CN103768408B - A kind of medicine preventing and treating anal and intestinal disease postoperative pain - Google Patents
A kind of medicine preventing and treating anal and intestinal disease postoperative pain Download PDFInfo
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- CN103768408B CN103768408B CN201410043752.6A CN201410043752A CN103768408B CN 103768408 B CN103768408 B CN 103768408B CN 201410043752 A CN201410043752 A CN 201410043752A CN 103768408 B CN103768408 B CN 103768408B
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Abstract
The invention discloses a kind of medicine preventing and treating anal and intestinal disease postoperative pain, to solve the treatment problem of pain after anorectal operation.It is characterized in that being prepared from by the crude drug of following weight proportion: Folium fici wightianae (Ficus wightiana Wall), Herba Sarcandrae, Herba Dendrobii, Nostoc, Radix Platycodonis, Radix Peucedani, Semen Benincasae, Flos lupuli (Flos Humuli Lupuli), Fructus Mume, Semen Celosiae, Fructus Chaenomelis, Radix Serissae.Clinical trial certificate: the present invention is alleviated postoperative pain and had good effect and the higher feature of safety, clinic application, promotes.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of medicine preventing and treating anal and intestinal disease postoperative pain.
Background technology
Recent study shows, anal and intestinal disease postoperative pain except with operation wound mutually outside the Pass, also with " postoperative pain hypersensitive state " height correlation.This kind of state factor that starts is various, and by local MDA receptor high expressed, nitric oxide and nitricoxide synthase hypersusceptibility etc. affect the threshold of pain.The so-called threshold of pain (painthreshold) refers to the minimum stimulation intensity causing the human body aesthesia pain sensation.
" postoperative pain hypersensitive state " has nothing to do with injury pain, the former is threshold of pain reduction in particular cases, latter mostly is the optimum reaction being distributed widely in nociceptor (nociceptor) in skin, muscle, joint and internal organs and producing multiple noxious stimulation of different nature (chemical, mechanical, scorching hot etc.), and the impulsion of nociceptor activates central nervous system and causes the pain sensation to respond to.So this kind of situation uses analgesic after surgery, often cover the state of an illness, and be unfavorable for local recovery.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the medicine of the little control anal and intestinal disease postoperative pain of side effect.
The technical scheme that the present invention solves its technical problem is: a kind of medicine preventing and treating anal and intestinal disease postoperative pain, it is characterized in that being prepared from by the crude drug of following weight proportion: Folium fici wightianae (Ficus wightiana Wall) 10 ~ 30 parts, Herba Sarcandrae 6 ~ 12 parts, Herba Dendrobii 3 ~ 10 parts, Nostoc 6 ~ 12 parts, Radix Platycodonis 3 ~ 10 parts, Radix Peucedani 6 ~ 12 parts, Semen Benincasae 6 ~ 12 parts, Flos lupuli (Flos Humuli Lupuli) 6 ~ 12 parts, Fructus Mume 6 ~ 12 parts, Semen Celosiae 1 ~ 5 part, Fructus Chaenomelis 3 ~ 10 parts, Radix Serissae 10 ~ 25 parts.
Chinese medicine of the present invention is prepared from by the raw material of following optimum weight part proportioning: Folium fici wightianae (Ficus wightiana Wall) 20 parts, Herba Sarcandrae 10 parts, Herba Dendrobii 6 parts, Nostoc 10 parts, Radix Platycodonis 6 parts, Radix Peucedani 10 parts, Semen Benincasae 10 parts, Flos lupuli (Flos Humuli Lupuli) 10 parts, Fructus Mume 10 parts, Semen Celosiae 2 parts, Fructus Chaenomelis 6 parts, Radix Serissae 20 parts.
Wherein said: Folium fici wightianae (Ficus wightiana Wall), be the leaf of moraceae plants shaft of a writing brush banyan FicusvirensAit. [F.wightana(Miq.)] Benth..Sweet in the mouth; Micro-hardship; Property is put down.Merit can heat-clearing and toxic substances removing; Removing damp to relieve itching.
