CN107875370A - For promoting enterocinesia exhaust to prevent the Chinese medicine composition and preparation method of intestinal adhesion - Google Patents
For promoting enterocinesia exhaust to prevent the Chinese medicine composition and preparation method of intestinal adhesion Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition and preparation method for being used to promote enterocinesia exhaust to prevent intestinal adhesion.The raw material components of Chinese medicine composition include：The parts by weight of another name for Sichuan Province green pepper 6~10, the parts by weight of rhizoma zingiberis 10~15, the parts by weight of ginseng 6~10 and the parts by weight of maltose 20~30.Preparation method：Each raw material components are mixed, is well mixed afterwards with matrix lotion, obtains creme；Creme is spread evenly across to the non-woven fabrics of back sheet, pressed afterwards, obtains emplastrum.Chinese medicine composition provided by the invention is made of pure Chinese medicine, without having an injection, no pain, good absorbing, it is easy to use, curative for effect, work it is quick and economical and practical, Intestinal Mucosal Injury in Patients Undergoing function can be recovered as early as possible, promote enterocinesia and intestines ventilation and the generation for preventing intestinal adhesion, overcome the shortcomings of existing clinic application；And then patient is regained one's strength as early as possible, and promote the healing of wound, reduce length of stay, mitigate household economy burden, offer convenience, great convenience doctor and patient.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine for being used to promote enterocinesia exhaust to prevent intestinal adhesion
Composition and preparation method.
Background technology
Medically, exhaust is to examine surgical operation into whether mark.Exhaust then shows that gastrointestinal peristalsis has recovered normal, is
The signal that prompting patient can feed.Clinically postoperative exhaust as early as possible is the key one for being directly connected to postoperative patient physical recovery
Step, because the absorption of postoperative patient nutrition, the recovery of constitution, rely primarily on the maintenance of diet.
The reason for clinically surgical operation final vacuum is slow has following several：Firstth, operation stimulates.In surgical procedure, by
It can suppress in intestinal tube exposure, the direct stimulation of operation technique, mesenteric mesaraic damage, the stimulation of intraperitoneal inflammation and Diagnostic value etc.
Gastrointestinal function, weaken postoperative enterocinesia.Secondth, due to the influence of anaesthetic so that enterocinesia weakens.3rd, perform the operation
Wound, be suppressed enteron aisle normal creepage of gastrointestinal functions.4th, postoperative bed, due to pain, indwelling intubation etc. makes patient's long period
Lie up, activity is reduced.5th, patient is postoperative ties up abdominal belt, reduces the space shared by intestinal tube, constrains the compacted of intestinal tube
It is dynamic.
The method that clinically physician guidance patient is vented early stage as early as possible at present will be turned over frequently when being mainly doctor's advice bedridden patient,
Help a Go to ground activity as early as possible, postoperative 24h starts to mend potassium, receives anus with enema, makes blind enema, to the obvious flatulence of belly and again not
Exhaust person, also the method for intubation is used to be exhausted sometimes；Or with finger pinch point st 36, promote to be vented, doctor's advice drink lotus root starch,
The methods of drinking radish soup, to promoting postoperative bowel to have a certain curative effect, but evacuation time is more than 24~48 days, during not being vented
The nutrition intake of patient is supplemented using the method for transfusion, due to that can not feed unbalanced, the wound healing that brings nutrition intake
The burdens such as extension, extended hospital stay, expense increase, especially for cardiac insufficiency, severe infections, high fever and body extremely
The middle-older patient of the postoperative feed that can not drink water of weak headstroke, it is even more helpless；Clinically advanced age operation patients are quite a few,
But the ventilation medication of improvement intestines is more difficult after these patients operation, particularly decoction easily causes the alimentary canal disease such as Nausea and vomiting
Shape, and the medicinal granule formulation problem such as be difficult to swallow are also required to improve.One of the problem of non-compliance of formulation is wherein,
Heighten the effect of a treatment, it is easy to use be to require greatly the two of postoperative patient.So shortening the evacuation time of postoperative patient, strive for earliest
Promote the ventilation of enterocinesia intestines, allow patient to drink water feed with real clinical meaning.
Use builds middle soup to be substantially square more among cold of insufficiency type disease based on the digestive systems such as surgical postoperative gastrointestinal motility disorder
Changed utilization, dajianzhong decoction has the orthopaedics patient of the symptoms such as belly turgor concurrently and except lower digestive tract hand for long-term bed
The patient of art, no matter actual situation can reach certain curative effect.Chronic gastritis, peptic ulcer, ulcerative colitis, orthopaedics patient abdomen
The all visible tympanites of portion's visual examination and bulge, appendicitis develop into rectum uterus nest purulence ulcer simple intestinal obstruction, repeatability stalk
Patient is hindered, frequently occurs the schizophrenia patients of paralytic ileus, simple adhesive ileus patient, operation on digestive tract history
Adhesive ileus patient, be to adapt to the phase after enterocinesia uneasiness disease, peritonitis, pericecitis and caesarean section etc.
