CN110051744B - Compound traditional Chinese medicine essential oil for treating insomnia - Google Patents
Compound traditional Chinese medicine essential oil for treating insomnia Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
The invention provides compound traditional Chinese medicine essential oil for treating insomnia, which consists of base oil and compound essential oil, wherein the compound essential oil consists of the following essential oils in parts by volume: 5-10 parts of lavender essential oil, 1-5 parts of cypress essential oil, 1-4 parts of sandalwood essential oil, 0.5-2 parts of cinnamon essential oil, 1-4 parts of dried orange peel essential oil, 1-4 parts of clove essential oil and 1-4 parts of benzoin essential oil.
Description
Technical Field
The invention provides compound traditional Chinese medicine essential oil for treating insomnia, belonging to the field of traditional Chinese medicine health care.
Background
Modern people have fast pace of life and high working pressure, and are troubled by more and more human health problems, particularly insomnia. In order to treat insomnia, most people take sedative hypnotic drugs for treatment, but the adverse drug reactions are obvious, and the adverse effects are caused to the health of human bodies. Compared with the traditional Chinese medicine aromatherapy, the traditional Chinese medicine aromatherapy has less side effects and good curative effect.
A great deal of records about traditional Chinese medicine sachets in ancient books of China are recorded and used for treating and preventing diseases. The aromatic medicine of the traditional Chinese medicine has the effects of promoting the circulation of qi, inducing resuscitation, tranquilizing and allaying excitement, and the fragrance of the aromatic medicine of the traditional Chinese medicine is pungent and fragrant. The existing research shows that the effective components of the medicinal materials containing more traditional Chinese medicine essential oil, such as benzoin, grassleaf sweelflag rhizome, cassia twig, silktree albizzia bark, platycladi seed, sandalwood, nutgrass galingale rhizome and other aromatic medicines, have the effects of tranquilizing and allaying excitement and assisting sleep. Besides the feasibility proved by pharmacological research, the extract of aromatic plants is also proved to be absorbed by the organism through the skin or nasal cavity of the human body and act on the organism in modern biological and physiological research.
At present, a plurality of sachets, medicine pillows, medicine fragrances, navel patches, single Chinese medicine essential oils and the like which apply traditional Chinese medicine aromatherapy and assist in improving insomnia exist in the market: the sachet medicine pillow has the advantages that if the storage environment is poor, the decoction pieces filled in the sachet medicine pillow are easy to be affected with damp, go mouldy and breed insect pests, are not beneficial to health, even can harm the health, and the ground decoction pieces are easy to scatter and harm the environmental sanitation; the navel patch is in direct contact with the skin, the effect is good, but some toxic traditional Chinese medicines are possibly absorbed by a human body through the skin of the navel, and the excipient and the traditional Chinese medicines form a small environment in the navel, so that bacteria are easy to breed and peculiar smell is generated if the small environment is not cleaned in time; the medicine is fragrant, smoke is generated when the medicine is ignited, the medicine is harmful to health, and fire hazard is increased because the medicine needs to be ignited; the single-prescription traditional Chinese medicine essential oil has single fragrance and cannot embody the characteristics of the traditional Chinese medicine formula.
In order to bring the advantages of traditional Chinese medicines into full play, the invention aims to provide the compound traditional Chinese medicine essential oil which is convenient to use, carry and store and can better embody the compatibility characteristics of traditional Chinese medicine formulas.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides the compound traditional Chinese medicine essential oil which is convenient to use and carry and has a remarkable effect of treating insomnia.
The invention provides a compound traditional Chinese medicine essential oil for treating insomnia, which is composed of base oil and compound essential oil, wherein the compound essential oil is composed of the following essential oils in parts by volume:
5-10 parts of lavender essential oil, 1-5 parts of cypress essential oil, 1-4 parts of sandalwood essential oil, 0.5-2 parts of cinnamon essential oil, 1-4 parts of dried orange peel essential oil, 1-4 parts of clove essential oil and 1-4 parts of benzoin essential oil.