Herba Sarcandrae is Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandraglabra(Thunb.) the dry Herb of Nakai.Bitter, pungent, flat.GUIXIN, Liver Channel.Merit can clearing away heat and cooling blood, speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.
Herba Dendrobii is the fresh or dry stem of orchid dendrobium loddigesii Rolfe DendrobiumloddigesiiRolfe., Herba Dendrobii oculati DendrobiumfimbriatumHook.var.oculatumHook., HERBA DENDROBII DendrobiumchrysanthumWall., Herba Dendrobii DendrobiumcandidumWall.exLindl. or Dendrobium nobile DendrobiumnobileLindl..Nature and flavor are sweet, are slightly cold.Return stomach, kidney channel.Merit can reinforcing stomach reg fluid, nourishing YIN and clearing away heat.
Nostoc is algae Cyanophyceae nostocaceae nostoc nostoc NostoccommuneVauch..Nature and flavor are light, cold.Return liver, heart channel.Merit can heat clearing away, convergence, QI invigorating, improving eyesight.
Radix Platycodonis is Campanulaceae Radix Platycodonis Platycodongrandiflorum(Jacq.) dry root of A.DC..Nature and flavor are bitter, pungent, flat.Return lung meridian.Merit can lung qi dispersing, and sore-throat relieving, eliminates the phlegm, evacuation of pus.
Radix Peucedani is the dry root of samphire Peucedanum praeruptorum DUNN PeucedanumpraeruptorumDunn or RADIX PEUCEDANI PeucedanumdecursivumMaxim..Nature and flavor are bitter, pungent, are slightly cold.Return lung meridian.Merit can be fallen apart wind heat clearing away, lowering the adverse-rising QI to resolve phlegm.
Semen Benincasae is Cucurbitaceae herbaceous plant Fructus Benincasae Benincasahispida(Thumb.) seed of Cogn..Nature and flavor are sweet, cold.Return spleen, stomach, large intestine, small intestine meridian.Function lung heat clearing, reduce phlegm, evacuation of pus.
Flos lupuli (Flos Humuli Lupuli), the green fruit ear of the immaturity for Moraceae humulus plants Flos lupuli (Flos Humuli Lupuli) HumuluslupulusL..Bitter in the mouth; Slightly cool in nature.Return liver; Stomach warp.Merit can invigorating the stomach and promoting digestion; Inducing diuresis to remove edema; Anti-consumptive disease antiinflammatory.
Fructus Mume is the dry almost ripe fruit of rose department plant plum.Sour, puckery, flat.Return liver, spleen, lung, large intestine channel.Merit can be astringed the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.
Semen Celosiae is the dry mature seed of amaranthaceous plant Herba Celosiae argenteae CelosiaargenteaL..Nature and flavor are bitter, are slightly cold.Return Liver Channel.Merit can liver heat removing, improving eyesight, nebula removing.
Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria.Acid, temperature.Return liver, spleen channel.Merit can suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.
Radix Serissae is dicotyledon medicine Maguireothamnus speciosus Radix Serissae Serissaserissoides(DC.) Druce or Serissa foetida Serissajaponica(Thunb.) the herb strain of Thunb..Nature and flavor toil; Cool; Nontoxic.Return liver; Spleen channel.Merit can be dispeled the wind; Dampness removing; Heat clearing away; Removing toxic substances.
Composition principle: anal and intestinal disease postoperative " postoperative pain hypersensitive state ", with nmda receptor high expressed, nitric oxide is relevant with nitricoxide synthase.This kind of hypersensitive state and injury pain have nothing to do, the former is threshold of pain reduction in particular cases, latter mostly is the optimum reaction being distributed widely in nociceptor (nociceptor) in skin, muscle, joint and internal organs and producing multiple noxious stimulation of different nature (chemical, mechanical, scorching hot etc.), and the impulsion of nociceptor activates central nervous system and causes the pain sensation to respond to.So this kind of situation uses analgesic after surgery, often cover the state of an illness, and be unfavorable for local recovery.Inventor's clinical research finds, anal and intestinal disease postoperative " postoperative pain hypersensitive state " is relevant with the pathogenic wind toxic phlegm-fire among meridians, and pathogenic wind toxic phlegm-fire is burnt channels, causes pain hypersensitive state.