Disease.
Interpretation of the cause, onset and process of an illness main points are based on deficiency-cold in spleen and stomach, and basic goal is warming middle-Jiao and tonifying deficiency, are primarily directed toward, to build middle qi-restoratives and inner slow
Anxious, so no matter on theoretical or practice principle, the patch agent of the oral administration and externally all quite has research invention value.
It is by stimulating choline excitement nerve in intestinal walls and serotonin nerve to send out after dajianzhong decoction is for oral administration
Wave effect.By expanding insufficiency of the spleen-yang rat model mesenteric microvessels, increase perfusion of the capillary to gastrointestinal tissue, so as to
Improve Rat Mesenteric Microcirculation function, and obvious dose-effect relationship be present；Research also found, in insufficiency of the spleen-yang rat model body
TXB2/6-Keto-PGFla regulating systems are lacked of proper care, and by reducing TXB2 contents in blood plasma, are made its vasoconstriction and are promoted blood platelet
Aggtegation weakens；Blood plasma 6-Keto-PGFl alpha contents are raised, makes vasodilator and suppresses platelet aggregation reinforcement, so as to
Improve gastronintestinal system microcirculatory perfusion.
Existing various preparations such as dajianzhong decoction, middle granule etc. is built, to promoting enterocinesia to have certain effect, but needed
It is oral after to postoperative patient restoration of gastrointestinal function, delay patient to drink water time of feed, difficult especially for medication
Have no idea to obtain medical treatment in time after severe case and infant and operation in senile patients.
Based on this, to overcome the shortcomings of existing clinic application, there is provided a that there is inner disease outer treat, method simplicity, make
With the Post operation of safety rapidly promote enterocinesia intestines ventilate effect product it is particularly important.
The content of the invention
For in the prior art the defects of, the present invention is intended to provide it is a kind of be used for promote enterocinesia exhaust prevent intestinal adhesion
Chinese medicine composition and preparation method.Chinese medicine composition provided by the invention is made of pure Chinese medicine, without having an injection, no pain, suction
Keep well, be easy to use, be curative for effect, work it is quick and economical and practical.The Chinese medicine composition inner disease outer treat, it is without any side effects,
Can greatly meet and facilitate recover Intestinal Mucosal Injury in Patients Undergoing function as early as possible after clinician's operation, promote enterocinesia and intestines ventilation with
And the active demand for preventing intestinal adhesion from occurring, mitigate the pain for the patient that can not take medicine and be not easy to take medicine, overcome existing clinical treatment
The deficiency of technology；And then cause patient feeds as early as possible to regain one's strength, promote the healing of wound, reduce length of stay, mitigate family
Financial burden, offer convenience, so as to great convenience doctor and patient.
To achieve the above object, present invention offer following technical scheme is：
In a first aspect, the present invention provides a kind of Chinese medicine composition for promoting enterocinesia, raw material components by weight, wrap
Include：The parts by weight of another name for Sichuan Province green pepper 6~10, the parts by weight of rhizoma zingiberis 10~15, the parts by weight of ginseng 6~10 and the parts by weight of maltose 20~30.
Another name for Sichuan Province green pepper：Smell is pungent and numb, warm, enters the warp of the heart, spleen, kidney.The big heat of great Xin, enters lung and dispelling cold, enters spleen warm stomach, warming spleen and stomach for dispelling cold
By numbness pain, drop check pain, enter kidney and help life fire, eliminating cold to stop pain, lower gas dissipating bind, be monarch drug in a prescription.Pharmacological research：Another name for Sichuan Province green pepper has antibacterial, suppression
Platelet aggregation processed and the effect such as anti-oxidant, containing volatile oil (terpene linalool and limonene), alkaloid, acid amides, cumarin,
Flavone compound, aliphatic acid, sterol, lignin etc..Rhizoma zingiberis：Gas fragrance is pungent, property heat, returns spleen, stomach, kidney, the heart, lung channel, does
Jiang Xinre leads to the heart, warming spleen and stomach for dispelling cold, supporing yang to dissipate inverse by cold, helps another name for Sichuan Province green pepper cold dispelling temperature spleen, go directly taste, also stopping nausea and vomiting by lowering the adverse flow of QI the effect of,
For ministerial drug；Pharmacological research rhizoma zingiberis principle active component is that volatile oil (for alkene and terpenoid) and performance easing pain and diminishing inflammation act on
Gingerol class (6-gingerol), in addition also cupreol, daucosterol, palmitic acid, ring succinic anhydride etc. it is non-volatile into
Point.Pharmacological research proves that there is rhizoma zingiberis easing pain and diminishing inflammation, antibacterial, antidiarrheal, antitumor, anti anoxia, improvement local blood circulation etc. to make
With.Another name for Sichuan Province green pepper and rhizoma zingiberis Papillary can make that cold-evil disperses and pain disappears only, and turbid yin drops and inverse remove of vomitting.Maltose：Nature and flavor are sweet, warm, return
Spleen, stomach, lung channel.Tepor is sweet slow, empty in temperature compensation, and sweet energy tonifying spleen soil, relieving spasm to stop pain helps the work(of another name for Sichuan Province green pepper analgesic, while can also relax
Another name for Sichuan Province green pepper and the dry strong property of rhizoma zingiberis, are ministerial drug；It is main to contain maltose, and containing vitamin B and iron etc..For peptic ulcer,
Enterospasm etc..Ginseng：Sweet, slight bitter, tepor, returns spleen, lung, the heart, kidney channel.The gas of big tonifying spleen lung, invigorates the spleen and benefits qi, can help maltose weight
Apoplexy involving the solid organs is built, it is raw to reach the prosperous then sun of gas, it is adjutant.As long as containing ginsenoside (Rg1, Re, Rb1), panaxan, ginseng protein etc.