Preferably, the compound essential oil consists of the following essential oils in parts by volume:
6-9 parts of lavender essential oil, 2-4.5 parts of cypress essential oil, 1.5-3.5 parts of sandalwood essential oil, 0.8-1.5 parts of cinnamon essential oil, 1.5-3.5 parts of dried orange peel essential oil, 1.5-3.5 parts of clove essential oil and 1.5-3.5 parts of benzoin essential oil.
Further preferably, the compound essential oil consists of the following essential oils in parts by volume:
7-8.5 parts of lavender essential oil, 2.5-4 parts of cypress essential oil, 1.8-3 parts of sandalwood essential oil, 1-1.3 parts of cinnamon essential oil, 1.8-3 parts of dried orange peel essential oil, 1.8-3 parts of clove essential oil and 1.8-3 parts of benzoin essential oil.
Most preferably, the compound essential oil consists of the following essential oils in parts by volume:
8 parts of lavender essential oil, 3 parts of cypress essential oil, 2 parts of sandalwood essential oil, 1 part of cinnamon essential oil, 2 parts of dried orange peel essential oil, 2 parts of clove essential oil and 2 parts of benzoin essential oil.
In a specific embodiment, the compound Chinese medicinal essential oil has a volume percentage of 5-20%. Preferably 10%.
In a specific embodiment, the base oil is selected from any one or more of grape seed oil, jojoba oil, tea seed oil, sunflower seed oil, sweet almond oil, etc.; grape seed oil is preferred.
In specific embodiments, the base oil and essential oil can be obtained directly by purchase, or can be obtained by extracting the original plant material using conventional methods for extracting essential oil, including but not limited to squeezing extraction, steam distillation extraction, supercritical carbon dioxide extraction, etc. In a preferred embodiment, the sandalwood essential oil, benzoin essential oil, lavender essential oil and dried orange peel essential oil are respectively prepared by taking sandalwood, benzoin, lavender and dried orange peel as raw materials and extracting the volatile oil by adopting a steam distillation method; the cedar essential oil, cinnamon essential oil and clove essential oil are prepared by respectively taking cedar, cinnamon and clove as raw materials and extracting the volatile oil by a supercritical carbon dioxide extraction method.
As another aspect of the invention, the invention provides application of the compound traditional Chinese medicine essential oil in preparing health-care products for treating or improving sleep.
In a specific embodiment, the compound Chinese medicinal essential oil can be prepared into Chinese medicinal sachets, perfumes, decoction, soft extract and the like; or soaking or dripping into other daily necessities by adding perfume to make into eye mask, nightwear, bedding, body lotion, bath lotion, etc. with sleep improving effect.
The compound traditional Chinese medicine essential oil takes lavender as a monarch, and has the effects of tranquilizing and allaying excitement, promoting qi circulation and removing obstruction in channels; the cedar wood and benzoin are used as ministers to clear away heart-fire and induce resuscitation; sandalwood, dried orange peel and clove are used for regulating qi and warming yang; cinnamon is used as a guide to induce fire to return to original origin. The prescription compatibility of the medicine can tonify without stagnation, lead the stagnated qi to be relaxed, lead the heart spirit to be peaceful, and play the roles of soothing the nerves, helping sleep, regulating qi and resolving depression together. The traditional Chinese medicine preparation embodies the treatment concept of 'seeking yang from yin and seeking yin from yang' in the traditional Chinese medicine, and the total effective rate of the clinical treatment of insomnia is up to 89%.
Detailed Description
Example 1
A compound Chinese medicinal essential oil comprises 90% of grape seed base oil and 10% of compound essential oil; the compound essential oil consists of the following essential oils in parts by volume:
8ml of lavender essential oil, 3ml of cedar essential oil, 2ml of sandalwood essential oil, 1ml of cinnamon essential oil, 2ml of dried orange peel essential oil, 2ml of clove essential oil and 2ml of benzoin essential oil.
The above base oils and single component essential oils are commercially available.