Compared with prior art, the present invention has following characteristics:
1, prescription is unique: get Folium fici wightianae (Ficus wightiana Wall) in side, Herba Sarcandrae is monarch, described Folium fici wightianae (Ficus wightiana Wall) coordinates with Herba Sarcandrae, for the pathogenic wind toxic phlegm-fire among the postoperative meridians of anal and intestinal disease; Rat root knot verifies reality in a down-to-earth manner: the Aqueous extracts of 10mg/kg Folium fici wightianae (Ficus wightiana Wall) and Herba Sarcandrae has and can reduce postoperative nmda receptor and express;
2, anus is anus outlet, and body fluid balance is most important for anus, is dry Tianjin wound of preventing fires, therefore gets the heat clearing away of Herba Dendrobii Yin-nourishing and body fluid promoting, Nostoc heat clearing away QI invigorating;
3, get Fructus Chaenomelis relaxing muscles and tendons, Flos lupuli (Flos Humuli Lupuli) emergency in side, Radix Serissae detoxifies, and alleviates this postoperative hypersensitive state from meridians angle, and Flos lupuli (Flos Humuli Lupuli) extract can the spasm that causes of antagonism acetylcholine, has smooth muscle muscle relaxation effect;
3, get Fructus Mume simply and hold back puckery using corrigent, prevent postoperative pungent and wander away, and Fructus Mume convergence and the property of medicine is steady, can not cause that local venation is not all right and impact recovers;
4, get Radix Platycodonis, expectorant that Radix Peucedani, Semen Benincasae remove meridians;
5, do not take analgesia, blood circulation promoting medicine in side, its reason is to remove phlegm-fire pathogenic wind toxic, and natural pain relief, as being then unfavorable for local recovery with analgesic again;
6, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.
Detailed description of the invention
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: Folium fici wightianae (Ficus wightiana Wall) 20 parts, Herba Sarcandrae 10 parts, Herba Dendrobii 6 parts, Nostoc 10 parts, Radix Platycodonis 6 parts, Radix Peucedani 10 parts, Semen Benincasae 10 parts, Flos lupuli (Flos Humuli Lupuli) 10 parts, Fructus Mume 10 parts, Semen Celosiae 2 parts, Fructus Chaenomelis 6 parts, Radix Serissae 20 parts.
The preparation method of embodiment 1 is: Folium fici wightianae (Ficus wightiana Wall), Herba Sarcandrae, Herba Dendrobii, Nostoc, Radix Platycodonis, Radix Peucedani, Semen Benincasae, Flos lupuli (Flos Humuli Lupuli), Fructus Mume, Semen Celosiae, Fructus Chaenomelis, Radix Serissae mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts of uses.
Embodiment 2, crude drug weight proportion: Folium fici wightianae (Ficus wightiana Wall) 10 parts, Herba Sarcandrae 6 parts, Herba Dendrobii 3 parts, Nostoc 6 parts, Radix Platycodonis 3 parts, Radix Peucedani 6 parts, Semen Benincasae 6 parts, Flos lupuli (Flos Humuli Lupuli) 6 parts, Fructus Mume 6 parts, Semen Celosiae 1 part, Fructus Chaenomelis 3 parts, Radix Serissae 10 parts.
Embodiment 3, crude drug weight proportion: Folium fici wightianae (Ficus wightiana Wall) 20 parts, Herba Sarcandrae 10 parts, Herba Dendrobii 6 parts, Nostoc 10 parts, Radix Platycodonis 6 parts, Radix Peucedani 10 parts, Semen Benincasae 10 parts, Flos lupuli (Flos Humuli Lupuli) 10 parts, Fructus Mume 10 parts, Semen Celosiae 2 parts, Fructus Chaenomelis 6 parts, Radix Serissae 20 parts.