Bioactive ingredients.Can improve a poor appetite, cardiac stimulant, antifatigue, anti-aging, antitumor, the disease such as eliminate-poverty blood, neurasthenia.
Principle and postoperative basic pathophysiological features, its cause of disease according to the organic conception of the traditional Chinese medical science and diagnosis and treatment are
Internal organs physiological function caused by operation and anaesthetic is affected, so that taste disturbance in ascending and descending, transporting conduction function obstacle, is promoted
Powerless, harmony is stagnant obstructed.The motion of stomach and intestine, secretion, digestion, absorption function are disorderly, it is impossible to carry out normal gastrointestinal peristalsis and exhaust
Defecation.The traditional Chinese medical science thinks " The spleen and stomach provide the material basis of the acquired, source of generating QI and blood " that stomach and intestine are suitable to be reduced to lead to for use.Not after operation
In the case of feeding, it need to recover the lifting function of stomach and intestine with the logical zang-fu organs qi movement of temperature, be administered from navel cave and play drug percutaneous suction
The dual superposition therapeutic action with acupuncture point dredging the channel internal organs is received, wakes up the normal function of taste as early as possible.Four traditional Chinese medicine is harmonious, another name for Sichuan Province green pepper
The big heat of great Xin, enters spleen warm stomach, and warming spleen and stomach for dispelling cold drop check pain, enters kidney and help life fire, eliminating cold to stop pain by numbness pain.Rhizoma zingiberis warming spleen and stomach for dispelling cold, stop
Vomit, help the power of another name for Sichuan Province green pepper cold dispelling, maltose is warming middle-Jiao and tonifying deficiency, relieving spasm to stop pain, and ginseng reinforces vital energy and QI of the spleen and stomach, helps in maltose reconstruction
It is dirty, it is arrogant and middle in making empty to answer.Full side focuses on strong medium temperature sun and preventing or arresting vomiting.It is yin-cold excess for postoperative YANG deficiency of the spleen and stomach, stomachache,
Vomiting, loss of appetite.
Preferably, the raw material components of Chinese medicine composition also include：The parts by weight of chlorella 2~3 and the weight of Tea Polyphenols 0.3~0.6
Measure part.
Preferably, ginseng selects general ginsenoside, and the preparation method of general ginsenoside comprises the following steps：S201：Will
Ginseng is cut into slices, and is added water to cook, is filtered afterwards and collect filtrate；Wherein, add water to cook twice, and be for the first time 2h, be for the second time
1.5h；S202：By filtrate by resin absorbing column, water elution is to colourless, then with the ethanol elution that mass percentage concentration is 60%,
Collect ethanol eluate；Wherein, resin absorbing column selects D101 type macroporous absorption posts；S203：Ethanol eluate is concentrated into 80
DEG C when relative density be 1.06~1.08 clear cream, afterwards dry, crush, obtain general ginsenoside.
Preferably, rhizoma zingiberis selects extractum zingiberis liquidum, and the preparation method of extractum zingiberis liquidum comprises the following steps：S301：By rhizoma zingiberis
Powder alcohol dipping, afterwards with 1~3mL/min speed diacolation, collect liquid of just filtering；S302：By the product after the first liquid of filtering of removing
Continue diacolation to liquid of filtering to be colourless, the continuous liquid of filtering of collection；Relative density is 1.2~1.3 when continuous liquid of filtering being concentrated into 60 DEG C afterwards
Thick paste；S303：Liquid of just filtering is well mixed with thick paste, filters afterwards, obtains extractum zingiberis liquidum.
