A kind of Chinese medicine composition for the treatment of hypertensive heart disease and preparation method thereof
Technical field
The invention discloses a kind of Chinese medicine composition, especially treat Chinese medicine composition of hypertensive heart disease and preparation method thereof.Belong to the Chinese medicine field.
Background technology
Hypertensive heart disease is because long-term rising of blood pressure increased the weight of the left ventricle load gradually, the organic heart disease that left ventricle forms because of compensatory gradually plump and expansion.More than generally appearing at the hypertension onset several years to ten, hypertensive heart disease after year, can be divided into cardiac functional compensatory period and cardiac functional decompensatory period according to the changes of cardiac function situation.In cardiac functional compensatory period, patient can be without obvious subjective symptoms, but in cardiac functional decompensatory period, then engender the symptom of left heart failure, only in tired, be satiated with food or speak sense cardiopalmus, asthma, cough when too much, later symptom increases the weight of gradually during beginning, and above-mentioned symptom is the paroxysmal outbreak, show as nocturnal paroxysmal dyspnea and sputum mixed with blood more, when serious acute lung edema can occur.
Hypertension can be divided into constitutional and two kinds of Secondary cases, various hypertension reach the regular hour and degree increases the weight of left chamber load, and left ventricular hypertrophy, increase occur then, all can be described as hypertensive heart disease.
The hypertensive heart disease Early manifestation generally is not true to type, and patient can or only have slight discomfort such as cardiopalmus, headache etc. without obvious subjective symptoms, and these symptoms mainly are hypertensive general symptoms, without particularity.With the progress of hypertensive disease, patient engenders in early days at the left ventricle concentric hypertrophy and without the expansion stage, and hypertension, pulse are loud, apex beat strengthens, and second sound of aortic area is hyperfunction; Enlarge the stage in left ventricle, apex beat is shifted to left down, is to praise the sample apex beat, and border of cardiac dullness enlarges to left down, and the apex first heart sound strengthens, and second sound of aortic area is loud and sonorous metal and transfers; The course of disease further develops, when left ventricle obviously enlarges, and when atherosclerotic lesion also occurs in aortic valve, aortic valve the second area of auscultation audible and relaxing period ripples sample noise, audible and fourth heart sound and various arrhythmia such as atrium fibrillation, premature beat etc.
Because the arteries hypertonia hinders heart pump and goes out blood, and the long-term high load capacity work of heart myocardial hypertrophy just occurred and stiffness index increases, the pulmonary vein that finally causes entering heart is obstructed, and forms pulmonary venous pleonaemia during hypertension.Oxygen demand increases during myocardial hypertrophy, and the blood supply relative deficiency often causes the heart failure outbreak.Hypertensive heart disease clinical manifestation in late period is:
1, because left ventricular diastolic function is unusual, can cause pulmonary venous pleonaemia, main manifestations is: the symptoms such as fatigue, asthma, cardiopalmus, cough, spitting of blood appear in ⑴; ⑵ occur out of breathly when flat sleeping, namely take a turn for the better after sitting up; ⑶ activity is little, but dyspnea occurs, and the patient can wake up with a start in one's sleep when serious.
2, left heart failure often can involve right ventricular function decline, forms whole heart failure, and main manifestations is: the ⑴ cyanosis; ⑵ jugular vein is obviously full; ⑶ upper right abdomen pain, and hepatomegaly is arranged; ⑷ edema of pair of lower extremities anasarca can occur when serious; ⑸ oliguria comes across heart failure more and loses the compensatory phase; ⑹ cerebrovascular disease often appears in middle-aged and elderly people.
In the technology of existing field of Chinese medicines treatment hypertensive heart disease, Chinese invention patent application CN200910045755.2 discloses a kind of name on August 4th, 2010 and has been called " Ramulus Uncariae Cum Uncis extract and the purposes in preparation blood fat reducing and resisting cardiac hypertrophy medicine thereof ", its chief component thing is Ramulus Uncariae Cum Uncis, prescription is simply and only for reducing blood fat, can't wholely nurse one's health health, effect is single.
