CN105106068B - Calm the nerves perfume - Google Patents
Calm the nerves perfume Download PDFInfo
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- CN105106068B CN105106068B CN201510576560.6A CN201510576560A CN105106068B CN 105106068 B CN105106068 B CN 105106068B CN 201510576560 A CN201510576560 A CN 201510576560A CN 105106068 B CN105106068 B CN 105106068B
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- 235000019640 taste Nutrition 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
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- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Calm the nerves perfume the invention provides one kind, its raw material includes calming the nerves essential oil, ethanol, glycerine, distilled water, sodium alginate, Chinese herbal medicine absorption enhancers, hydroxypropyl methyl cellulose and the pyrrolidone sodium carboxylate of Chinese herbal medicine acquisition.Mood anxiety is adjusted in the perfume use of calming the nerves, contributes to physical and mental health while fragrance.
Description
Technical field
The present invention relates to cosmetic technical field, more particularly to one kind is calmed the nerves perfume.
Background technology
Perfume in the market is largely formed using the configuration of chemical spices, and these chemical spices contain aromatic series phenyl ring
Compound, evaporated with alcohol, stimulation is produced to human organ particularly respiratory system, occupant's appearance is coughed,
The symptoms such as dizzy, vomiting, negative unhealthy.It is if long-term use of, it is also possible to baryodmia, eyesight to be caused to weaken, even
As carcinogenic inducement.Meanwhile some perfume inferior, also containing the phosphorus benzene bis-acid potassium ester of lasting fragrance is allowed, this chemical substance can be led
Motility of sperm step-down or even death are caused, has become the big killer for causing mankind spermatozoon dead at present.In addition, this kind of perfume (or spice)
The purposes of water is relatively simple, i.e., emphasizes its smell merely without focusing on other effects, therefore, also limit its application.
Contain the herbaceous plant of substantial amounts of armaticity in Chinese herbal medicine, fragrant plant is compared with other general plants, unique perfume (or spice)
Change value, therefore be widely used in " aromatotherapy ", i.e., extracted the medicine of fragrant odour from these herbaceous plant largely
Appropriate formulation is made in thing, acts on whole body or local with disease preventing and treating.Traditional Chinese medical theory thinks that incense drug is homologous always, the traditional Chinese medical science
In addition to four natures and five flavors of drug.Separately there is the fragrant property of medicine, for thousands of years, the traditional Chinese medical science utilizes the fragrance ingredient of natural aromatic plant, by massaging,
The number of ways such as shower, outer painting, Wen Xiang, human body is produced and got rid of illness and health-care effect, for refreshing the mind, exorcised evil spirits by dirty, except pest
Epidemic disease, mosquito dispersing is also clearing and activating the channels and collaterals, the work(of crease-resistant skin care, wound beauty broader applications, therefore, is extracted into using Chinese herbal medicine
Divide and prepare emphasis of the perfume as current people research, it not only avoids malicious possessed by the perfume that traditional chemical spices is made into
Evil property, and has extra health care, the effect for the treatment of disease.
Stable mind is mainly used in the heart caused by a variety of causes such as the treatment heart qi deficiency, the deficienty of the heart blood for the Chinese herbal medicine of primary efficacy
God is not peaceful, irritable, insomnia and dreamful sleep, has a dizzy spell, be forgetful, the disease such as infantile convulsion and epilepsy.Modern study prove have improvement sleep,
Promote the pharmacological action of learning and memory, antianxiety, antipsychotic and anti-epileptic, wherein, it is stable god using Chinese herbal medicine antianxiety
One major embodiment of will.
Anxiety disorder is also known as anxiety neurosis, it is worried by lasting sexual tension, it is frightened or it is ictal in terror characterized by
Emotional handicap, with the behavioural characteristic such as automatic nervous system symptom and motion uneasiness.The anxiety or fear that anxiety patient is shown
Fear and be not often inconsistent without substantive content or with real situation.Doctor trained in Western medicine mainly uses pharmaceutical intervention to this sick treatment at present, but existing
There is dependence in medicine, work the problems such as slow, adverse reaction.Preferable anxiolytic drugs should have rapid-action, energy
Maintain to alleviate well and prevention recurs, mitigates adjoint depressive symptom, improves the quality of life of patient and reduce patient to doctor
The features such as treating the demand of service.
The traditional Chinese medical science has no the name of disease of anxiety disorder, and in terms of clinical manifestation, this disease belongs to emotional disorder, worry category, " strongly fragrant with the traditional Chinese medical science
Card ", " frightened ", " fearing ", " palpitation with fear ", " palpitaition ", " palpitation ", " being insomnia ", " hysteria ", " lily disease ", " inferior spy disease ", " lantern disease " etc.
Disease is relevant.Spiritual feelings will activity exception or internal damage by the excessive seven emotions are that anxiety is caused by impairment of yin more as feelings will obstacle the reason for causing a disease
There are heat or hyperactivity of fire, its etiology and pathogenesis is mostly that heresy disturbs cardiopulmonary, and gas is cloudy impaired, and god is not interior to be kept, strongly fragrant and change heat, all diseases of anxiety occurs, with
The heart, stomach, courage functional disturbance are closely related.Wherein, courage is fu-viscera with decisive character, and under physiological status, courage helps to resist extraneous bad
Direct stimulation influences, and maintains energy and blood of human body normal operation and function to coordinate, once courage internal organs appraxia, stomach Qi upward reversal, trough is not
Change, then phlegm Re Neisheng, qi-movement disturbance, courage internal organs is lost resolution ability, so as to cause abnormal anxiety to be reacted.For the main disease of this disease
Machine is " being disturbed in courage stomach discord, phlegm heat ", and treatment is worked as with " regulating qi-flowing for eliminating phlegm, clearing gallbladder and stomach " for big method.