Each bulk drug for preparing Chinese medicine composition of the present invention is to be used as to match according to mass parts, can be according to corresponding in production
Ratio increase or reduce, as large-scale production can by kilogram or in units of ton, small-scale production can also gram be unit,
Weight can increase or reduce, but the bulk drug quality proportioning constant rate between each composition.
Second aspect, the present invention provide a kind of preparation method of Chinese medicine composition, comprised the following steps：S101：By each original
Material component is well mixed, and is well mixed afterwards with matrix lotion, is obtained creme；Wherein, the gross mass of raw material components and matrix cream
The mass ratio of body is 1：(4~10)；S102：Creme is spread evenly across to the non-woven fabrics of back sheet, pressed afterwards.
Preferably, the raw material components of matrix lotion are followed successively by 1 including mass ratio：l：2 glycerine, gelatin and water；Wherein, will
The heat fusion in water-bath, afterwards distillation remove water in proportion for gelatin, glycerine, water, obtain matrix lotion.
Chinese medicine composition prepared by the above method can be further prepared into pharmaceutically acceptable formulation as needed.Pass through
By aforementioned pharmaceutical compositions, prepared after directly preparing or adding pharmaceutically acceptable auxiliary material, can be made into and any pharmaceutically may be used
The formulation of receiving.Include by taking external preparation as an example：Solution, patch, vina, tincture, gel, liniment, aerosol, spraying
Agent, ointment, suppository and plastics.The medicine of above-mentioned various formulations can be prepared according to the conventional method of pharmaceutical field.
The third aspect, Chinese medicine composition provided by the invention are preparing promotion enterocinesia exhaust, are preventing the navel of intestinal adhesion
Application in emplastrum product.
Preferably, long-term bedridden patients paste per 12h mono-；Surgery Balance anesthesia patient pastes per 6h mono-；Local anaesthesia patient's surgery
Pasted afterwards per 6h mono-, and one day 2~3 pastes；Premenstruum (premenstrua) abdominal distension crymodynia is pasted per 6h mono-, and one day 2~3 pastes.
Preferably, after using Chinese medicine composition, 3~6h of surgical site infections realizes enterocinesia and/or intestines ventilation.
Specifically, the emplastrum that the present invention is prepared is spread on postoperative patient navel, is administered from umbilical region (SHENQUE acupoint),
Play the dual superposition therapeutic action of percutaneous drug absorption and acupuncture point dredging the channel internal organs, cave drug effect should by the integration of channels and collaterals,
So as to excitating organism regulatory function, the suppression of pip peripheral region, in addition medicine cause brain to anelasticity at acupuncture point
The sensing of cortex focus keeps the continuation of administration and the stability of dosage, maintains constant blood concentration.
The above-mentioned technical proposal of the present invention has advantages below compared with prior art：
(1) Chinese medicine composition provided by the invention is made of pure Chinese medicine, without having an injection, no pain, good absorbing, user
Just it is, curative for effect, work it is quick and economical and practical.The Chinese medicine composition inner disease outer treat, it is without any side effects, it can greatly expire
It is sufficient that intestinal adhesion is ventilated and prevented to recovery Intestinal Mucosal Injury in Patients Undergoing function, promotion enterocinesia and intestines as early as possible afterwards with clinician's operation is facilitated
The active demand of generation, mitigate the pain for the patient that can not take medicine and be not easy to take medicine, overcome the shortcomings of existing clinic application；Enter
And make it that patient feeds as early as possible and regain one's strength, promote the healing of wound, reduce length of stay, mitigate household economy burden, bring
It is convenient, so as to great convenience doctor and patient.
(2) it is administered, the peculiar shape to be caved inward based on navel, is preserved suitable for medicine and fixed, navel table using navel
Skin and its cuticula are the most poor, have the electrical characteristic that impedance is low, electric capacity is big, point position is high, there is special acoustics and calorifics change
Change, barrier function is most weak, and Qi Xia fat-free masses, and skin manadesma is joined directly together, and anatomical structure is easy to Medicated Permeation, is advantageous to
Drug Percutaneous Absorption and dredging the channel internal organs, the medicine into human body can be done directly on belly, there is obvious channels and collaterals importing property,
Enterocinesia is promoted to have effect rapid after surgery, curative effect is obvious.Inwardly adjoining with small intestine, the more other positions of umbilical region temperature are high,
It is not easy to fluctuate, therefore umbilicus compares with other positions absolute absorption advantage.Umbilical region hyperesthesia, have well
Experience function and conduction function, umbilicus is stimulated, it is independently refreshing by the reflection and conduction of nervous system, adjustment body
The function of warp, the physiological activity of internal organ and tissue is improved, enhance the immunity of body, so as to reach physical fitness, diseases prevention
The purpose cured the disease.The drug molecule penetrated by Qizhong cave can enter blood by the capillary absorbance of omentum majus, through navel week vein
Net, venae parumbilicales, portal vein, liver, inferior caval vein enter blood circulation, reach target cell.