Summary of the invention
For existing treatment present situation, one of purpose of the present invention is to provide a kind of Chinese medicine composition for the treatment of hypertensive heart disease, have no pain, easy to operate, evident in efficacy, the characteristics that have no side effect, and its adopts comparatively common in the localities Chinese crude drug as raw material, with low cost.
Another object of the present invention just provides the preparation method of above-mentioned Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of Chinese medicine composition for the treatment of hypertensive heart disease, preferred proportioning is taken off the primary raw material of stating weight proportion and is prepared from: Radix Panacis Quinquefolii 1-5 part, Radix Astragali 25-35 part, Stigma Croci 1-5 part, Poria 15-35 part, Radix Trichosanthis 15-30 part, Semen Platycladi 5-12 part, Lignum Dalbergiae Odoriferae 1-5 part, Radix Ophiopogonis 5-15 part, Radix Paeoniae Alba 25-35 part, Spica Prunellae 8-15 part, natural Broneolum Syntheticum (dextro Borneolum Syntheticum) 0.3-0.9 part, Ramulus Uncariae Cum Uncis 9-15 part.
A kind of Chinese medicine composition for the treatment of hypertensive heart disease, preferred proportioning is taken off the primary raw material of stating weight proportion and is prepared from: Radix Panacis Quinquefolii 2-4 part, Radix Astragali 28-32 part, Stigma Croci 2-4 part, Poria 20-30 part, Radix Trichosanthis 20-25 part, Semen Platycladi 7-10 part, Lignum Dalbergiae Odoriferae 2-4 part, Radix Ophiopogonis 8-12 part, Radix Paeoniae Alba 28-32 part, Spica Prunellae 10-13 part, natural Broneolum Syntheticum (dextro Borneolum Syntheticum) 0.4-0.7 part, Ramulus Uncariae Cum Uncis 11-14 part.
A kind of Chinese medicine composition for the treatment of hypertensive heart disease, best proportioning is taken off the primary raw material of stating weight proportion and is prepared from: 3 parts of Radix Panacis Quinquefoliis, 30 parts of the Radixs Astragali, 3 parts of Stigma Crocis, 25 parts in Poria, 22 parts of Radix Trichosanthis, 8 parts of Semen Platycladi, 3 parts of Lignum Dalbergiae Odoriferaes, 10 parts of Radix Ophiopogonis, 30 parts of the Radix Paeoniae Albas, 11 parts of Spica Prunellaes, 0.6 part of natural Broneolum Syntheticum (dextro Borneolum Syntheticum), 12 parts of Ramulus Uncariae Cum Uncis.
A kind of preparation method for the treatment of the hypertensive heart disease Chinese medicine composition, preparation process is as follows:
1. with Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis place in the non iron container, be blended into cold water soak 10-30 minute, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, turn 20-40 at a simmer minute, leach medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 15-35 at a simmer minute, leaches medicinal liquid, and twice medicinal liquid mixes.
1. the preparation method of above-mentioned Chinese medicine composition, step are blended into cold water soak 10-30 minute (preferred 15-25 minute, be more preferably 20 minutes).
1. the preparation method of above-mentioned Chinese medicine composition, step turn 20-40 at a simmer minute (preferred 25-35 minute, be more preferably 30 minutes).
2. the preparation method of above-mentioned Chinese medicine composition, step turn 15-35 at a simmer minute (preferred 20-30 minute, be more preferably 25 minutes).
Using method: reach optimum therapeuticing effect for making the present invention, medicinal liquid is divided into two parts, in sooner or later taking half an hour after meal.
