CN107233412A - It is a kind of to promote compound essential oil composition of sleep and its production and use - Google Patents

It is a kind of to promote compound essential oil composition of sleep and its production and use Download PDF

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Publication number
CN107233412A
CN107233412A CN201710392880.5A CN201710392880A CN107233412A CN 107233412 A CN107233412 A CN 107233412A CN 201710392880 A CN201710392880 A CN 201710392880A CN 107233412 A CN107233412 A CN 107233412A
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parts
essential oil
oil
sleep
composition
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CN107233412B (en
Inventor
杨明
张小飞
杜清
伍振峰
朱根华
美丽
苏柘潼
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Jiangxi Guxiang jinyunda Health Industry Co.,Ltd.
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Jiangxi University of Traditional Chinese Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47G—HOUSEHOLD OR TABLE EQUIPMENT
    • A47G9/00—Bed-covers; Counterpanes; Travelling rugs; Sleeping rugs; Sleeping bags; Pillows
    • A47G9/007—Bed-covers; Counterpanes; Travelling rugs; Sleeping rugs; Sleeping bags; Pillows comprising deodorising, fragrance releasing, therapeutic or disinfecting substances
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47G—HOUSEHOLD OR TABLE EQUIPMENT
    • A47G9/00—Bed-covers; Counterpanes; Travelling rugs; Sleeping rugs; Sleeping bags; Pillows
    • A47G9/10—Pillows
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/10—Peat; Amber; Turf; Humus
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/13—Coniferophyta (gymnosperms)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009—Sachets, pouches characterised by the material or function of the envelope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
    • C11B9/025—Recovery by solvent extraction
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • C11B9/02—Recovery or refining of essential oils from raw materials
    • C11B9/027—Recovery of volatiles by distillation or stripping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

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Abstract

The invention provides a kind of compound essential oil composition for promoting to sleep, it includes the component of following weight proportion：20 parts of sandalwood essential oil 5 part, 3 parts of amber essential oil 0.01 part, 20 parts of frankincense essential oil 5 part, 10 parts of Rosa Damascana 1 part, 40 parts of Lavender 5 part, 40 parts of sweet orange oil 5 part.Present invention also offers the preparation method of said composition and its fragrance product purposes.The present invention research shows, after sandalwood essential oil, amber essential oil, frankincense essential oil, Rosa Damascana, Lavender, sweet orange oil are used cooperatively under specific consumption, insomnia can be effectively improved, with calmness, sleeping, calm the nerves the effect of.

Description

It is a kind of to promote compound essential oil composition of sleep and its production and use
Technical field
The present invention relates to a kind of compound essential oil composition for promoting to sleep and its production and use.More particularly, to one Plant the compound essential oil for promoting sleep, coating essential oil and its fragrance product.
Background technology
Have a sleepless night the difficulty falling asleep referred to, easily wake up in the middle of sleep and early awakening, sleep quality be low, the length of one's sleep significantly reduces, have Serious patient also lies awake all night.Chronic insomnia easily cause upset, fatigue and weak, or even with headache, dreaminess, hidrosis, Failure of memory, can also cause a series of clinical symptoms, and induce some psychosomatic diseases.The operating pressure of present people compared with Greatly, the thing thought deeply in brain is more, causes people to be still in active state, or the reason such as anxiety at heart in brain during sleep Cause insomnia.Many people can use medicine to carry out assisting sleep, but medicine can not be used for a long time, long-term use can not only produce according to Rely psychology, also people's brain response can be allowed blunt, body is had undesirable effect.Often show as：The length of one's sleep, the deficiency of depth are led Cause is unable to dispelling fatigue, regained one's strength and energy, the lighter's difficulty falling asleep, or sleep but not soundly, sometimes sleeping and sometimes waking, or wake up after can not be again Sleep, it is heavy then be insomnia all night.