(3) navel administration has that horny layer of epidermis is most thin, and barrier function is most weak, subcutaneous fat-free mass, skin and manadesma,
The characteristics of peritonaeum is joined directly together, be advantageous to the absorption of medicine.The method avoids the liver first-pass effect that is administered orally and may occur
And stomach and intestine deactivation, liver is protected, reduces toxicity damage；In percutaneous dosing, medicine maintains constant blood concentration, and phase
To reducing patient individual difference；Drug treating time can be extended, reduce administration number of times and accumulated dose；The treatment effect of medicine can be improved
Fruit.
(4) it is administered using navel, avoids conventional oral medicine and often largely decomposed and led through liver metabolism, active ingredient
What is caused takes the shortcomings that dose is larger, and side effect is more, and catabolite is more, and serious aggravation excretory system is born.It is provided by the invention
The medicine that medicine absorbs through Qizhong cave is few by the amount of liver, and it is dense to decompose the blood medicine also less, reached when dosage is few needed for treatment
Degree, therefore toxic side effect is few, and avoids stimulation of the endo-medicine to intestines and stomach, is particularly suitable for the difficult the elderly of medication, again
Patient and infant, patient are easier to receive.
(5) Chinese medicine composition of the invention has oral medicinal herb and Western medicine is oral and injection not available for the characteristics of：Letter
Easy row, is had no adverse reaction, safe to use, overcomes the deficiency of existing clinic application, and postoperative 3~6h can be rapidly promoted
Enterocinesia, intestines ventilation.Specifically, Chinese medicine composition of the invention anaesthetic inhibitory action can weaken and can start after surgery
Use, 3~6h can wake up patient's gastrointestinal function, promote enterocinesia to prevent the generation of intestinal adhesion, allow evacuation time from postoperative
24~72h is shortened within 8h, to patient with great convenience, alleviates the pain for the patient that can not take medicine and be not easy to take medicine, gram
Take the deficiency of existing clinic application.In addition, the Chinese medicine composition is free of poisonous or habituation composition, it is not easy to accumulate in vivo,
Drug resistance will not be produced, is worth numerous doctors and patient clinical to promote and use.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
The embodiment of technical solution of the present invention will be described in detail below.Following examples are only used for clearer
Explanation technical scheme, therefore be only used as example, and can not be limited the scope of the invention with this.
The present invention provide it is a kind of promote enterocinesia Chinese medicine composition, raw material components by weight, including：Another name for Sichuan Province green pepper 6~
10 parts by weight, the parts by weight of rhizoma zingiberis 10~15, the parts by weight of ginseng 6~10 and the parts by weight of maltose 20~30.
Wherein, ginseng selects general ginsenoside, and the preparation method of general ginsenoside comprises the following steps：S201：By people
Ginseng section, adds water to cook, filters afterwards and collect filtrate；Wherein, add water to cook twice, and be for the first time 2h, be for the second time
1.5h；S202：By filtrate by resin absorbing column, water elution is to colourless, then with the ethanol elution that mass percentage concentration is 60%,
Collect ethanol eluate；Wherein, resin absorbing column selects D101 type macroporous absorption posts；S203：Ethanol eluate is concentrated into 80
DEG C when relative density be 1.06~1.08 clear cream, afterwards dry, crush, obtain general ginsenoside.Rhizoma zingiberis selects extractum zingiberis liquidum,
And the preparation method of extractum zingiberis liquidum comprises the following steps：S301：By ginger powder alcohol dipping, afterwards with 1~3mL/min speed
Diacolation is spent, collects liquid of just filtering；S302：Product after the first liquid of filtering of removing is continued into diacolation to liquid of filtering to be colourless, collection continues liquid of filtering；It
The thick paste that relative density is 1.2~1.3 when continuous liquid of filtering being concentrated into 60 DEG C afterwards；S303：Liquid of just filtering is well mixed with thick paste, it
After filter, obtain extractum zingiberis liquidum.
Preferably, raw material components also include：The parts by weight of chlorella 2~3 and the parts by weight of Tea Polyphenols 0.3~0.6.
In addition, for the Chinese medicine composition of the present invention, the present invention specially devises preparation method, comprised the following steps：
S101：Each raw material components are well mixed, is well mixed afterwards with matrix lotion, obtains creme；Wherein, raw material group
The mass ratio of the gross mass divided and matrix lotion is 1：(4~10).Wherein, the raw material components of matrix lotion include mass ratio successively
For 1：l：2 glycerine, gelatin and water；Wherein, by gelatin, glycerine, water, the heat fusion in water-bath, afterwards distillation remove in proportion
Water, obtain matrix lotion.