The present invention utilizes " aromatotherapy " to adjust mood anxiety in daily perfume use, prepares and new contains medium-height grass
The perfume of medicine composition.
The content of the invention
The technical problems to be solved by the invention are to provide one kind and calmed the nerves perfume, by adjusting the heart in daily perfume use
Feelings anxiety, contribute to physical and mental health while fragrance.
In order to solve the above technical problems, calming the nerves perfume present invention also offers one kind, its raw material includes：Chinese herbal medicine of calming the nerves obtains
Essential oil, ethanol, glycerine, distilled water, sodium alginate, Chinese herbal medicine absorption enhancers, hydroxypropyl methyl cellulose and the pyrrolidines obtained
Keto carboxylic acid sodium.
Wherein, the parts by weight of the parts by weight of parts by weight of essential oil 3~6 of the Chinese herbal medicine acquisition of calming the nerves, the parts by weight of ethanol 15~25,
The parts by weight of the parts by weight of the parts by weight of parts by weight of glycerine 2~5, the parts by weight of distilled water 95~105, the parts by weight of sodium alginate 1~3, in
The parts by weight of the parts by weight of parts by weight of herbal medicine absorption enhancers 0.5~1.5, the parts by weight of hydroxypropyl methyl cellulose 0.5~1.5, pyrrolidines
3~6 parts of keto carboxylic acid sodium.
Wherein, the raw material of the Chinese herbal medicine includes ginkgo leaf, agalloch eaglewood, rhizoma Gastrodiae, the fruit of Chinese magnoliavine, cape jasmine, dried orange peel, cymbopogon distans, meat
Desert cistanche, rattletop, bean cotyledon perfume, sweet osmanthus, night fragrant flower, giant knotweed, the coptis, the vine of multiflower knotweed, the red sage root, peppermint.
The Chinese herbal medicine absorption enhancers areN- octyl group chitosan.
Wherein, it is describedNThe preparation method of-octyl group chitosan is specially：Chitosan 100g is weighed, it is 2% to be dissolved in 2L concentration
The in the mixed solvent of acetic acid and 2L methanol, stirs 12h at room temperature, and thoroughly swelling is uniformly dispersed, and nitrogen deoxygenation 15min, adds
Octanal 200ml, reaction 12h system add 6L ethanol after becoming sticky, and 48h is stirred in continuation at room temperature, is adjusted with 1mol/L potassium hydroxide
Reaction solution is saved to neutrality, afterwards using 50g potassium borohydrides configuration weak alkaline aqueous solution 60ml, reaction bulb is added drop-wise to dropping funel
In, continuing to be stirred at room temperature 24h, final reaction liquid is adjusted to neutrality, product with 1mol/L hydrochloric acid and filtered, and with water, methanol, acetone
Wash 3 times respectively, collect product and thoroughly dried in 30 DEG C of vacuum, finally weigh product, obtainN- octyl group chitosan.
The present invention also provides the preparation method of above-mentioned perfume of calming the nerves, and it includes：
The first step, sodium alginate is added in the distilled water of part, is heated to 65 DEG C, stirred in insulation, until marine alga
Sour sodium is dissolved completely in water, and the amount of the distilled water used per 5g sodium alginates is 100ml；
Second step, said herbal medicine composition is mixed, Chinese herbal medicine essential oil is extracted and purified by extraction element, received
Collect essential oil；
3rd step, essential oil and Chinese herbal medicine absorption enhancers prepared by second step are dissolved in above-mentioned ethanol dissolving, stirring
To being completely dissolved；
4th step, sodium alginate aqueous solution prepared by the first step, ethanol solution, glycerine, the hydroxypropyl of the preparation of the 3rd step
Ylmethyl cellulose and pyrrolidone sodium carboxylate are added in the distilled water of surplus, are stirred, and after standing 37 hours, are put into sealing
In container, after being aged 6 weeks, you can.
The second step further comprises,
2.1st step, sweet osmanthus and night fragrant flower are respectively crushed into coarse powder, mix, using carbon dioxide supercritical extraction,
33~35MPa of extracting pressure, 40~43 DEG C, 110~130min of extraction time of extraction temperature, collect the first essential oil；
2.2nd step, ginkgo leaf, rhizoma Gastrodiae, cloud vanilla are respectively crushed into coarse powder, mixed, and face using carbon dioxide is super
Boundary extracts, 22~25MPa of extracting pressure, 28~32 DEG C, extraction time 160-180min of extraction temperature, collects the second essential oil；
2.3rd step, agalloch eaglewood, bean cotyledon perfume, the coptis, the red sage root are ground into coarse powder, using carbon dioxide supercritical extraction, extraction pressure
26~30MPa of power, 45~48 DEG C, 180~200min of extraction time of extraction temperature, collect the 3rd essential oil；
2.4th step, remaining components are respectively crushed into coarse powder, mixed, using carbon dioxide supercritical extraction, extraction
Pressure 24~27MPa of power, 51~54 DEG C, 200~220min of extraction time of extraction temperature, collect the 4th essential oil；
2.5th step, above-mentioned essential oil is mixed, it is standby.
Beneficial effects of the present invention:
Mood anxiety is adjusted in the perfume use of calming the nerves, contributes to physical and mental health while fragrance.
Brief description of the drawings
Fig. 1NThe infrared spectrum of-octyl group chitosan.
Embodiment
The invention provides the herbal composite used in a kind of perfume of calming the nerves for calming the nerves, its raw material includes ginkgo
Leaf, agalloch eaglewood, rhizoma Gastrodiae, the fruit of Chinese magnoliavine, cape jasmine, dried orange peel, cymbopogon distans, saline cistanche, rattletop, bean cotyledon perfume, sweet osmanthus, night fragrant flower, giant knotweed, Huang
Company, the vine of multiflower knotweed, the red sage root, peppermint.