Preferably the medicine of sleep is promoted to possess following condition：1) rapid sleep inducing；2) do not have to Sleep architecture Influence；3) drug residue free effect in second day；4) memory function, including no forgetting symptom are not influenceed；5) breathing is not pressed down Make and use；6) it is used for a long time without drug dependence or drug withdrawal disorders；7) with alcohol and other drugs without interaction.But city The product that insomnia has been treated on face is difficult to comply fully with these conditions.Clinically there is its limitation using western medicine insomnia at present Property, negative interaction is larger, and long-term taking is also easy to produce dependence.And diagnosis and treatment of the traditional Chinese medicine under instruction of Chinese Medicine theory, it is overall to adjust Section, by Yin Yang balancing, coordinates internal organs, harmonizing the functional activities of vital QI reaches the flexible treatment to insomnia, determined curative effect.
Essential oil of traditional Chinese medicine refines the volatile flavor extracted in being the flower from medicinal material, leaf, stem, root or fruit, pass Hold from Chinese tcm health preserving, important therapeutic action is played in more Chinese medicine, is indispensable active ingredient.Study Show such as medicinal material such as grass-leaved sweetflag, cortex albiziae, rose, frankincense, the seed of Oriental arborvitae, spina date seed, santal of the medicinal material containing more essential oil of traditional Chinese medicine With the preferable effect for promoting to sleep.Essential oil of traditional Chinese medicine is mostly used for skin nursing, less to be used to calm the nerves.And current pin on the market To the existing essential oil patent of essential oil level calmed the nerves, such as：Number of patent application：CN200910165044.9, patent name：A kind of compound Calm the nerves oil and essential oil of traditional Chinese medicine and fragrant product with effect of calming the nerves.It is main to use grass-leaved sweetflag, Chinese anise, schizonepeta, folium eucalypti It is raw material to extract essential oil with the traditional Chinese medicine ingredients such as camphortree leaf, but grass-leaved sweetflag essential oil is due to having certain carcinogenic work containing safrole With limiting its application.
In the report calmed the nerves with essential oil of traditional Chinese medicine, such as：The evaluation of 4 kinds of aromatic essential oil angst resistance effects, Hu Yixue, Shanghai University of communications's journal (agricultural sciences version), in August, 2013 the 4th phase of volume 31.Using Lavender, fragrant Fructus Perillae quintessence oil, santal Essential oil, sweet orange oil are acted on respectively to be probed into essential oil and calms the nerves, alleviates the effect of anxiety.Lavender is taken in SD using snorting The angst resistance effect of rat is secondly fragrant Fructus Perillae quintessence oil, sweet orange and sandalwood essential oil are without obvious angst resistance effect preferably.But it is right During the compound essential oil with angst resistance effect, how compatibility and prepare obtained by compound essential oil angst resistance effect It need further research.Therefore develop that a kind of smell is good, toxic side effect is low, Chinese medicine compound prescription evident in efficacy, easy to use Essential oil and the coating essential oil and its related aromatic props of the promotion sleep conveniently applied are particularly significant.
The content of the invention
It is an object of the invention to provide a kind of compound essential oil for promoting to sleep.
It is another object of the present invention to provide a kind of coating essential oil for promoting to sleep.
It is yet a further object of the present invention to provide promote sleep effect using having for described essential oil of traditional Chinese medicine preparation The fragrance products such as sachet, sachet, fragrant pillow.
The present invention promotes the compound essential oil composition of sleep, and it includes the component of following weight proportion：
5 parts -20 parts of sandalwood essential oil, 0.01 part -3 parts of amber essential oil, 5 parts -20 parts of frankincense essential oil, 1 part -10 of Rosa Damascana Part, 5 parts -40 parts of Lavender, 5 parts -40 parts of sweet orange oil.
Preferably, the composition is made up of the component of following weight proportion：
9.5 parts of sandalwood essential oil, 0.5 part of amber essential oil, 20 parts of frankincense essential oil, 10 parts of Rosa Damascana, 30 parts of Lavender, 30 parts of sweet orange oil.
Wherein, the sandalwood essential oil, frankincense essential oil, Rosa Damascana, Lavender, amber essential oil, sweet orange oil, cedar seed Benevolence oil, spine date seed oil are respectively, using santal, frankincense, rose, lavender, amber, sweet orange, the seed of Oriental arborvitae or spina date seed as raw material, to adopt With waving that steam distillation, low polar organic solvent extraction method, carbon dioxide supercritical extraction method or milling process are prepared Hair oil.