S102：Creme is spread evenly across to the non-woven fabrics of back sheet, pressed afterwards.
Illustrated with reference to embodiment：
Embodiment one
The present invention provides a kind of Chinese medicine composition, raw material components by weight, including：The parts by weight of another name for Sichuan Province green pepper 8, the weight of rhizoma zingiberis 10
Measure part, the parts by weight of ginseng 9 and the parts by weight of maltose 23.
Wherein, another name for Sichuan Province green pepper goes the impurity such as green pepper mesh, carpopodium to be fried with the method for frying (general rule 0213) to aromatic and finely ground, standby of sieving
With.Maltose is finely ground, it is standby after sieving.Ginseng selects general ginsenoside, and the preparation method of general ginsenoside includes following step
Suddenly：S201：Ginseng is cut into slices, added water to cook, filters afterwards and collects filtrate；Wherein, add water to cook twice, and be for the first time
2h, second is 1.5h；S202：By filtrate by resin absorbing column, water elution is 60% to colourless, then with mass percentage concentration
Ethanol elution, collect ethanol eluate；Wherein, resin absorbing column selects D101 type macroporous absorption posts；S203：By ethanol elution
Relative density is 1.06~1.08 clear cream when liquid is concentrated into 80 DEG C, dries, crushes afterwards, obtains general ginsenoside.Rhizoma zingiberis selects
Comprised the following steps with the preparation method of extractum zingiberis liquidum, and extractum zingiberis liquidum：S301：By ginger powder alcohol dipping, afterwards with 1~
3mL/min speed diacolation, collect liquid of just filtering；S302：Product after the first liquid of filtering of removing is continued into diacolation to liquid of filtering to be colourless, receipts
The continuous liquid of filtering of collection；The thick paste that relative density is 1.2~1.3 when continuous liquid of filtering being concentrated into 60 DEG C afterwards；S303：By liquid and the thick paste of just filtering
It is well mixed, filter afterwards, obtain extractum zingiberis liquidum.
Using above-mentioned raw materials component, the required Chinese medicine composition of the present invention is prepared, is comprised the following steps：
S101：Each raw material components are well mixed, is well mixed afterwards with matrix lotion, obtains creme；Wherein, raw material group
The mass ratio of the gross mass divided and matrix lotion is 1：(4~10).Wherein, the raw material components of matrix lotion include mass ratio successively
For 1：l：2 glycerine, gelatin and water；By gelatin, glycerine, water, the heat fusion in water-bath, afterwards distillation are removed water, obtained in proportion
Matrix lotion.
S102：Creme is spread evenly across to the non-woven fabrics of back sheet, pressed afterwards.
Embodiment two
The present embodiment sets on the basis of embodiment one and formed.In the embodiment, except the raw material components of Chinese medicine composition
Different from embodiment one outer, remaining parameter is identical with embodiment one.
Specifically, the present invention provides a kind of Chinese medicine composition, raw material components by weight, including：The parts by weight of another name for Sichuan Province green pepper 10,
The parts by weight of rhizoma zingiberis 10, the parts by weight of ginseng 6 and the parts by weight of maltose 30.
Embodiment three
The present embodiment sets on the basis of embodiment one and formed.In the embodiment, except the raw material components of Chinese medicine composition
Different from embodiment one outer, remaining parameter is identical with embodiment one.
Specifically, the present invention provides a kind of Chinese medicine composition, raw material components by weight, including：The parts by weight of another name for Sichuan Province green pepper 8,
The parts by weight of rhizoma zingiberis 10, the parts by weight of ginseng 9, the parts by weight of maltose 23, the parts by weight of chlorella 2 and the parts by weight of Tea Polyphenols 0.3.
In addition, in order to further illustrate the advantage of technical solution of the present invention, following functions experiment is carried out：
First, observe intestinal tympanites and recover case
Collect patients with abdominal operation 160；Wherein, postoperative 30 of acute suppurative appendicitis Complicating Peritonitis, pylorus stalk
Hinder postoperative 30, postoperative 20 of infection of biliary tract, postcholecystectomy 20,30 after gastric perforation neoplasty, complete intestinal obstruction
Postoperative 30；In all patients, using caudal anaesthesia 100, general anesthesia 60.