The use method comprises the following steps: before sleeping, the Chinese medicinal composition is applied to a temple point, a Fengchi point, a Shenque point and a hypnotic point, wherein each point is 1-3 ml.
Example 2
A compound Chinese medicinal essential oil comprises 90% of grape seed base oil and 10% of compound essential oil; the compound essential oil consists of the following essential oils in parts by volume:
7.5ml of lavender essential oil, 3.5ml of cedar essential oil, 1.8ml of sandalwood essential oil, 1.3ml of cinnamon essential oil, 1.8ml of dried orange peel essential oil, 2.5ml of clove essential oil and 2ml of benzoin essential oil.
The above base oils and single component essential oils are commercially available. The procedure is as in example 1.
Example 3
A compound Chinese medicinal essential oil comprises 90% of grape seed base oil and 10% of compound essential oil; the compound essential oil consists of the following essential oils in parts by volume:
8.4ml of lavender essential oil, 2.8ml of cedar essential oil, 2.5ml of sandalwood essential oil, 1ml of cinnamon essential oil, 2.5ml of tangerine peel essential oil, 1.8ml of clove essential oil and 2.8ml of benzoin essential oil.
The above base oils and single component essential oils are commercially available. The procedure is as in example 1.
Example 4
A compound Chinese medicinal essential oil comprises 90% of grape seed base oil and 10% of compound essential oil; the compound essential oil consists of the following essential oils in parts by volume:
6.5ml of lavender essential oil, 4.2ml of cedar essential oil, 1.6ml of sandalwood essential oil, 1.5ml of cinnamon essential oil, 1.6ml of dried orange peel essential oil, 3.2ml of clove essential oil and 1.6ml of benzoin essential oil.
Soaking and cleaning sandalwood, benzoin, lavender and dried orange peel respectively, crushing by using a powdering machine, adding into a water vapor extraction tank, introducing steam, extracting until the oil amount is not increased, collecting the obtained essential oil, drying by using anhydrous sodium sulfate, and filtering to obtain raw material essential oil; extracting the essential oil of cedar wood, cinnamon and clove by a supercritical carbon dioxide extraction method. Crushing sun-dried grape seeds by a squeezing method, squeezing for 2 hours at 42 ℃ and 55MPa, collecting squeezed grape seed oil, and filtering for three times to obtain the grape seed base oil.
The procedure is as in example 1.
Example 5
A compound Chinese medicinal essential oil comprises 90% of grape seed base oil and 10% of compound essential oil; the compound essential oil consists of the following essential oils in parts by volume:
9ml of lavender essential oil, 2ml of cypress essential oil, 3.3ml of sandalwood essential oil, 0.8ml of cinnamon essential oil, 3.2ml of dried orange peel essential oil, 1.5ml of clove essential oil and 3ml of benzoin essential oil.
The preparation method of each essential oil is the same as that of example 4.
The use method comprises the following steps: and (3) taking the eye mask, dripping 2-3 drops of the compound Chinese medicinal essential oil, and wearing the eye mask before sleep.
Example 6
A compound Chinese medicinal essential oil comprises 90% of grape seed base oil and 10% of compound essential oil; the compound essential oil consists of the following essential oils in parts by volume:
5.5ml of lavender essential oil, 4.8ml of cedar essential oil, 1.2ml of sandalwood essential oil, 2ml of cinnamon essential oil, 1.2ml of dried orange peel essential oil, 3.8ml of clove essential oil and 1ml of benzoin essential oil.
The preparation method of each essential oil is the same as that of example 4.
The use method comprises the following steps: adding the compound Chinese medicinal essential oil into body milk, and applying on the whole body before sleep.
Example 7
A compound Chinese medicinal essential oil comprises 90% of grape seed base oil and 10% of compound essential oil; the compound essential oil consists of the following essential oils in parts by volume:
10ml of lavender essential oil, 1.5ml of cedar essential oil, 3.8ml of sandalwood essential oil, 0.5ml of cinnamon essential oil, 3.8ml of tangerine peel essential oil, 1ml of clove essential oil and 4ml of benzoin essential oil.