Wherein, the purity of every kind of component of compound essential oil is all higher than 99%.
Present invention also offers foregoing compound essential oil composition prepare with calmness, sleeping, the medicine of effect of calming the nerves, Purposes in daily chemical product, sachet, sachet, fragrant pillow, fragrance product.
Present invention also offers a kind of coating essential oil for having and promoting sleep effect, include the composition of following weight proportion
30 parts -60 parts of 30 parts -60 parts of 5 parts -20 parts of compound essential oil, oriental arborvitae seed oil, spine date seed oil described in claim 1.
Preferably, the coating essential oil includes the composition of following weight proportion：
10 parts of compound essential oil, 45 parts of oriental arborvitae seed oil, 45 parts of spine date seed oil.
Present invention also offers it is a kind of have promote sleep effect sachet or sachet, including following weight proportion into Point：
Fragrant 70 parts -95 parts of medicinal material；
5 parts -30 parts of compound essential oil.
Preferably, it is made up of the composition of following weight proportion：
Present invention also offers a kind of fragrant pillow for having and promoting sleep effect, prepared by the composition of following weight proportion and Into：
70 parts -95 parts of pillowcase, preferably 95 parts；
5 parts -30 parts of compound essential oil, preferably 5 parts.
The present invention is under instruction of Chinese Medicine theory, by substantial amounts of preparation technology experiment and pharmacology, pharmacodynamics test Resulting preparation.Compound essential oil of the present invention contains prescription：Sandalwood essential oil, amber essential oil, frankincense essential oil, rhodamine toner The compositions such as oil, Lavender, sweet orange oil.Sandalwood essential oil tool is pungent, warm-natured；Enter spleen, stomach, lung channel, it is neural tight with pacifying Open and anxiety, sedation；Amber essential oil has tranquillizing the mind by relieving convulsion, dissipate stasis of blood hemostasis, promoting diuresis for stranguria.Control infantile convulsion epilepsy, insomnia of palpitating with fear etc. Disease.Frankincense has the effect of analgesic, treatment insomnia,《Classified Materia Meidca》Described in frankincense can control egersis.Rosa Damascana have it is calm, Decompression, it is sleeping the effects such as.
Coating essential oil of the present invention not only contains described compound essential oil, also containing oriental arborvitae seed oil and spine date seed oil. Spina date seed nourishing heart blood and seed of Oriental arborvitae nourishing heart gas are to commonly use mental-tranquilization Chinese medicine to medicine, and mental-tranquilization relaxes bowel.Palpitation with fear is controlled, is lost The diseases such as dormancy.The effect of spina date seed has antitoxic heart-soothing and sedative.Cure mainly restlessness of asrhenia type and insomnia；Palpitation with fear palpitation；Physically weak spontaneous perspiration, night sweat.For dysphoria Egersis, horrified to much dream, body void hidrosis.Coating essential oil of the present invention has effects that calmness, calms the nerves, promotes sleep.
Sachet of the present invention, sachet be prepared by the way that above-mentioned compound essential oil is sprayed onto among fragrant medicinal material and Into.The sachet sachet volatilizees liquid in ingress of air, and the volatile ingredient in essential oil of traditional Chinese medicine therein and fragrant medicinal material is released Into air, so that the smell given out a sweet perfume, and the effects such as play calmness, sleeping, calm the nerves.
Fragrant pillow of the present invention is by the way that above-mentioned compound essential oil is sprayed on pillowcase and is prepared from drying. The perfume is rested the head in ingress of air, and compound essential oil therein is released in air, so that the smell given out a sweet perfume, and play Calmness, sleeping, the effects such as calm the nerves.
Obviously, according to the above of the present invention, according to the ordinary technical knowledge and customary means of this area, do not departing from Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification of other diversified forms can also be made, replaces or changes.