Each patient is divided into 4 groups, every group 40.First group to the 3rd group is observation group, respectively using embodiment one to
The medicine that embodiment three is prepared；Specifically, observation group is using the outer method of Chinese medicine navel paster paste SHENQUE acupoint；Tear packaging bag,
Paster is taken out, peels off adherent layer, cream face is affixed on to navel (SHENQUE acupoint) place for cleaning and drying, firm pasting.4th group of conduct pair
According to group, using traditional intramuscular injection Neostigmine method.Two groups are observed therapeutic effect after treatment 24h, and carried out
Statistical procedures.
Statistical method：Two groups of therapeutic effects use χ2Examine
Curative effect is judged as：Recovery from illness：There are significantly conscious enterocinesia and passage of gas by anus reaction, no abdominal distension, auscultation within 3~6h
Have that gurgling sound is per minute 3~4 times, abdominal touch has enterocinesia, symptom has obvious mitigation.It is effective：There have within 6~12h to be conscious
Enterocinesia and passage of gas by anus reaction, without obvious abdominal distension, auscultation has that gurgling sound is per minute 2~3 times, symptom has mitigated.Effectively：12
There are conscious enterocinesia and anus to have exhaust reaction within~24h, without obvious abdominal distension, symptom has mitigated.It is invalid：24~72h
Within without enterocinesia, abdominal distension without mitigation, anus is without exhaust, and symptom is without improvement.
1 two groups of therapeutic effects of table compare (example %)
By the total effective rate of observation group and control group through χ2Examine, P<0.05 two groups of curative effects of prompting have significant difference.
2nd, observe enterocinesia and recover case
Collect surgery, tumor chemoradiotherapy section and post gynecologic operation inpatient treatment group and each 150 of control group；Wherein,
Tumor chemoradiotherapy 80, postoperative 44 of orthopaedics, acute appendicitis 46, infection of biliary tract 60, caesarean birth 40, the lienal rupture 30
Example.Each patient is divided into four groups, four groups of Genders, age, disease types compare, no significant difference (P>
0.05), there is comparativity.
Four groups of patients are used into the postoperative conventional treatment of doctor trained in Western medicine, i.e., anti-infective and symptomatic treatment, maintain water, electrolyte to put down
Weighing apparatus, supportive treatment and encouragement patient's morning out-of-bed activity etc..First group to the 3rd group is observation group, respectively using embodiment one to reality
The medicine that example three is prepared is applied, the emplastrum of each embodiment is affixed on navel cave after surgery, often patch uses 12h, until intestines
Functional rehabilitation；4th group as a control group, using the postoperative conventional treatment of doctor trained in Western medicine.Record when four groups of enterocinesias recover and anus is arranged
The gas time, recovery index is used as using gurgling sound 4~5 times/mi n.
Criterion of therapeutical effect reference《Surgical Nursing》Criterion of therapeutical effect is determined with reference to clinical symptoms and patient main suit.It is effective：It is postoperative
Anus is vented automatically in 24h, no abdominal distension.Effectively：Anus is vented automatically in postoperative 24~48h, without obvious abdominal distension.It is invalid：It is postoperative
48h anuses are not vented, hence it is evident that abdominal distension.Using SPSS17,0 software is carried out statistical procedures, examined using t, with P<0.05 represents
Difference has statistical significance.
Treatment results：Treatment group patient postoperative gurgling sound recovery time and first micturition time compared with control group,
Difference is respectively provided with statistical significance (P<0.05), prompt treatment group's postoperative gurgling sound recovery time and micturition time is equal first
It is obvious to shorten.
2 two groups of patient's gurgling sound recovery times of table and first micturition time compare (h)
Note：Observation group P compared with control group<0.05
In addition, pasted after each section office are postoperative using the intestines ventilation navel paster paste of the present invention, the recovery and operation of enterocinesia
Species and anesthesia method also have a relation, in general is with the most fast about 3~6h of Orthopeadic Surgery, next to that 4~8h of post gynecologic operation, most slowly
Be the postoperative 6~12h of general surgery's long-term bedridden patients.The morphine that tumor patient uses may act on spinal cord and midbrain opium by
Body, small intestine is acted on by peripheral nerve, suppress enterocinesia, but good Postoperative Analgesia After, postoperative stress can be reduced and drawn
The complication risen, is advantageous for the recovery of gastrointestinal function.
Certainly, except the situation that embodiment one is enumerated to embodiment three, the species and proportioning of other raw material components, prepared
Condition and parameter in journey etc. are also possible.
Chinese medicine composition provided by the invention is made of pure Chinese medicine, without having an injection, no pain, good absorbing, it is easy to use,
It is curative for effect, work it is quick and economical and practical.The Chinese medicine composition inner disease outer treat, it is without any side effects, it can greatly meet
Recovery Intestinal Mucosal Injury in Patients Undergoing function, promotion enterocinesia and intestines are ventilated and prevent intestinal adhesion from sending out as early as possible afterwards with clinician's operation is facilitated
Raw active demand, mitigate the pain for the patient that can not take medicine and be not easy to take medicine, overcome the shortcomings of existing clinic application；And then
Regained one's strength so that patient feeds as early as possible, promote the healing of wound, reduce length of stay, mitigated household economy burden, bring just
Profit, so as to great convenience doctor and patient.
