CN109790145A - 二氢嘧啶类化合物及其制备方法和用途 - Google Patents

二氢嘧啶类化合物及其制备方法和用途 Download PDF

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CN109790145A
CN109790145A CN201780057446.XA CN201780057446A CN109790145A CN 109790145 A CN109790145 A CN 109790145A CN 201780057446 A CN201780057446 A CN 201780057446A CN 109790145 A CN109790145 A CN 109790145A
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compound
alkyl
cooh
ester
pharmaceutically acceptable
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CN109790145B (zh
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宋帅
蔡家强
田强
曾宏
宋宏梅
邓汉文
唐祖建
段小凡
龙蓉蓉
刘瑶
王利春
王晶翼
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Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/12—Antivirals
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    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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Abstract

本发明涉及具有抗病毒活性的二氢嘧啶类化合物、包含其的药物组合物、其制备方法及其在预防或治疗包括但不限于甲型病毒性肝炎、乙型病毒性肝炎、丙型病毒性肝炎、流行性感冒、疱疹和获得性免疫缺陷综合征(AIDS)的病毒性疾病中的用途。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN201780057446.XA 2016-11-18 2017-11-09 二氢嘧啶类化合物及其制备方法和用途 Active CN109790145B (zh)

Applications Claiming Priority (5)

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CN201611015150 2016-11-18
CN2016110151505 2016-11-18
CN201710328659 2017-05-11
CN2017103286593 2017-05-11
PCT/CN2017/110123 WO2018090862A1 (zh) 2016-11-18 2017-11-09 二氢嘧啶类化合物及其制备方法和用途

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EP (1) EP3508483B1 (zh)
JP (1) JP7139568B2 (zh)
KR (1) KR102496508B1 (zh)
CN (1) CN109790145B (zh)
AU (1) AU2017359773B2 (zh)
BR (1) BR112019005205A2 (zh)
CA (1) CA3037218A1 (zh)
ES (1) ES2901401T3 (zh)
IL (1) IL266345A (zh)
MX (1) MX2019005119A (zh)
MY (1) MY194471A (zh)
PH (1) PH12019550039A1 (zh)
PL (1) PL3508483T3 (zh)
SG (1) SG10202010180YA (zh)
WO (1) WO2018090862A1 (zh)

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CN112575389A (zh) * 2019-09-30 2021-03-30 成都先导药物开发股份有限公司 一种dna编码化合物库的液相色谱纯化方法
WO2022166923A1 (zh) 2021-02-05 2022-08-11 和博医药有限公司 苯基二氢嘧啶类化合物及其应用

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CN108329308B (zh) * 2018-05-16 2022-11-01 四川科伦博泰生物医药股份有限公司 一种二氢嘧啶类化合物的固体形式及其制备方法
WO2020255015A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
CN114853761A (zh) * 2021-02-05 2022-08-05 刘沛 一种含有二氢嘧啶的双功能衍生物及其用途
CN113512035B (zh) * 2021-04-26 2023-11-24 山东大学 二氢嘧啶-泊马度胺缀合物及其制备方法与应用

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CN103664899A (zh) * 2012-09-11 2014-03-26 广东东阳光药业有限公司 杂芳基取代的二氢嘧啶类化合物及其在药物中的应用
CN104650068A (zh) * 2013-11-19 2015-05-27 广东东阳光药业有限公司 二氢嘧啶类化合物及其在药物中的应用
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Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN112575389A (zh) * 2019-09-30 2021-03-30 成都先导药物开发股份有限公司 一种dna编码化合物库的液相色谱纯化方法
CN112575389B (zh) * 2019-09-30 2023-09-19 成都先导药物开发股份有限公司 一种dna编码化合物库的液相色谱纯化方法
WO2022166923A1 (zh) 2021-02-05 2022-08-11 和博医药有限公司 苯基二氢嘧啶类化合物及其应用

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EP3508483A4 (en) 2020-04-15
US10696669B2 (en) 2020-06-30
AU2017359773B2 (en) 2021-05-20
JP2019535644A (ja) 2019-12-12
CA3037218A1 (en) 2018-05-24
PL3508483T3 (pl) 2022-02-07
AU2017359773A1 (en) 2019-04-11
PH12019550039A1 (en) 2019-11-25
IL266345A (en) 2019-06-30
MY194471A (en) 2022-11-30
US20190225603A1 (en) 2019-07-25
KR102496508B1 (ko) 2023-02-03
EP3508483A1 (en) 2019-07-10
BR112019005205A2 (pt) 2019-06-11
WO2018090862A1 (zh) 2018-05-24
SG10202010180YA (en) 2020-11-27
KR20190077312A (ko) 2019-07-03
CN109790145B (zh) 2020-09-22
MX2019005119A (es) 2019-06-20
ES2901401T3 (es) 2022-03-22
EP3508483B1 (en) 2021-10-06
JP7139568B2 (ja) 2022-09-21

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