Further preferably, the herbal composite is only prepared by above-mentioned raw materials.
The parts by weight of each raw material are respectively the parts by weight of parts by weight of ginkgo leaf 15~25, agalloch eaglewood 20 in the herbal composite
The parts by weight of the parts by weight of the parts by weight of parts by weight~30, the parts by weight of rhizoma Gastrodiae 10~20, the parts by weight of the fruit of Chinese magnoliavine 15~25, the parts by weight of cape jasmine 10
The parts by weight of the parts by weight of~20 parts by weight, the parts by weight of dried orange peel 15~25, the parts by weight of cymbopogon distans 15~25, parts by weight~35 of saline cistanche 25
The parts by weight of the parts by weight of fragrant 5 parts by weight of the parts by weight of parts by weight, the parts by weight of rattletop 10~20, bean cotyledon~15, the parts by weight of sweet osmanthus 55~65,
The parts by weight of the parts by weight of the parts by weight of parts by weight of night fragrant flower 35~45, the parts by weight of giant knotweed 20~30, the parts by weight of the coptis 25~35, the vine of multiflower knotweed
The parts by weight of the parts by weight of the parts by weight of 25 parts by weight~35, the parts by weight of the red sage root 25~35, the parts by weight of peppermint 15~25.
Further preferably, the parts by weight of each raw material are respectively the weight of parts by weight of ginkgo leaf 15~20 in the herbal composite
Measure part, the parts by weight of parts by weight of agalloch eaglewood 20~25, the parts by weight of parts by weight of rhizoma Gastrodiae 10~15, the parts by weight of parts by weight of the fruit of Chinese magnoliavine 15~20,
The parts by weight of the parts by weight of the parts by weight of parts by weight of cape jasmine 10~15, the parts by weight of dried orange peel 15~20, the parts by weight of cymbopogon distans 15~20, saline cistanche
The parts by weight of the parts by weight of the parts by weight of 25 parts by weight~30, the parts by weight of rattletop 15~20, fragrant 10 parts by weight of bean cotyledon~15, the weight of sweet osmanthus 60
Part~parts by weight of parts by weight of the 65 parts by weight, parts by weight of the night fragrant flower 40~45, parts by weight of giant knotweed 25~30, parts by weight~35 of the coptis 30
The weight of the parts by weight of the parts by weight of parts by weight, the parts by weight of the vine of multiflower knotweed 30~35, the parts by weight of the red sage root 30~35, the parts by weight of peppermint 20~25
Part.
Most preferably, the parts by weight of each raw material are respectively the parts by weight of ginkgo leaf 20, the weight of agalloch eaglewood 25 in the herbal composite
Measure part, the parts by weight of rhizoma Gastrodiae 15, the parts by weight of the fruit of Chinese magnoliavine 20, the parts by weight of cape jasmine 15, the parts by weight of dried orange peel 20, the parts by weight of cymbopogon distans 20, meat
Fragrant 10 parts by weight of the parts by weight of desert cistanche 30, the parts by weight of rattletop 15, bean cotyledon, the parts by weight of sweet osmanthus 60, the parts by weight of night fragrant flower 40, the weight of giant knotweed 25
Measure part, the parts by weight of the coptis 30, the parts by weight of the vine of multiflower knotweed 30, the parts by weight of the red sage root 30, the parts by weight of peppermint 20.
Each raw material pharmacology is as follows：
Ginkgo leaf：It is sweet, bitter, puckery, it is mild-natured, enter the heart, lung channel, have to astringe the lung and relieving asthma, promoting blood circulation nourishing heart, the work(of relieving diarrhea with astringents
The card such as effect, uncomfortable in chest pained for deficiency syndrome of the lung cough and asthma, dizziness headache, diarrhea, dysentery.
Agalloch eaglewood：Acrid flavour, hardship, warm-natured, returns spleen, stomach, kidney, lung channel have a sending down abnormally ascending middle benefit gas, warm kidney receive gas the effect of, cure mainly gas
It is inverse to pant, hiccup is vomitted, abdominal distention, waist and knee void is cold, and large intestine void is secret, the leaching of urine gas, the card such as man's cold sperm.
Rhizoma Gastrodiae：It is sweet, mild-natured, enter Liver Channel, there is calming the liver to stop the wind, spasmolysis, the effect removed obstruction in channels to relieve pain, be mainly used in liver-fire flaming
Dizziness headache, strong wind twitch, epilepsy caused by liver-yang hyperactivity, liver wind agitation etc. demonstrate,prove.
The fruit of Chinese magnoliavine：It is warm-natured, sour, sweet, return lung, the heart, kidney channel, have and restrain astringent or styptic treatment for spontaneous sweating, nourishing generate fluid, the work(of kidney calming
Effect, disappear for empty asthma of coughing long, emission, enuresis frequent micturition, endless diarrhea, spontaneous perspiration, night sweat, injury thirst, feeble pulse of losing heart, interior heat
Yearningly, palpitation and insomnia etc. is demonstrate,proved.
Cape jasmine：Latin namegardeniae fructus, bitter is cold in nature, enters the heart, lung, three Jiao, there is relieving restlessness purging intense heat, soothing the liver solution
Strongly fragrant, clearing heat and promoting diuresis, the effect of cooling blood and hemostasis, be mainly used in the strongly fragrant chest gastral cavity of warm heat disease heat it is vexed it is uneasy, bother it is not peaceful；Liver depression is not relaxed
Or Liver Channel has having a dizzy spell for heat, pain in chest and hypochondrium, hot eyes dry throat；Jaundice with damp-heat pathogen；The symptoms such as the abdominal distention of qi depression to blood stasis.