The pharmacological effect of each crude drug is respectively: 3 parts of Radix Panacis Quinquefoliis, 30 parts of the Radixs Astragali, 3 parts of Stigma Crocis, 25 parts in Poria, 22 parts of Radix Trichosanthis, 8 parts of Semen Platycladi, 3 parts of Lignum Dalbergiae Odoriferaes, 10 parts of Radix Ophiopogonis, 30 parts of the Radix Paeoniae Albas, 11 parts of Spica Prunellaes, 0.6 part of natural Broneolum Syntheticum (dextro Borneolum Syntheticum), 12 parts of Ramulus Uncariae Cum Uncis.
Radix Panacis Quinquefolii: sweet in the mouth, little hardship, cool in nature.GUIXIN, lung, kidney channel.Boosting qi and nourishing yin is arranged, and the effect of clearing away heat and promoting production of body fluid is used for improving immunity of organisms, the anticancer growth, and the deficiency of vital energy is cloudy loses.
The Radix Astragali: sweet in the mouth, warm in nature.The effect that invigorating QI to consolidate the body surface resistance, diuretic detumescent are arranged, it is weak to be used for the deficiency of vital energy, and blood deficiency and yellow complexion is Qi-tonifying drug.
Stigma Croci: sweet in the mouth, property is flat.The intracellular oxygen metabolism function of enhancing is arranged, improve the hypoxia-bearing capability of heart, blood circulation promoting and blood stasis dispelling, the effect of removing pathogenic heat from blood and toxic substance from the body has certain protective role to heart, and has the anticancer effect of cancer that significantly presses down.
Poria: sweet in the mouth, light, property is flat.Promoting diuresis to eliminate damp pathogen is arranged, and the effect of spleen invigorating mind calming is used for the edema oliguria, irritability, insufficiency of the spleen lack of appetite.
Radix Trichosanthis: sweet in the mouth, cold nature.The promoting the circulation of QI the chest stuffiness relieving is arranged, and the effect of detumescence and apocenosis is had a pain the calentura excessive thirst for uncomfortable in chest.
Semen Platycladi: sweet in the mouth, property is flat.Tranquilizing by nourishing the heart is arranged, hidroschesis, the effect of intestine moistening is used for the fidgets due to deficiency insomnia, the cardiopalmus severe palpitation.
Lignum Dalbergiae Odoriferae: acrid in the mouth, warm in nature.Promoting flow of QI and blood is arranged, pain relieving, the effect of hemostasis is used for epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge.
Radix Ophiopogonis: sweet in the mouth, property cold syndrome of the stomach.YIN nourishing and the production of body fluid promoting is arranged, and lung moistening clears away heart-fire, On Antagonizing Experimental Arrhythmia, and the effect of increase coronary flow is used for vexed insomnia, and Tianjin wound is thirsty.
The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature.The suppressing the hyperactive liver pain relieving is arranged, nourishing blood for regulating menstruation, the effect of astringing YIN to stop sweating, it is dizzy to be used for having a headache, hypochondriac pain, stomachache, blood deficiency and yellow complexion.
Spica Prunellae: acrid in the mouth, hardship, cold in nature.Relieve inflammation or internal heat, make eye bright, eliminating stagnation, the effect of detumescence, it is dizzy to be used for having a headache, hypertension.
Natural Broneolum Syntheticum (dextro Borneolum Syntheticum): acrid in the mouth, cool in nature.Loose stagnated fire is arranged, reducing swelling and alleviating pain, the effect of the refreshment of having one's ideas straightened out.
Ramulus Uncariae Cum Uncis: sweet in the mouth, cool in nature.The heat clearing away suppressing the hyperactive liver is arranged, the effect of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., it is dizzy to be used for having a headache, and hypertension is twitched.
Chinese medicine composition of the present invention meets the principle of Chinese traditional treatment hypertensive heart disease.The medical material of selecting has efficacy in lowering high blood pressure, and strongly fragrant depressed, the pain relieving of the heart of releiving, the arresting convulsion of calming the nerves, and the hypertensive heart disease patient is had fabulous therapeutical effect, is to treat at present the comparatively desirable medicine of hypertensive heart disease.