In the description of this specification, reference term " one embodiment ", " some embodiments ", " example ", " specifically show
The description of example " or " some examples " etc. means specific features, structure, material or the spy for combining the embodiment or example description
Point is contained at least one embodiment or example of the present invention.In this manual, to the schematic representation of above-mentioned term not
Identical embodiment or example must be directed to.Moreover, specific features, structure, material or the feature of description can be with office
Combined in an appropriate manner in one or more embodiments or example.In addition, in the case of not conflicting, the skill of this area
Art personnel can be tied the different embodiments or example and the feature of different embodiments or example described in this specification
Close and combine.
Although embodiments of the invention have been shown and described above, it is to be understood that above-described embodiment is example
Property, it is impossible to limitation of the present invention is interpreted as, one of ordinary skill in the art within the scope of the invention can be to above-mentioned
Embodiment is changed, changed, replacing and modification.
Claims (9)
1. it is a kind of promote enterocinesia Chinese medicine composition, it is characterised in that raw material components by weight, including：
The parts by weight of another name for Sichuan Province green pepper 6~10, the parts by weight of rhizoma zingiberis 10~15, the parts by weight of ginseng 6~10 and the parts by weight of maltose 20~30.
2. the Chinese medicine composition according to claim 1 for promoting enterocinesia, it is characterised in that also include：
The parts by weight of chlorella 2~3 and the parts by weight of Tea Polyphenols 0.3~0.6.
3. the Chinese medicine composition according to claim 1 or 2 for promoting enterocinesia, it is characterised in that：
The ginseng selects general ginsenoside, and the preparation method of the general ginsenoside comprises the following steps：
S201：Ginseng is cut into slices, added water to cook, filters afterwards and collects filtrate；Wherein, add water to cook twice, and be for the first time
2h, second is 1.5h；
S202：By the filtrate by resin absorbing column, water elution is washed to colourless, then with the ethanol that mass percentage concentration is 60%
It is de-, collect ethanol eluate；Wherein, the resin absorbing column selects D101 type macroporous absorption posts；
S203：Relative density is 1.06~1.08 clear cream when the ethanol eluate is concentrated into 80 DEG C, is dried afterwards, powder
It is broken, obtain the general ginsenoside.
4. Chinese medicine composition according to claim 1 or 2, it is characterised in that：
The rhizoma zingiberis selects extractum zingiberis liquidum, and the preparation method of the extractum zingiberis liquidum comprises the following steps：
S301：By ginger powder alcohol dipping, afterwards with 1~3mL/min speed diacolation, liquid of just filtering is collected；
S302：Product after the first liquid of filtering of removing is continued into diacolation to liquid of filtering to be colourless, collection continues liquid of filtering；Afterwards by the continuous liquid of filtering
Relative density is 1.2~1.3 thick paste when being concentrated into 60 DEG C；
S303：The liquid of just filtering is well mixed with the thick paste, filters afterwards, obtains extractum zingiberis liquidum.
5. the preparation method of any one of Claims 1 to 4 Chinese medicine composition, it is characterised in that comprise the following steps：
S101：Each raw material components are well mixed, is well mixed afterwards with matrix lotion, obtains creme；Wherein, the raw material group
The mass ratio of the gross mass divided and the matrix lotion is 1：(4~10)；
S102：The creme is spread evenly across to the non-woven fabrics of back sheet, pressed afterwards.
6. the preparation method of Chinese medicine composition according to claim 5, it is characterised in that：
The raw material components of the matrix lotion are followed successively by 1 including mass ratio：l：2 glycerine, gelatin and water；
Wherein, by gelatin, glycerine, water, the heat fusion in water-bath, afterwards distillation remove water in proportion, obtain matrix lotion.
7. the Chinese medicine composition described in any one of Claims 1 to 4 is preparing promotion enterocinesia exhaust, the navel of intestinal adhesion is prevented
Application in emplastrum product.
8. application according to claim 7, it is characterised in that：
Long-term bedridden patients paste per 12h mono-；Surgery Balance anesthesia patient pastes per 6h mono-；Local anaesthesia patient surgical postoperative pastes per 6h mono-,
And one day 2~3 pastes；Premenstruum (premenstrua) abdominal distension crymodynia is pasted per 6h mono-, and one day 2~3 pastes.
9. application according to claim 8, it is characterised in that：
After the Chinese medicine composition, 3~6h of surgical site infections realizes enterocinesia and/or intestines ventilation.
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