Dried orange peel：It is warm-natured, acrid flavour, hardship；Returns spleen, lung channel, spread of pungent taste helps to keep warm, fragrant odour, are longer than qi-regulating, can enter spleen and lung, therefore both
It can manage it and dissipate sluggishness of lung-QI, during and can promoting the circulation of qi is wide, the card such as stagnant, chest diaphragm feeling of fullness and the taste stagnation of the circulation of vital energy, abdominal fullness and distention is gathered around for lung qi.
Cymbopogon distans：Acrid flavour, slight bitter, it is warm-natured, there is inducing diaphoresis；Dampness removing；The effect of relieving cough and asthma, cure mainly anemofrigid cold；Wound
Heat；Vomit and diarrhoea and suffer from abdominal pain；Urine leaching pain；Arthralgia pain due to rheumatism；Cough and asthma etc. is demonstrate,proved.
Saline cistanche：For Orobanchaceae Cistanche deserticola plant saline cistanche and the fleshy stem of Cistanche tubulosa, latin nameherba cistanches, it is sweet, salty, it is warm-natured, enter kidney, large intestine channel, there is kidney-replenishing, benefiting essence-blood, the effect to relax bowel, for kidney-yang deficiency
Decline, the impotence and premature ejaculation of asthenia of essence and blood, infertile, soreness of waist and knee joint, Hiccough and deaf, frequent micturition urine number, kidney deficiency intestinal dryness and the postpartum deficiency of blood,
Constipation that body fluid deficiency after being ill etc. is demonstrate,proved.
Rattletop：Acrid flavour, micro-sweet, cold nature, enter lung, spleen, stomach, large intestine channel, have and deliver promoting eruption, it is clearing heat and detoxicating, rise and lift sun
The effect of gas.For headache due to pathogenic wind-heat, dentalgia, aphtha, abscess of throat, measles without adequate eruption, sun poison hair spot；Prolapse of the anus, prolapse of uterus etc. are demonstrate,proved.
Bean cotyledon is fragrant：It is sweet for the leaf and stem skin of Oleaceae Osmanthuss fabric watter milkwort root leaf or bark, it is bitter, it is mild-natured, there is heat clearing and inflammation relieving,
The effect of hemostasia and promoting granulation, chronic bronchitis is cured mainly, external application controls fracture, traumatism and bleeding, sprains the card such as pain.
Sweet osmanthus：Acrid flavour, warm-natured, return lung, spleen, kidney channel, there is the effect of Wenfei of drink, eliminating cold to stop pain, cure mainly phlegmatic cough,
The cards such as coldness and pain in the epigastrium, intestines wind bloody flux, closed dysmenorrhea, toothache, halitosis.
Night fragrant flower：It is sweet, light for flower, the leaf of Asclepiadaceae tuberose plant cordate telosma, it is mild-natured, have and clear liver and improve vision, go
Screen, the effect of removing toxic substances and promoting tissue regeneration, cures mainly red eye, swell pain, the cards such as ulcerative carbuncle is festered.
Giant knotweed：Latin name Polygoni Cuspidati Rhizoma et Radix, slight bitter, it is slightly cold.Return liver, courage, lung
Through, there is clearing heat and detoxicating, normalizing gallbladder to cure jaundice, expelling wind and removing dampness, scattered stasis pain, it is relieving cough and reducing sputum the effect of, for joint pain, damp and hot Huang
Subcutaneous ulcer, Amenorrhea , wei lumps in the abdomen, coughing with a lot of sputum, scald, injury from falling down, carbuncle sore tumefacting virus etc. are demonstrate,proved.
The coptis：It is bitter, cold in nature, enter the heart, lung, courage, stomach, large intestine channel, there is heat-clearing and damp-drying drug, purging intense heat and detonicating, the work of cooling blood for improving eyesight
With, be longer than the fire of removing the heart-fire stomach, have preventing or arresting vomiting concurrently and disappear the work(of ruffian, available for dysphoria and insomnia of the treatment internal heat caused by prosperous, and warm heat disease it
It is high fever coma, vexed, thirsty；Can be additionally used in it is damp and hot caused by dysentery, tenesmus；It is heat toxin sore carbuncle, eczema, aphthae, sudden and violent
Ignition eye etc. is demonstrate,proved, and the coptis plays the role of cholagogic, expansion thin vessels, reduced blood pressure, and can strengthen the phagocytic activity of leucocyte, to gold
Staphylococcus aureus, hemolytic streptococcus, streptococcus pneumonia, meningococcus, comma bacillus, bacillus anthracis, shigella dysenteriae have
Stronger bacteriostasis.
The vine of multiflower knotweed：Sweet, slight bitter, it is mild-natured；The thoughts of returning home, Liver Channel, there is the effect of energy mental-tranquilization, dispelling wind and removing obstruction in the meridians, cure mainly mistake
Dormancy dreaminess, deficiency of blood bodily pain, numbness, arthralgia pain due to rheumatism, wind sore scabies tinea etc. are demonstrate,proved.
The red sage root：Bitter, cold nature, enter the heart, Liver Channel, there is promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness that clears away heart-fire, support
The effect of blood and tranquilizing mind, for irregular menstruation, closed dysmenorrhea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, and sore swell and ache curative is vexed
Egersis；Hepatosplenomegaly, angina pectoris etc. are demonstrate,proved.
Traditional perfume is all solvent type product, and essence and flavoring agent, which is dissolved in ethanol or isopropanol, turns into transparent molten
Liquid.Solvent-borne type perfume appearance looks elegant, preparing process are simple, after sprinkling evaporation rate it is fast thus fragrance easily come out, compare
Get consumer reception, be always the main product in perfume.But solvent-borne type perfume will use substantial amounts of ethanol and isopropanol, by
This also brings many defects.Solvent, although being handled using deodorization was preceding done, can not possibly always be accomplished per se with the smell of oneself
There is no smell completely.Further, since ethanol content is high in product, so higher to the excitant of skin.