The embodiment of form, remakes further specifically to the above of the invention by the following examples It is bright.But the scope that this should not be interpreted as to above-mentioned theme of the invention is only limitted to following example.It is all to be based on the above of the present invention The technology realized belongs to the scope of the present invention.
Embodiment
Embodiment 1：The preparation of present composition compound essential oil
Santal, frankincense, rose, lavender are taken respectively, is extracted with steam distillation, are comprised the following steps that：Respectively After each raw material is cleaned up and crushed, it is put into steam extraction tank, is passed through steam, extraction is collected after not being further added by oil mass Gained essential oil, with being filtered after anhydrous sodium sulfate drying, obtains the essential oil of each raw material after refined.Amber essential oil is faced using super Boundary's carbon dioxide extraction is extracted.Orange peel is taken, is soaked, crosses and washes.Washed orange peel is placed in mixer and squeezed in batches, plus Enter appropriate distilled water, squeeze repeatedly, to ensure that orange peel squeezing is complete.It is separated by filtration and squeezes the juice and filter residue after squeezing；By in filter residue Oil-water fluid is extracted in time, filters off residue.The oil-water mixture filtered is precipitated, using high speed mandarin oil seperator by water-oil separating, Oil reservoir is taken after separation and tangerine oil is obtained.
The various essential oils of the present invention can also directly take the mode of purchase to obtain.
Above-mentioned essential oil is taken, prescription is carried out according to following weight, mixing obtains the compound of the present invention for promoting to sleep Essential oil：
Sandalwood essential oil：9.5g, amber essential oil：0.5g, frankincense essential oil：20g, Rosa Damascana：10g, Lavender：30g、 Sweet orange oil：30g.
Embodiment 2：The preparation of present invention coating essential oil
Take the seed of Oriental arborvitae, spina date seed that essential oil is made using milling process respectively.The seed of Oriental arborvitae, spina date seed are taken, is placed in squeezer and divides Squeezing is criticized, appropriate distilled water is added, squeezes repeatedly, to ensure that the two squeezing is complete.It is separated by filtration and squeezes the juice and filter residue after squeezing；Will Oil-water fluid in filter residue is extracted in time, filters off residue.The oil-water mixture filtered is precipitated, is divided profit using high speed separator From, take oil reservoir after separation and oriental arborvitae seed oil and spine date seed oil.
Oriental arborvitae seed oil, spine date seed oil can also directly take the mode of purchase to obtain.
Compound essential oil obtained by embodiment 1 is well mixed with oriental arborvitae seed oil, spine date seed oil, that is, is made of the present invention Have promote sleep coating essential oil：
Compound essential oil:10g, oriental arborvitae seed oil:45g, spine date seed oil:45g.
The preparation of the sachet of the present invention of embodiment 3 or sachet
According to following weight ratio, compound essential oil and rose, lavender, santal, frankincense obtained by Example 1,
Each medicinal material is beaten after powder and sprays compound essential oil thereon, i.e., obtained sachet of the present invention with promotion sleep effect, Sachet.
The preparation of the fragrant pillow of the present invention of embodiment 4
According to following weight ratio, compound essential oil and pillowcase obtained by Example 1：
Pillowcase 95%；
Compound essential oil 5%.
By pillowcase infiltration with compound essential oil, being produced after drying with the fragrant pillow for promoting sleep effect.
Beneficial effects of the present invention are illustrated below by way of test example.
Experimental example (promotes the compound essential oil of sleep and coats the pharmacodynamic experiment of essential oil)
The calmness experiment of the champignon essence oil of test example 1
1. the influence (autonomic activities instrument method) of pair mouse autonomic activities
Experiment is randomly divided into 6 groups from 60 mouse, male and female half and half：(1) control group, immersion 0.5g is put into mouse cage The cotton balls of physiological saline；(2) group is stabilized, in the preceding 1 gastric infusion 5mg/kg dosage of experiment；(3) positive drug group, gavage gives benefit The heart is allayed excitement piece 1.58g powder/kg；(4) promote sleep compound essential oil (prepared by embodiment 1) high dose group, placed into mouse cage to Give the cotton balls for absorbing 1g weight essential oils；(5) promote compound essential oil (prepared by embodiment 1) middle dose group of sleep, put into mouse cage Put the cotton balls given and absorb 0.5g weight essential oils；(6) compound essential oil (prepared by embodiment 1) low dose group of sleep is promoted, to mouse The cotton balls given and absorb 0.1g weight essential oils is placed in cage；In addition to being organized except (2), remaining each group changes cotton balls 2 times daily.Given in last 20 minutes after medicine, every mouse is respectively placed in ZH-LUO/8D type autonomic activitieses instrument (the limited public affairs of the positive magnificent biological Instrument and equipments in Anhui Department) in, treat that it is adapted to 5 minutes, mouse autonomic activities number of times in 5 minutes is then recorded, by the average and control group of administration group Average carries out statistics T tests.