Embodiment 4, crude drug weight proportion: Folium fici wightianae (Ficus wightiana Wall) 30 parts, Herba Sarcandrae 12 parts, Herba Dendrobii 10 parts, Nostoc 12 parts, Radix Platycodonis 10 parts, Radix Peucedani 12 parts, Semen Benincasae 12 parts, Flos lupuli (Flos Humuli Lupuli) 12 parts, Fructus Mume 12 parts, Semen Celosiae 5 parts, Fructus Chaenomelis 10 parts, Radix Serissae 25 parts.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) by Folium fici wightianae (Ficus wightiana Wall), Semen Benincasae, Herba Sarcandrae, Semen Celosiae, Radix Platycodonis coarse powder respectively with extraction by steam distillation volatile oil, and collect after mixing for standby use, medicinal residues are continued to employ;
(2) Nostoc, Radix Serissae, Herba Dendrobii, Radix Peucedani, Fructus Mume, Flos lupuli (Flos Humuli Lupuli), Fructus Chaenomelis, and in step 1, the mixing of gained medicinal residues adds 10 times of water yields, decocts with water 2 times, each 1 hour, collecting decoction, leaves standstill; Then in decocting liquid, add the ethanol of 95% of 3 ~ 4 times of medicinal liquids, leave standstill 15 minutes, then with 3000rpm centrifugal 20 minutes, get clear liquid, spraying dry after concentrated, draw just material;
(3) sprayed into by gained volatile oil in step 1 during step 3 gained just expects, pulverized 100 mesh sieves, subpackage forms.
The medicated bag outward appearance installed is divided to be elongated gauze bag.
The efficient combination of said medicine, coordinates mutually, effectively reach the object alleviating postoperative pain, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.
1 object and method.
1.1 objects: in June, 2011 ~ 2013 anal-surgery 120 example in year October, man 84 example, female 36 example; 18 ~ 64 years old age, average 28.5 years old.Wherein hemorrhoid 56 example, concurrent hemorrhoid 39 example of anal fissure, anal fistula 25 example.Modus operandi has mixed hemorrhoid external hemorrhoid to peel off ligation of internal hemorrhoid, external hemorrhoidectomy, and anal fissure excision, internal sphincter side cut art, anal fistulectomy, anal fistula Lower resection, high-order hanging wire art etc.Be divided into 3 groups at random by patient's date of surgery, often organize 40 people.Through statistical procedures, age, sex, sick kind, Surgical Operation compare, and no significant difference (P>0.05), has comparability.
1.2 method.
1.2.1 Therapeutic Method: the postoperative conventional anus of matched group fills normal saline gauze (outer wrapping monolayer oil yarn), soak group infiltrates gauze (outer wrapping monolayer oil yarn) with gained decoction in the embodiment of the present invention 1 and fills, medicated bag group is filled with gained medicated bag in the embodiment of the present invention 3 (outer wrapping monolayer oil yarn), changes dressings and is 1 time on the 1st.
1.2.2 pain intensity: judged by sufferers themselves, 0 ~ 10 digital pain intensity staging (NPIS), record 0 ~ 2 is without pain, and 3 ~ 5 is mild pain, and 6 ~ 7 is moderate pain, and 8 ~ 10 is severe pain.
1.2.3 pain Visual analogue scale (VAS) is scored: have doctor to carry out score evaluation.
1.2.4 safety monitoring index before patient consumes in detail inquiry with or without dizzy, Nausea and vomiting, nervous, uncomfortable in chest, breathe hard, drowsiness, erythra, all over the body symptom such as weak.Go forward side by side promoting the circulation of blood pressure, pulse, breathing and pupil examination, 7d detects liver function, kidney merit, routine blood test and routine urinalysis before taking medicine and after medication simultaneously.
1.2.5 observe Post operation and ask for analgesics situation because of pain.
1.2.6 statistical analysis: SPSS13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ
2inspection.
2 results.