Therefore, the present invention considers Chinese herbal medicine extraction volatile spirits replacing alcohol solvent using more aqueous solvents, so as to
Reduce strong stimulation of the perfume to skin.
In addition, absorbing state is more weak in vitro for Chinese herbal medicine extract component, it is difficult to plays drug effect well, the present invention is logical
Offer absorption enhancers are crossed, the perfume with Chinese herbal medicine extract component for promoting to spray obtains good suction on human body skin
Receive, so as to improve its drug effect, preferably play the effect of calming the nerves.
Calm the nerves perfume present invention also offers one kind, its raw material includes：Parts by weight~6 of essential oil 3 that said herbal medicine obtains
The weight of the parts by weight of the parts by weight of parts by weight, the parts by weight of ethanol 15~25, the parts by weight of glycerine 2~5, the parts by weight of distilled water 95~105
Part, the parts by weight of the parts by weight of parts by weight of sodium alginate 1~3, the parts by weight of Chinese herbal medicine absorption enhancers 0.5~1.5, hydroxypropyl methyl fiber
The parts by weight of plain 0.5 parts by weight~1.5,3~6 parts of pyrrolidone sodium carboxylate.
Further preferably, the weight of each raw material in perfume of calming the nerves is respectively the parts by weight of essential oil 5, the second that the Chinese herbal medicine obtains
The parts by weight of alcohol 20, the parts by weight of glycerine 4, the parts by weight of distilled water 100, the parts by weight of sodium alginate 2, the weight of Chinese herbal medicine absorption enhancers 1
Part, the parts by weight of hydroxypropyl methyl cellulose 1,4 parts of pyrrolidone sodium carboxylate.
The Chinese herbal medicine absorption enhancers are modification of chitosan, and chitosan is the product of de-acetyl chitin, its skeleton knot
Structure is combined to be formed by D- Glucosamines by β-Isosorbide-5-Nitrae-glycosidic bond, dissolves in acidic aqueous solution, nontoxic, nonirritant, tool
There are good biocompatibility and biodegradability.It is generally believed that chitosan, which promotees mechanism of absorption, to be carried just on its molecule
Electric charge produces electrostatic interaction with cell membrane, the protein-bonded structure of biomembrane is changed, so as to cause opening for transmembrane channel
Put.Modification of chitosan provided by the invention isN- octyl group chitosan.
It is describedNThe preparation method of-octyl group chitosan is specially：Chitosan 100g is weighed, is dissolved in the acetic acid that 2L concentration is 2%
With the in the mixed solvent of 2L methanol, 12h is stirred at room temperature, and thoroughly swelling is uniformly dispersed, and nitrogen deoxygenation 15min, adds octanal
200ml, reaction 12h system add 6L ethanol after becoming sticky, and 48h is stirred in continuation at room temperature, are adjusted with 1mol/L potassium hydroxide anti-
Liquid is answered to neutrality, afterwards using 50g potassium borohydrides configuration weak alkaline aqueous solution 60ml, is added drop-wise to dropping funel in reaction bulb, after
Continuous that 24h is stirred at room temperature, final reaction liquid is adjusted to neutrality, product with 1mol/L hydrochloric acid and filtered, and is distinguished with water, methanol, acetone
Washing 3 times, collect product and thoroughly dried in 30 DEG C of vacuum, finally weigh product, obtainN- octyl group chitosan.
The present invention also provides the preparation method of above-mentioned perfume of calming the nerves, and it includes：
The first step, sodium alginate is added in the distilled water of part, is heated to 65 DEG C, stirred in insulation, until marine alga
Sour sodium is dissolved completely in water, and the amount of the distilled water used per 5g sodium alginates is 100ml；
Second step, said herbal medicine composition is mixed, Chinese herbal medicine essential oil is extracted and purified by extraction element, received
Collect essential oil；
3rd step, essential oil and Chinese herbal medicine absorption enhancers prepared by second step are dissolved in above-mentioned ethanol dissolving, stirring
To being completely dissolved；
4th step, sodium alginate aqueous solution prepared by the first step, ethanol solution, glycerine, the hydroxypropyl of the preparation of the 3rd step
Ylmethyl cellulose and pyrrolidone sodium carboxylate are added in the distilled water of surplus, are stirred, and after standing 37 hours, are put into sealing
In container, after being aged 6 weeks, you can.
The second step further comprises,
2.1st step, sweet osmanthus and night fragrant flower are respectively crushed into coarse powder, mix, using carbon dioxide supercritical extraction,
33~35MPa of extracting pressure, 40~43 DEG C, 110~130min of extraction time of extraction temperature, collect the first essential oil；
2.2nd step, ginkgo leaf, rhizoma Gastrodiae, cloud vanilla are respectively crushed into coarse powder, mixed, and face using carbon dioxide is super
Boundary extracts, 22~25MPa of extracting pressure, 28~32 DEG C, extraction time 160-180min of extraction temperature, collects the second essential oil；
2.3rd step, agalloch eaglewood, bean cotyledon perfume, the coptis, the red sage root are ground into coarse powder, using carbon dioxide supercritical extraction, extraction pressure
26~30MPa of power, 45~48 DEG C, 180~200min of extraction time of extraction temperature, collect the 3rd essential oil；
2.4th step, remaining components are respectively crushed into coarse powder, mixed, using carbon dioxide supercritical extraction, extraction
Pressure 24~27MPa of power, 51~54 DEG C, 200~220min of extraction time of extraction temperature, collect the 4th essential oil；
2.5th step, above-mentioned essential oil is mixed, it is standby.