As a result it is shown in Table 1 as follows：
The champignon essence oil of table 1 influences on mouse autonomic activities
* p ＜ 0.05**p ＜ 0.01***p ＜ 0.001
As can be seen from Table 1, compared with control group, three experimental groups of compound essential oil of the present invention can substantially reduce mouse Autonomic activities number of times, with good sedation, wherein, the best results of high dose group.
Test example 2 coats essential oil sedative experiment
Experiment is randomly divided into 6 groups from 60 mouse, male and female half and half：(1) control group, to mouse with wipe 0.5g Physiological saline；(2) positive drug group, gavage gives Yixinningshen tablet 1.58g powder/kg；(3) compound essential oil of sleep is promoted (to implement It is prepared by example 1) group, give the cotton balls that mouse absorbs 0.5g weight essential oils；(4) the coating essential oil (prepared by embodiment 2) of sleep is promoted Group, gives mouse and wipes the cotton balls for absorbing 0.5g weight essential oils；(5) orange oil group, gives mouse and wipes absorption 0.5g weight essences The cotton balls of oil；(6) lavender oil group, gives mouse and wipes the cotton balls for absorbing 0.5g weight essential oils；(7) sandalwood oil group, gives small Mouse wipes the cotton balls for absorbing 0.5g weight essential oils；(8) the 1 of oriental arborvitae seed oil and spine date seed oil:1 ratio miscella, gives mouse suction Receive the cotton balls of 0.5g weight essential oils；In addition to being organized except (2), remaining each group changes cotton balls 2 times daily., will in 40 minutes after last dose Every mouse is respectively placed in ZH-LUO/8D type autonomic activities instrument (Anhui Zhenghua Biology Instrument Equipment Co., Ltd.), treats that it is fitted Answer 5 minutes, then record mouse autonomic activities number of times in 5 minutes, the average of administration group is united with compareing class mean Meter learns T tests.
It the results are shown in Table 2：
Table 2 coats essential oil to be influenceed on mouse autonomic activities
* p ＜ 0.05**p ＜ 0.01***p ＜ 0.001
As can be seen from Table 2, compared with control group, compound essential oil of the present invention and coating essential oil experimental group can be substantially reduced Mouse autonomic activities number of times, with good sedation, wherein, the best results of high dose group；Meanwhile, and compared with oriental arborvitae seed oil Compared with the miscella of spine date seed oil physics, sweet orange oil, Lavender and sandalwood essential oil, present invention coating essential oil can show Write ground and reduce mouse autonomic activities number of times.
The influence that the champignon essence oil of test example 3 is fallen asleep again to threshold dose yellow Jackets sleep mouse
Experiment is randomly divided into 6 groups from 50 mouse, male and female half and half：(1) control group, immersion 0.5g is put into mouse cage The cotton balls of physiological saline；(2) positive drug group, gavage gives Yixinningshen tablet 1.58g powder/kg；(3) compound essential oil of sleep is promoted (prepared by embodiment 1) high dose group, the cotton balls given and absorb 1g weight essential oils is placed into mouse cage；(4) compound of sleep is promoted Essential oil (prepared by embodiment 1) middle dose group, the cotton balls given and absorb 0.5g weight essential oils is placed into mouse cage；(5) sleep is promoted Compound essential oil (prepared by embodiment 1) low dose group, into mouse cage place give absorb 0.1g weight essential oils cotton balls；Except (2) outside organizing, remaining each group changed cotton balls 2 times daily, in 30 minutes after last dose, the penta of each group intraperitoneal injection 40mg/kg dosage Barbital sodium, observes and records the number of animals fallen asleep again after sleep mouse revival (with righting reflex loss up to more than 1 minute person For sleep), each group again sleep number of animals compared with control group.
