicine feed of administration group 1 time, records the health of each small white mouse, ingests, drinks water, body weight daily, tries Test lasting six months, compared with control group, administration group small white mouse health, ingest, drink water, body weight increase it is normal, and not See that small white mouse is sick or dead.Prompt the medicine security good, have no toxic side effect.

The treatment case of the Chinese medicine composition of the treatment chronic cor pulmonale of the present invention is as follows：

Case one, week so-and-so, man, 35 years old.Long-term chronic is coughed, expectoration, expiratory dyspnea, is diagnosed as chronic pulmonary heart Disease, the dificiency of the lung due to protracted disease, weakened defensive QI, heart arteries and veins stasis blocking, awards Chinese medicine provided by the invention, breathed after two weeks it is smooth, cough substantially subtract Weak, after four weeks, no longer cough, expectoration, is after treatment, and medication one week.Visited after 1 year：Recovery from illness, no recurrence.

Case two, Lv, female, 56 years old.Long-term chronic is coughed, expectoration, and expiratory dyspnea, palpitaition is weak, and the traditional Chinese medical science thinks, this It is caused by the dificiency of the lung due to protracted disease, weakened defensive QI, heart arteries and veins stasis blocking, awards Chinese medicine provided by the invention, breathe smooth after two weeks, cough subtracts Weak, no longer cough, expectoration after four weeks, palpitaition, still weak once in a while, after six weeks, no longer palpitaition, weak, recovery completely.After 1 year Visit：Recovery from illness, no recurrence.

Case three, Liang, man, 60 years old.Patient suffers from chronic cor pulmonale, and with chronic obstructive pulmonary disease, cough To cough, expectoration phenomenon is more than, every time the phenomenon through often there is asthma to suppress after activity, using relievining asthma and some anti-infectious drug therapies, Effect is undesirable always, takes decoction 2 months made of the embodiment of the present invention four, and cough, expectoration phenomenon substantially mitigate, after activity Asthma is suppressed phenomenon and is eased, and continues after taking 2 months, and patient clinical symptom is wholly absent, and freely, the state of mind also obtains for activity Improve.Visited after 1 year：Recovery from illness, no relapse.

Case four, Mr. Wang, female, 45 years old.Occur that asthma is anxious, and cough, gas is tight after work is tired, abundant expectoration and phlegm is yellow and thick, With uncomfortable in chest, palpitaition symptom.Traditional Chinese herbal decoction made of the present invention is taken after 1 month, above-mentioned symptom substantially mitigates, and continuously takes 2 After individual month, above-mentioned symptom all disappears.Visit, fully recover after 1 year, no recurrence.

The foregoing description of the disclosed embodiments, those skilled in the art are enable to realize or using the present invention.To this A variety of modifications of a little embodiments will be apparent for a person skilled in the art, and generic principles defined herein can Without departing from the spirit or scope of the present invention, to realize in other embodiments.Therefore, the present invention will not be limited The embodiments shown herein is formed on, and is to fit to consistent with principles disclosed herein and features of novelty most wide Scope.

Claims

1. a kind of Chinese medicine composition for treating chronic cor pulmonale, it is characterised in that by the Chinese medicine of following weight Raw material forms：Chinese ephedra 6-9 parts, asarum 3-6 parts, schizonepeta 10-15 parts, windproof 10-20 parts, rhizoma zingiberis 10-20 parts, fruit of Chinese magnoliavine 10-25 Part, honeysuckle 20-30 parts, capsule of weeping forsythia 10-15 parts, gypsum 20-30 parts, radix scutellariae 10-15 parts, root bark of white mulberry 10-15 parts, reed rhizome 10-20 Part, coix seed 10-15 parts, Semen Benincasae 8-15 parts, almond 10-20 parts, radix scrophulariae 15-20 parts, caulis bambusae in taenian 10-15 parts, radix glycyrrhizae 6-10 parts.