Embodiments of the present invention are described in detail using embodiment below, whereby to the present invention how application technology means
To solve technical problem, and the implementation process for reaching technique effect can fully understand and implement according to this.
The essential oil of traditional Chinese medicine of embodiment 1
Sweet osmanthus 60g and night fragrant flower 40g are respectively crushed into coarse powder, mixed, using carbon dioxide supercritical extraction,
Extracting pressure 35MPa, 43 DEG C, extraction time 130min of extraction temperature, the first essential oil is collected, by ginkgo leaf 20g, rhizoma Gastrodiae 15g, cloud
Vanilla 20g is respectively crushed into coarse powder, mixes, using carbon dioxide supercritical extraction, extracting pressure 25MPa, extraction temperature
32 DEG C, extraction time 180min of degree, the second essential oil is collected, agalloch eaglewood 25g, bean cotyledon perfume (or spice) 10g, coptis 30g, red sage root 30g are ground into
Coarse powder, using carbon dioxide supercritical extraction, extracting pressure 30MPa, 48 DEG C, extraction time 200min of extraction temperature, collect the
Three essential oils, by fruit of Chinese magnoliavine 20g, cape jasmine 15g, dried orange peel 20g, saline cistanche 30g, rattletop 15g, giant knotweed 25g, the parts by weight of the vine of multiflower knotweed 30,
The parts by weight of peppermint 20 are respectively crushed into coarse powder, mix, using carbon dioxide supercritical extraction, extracting pressure 27MPa, extraction
54 DEG C, extraction time 220min of temperature is taken, the 4th essential oil is collected, above-mentioned essential oil is mixed, it is standby.
Toxicology detects
(1) rat acute percutaneous toxicity test
1st, tested material：Essential oil of traditional Chinese medicine prepared by embodiment 1, weigh tested material 50g and add distilled water to modulate the pasty state of finished product 50%
Thing is standby.
2nd, experimental animal：SD big white mouse 20, male and female half and half, body weight 180-220g.
3rd, animal room environmental：22-25 DEG C of temperature, relative humidity：45-55%.
4th, test method：24 hours before experiment, in back part of animal backbone both sides unhairing, unhairing scope is about body surface area
10%.By 5000mg/kg.bw dosage (coating amount 1.0g/100g.bw), examination mouse unhairing position is coated and fixed, 24
After hour, warm water removes residual tested material, Continuous Observation 7 days.
5th, result of the test：Examination mouse whole body anomalous variation is had no in observation period, also has no dead, applies the local non-show of tested material
Swell, fester, inflammation, the reaction such as necrosis.Therefore, to the percutaneous LD of white mouse female, great and mighty or powerful50It is all higher than 5000mg/kg.bw.
6th, evaluate：According to DB61-267-1998《Health treatment Toxicological evaluation program and test method》Middle urgency
Property percutaneous toxicity grade scale, the essential oil of traditional Chinese medicine is to the nontoxic level in the true border of rat acute percutaneous toxicity.
(2) multiple Skin Irritation Test
1st, tested material：Essential oil of traditional Chinese medicine prepared by embodiment 1, weighs tested material essential oil 10g and adds distilled water to be modulated into 50% paste
Shape thing is standby.
2nd, experimental animal：Japanese white big ear rabbit 4, male and female half and half, body weight 2.5-3.0kg.
3rd, animal room environmental：22-25 DEG C of temperature, relative humidity：45-55%.
4th, test method：24 hours before experiment, in every rabbit back backbone both sides cropping preserved skin, unhairing scope each 3 ×
6cm2.Respectively take tested material 0.5g/ to be only coated in after modulated on the skin of every rabbit side, smear once daily, offside makees solvent pair
According to.It is continuous to smear 14 days.Cropping before applying daily, skin must not be damaged, ensure that tested material fully contacts with skin.Observation skin daily
Skin reacts and marking.Off-test.Take and smear area skin progress histopathologic examination.
5th, result of the test：Multiple skin irritatin highest stimulus index and pathological tissue integration are 0, according to DB61267-
1998《Health treatment Toxicological evaluation program and test method》Middle skin irritatin strength grading standard, the essential oil of traditional Chinese medicine
Multiple skin irritatin intensity belongs to nonirritant.
(3) skin anaphylactic test
1st, tested material：Essential oil of traditional Chinese medicine prepared by embodiment 1, weighs tested material essential oil 10g and adds distilled water to be modulated into 50% paste
Shape thing is standby.
Positive control：2,4- dinitro-chloro-benzenes (DNCB), Beijing Xing Jin chemical plant are produced.
2nd, experimental animal：Cavy 30, male and female half and half, body weight 250-300g.
3rd, animal room environmental：22-25 DEG C of temperature, relative humidity：45-55%.
4th, test method：Experiment cavy is randomly divided into three groups, every group 10, male and female half and half, respectively tested material group, the moon
Property control group and positive controls.
Sensitization contact：Guinea pig back left of spine hair is removed to 24 hours before tested material, unhairing scope about 3 × 3cm.Take
Tested material 0.2g/ only, modulated rear even application hair removal section on the left of back part of animal, continues 6 hours.7th day and the 14th day, use
Same method is repeated once, and positive controls apply 1%DNCB, and negative control group is not dealt with.
Excite contact：Yu Weici was to 14 days after tested material, and, modulated rear even application is in cavy by tested material 0.2g/ only
Hair removal section on the right side of back, removes tested material after 6 hours, observe allergic reaction situation at once, then in 1,24,48,72 hour again
Secondary observation.Positive controls apply 0.1%DNCB, and negative control group is not dealt with.Observational technique is the same as tested group.As a result according to
DB61-267-1998《Health treatment Toxicological evaluation program and test method》In relevant sensitization of skin evaluation criterion enter
Row evaluation.