It the results are shown in Table 3：
Influence of the champignon essence oil of table 3 to the mouse yellow Jackets length of one's sleep
* p ＜ 0.05**p ＜ 0.01***p ＜ 0.001
As can be seen from Table 3, compared with control group, compound essential oil experimental group of the present invention can significantly shorten sleep latency Phase, extend the length of one's sleep, the effect fallen asleep with good promotion, wherein, the best results of high dose group.
Test example 4 coats the influence that essential oil is fallen asleep again to threshold dose yellow Jackets sleep mouse
Experiment is randomly divided into 5 groups from 60 mouse, male and female half and half：(1) control group, to mouse with wipe 0.5g Physiological saline；(2) positive drug group, gavage gives Yixinningshen tablet 1.58g powder/kg；(3) promote the compound essential oil group of sleep, give Mouse is given to absorb the cotton balls of 0.5g weight essential oils；(4) promote the coating essential oil group of sleep, give mouse and wipe absorption 0.5g weight The cotton balls of essential oil；(5) orange oil group, gives mouse and wipes the cotton balls for absorbing 0.5g weight essential oils；(6) lavender oil group, gives Mouse wipes the cotton balls for absorbing 0.5g weight essential oils；(7) sandalwood oil group, gives mouse and wipes the cotton for absorbing 0.5g weight essential oils Ball；(6) the prescription scalemic thereof of oriental arborvitae seed oil and spine date seed oil, gives the cotton balls that mouse absorbs 0.5g weight essential oils；Each group Change cotton balls 2 times daily.In 30 minutes after last dose, the yellow Jackets of 40mg/kg dosage were injected intraperitoneally in each group, observe and remember The number of animals (using righting reflex loss up to more than 1 minute person as sleep) fallen asleep again after record sleep mouse revival, each group is reentered Number of animals is slept compared with control group, the results are shown in Table 4：
Table 4 coats influence of the essential oil to the mouse yellow Jackets length of one's sleep
* p ＜ 0.05**p ＜ 0.01***p ＜ 0.001
As can be seen from Table 4, compared with control group, compound essential oil of the present invention and coating essential oil experimental group can significantly shorten Sleep latency, extends the length of one's sleep, the effect fallen asleep with good promotion；Meanwhile, and compared with oriental arborvitae seed oil and spine date seed oil Miscella, sweet orange oil, the Lavender of physics are compared with sandalwood essential oil, and present invention coating essential oil can significantly shorten sleep In incubation period, extend the length of one's sleep.
To sum up, the present invention research show, by sandalwood essential oil, amber essential oil, frankincense essential oil, Rosa Damascana, Lavender, After sweet orange oil is used cooperatively under specific consumption, insomnia can be effectively improved, with calmness, sleeping, calm the nerves the effect of.

Claims (10)

1. a kind of compound essential oil composition for promoting to sleep, it is characterised in that：It includes the component of following weight proportion：
5 parts -20 parts of sandalwood essential oil, 0.01 part -3 parts of amber essential oil, 5 parts -20 parts of frankincense essential oil, 1 part -10 parts of Rosa Damascana, smoke 5 parts -40 parts of essential oil of clothing grass, 5 parts -40 parts of sweet orange oil.
2. composition according to claim 1, it is characterised in that：It is made up of the component of following weight proportion：
9.5 parts of sandalwood essential oil, 0.5 part of amber essential oil, 20 parts of frankincense essential oil, 10 parts of Rosa Damascana, 30 parts of Lavender, sweet orange 30 parts of essential oil.