The specific embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1
Radix Panacis Quinquefolii 1 gram, the Radix Astragali 25 grams, Stigma Croci 1 restrains, Poria 15 grams, Radix Trichosanthis 15 grams, Semen Platycladi 5 grams, Lignum Dalbergiae Odoriferae 1 gram, restrain Radix Ophiopogonis 5, the Radix Paeoniae Alba 25 grams, Spica Prunellae 8 grams, natural Broneolum Syntheticum (dextro Borneolum Syntheticum) 0.3 gram, Ramulus Uncariae Cum Uncis 9 grams.
1. with Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis place in the non iron container, be blended into cold water soak 10 minutes, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, and turns 20 minutes at a simmer, leaches medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 15 minutes at a simmer, leaches medicinal liquid, and twice medicinal liquid mixes.
Embodiment 2
Radix Panacis Quinquefolii 2 grams, the Radix Astragali 28 grams, Stigma Croci 2 restrains, Poria 20 grams, Radix Trichosanthis 20 grams, Semen Platycladi 7 grams, Lignum Dalbergiae Odoriferae 2 grams, restrain Radix Ophiopogonis 8, the Radix Paeoniae Alba 28 grams, Spica Prunellae 10 grams, natural Broneolum Syntheticum (dextro Borneolum Syntheticum) 0.4 gram, Ramulus Uncariae Cum Uncis 11 grams.
1. with Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis place in the non iron container, be blended into cold water soak 15 minutes, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, and turns 25 minutes at a simmer, leaches medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 20 minutes at a simmer, leaches medicinal liquid, and twice medicinal liquid mixes.
Embodiment 3
Radix Panacis Quinquefolii 4 grams, the Radix Astragali 32 grams, Stigma Croci 4 restrains, Poria 30 grams, Radix Trichosanthis 25 grams, Semen Platycladi 10 grams, Lignum Dalbergiae Odoriferae 4 grams, restrain Radix Ophiopogonis 12, the Radix Paeoniae Alba 32 grams, Spica Prunellae 13 grams, natural Broneolum Syntheticum (dextro Borneolum Syntheticum) 0.7 gram, Ramulus Uncariae Cum Uncis 14 grams.
1. with Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis place in the non iron container, be blended into cold water soak 25 minutes, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, and turns 35 minutes at a simmer, leaches medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 30 minutes at a simmer, leaches medicinal liquid, and twice medicinal liquid mixes.
Embodiment 4
Radix Panacis Quinquefolii 5 grams, the Radix Astragali 35 grams, Stigma Croci 5 restrains, Poria 35 grams, Radix Trichosanthis 30 grams, Semen Platycladi 12 grams, Lignum Dalbergiae Odoriferae 5 grams, restrain Radix Ophiopogonis 15, the Radix Paeoniae Alba 35 grams, Spica Prunellae 15 grams, natural Broneolum Syntheticum (dextro Borneolum Syntheticum) 0.9 gram, Ramulus Uncariae Cum Uncis 15 grams.
1. with Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis place in the non iron container, be blended into cold water soak 30 minutes, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, and turns 40 minutes at a simmer, leaches medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 35 minutes at a simmer, leaches medicinal liquid, and twice medicinal liquid mixes.
Embodiment 5
Radix Panacis Quinquefolii 3 grams, the Radix Astragali 30 grams, Stigma Croci 3 restrains, Poria 25 grams, Radix Trichosanthis 22 grams, Semen Platycladi 8 grams, Lignum Dalbergiae Odoriferae 3 grams, restrain Radix Ophiopogonis 10, the Radix Paeoniae Alba 30 grams, Spica Prunellae 11 grams, natural Broneolum Syntheticum (dextro Borneolum Syntheticum) 0.6 gram, Ramulus Uncariae Cum Uncis 12 grams.