5th, result of the test：Tested group without sensitization negative control without sensitization positive control extreme sensitization
6th, evaluate：According to DB61-267-1998《Health treatment Toxicological evaluation program and test method》In have
Sensitization of skin standard is closed, the essential oil of traditional Chinese medicine category is without sensitization.Experiment proves：Tested material group sensitization rate is 0.
Embodiment 2N- octyl group chitosan
Chitosan 100g is weighed, the in the mixed solvent of acetic acid and 2L methanol that 2L concentration is 2% is dissolved in, stirs at room temperature
12h, thoroughly swelling are uniformly dispersed, nitrogen deoxygenation 15min, add octanal 200ml, and reaction 12h systems add 6L after becoming sticky
48h is stirred in ethanol, continuation at room temperature, is adjusted reaction solution to neutrality with 1mol/L potassium hydroxide, is configured afterwards using 50g potassium borohydrides
Weak alkaline aqueous solution 60ml, is added drop-wise in reaction bulb with dropping funel, continues that 24h, final reaction liquid 1mol/L is stirred at room temperature
Hydrochloric acid is adjusted to neutrality, and product filters, and is washed respectively 3 times with water, methanol, acetone, is collected product and is thoroughly done in 30 DEG C of vacuum
It is dry, product is finally weighed, is obtainedN- octyl group chitosan.
NThe infrared spectrum of-octyl group chitosan is as shown in Figure 1.
Embodiment 3 is calmed the nerves perfume
Sodium alginate 20g is added in 400ml distilled water, is heated to 65 DEG C, is stirred in insulation, until sodium alginate
It is dissolved completely in water, essential oil of traditional Chinese medicine prepared by 50g embodiments 1 mixes, and Chinese herbal medicine prepared by embodiment 2 promotees to absorb
AgentN- octyl group chitosan is dissolved in 200g ethanol, and stirring obtains ethanol solution to being completely dissolved, will above sodium alginate it is water-soluble
Liquid, ethanol solution, 40g glycerine, 10g hydroxypropyl methyl celluloses and 40g pyrrolidone sodium carboxylates add the distilled water of surplus
In, stir, after standing 37 hours, be put into sealing container, after being aged 6 weeks, you can.
The mouse experiment of embodiment 4
Animal and packet：Male Kunming strain mice 60, weight (20+2) g.Mouse adaptability is divided at random after raising 1 week
Into 2 groups：Control group 30 and perfume group 30 of calming the nerves.Control group calms the nerves perfume group in experimentation without any operation
It is covered with whole space using perfume of calming the nerves.
Experimental method：Mouse is put into equipped with 40 cm the joint open field test case of × 40 cm 16 hole plates by behavioral value
Center area, start simultaneously at timing.RF transmitter and camera device are mounted with joint open field test case, can be had simultaneously
Various the spontaneous activity behaviors and exploratory heading behavior of effect record mouse.The depth in hole is 2. 2 cm, is mounted with 1 cm depths infrared
Line, when the exploratory heading depth of mouse is more than 1 cm, due to being blocked by infrared ray, instrument will record an exploratory heading behavior automatically, and
Accumulative exploratory heading number.Every mouse is carried out continuously 6 min records, keeps during operation external environment quiet, before putting people mouse every time
The excreta cleaned out in case, ensure the objectivity of the detection per batch as far as possible.
Statistical method
Measurement data uses± s is represented, is compared between group using χ2Examine, all data are united using SPSS12.0
Count software processing.
As a result
Each group mouse central area activity time, activity distance and time of shuttling compare, and are shown in Table 1.
The each group mouse central area activity time of table 1, activity distance and time of shuttling compare
Table 1 can be seen that whether central area activity time, central area activity distance or shuttle the time, perfume of calming the nerves
Group is compared with control group, and all there were significant differences, p<0.01.
Each group mouse exploratory heading number compares, and the results are shown in Table 2.
The each group mouse exploratory heading number of table 2 compares
From table 2 it can be seen that perfume group mouse exploratory heading number of calming the nerves is compared with control group significant difference, p<0.01.
All above-mentioned this intellectual properties of primarily implementation, the not this new product of implementation of setting limitation other forms
And/or new method.Those skilled in the art will utilize this important information, the above modification, to realize similar execution feelings
Condition.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above described is only a preferred embodiment of the present invention, being not the limitation for making other forms to the present invention, appoint
What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc.
Imitate embodiment.But it is every without departing from technical solution of the present invention content, the technical spirit according to the present invention is to above example institute
Any simple modification, equivalent variations and the remodeling made, still fall within the protection domain of technical solution of the present invention.
Claims (4)
- The perfume 1. one kind is calmed the nerves, it is characterised in that：Raw material by calm the nerves Chinese herbal medicine acquisition essential oil, ethanol, glycerine, distilled water, Sodium alginate, Chinese herbal medicine absorption enhancersN- octyl group chitosan, hydroxypropyl methyl cellulose and pyrrolidone sodium carboxylate are formed；The parts by weight of the parts by weight of parts by weight of essential oil 3~6 of the Chinese herbal medicine acquisition of calming the nerves, the parts by weight of ethanol 15~25, the weight of glycerine 2 Measure the parts by weight of the parts by weight of the parts by weight of part~5, the parts by weight of distilled water 95~105, the parts by weight of sodium alginate 1~3, Chinese herbal medicine promotees to absorb The parts by weight of the parts by weight of parts by weight of agent 0.5~1.5, the parts by weight of hydroxypropyl methyl cellulose 0.5~1.5, pyrrolidone sodium carboxylate 3~ 6 parts；The raw material of the Chinese herbal medicine of calming the nerves is by ginkgo leaf, agalloch eaglewood, rhizoma Gastrodiae, the fruit of Chinese magnoliavine, cape jasmine, dried orange peel, cymbopogon distans, saline cistanche, liter Fiber crops, bean cotyledon perfume, sweet osmanthus, night fragrant flower, giant knotweed, the coptis, the vine of multiflower knotweed, the red sage root, peppermint are formed.