The preparation method of each essential oil is the same as that of example 4.
The procedure is as in example 1.
Comparative example
A compound Chinese medicinal essential oil comprises 90% of grape seed base oil and 10% of compound essential oil; the compound essential oil consists of the following essential oils in parts by volume:
5ml of lavender essential oil, 1ml of rose essential oil, 2ml of angelica essential oil and 1ml of rosemary essential oil.
The above base oils and single component essential oils are commercially available.
The use method comprises the following steps: before sleeping, the Chinese medicinal composition is applied to a temple point, a Fengchi point, a Shenque point and a hypnotic point, wherein each point is 1-3 ml.
Example 8 Effect of essential oils of the invention on sleep in Insomnia patients (SRSS Scale grading)
The sleep condition self-rating scale (SRSS) is compiled by Chinese psychology and health society, Chinese health psychology journal, Chinese official and official professor, and Chinese norm (standard) is established in national cooperation group. The scale is suitable for screening the people with sleep problems in different crowds, and can also be used for the comparison research of the evaluation effect before and after treatment of the people with sleep problems.
Project and assessment criteria: the SRSS has 10 items, each item is graded to 5 (1-5), and the higher the grade is, the more serious the sleep problem is. This scale was rated at a minimum of 10 points (essentially no sleep problems) and at a maximum of 50 points (most severe).
In the test, 45 volunteers with SRSS scale scores of more than 25 points are screened, the compound Chinese medicinal essential oil prepared in example 1 is given, and the compound Chinese medicinal essential oil is applied to the temple, Fengchi, Shenque and hypnotic acupoints before sleep, wherein each acupoint is 1-3 ml, and the compound Chinese medicinal essential oil is continuously used for 1 month. After 1 month, the SRSS scale evaluation was performed again on 45 insomnia patients, and the score results before and after use are shown in Table 1. And evaluating the difference value of less than 4 for invalidity, 4-6 for significant effect, 7-10 for significant effect and more than 10 for significant effect. The total effective rate is (number of effective people + number of significant people)/total number of effective people + 100%. The results are shown in Table 2.
Table 1 SRSS score before and after use of compound essential oil (n ═ 45)
Before use | After use | t | p |
33.44±3.34 | 22.87±4.91 | 14.44 | 0.001 |
TABLE 2 sleep improvement of insomnia volunteers by compound Chinese medicinal essential oil
As can be seen from tables 1 and 2, the compound traditional Chinese medicine essential oil can obviously reduce the SRSS score (P is less than 0.01) of an insomnia patient, and has effectiveness in treating insomnia, wherein the total effective rate is 89%, and the effect is 31% when the effect is remarkable.
Example 9 Effect of essential oils of the invention on sleep in Insomnia patients (Asens Insomnia Scale scoring method)
The Asens Insomnia Scale (AIS) is an insomnia severity assessment scale prepared by professor Dan sedreal of state university medical college, ohio, 1985 according to international classification of diseases 10 (ICD-10) diagnosis standard for insomnia, and is used for measuring sleep quality and insomnia within 1 month, and has 8 entries, respectively: time to sleep, wake up at night, wake earlier than desired, total sleep time, total sleep quality, daytime mood, daytime body function, and daytime sleepiness. Each item is divided into four grades from none to serious, and the accumulated item score is the AIS total score. The AIS total score is less than 4, which is no sleep disorder, less than 6, which is suspicious insomnia, and the AIS score is more than 6, which is insomnia. The AIS has better confidence level and diagnosis efficiency, the Cronbach's alpha coefficient is 0.90, the total correlation coefficient is 0.70, and the re-measuring confidence level correlation coefficient is 0.90; has become a standard scale for evaluating insomnia recognized by the international medical community.
The test screens 60 volunteers with AIS insomnia scale score above 6. Two groups, 30 persons each, were randomized. Wherein the study group is administered with the compound Chinese medicinal essential oil prepared in example 1, and the control group is administered with the compound Chinese medicinal essential oil prepared in the control experiment.