3. composition according to claim 1 or 2, it is characterised in that：The sandalwood essential oil, frankincense essential oil, Rosa Damascana, Lavender, amber essential oil, sweet orange oil, oriental arborvitae seed oil, spine date seed oil be respectively with santal, frankincense, rose, lavender, Amber, sweet orange, the seed of Oriental arborvitae or spina date seed are raw material, using steam distillation, low polar organic solvent extraction method, carbon dioxide The volatile oil that supercritical extraction or milling process are prepared.
4. composition according to claim 3, it is characterised in that：The purity of every kind of component of compound essential oil is all higher than 99%.
5. the compound essential oil composition described in Claims 1 to 4 any one is being prepared with calmness, sleeping, effect of calming the nerves Purposes in medicine, daily chemical product, sachet, sachet, fragrant pillow, fragrance product.
6. a kind of have the coating essential oil for promoting sleep effect, it is characterised in that：Include the composition of following weight proportion：
30 parts -60 parts of 30 parts -60 parts of 5 parts -20 parts of compound essential oil, oriental arborvitae seed oil, spine date seed oil described in claim 1.
7. coating essential oil according to claim 6, it is characterised in that：Include the composition of following weight proportion：
10 parts of compound essential oil, 45 parts of oriental arborvitae seed oil, 45 parts of spine date seed oil.
8. a kind of have the sachet or sachet for promoting sleep effect, it is characterised in that：Include the composition of following weight proportion：
Fragrant 70 parts -95 parts of medicinal material；
5 parts -30 parts of compound essential oil.
9. sachet according to claim 8 or sachet, it is characterised in that：It is made up of the composition of following weight proportion：
10. a kind of have the fragrant pillow for promoting sleep effect, it is characterised in that：It is prepared from by the composition of following weight proportion：
70 parts -95 parts of pillowcase, preferably 95 parts；
5 parts -30 parts of compound essential oil, preferably 5 parts.
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CN107661453A (en) * 2017-11-05 2018-02-06 茆莉娟 A kind of sachet content with rush dormancy effect of calming the nerves
CN108635433A (en) * 2018-08-10 2018-10-12 江西中医药大学 The Chinese medicine composition of anti-insomnia, traditional Chinese medicine slow-releasing sachet and preparation method thereof
CN108888675A (en) * 2018-08-10 2018-11-27 江西中医药大学 The Chinese medicine composition of tranquilizing and allaying excitement, traditional Chinese medicine slow-releasing sachet and preparation method thereof
CN110179695A (en) * 2019-06-27 2019-08-30 东莞怀朴植物精油有限公司 A kind of improvement memory compound essential oil and preparation method thereof
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CN116196375A (en) * 2023-01-17 2023-06-02 四川省天府香疗健康技术研究院有限公司 Compound essential oil for preventing and/or treating insomnia
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CN107661453A (en) * 2017-11-05 2018-02-06 茆莉娟 A kind of sachet content with rush dormancy effect of calming the nerves
CN108635433B (en) * 2018-08-10 2021-01-29 江西中医药大学 Anti-insomnia traditional Chinese medicine composition, traditional Chinese medicine slow-release sachet and preparation method thereof
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CN110179695A (en) * 2019-06-27 2019-08-30 东莞怀朴植物精油有限公司 A kind of improvement memory compound essential oil and preparation method thereof
CN111558077A (en) * 2020-06-30 2020-08-21 辽宁东科药业有限公司 Traditional Chinese medicine nerve-soothing aromatherapy wax and preparation method thereof
CN111617013A (en) * 2020-07-23 2020-09-04 泉后(广州)生物科技研究院有限公司 Composition with sleep-aiding effect, spray and preparation method thereof
CN114259520A (en) * 2020-09-16 2022-04-01 广东工业大学 Formula for promoting sleep and improving sleep and sleep-promoting essential oil
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CN114652784A (en) * 2022-03-28 2022-06-24 江西中医药大学 Compound essential oil, preparation method thereof and product with sedative hypnotic and memory improving effects
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CN116407591A (en) * 2023-03-28 2023-07-11 科丽思化妆品（上海）有限公司 Sleep-aiding compound essential oil composition, essential oil microcapsule and preparation method of essential oil microcapsule
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