- 2. perfume as claimed in claim 1 of calming the nerves, it is characterised in that：It is describedNThe preparation method of-octyl group chitosan is specially： Chitosan 100g is weighed, the in the mixed solvent of acetic acid and 2L methanol that 2L concentration is 2% is dissolved in, stirs 12h at room temperature, it is thoroughly molten Swollen to be uniformly dispersed, nitrogen deoxygenation 15min adds octanal 200ml, and reaction 12h systems add 6L ethanol after becoming sticky, continue room The lower stirring 48h of temperature, reaction solution is adjusted to neutrality with 1mol/L potassium hydroxide, it is water-soluble using 50g potassium borohydrides configuration alkalescent afterwards Liquid 60ml, is added drop-wise in reaction bulb with dropping funel, continues to be stirred at room temperature 24h, final reaction liquid with 1mol/L hydrochloric acid adjust to Neutrality, product filters, and is washed respectively 3 times with water, methanol, acetone, collects product and finally claims in 30 DEG C of vacuum thorough dry 2 Volume production thing, is obtainedN- octyl group chitosan.
- 3. the preparation method for perfume of calming the nerves described in claim 1 or 2, it is characterised in that including：The first step, sodium alginate is added in the distilled water of part, is heated to 65 DEG C, stirred in insulation, until sodium alginate It is dissolved completely in water, the amount of the distilled water used per 5g sodium alginates is 100ml；Second step, said herbal medicine composition is mixed, Chinese herbal medicine essential oil is extracted and purified by extraction element, collect essence Oil；3rd step, essential oil and Chinese herbal medicine absorption enhancers prepared by second step are dissolved in above-mentioned ethanol dissolving, stirred to complete Fully dissolved；4th step, sodium alginate aqueous solution prepared by the first step, the ethanol solution of the 3rd step preparation, glycerine, hydroxypropyl first Base cellulose and pyrrolidone sodium carboxylate are added in the distilled water of surplus, are stirred, and after standing 37 hours, are put into sealing container In, after being aged 6 weeks, you can.
- 4. the preparation method for perfume of calming the nerves described in claim 3, it is characterised in that：The second step further comprises,2.1st step, sweet osmanthus and night fragrant flower are respectively crushed into coarse powder, mix, using carbon dioxide supercritical extraction, extraction 33~35MPa of pressure, 40~43 DEG C, 110~130min of extraction time of extraction temperature, collect the first essential oil；2.2nd step, ginkgo leaf, rhizoma Gastrodiae, cloud vanilla are respectively crushed into coarse powder, mixed, extracted using CO 2 supercritical Take, 22~25MPa of extracting pressure, 28~32 DEG C, extraction time 160-180min of extraction temperature, collect the second essential oil；2.3rd step, agalloch eaglewood, bean cotyledon perfume, the coptis, the red sage root are ground into coarse powder, using carbon dioxide supercritical extraction, extracting pressure 26 ~30MPa, 45~48 DEG C, 180~200min of extraction time of extraction temperature, collect the 3rd essential oil；2.4th step, remaining components are respectively crushed into coarse powder, mixed, using carbon dioxide supercritical extraction, extraction pressure 24~27MPa of power, 51~54 DEG C, 200~220min of extraction time of extraction temperature, collect the 4th essential oil；2.5th step, above-mentioned essential oil is mixed, it is standby.
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| CN113181414A (en) * | 2021-01-25 | 2021-07-30 | 福建路合环保科技有限公司 | Natural odor-expelling agent and preparation method and application thereof |
| CN113082184A (en) * | 2021-04-08 | 2021-07-09 | 安徽宝华药业有限公司 | Traditional Chinese medicine composition for resisting cancer and preparation method thereof |
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| CN101129316A (en) * | 2007-08-30 | 2008-02-27 | 中国热带农业科学院热带生物技术研究所 | Ligaloes perfumes and method of producing the same |
| CN101396563A (en) * | 2008-11-06 | 2009-04-01 | 中国药科大学 | Chitose derivates using octreotide as target ligand and use thereof in medicament |
| CN103622866A (en) * | 2013-06-30 | 2014-03-12 | 金玛瑙香水（明光）有限公司 | Perfume capable of whitening and preparation method thereof |
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| CN101129316A (en) * | 2007-08-30 | 2008-02-27 | 中国热带农业科学院热带生物技术研究所 | Ligaloes perfumes and method of producing the same |
| CN101396563A (en) * | 2008-11-06 | 2009-04-01 | 中国药科大学 | Chitose derivates using octreotide as target ligand and use thereof in medicament |
| CN103622866A (en) * | 2013-06-30 | 2014-03-12 | 金玛瑙香水（明光）有限公司 | Perfume capable of whitening and preparation method thereof |
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Denomination of invention: Nerve soothing perfume Effective date of registration: 20181228 Granted publication date: 20180209 Pledgee: Mingguang Company limited by guarantee financing Pledgor: GOLD ONYX PERFUME (MINGGUANG) Co.,Ltd. Registration number: 2018340000773 |
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Date of cancellation: 20200109 Granted publication date: 20180209 Pledgee: Mingguang Company limited by guarantee financing Pledgor: GOLD ONYX PERFUME (MINGGUANG) Co.,Ltd. Registration number: 2018340000773 |
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Denomination of invention: Soothing perfume Effective date of registration: 20231201 Granted publication date: 20180209 Pledgee: Mingguang Company limited by guarantee financing Pledgor: GOLD ONYX PERFUME (MINGGUANG) Co.,Ltd. Registration number: Y2023980068976 |