2. the Chinese medicine composition for the treatment of chronic cor pulmonale according to claim 1, it is characterised in that by following heavy Measure the Chinese medicine material composition of part proportioning：Chinese ephedra 6-8 parts, asarum 3-4 parts, schizonepeta 12-15 parts, windproof 12-18 parts, rhizoma zingiberis 12-18 Part, fruit of Chinese magnoliavine 12-25 parts, honeysuckle 22-28 parts, capsule of weeping forsythia 12-15 parts, gypsum 22-30 parts, radix scutellariae 12-15 parts, root bark of white mulberry 12- 15 parts, reed rhizome 12-18 parts, coix seed 12-15 parts, Semen Benincasae 10-15 parts, almond 12-18 parts, radix scrophulariae 18-20 parts, caulis bambusae in taenian 12- 15 parts, radix glycyrrhizae 6-8 parts.

3. the Chinese medicine composition for the treatment of chronic cor pulmonale according to claim 1, it is characterised in that by following heavy Measure the Chinese medicine material composition of part proportioning：7 parts of Chinese ephedra, 5 parts of asarum, 13 parts of schizonepeta, windproof 15 parts, 15 parts of rhizoma zingiberis, 20 parts of the fruit of Chinese magnoliavine, 25 parts of honeysuckle, 13 parts of the capsule of weeping forsythia, 25 parts of gypsum, 13 parts of radix scutellariae, 13 parts of the root bark of white mulberry, 15 parts of reed rhizome, 14 parts of coix seed, Semen Benincasae 13 Part, 15 parts of almond, 17 parts of radix scrophulariae, 13 parts of caulis bambusae in taenian, 7 parts of radix glycyrrhizae.

A kind of 4. preparation side of the Chinese medicine composition for the treatment of chronic cor pulmonale as any one of claim 1-3 Method, it is characterised in that comprise the following steps：

1) Chinese ephedra, asarum, schizonepeta, windproof, rhizoma zingiberis, the fruit of Chinese magnoliavine, honeysuckle, the capsule of weeping forsythia, gypsum, radix scutellariae, Sang Bai are weighed by weight Skin, reed rhizome, coix seed, Semen Benincasae, almond, radix scrophulariae, caulis bambusae in taenian, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into the small of soya bean size Block, after being well mixed under ultraviolet germicidal lamp sterilization treatment 1 hour, be subsequently placed in container with normal-temperature water immersion 40-60 point Clock；

2) Chinese medicine material after immersion and the water of immersion are placed in marmite, after boiling by intense fire, slow fire heat 30 minutes, dry in the air to After temperature is down to 40-70 DEG C, filtrate is taken, the dregs of a decoction in marmite are standby, and filtrate is poured into container, obtain a decoction；

3) hot water will be added in the dregs of a decoction in marmite in step 2), carries out secondary decoction, first boil by intense fire, then be cooked by slow fire 30 points Clock, dry in the air after being down to 40-70 DEG C to temperature, filter to obtain secondary decoction；

4) the secondary decoction obtained in obtained in step 2) decoction and step 3) is merged, and be well mixed, dried in the air to room Bottle or pack after temperature, obtain Traditional Chinese medicine composition liquid medicine.

5. the preparation method of the Chinese medicine composition of the treatment chronic cor pulmonale as any one of claim 1-3, It is characterised in that it includes following steps：

1) Chinese ephedra, asarum, schizonepeta, windproof, rhizoma zingiberis, the fruit of Chinese magnoliavine, honeysuckle, the capsule of weeping forsythia, gypsum, radix scutellariae, Sang Bai are weighed by weight Skin, reed rhizome, coix seed, Semen Benincasae, almond, radix scrophulariae, caulis bambusae in taenian, radix glycyrrhizae, screening removal of impurities, larger raw material are cut into the small of soya bean size Block, be well mixed after under ultraviolet germicidal lamp sterilization treatment 1 hour；

2) powder is then ground to, after crossing 500-800 mesh sieves point, obtains Chinese medicine composition powder.

6. the preparation method of the Chinese medicine composition for the treatment of chronic cor pulmonale according to claim 5, its feature exist In also comprising the following steps：

The Chinese medicine composition powder that step 2) obtains is fitted into capsule skin Chinese medicinal capsule is made, obtain Chinese medicinal composition capsules.

7. the preparation method of the Chinese medicine composition for the treatment of chronic cor pulmonale as claimed in claim 5, it is characterised in that：

The granularity of the Chinese medicine composition powder obtained in step 2) is 650 mesh.