CN110075229A - 一种芦笋提取物及其制备方法与应用 - Google Patents
一种芦笋提取物及其制备方法与应用 Download PDFInfo
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- CN110075229A CN110075229A CN201910473398.3A CN201910473398A CN110075229A CN 110075229 A CN110075229 A CN 110075229A CN 201910473398 A CN201910473398 A CN 201910473398A CN 110075229 A CN110075229 A CN 110075229A
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
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Abstract
Description
皂苷(%) | 多酚(%) | 黄酮(%) | γ-氨基丁酸(%) | |
实施例1 | 58.4 | 8.4 | 3.4 | 1.1 |
实施例2 | 62.2 | 10.9 | 4.1 | 1.5 |
实施例3 | 67.5 | 12.2 | 4.5 | 1.7 |
实施例4 | 70.1 | 14.8 | 5.0 | 1.9 |
对比例1 | 47.5 | 5.1 | 0.8 | 0.5 |
对比例2 | 45.3 | 4.7 | 1.1 | 0.4 |
对比例3 | 46.2 | 5.2 | 1.7 | 0.7 |
对比例4 | 43.4 | 4.3 | 1.5 | 0.8 |
对比例5 | 41.1 | 3.4 | 0.9 | 0.3 |
对比例6 | 42.9 | 3.6 | 1.3 | 0.6 |
对比例7 | 42.5 | 4.1 | 1.4 | 0.5 |
Claims (10)
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110559399A (zh) * | 2019-09-17 | 2019-12-13 | 齐鲁工业大学 | 一种芦笋根皂甙的高效提取方法 |
CN111011838A (zh) * | 2019-12-10 | 2020-04-17 | 广东绿宝堂健康科技有限公司 | 一种食品组合物及其制备方法 |
CN111802646A (zh) * | 2020-05-14 | 2020-10-23 | 河北康睿达脂质有限公司 | 一种阻止肌肉衰减的营养组合物及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101791371A (zh) * | 2009-12-22 | 2010-08-04 | 沈阳亿灵医药科技有限公司 | 芦笋皂苷提取制备方法 |
CN106213523A (zh) * | 2016-07-30 | 2016-12-14 | 山东胜伟园林科技有限公司 | 一种海芦笋膳食纤维的提取方法 |
CN106822618A (zh) * | 2015-12-03 | 2017-06-13 | 怀化市恒裕竹木开发有限公司 | 芦笋下脚料提取物及其制备方法 |
-
2019
- 2019-05-31 CN CN201910473398.3A patent/CN110075229B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101791371A (zh) * | 2009-12-22 | 2010-08-04 | 沈阳亿灵医药科技有限公司 | 芦笋皂苷提取制备方法 |
CN106822618A (zh) * | 2015-12-03 | 2017-06-13 | 怀化市恒裕竹木开发有限公司 | 芦笋下脚料提取物及其制备方法 |
CN106213523A (zh) * | 2016-07-30 | 2016-12-14 | 山东胜伟园林科技有限公司 | 一种海芦笋膳食纤维的提取方法 |
Non-Patent Citations (3)
Title |
---|
良石: "《巧招妙治高脂血症》", 31 August 2008, 黑龙江科学技术出版社 * |
随子房: "芦笋汁改善记忆和调节肠道菌群的研究", 《中国优秀硕士论文全文数据库工程科技I辑》 * |
黄云祥 等: "速溶芦笋粉改善小鼠睡眠的研究", 《中国实验方剂学杂志》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110559399A (zh) * | 2019-09-17 | 2019-12-13 | 齐鲁工业大学 | 一种芦笋根皂甙的高效提取方法 |
CN111011838A (zh) * | 2019-12-10 | 2020-04-17 | 广东绿宝堂健康科技有限公司 | 一种食品组合物及其制备方法 |
CN111802646A (zh) * | 2020-05-14 | 2020-10-23 | 河北康睿达脂质有限公司 | 一种阻止肌肉衰减的营养组合物及其制备方法 |
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