1. with Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Poria, Radix Trichosanthis, Semen Platycladi, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, the Radix Paeoniae Alba, Spica Prunellae, natural Broneolum Syntheticum (dextro Borneolum Syntheticum), Ramulus Uncariae Cum Uncis place in the non iron container, be blended into cold water soak 20 minutes, the water surface did not have 2 cun of powder to be advisable, and intense fire is fried open, and turns 30 minutes at a simmer, leaches medicinal liquid;
2. recrement is blended into cold water again, and the water surface did not have 1.5 cun of medical materials to be advisable, and intense fire is fried open, and turns 25 minutes at a simmer, leaches medicinal liquid, and twice medicinal liquid mixes.
Using method: reach optimum therapeuticing effect for making the present invention, medicinal liquid is divided into two parts, in sooner or later taking half an hour after meal.
Model case one
Cao XX, woman, 58 years old, Qingdao of Shandong province Laoshan District.Symptom: the patient suffered from hypertension 8 years, the symptoms such as asthma, cough, dyspnea occurred in the recent period, was hypertensive heart disease through hospital diagnosis, and with slight heart failure phenomenon.Sick age: 1 year.Examine the time: on January 27th, 2011; Use Chinese medicine composition of the present invention, in sooner or later taking half an hour after meal, used 3 days every day twice, the dyspnea symptom is alleviated; Used asthma, the complete obiteration of cough symptom 15 days; Used 20 days, and breathed and recover normal, symptoms of heart failure disappears, and recovers.
Model case two
Zou XX, man, 42 years old, Linzi District, Zibo City, Shandong Province.Symptom: begin to occur spitting of blood before patient's first quarter moon, the cardio palmus shape symptom out of breath occurs during flat crouching, and the rear symptom that sits up namely takes a turn for the better to some extent, understands through hospital, and the patient suffers from hypertension, and diagnosing it is hypertensive heart disease.Sick age: 1 month.Examine the time: on April 15th, 2011; Use Chinese medicine composition of the present invention, every day twice, in sooner or later taking half an hour after meal, use the same day, the cardiopalmus sx↓; Used 3 days, the spitting of blood number of times reduces, and cardiopalmus disappears, and flat sleeping seasonal epidemic pathogens emergency case shape takes a turn for the better to some extent; Used 10 days, the spitting of blood transference cure, flat sleeping seasonal epidemic pathogens emergency case shape has also disappeared; Consolidated 10 days, malaise symptoms does not occur again, has no side effect between the operating period.
Model case three
Bag XX, man, 35 years old, Weifang City, Shandong Province Hanting District.Symptom: the patient suffers from hypertension all the year round, occurs dyspneic symptom before 2 months, oneself is suppressed in bed awakely for several times, is hypertensive heart disease through hospital diagnosis.Sick age: 2 months.Examine the time: on July 22nd, 2011; Use Chinese medicine composition of the present invention, in sooner or later taking half an hour after meal, used 2 days every day twice, obviously the sensation breathing is smooth and easy, has not had sensation uncomfortable in chest; Used 15 days, during night the dyspnea symptom only appears 2 times; Continue to use 10 days, and breathed smooth and easyly, night do not occur breathing the phenomenon of suffering again; Consolidated 10 days, drug withdrawal so far, the dyspnea symptom occurs again.
In order to verify the effect of compound Chinese medicinal preparation of the present invention, we have carried out on a large scale, many person-times drug study (embodiment 5).Concrete experimental result such as following table:
Use traditional Chinese medicine composition for treating hypertensive heart disease of the present invention, effect is remarkable, prove that through clinical trial effective percentage is 95%, cure rate is 70%, compare with the medicine of simple blood pressure lowering, effective percentage is high by 25%, and cure rate is high by 40%, and do not need to take again other and treat cardiopathic medicine and carry out auxiliary treatment, alleviated patient body and burden economically; Treating cardiopathic medicine with the nitroglycerin class compares, effective percentage is high by 10%, cure rate is high by 45%, and the symptom in the time of not only can alleviating heart attack, can also thoroughly treat heart disease and regulate blood pressure, therefore, Chinese medicine composition of the present invention is the medicine that a kind of curative effect is comprehensively treated hypertensive heart disease.