Two groups of volunteers are bestowed on the temple, Fengchi, Shenque and Anmian acupoints before sleeping, each acupoint is 1-3 ml, and the application lasts for 1 month. After 1 month, the 60 insomnia patients were again evaluated on the AIS insomnia scale, and the scoring results before and after use are compared in Table 3.
TABLE 3 comparison of the Presence and Presence of the Assenss Insomnia Scale scores before and after treatment: (Minute)
Note: p is less than 0.05 compared with the control group
Statistical analysis of the data was performed using SPSS17.0 statistical software. The measured data is averaged + -SDIndicating that t test is adopted.
The difference of the score comparison of the asexual scale of the two groups before treatment has no statistical significance (P is more than 0.05); after 1 month of treatment, the score of the asexual scale of the study group is lower than that of the control group, and the difference has statistical significance (P is less than 0.05).
Claims (10)
1. The compound traditional Chinese medicine essential oil for treating insomnia is characterized by consisting of base oil and compound essential oil, wherein the compound essential oil consists of the following essential oils in parts by volume:
5-10 parts of lavender essential oil, 1-5 parts of cypress essential oil, 1-4 parts of sandalwood essential oil, 0.5-2 parts of cinnamon essential oil, 1-4 parts of dried orange peel essential oil, 1-4 parts of clove essential oil and 1-4 parts of benzoin essential oil.
2. The compound traditional Chinese medicine essential oil of claim 1, which consists of the following essential oils in parts by volume:
6-9 parts of lavender essential oil, 2-4.5 parts of cypress essential oil, 1.5-3.5 parts of sandalwood essential oil, 0.8-1.5 parts of cinnamon essential oil, 1.5-3.5 parts of dried orange peel essential oil, 1.5-3.5 parts of clove essential oil and 1.5-3.5 parts of benzoin essential oil.
3. The compound traditional Chinese medicine essential oil of claim 2, wherein the compound essential oil consists of the following essential oils in parts by volume:
7-8.5 parts of lavender essential oil, 2.5-4 parts of cypress essential oil, 1.8-3 parts of sandalwood essential oil, 1-1.3 parts of cinnamon essential oil, 1.8-3 parts of dried orange peel essential oil, 1.8-3 parts of clove essential oil and 1.8-3 parts of benzoin essential oil.
4. The compound traditional Chinese medicine essential oil of claim 3, which consists of the following essential oils in parts by volume:
8 parts of lavender essential oil, 3 parts of cypress essential oil, 2 parts of sandalwood essential oil, 1 part of cinnamon essential oil, 2 parts of dried orange peel essential oil, 2 parts of clove essential oil and 2 parts of benzoin essential oil.
5. The compound Chinese medicinal essential oil according to any one of claims 1 to 4, wherein the compound Chinese medicinal essential oil is 5 to 20 volume percent.
6. The compound Chinese herbal essential oil of claim 5, wherein the compound essential oil accounts for 10% by volume.
7. The compound Chinese herbal essential oil of claim 6, wherein the base oil is grape seed oil.
8. The compound Chinese herbal medicine essential oil of any one of claims 1 to 4, wherein the sandalwood essential oil, benzoin essential oil, lavender essential oil and dried orange peel essential oil are prepared by extracting volatile oil from sandalwood, benzoin, lavender and dried orange peel by steam distillation; the cedar essential oil, cinnamon essential oil and clove essential oil are prepared by respectively taking cedar, cinnamon and clove as raw materials and extracting the volatile oil by a supercritical carbon dioxide extraction method.
9. The compound Chinese herbal essential oil as claimed in any one of claims 1 to 4, wherein the base oil is selected from any one or more of grape seed oil, jojoba oil, tea seed oil, sunflower seed oil, sweet almond oil, etc.
10. The use of the compound Chinese medicinal essential oil as claimed in any one of claims 1 to 4 in the preparation of a medicament for treating insomnia or a health product for improving sleep.
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