During 2.1 postoperative 48h, three groups of pain intensities compare (not using analgesic in 6 hours): matched group 5.20 ± 0.85, soak group 3.37 ± 1.09, medicated bag group 3.20 ± 1.03.Three groups are compared, and soak group, medicated bag group pain intensity are starkly lower than matched group (P<0.05).
During 2.2 postoperative 48h, three groups of pain Visual Analogue amounts compare (not using analgesic in 6 hours): matched group 7.60 ± 1.47, soak group 3.84 ± 1.75, medicated bag group 3.09 ± 1.41.Three groups are compared, and soak group, medicated bag group pain condition are obviously better than matched group (P<0.05).
After 2.3 postoperative 3d, still demand wants analgesic (somedon sheet) to be respectively by lenitive case load: matched group 15 example, soak group 7 example, medicated bag group 5 example.Three groups are compared, and soak group, medicated bag group analgesics use and be starkly lower than matched group (P<0.05).
2.4 3 groups of adverse reactions of patients incidence rates compare: three groups all obvious adverse reaction do not occur.
3. conclusion.
This result of study shows, soak group of the present invention and medicated bag group postoperative pain situation is used obviously to be better than matched group, effectively can reduce the use of analgesic, and without obvious adverse reaction, illustrate that pharmaceutical composition of the present invention has the advantage that untoward reaction is comparatively light, safety is higher in alleviation postoperative pain.
Claims (2)
1. prevent and treat a medicine for anal and intestinal disease postoperative pain, it is characterized in that being prepared from by the crude drug of following weight proportion: Folium fici wightianae (Ficus wightiana Wall) 10 ~ 30 parts, Herba Sarcandrae 6 ~ 12 parts, Herba Dendrobii 3 ~ 10 parts, Nostoc 6 ~ 12 parts, Radix Platycodonis 3 ~ 10 parts, Radix Peucedani 6 ~ 12 parts, Semen Benincasae 6 ~ 12 parts, Flos lupuli (Flos Humuli Lupuli) 6 ~ 12 parts, Fructus Mume 6 ~ 12 parts, Semen Celosiae 1 ~ 5 part, Fructus Chaenomelis 3 ~ 10 parts, Radix Serissae 10 ~ 25 parts.
2. a kind of medicine preventing and treating anal and intestinal disease postoperative pain according to claim 1, is characterized in that being prepared from by the crude drug of following weight proportion: Folium fici wightianae (Ficus wightiana Wall) 20 parts, Herba Sarcandrae 10 parts, Herba Dendrobii 6 parts, Nostoc 10 parts, Radix Platycodonis 6 parts, Radix Peucedani 10 parts, Semen Benincasae 10 parts, Flos lupuli (Flos Humuli Lupuli) 10 parts, Fructus Mume 10 parts, Semen Celosiae 2 parts, Fructus Chaenomelis 6 parts, Radix Serissae 20 parts.
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| CN104547576A (en) * | 2015-01-04 | 2015-04-29 | 徐艳红 | Medicine for relieving postoperative pain of nose endoscopic operation |
| CN106389899A (en) * | 2016-05-31 | 2017-02-15 | 李春燕 | Pharmaceutical composition for anorectal postoperative filling |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526433A (en) * | 2012-01-31 | 2012-07-04 | 赵海霞 | Medicine for treating articular contracture |
| CN102614323A (en) * | 2012-04-20 | 2012-08-01 | 李凤荣 | Method for preparing atomized liquid for treating infantile asthmatic suffocating pneumonia |
| CN102698068A (en) * | 2012-07-02 | 2012-10-03 | 张秀香 | Preparation method for oral nursing solution for preventing oral mucositis caused by chemotherapy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526433A (en) * | 2012-01-31 | 2012-07-04 | 赵海霞 | Medicine for treating articular contracture |
| CN102614323A (en) * | 2012-04-20 | 2012-08-01 | 李凤荣 | Method for preparing atomized liquid for treating infantile asthmatic suffocating pneumonia |
| CN102698068A (en) * | 2012-07-02 | 2012-10-03 | 张秀香 | Preparation method for oral nursing solution for preventing oral mucositis caused by chemotherapy |
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