CN1095847C - 新的17,20-环氧孕甾烷衍生物 - Google Patents
新的17,20-环氧孕甾烷衍生物 Download PDFInfo
- Publication number
- CN1095847C CN1095847C CN97122440A CN97122440A CN1095847C CN 1095847 C CN1095847 C CN 1095847C CN 97122440 A CN97122440 A CN 97122440A CN 97122440 A CN97122440 A CN 97122440A CN 1095847 C CN1095847 C CN 1095847C
- Authority
- CN
- China
- Prior art keywords
- compound
- ketone
- alkene
- formula
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
- C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Epoxy Resins (AREA)
Abstract
Description
Claims (1)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9300290A FR2700339B1 (fr) | 1993-01-14 | 1993-01-14 | Nouveaux dérivés 17,20-époxydes du pregnane, leur préparation, leur application à la préparation de dérivés cortisoniques et intermédiaires. |
FR9300290 | 1993-01-14 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN94100614A Division CN1057304C (zh) | 1993-01-14 | 1994-01-13 | 17,20-环氧孕甾烷衍生物及其制法和用于制备可的松衍生物及其中间体 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1182092A CN1182092A (zh) | 1998-05-20 |
CN1095847C true CN1095847C (zh) | 2002-12-11 |
Family
ID=9443017
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN94100614A Expired - Lifetime CN1057304C (zh) | 1993-01-14 | 1994-01-13 | 17,20-环氧孕甾烷衍生物及其制法和用于制备可的松衍生物及其中间体 |
CN97122440A Expired - Lifetime CN1095847C (zh) | 1993-01-14 | 1997-11-05 | 新的17,20-环氧孕甾烷衍生物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN94100614A Expired - Lifetime CN1057304C (zh) | 1993-01-14 | 1994-01-13 | 17,20-环氧孕甾烷衍生物及其制法和用于制备可的松衍生物及其中间体 |
Country Status (18)
Country | Link |
---|---|
US (2) | US5504203A (zh) |
EP (1) | EP0607088B1 (zh) |
JP (1) | JP3356525B2 (zh) |
KR (1) | KR100312268B1 (zh) |
CN (2) | CN1057304C (zh) |
AT (1) | ATE151435T1 (zh) |
AU (1) | AU667413B2 (zh) |
CA (1) | CA2113404C (zh) |
DE (1) | DE69402441T2 (zh) |
DK (1) | DK0607088T3 (zh) |
ES (1) | ES2100023T3 (zh) |
FR (1) | FR2700339B1 (zh) |
GR (1) | GR3023106T3 (zh) |
HU (1) | HU217632B (zh) |
PL (1) | PL181805B1 (zh) |
RU (1) | RU2125060C1 (zh) |
UA (1) | UA40574C2 (zh) |
YU (1) | YU49025B (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2724174B1 (fr) * | 1994-09-06 | 1997-01-17 | Roussel Uclaf | Procede de preparation d'un derive steroide 17beta-carboxy et nouveaux intermediaires |
EP1079859B1 (en) | 1998-05-22 | 2010-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Crを含むタンパク質に対して特異的な受容体−結合タンパク質(rap)変異体を含む組成物およびその使用 |
DK2398500T3 (da) | 2009-02-20 | 2019-05-13 | 2 Bbb Medicines B V | Glutathion-baseret lægemiddelafgivelsessystem |
ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
US9554418B1 (en) | 2013-02-28 | 2017-01-24 | F5 Networks, Inc. | Device for topology hiding of a visited network |
CN107663171A (zh) * | 2017-10-10 | 2018-02-06 | 常州市阳光药业有限公司 | 高纯度托伐普坦的制备方法 |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3118882A (en) * | 1961-02-16 | 1964-01-21 | American Home Prod | Preparation of 17alpha-fluoroprogesterone and intermediates therein |
US3285940A (en) * | 1959-06-04 | 1966-11-15 | Merck & Co Inc | 16-methyl-delta-1, 4, 16-pregnatriene-3, 20-dione compounds |
US3378574A (en) * | 1966-03-30 | 1968-04-16 | Merck & Co Inc | Process of hydrolyzing 16beta-alkyl-16alpha, 17alpha-oxido-11, 20 bis-oxygenated-1, 4-pregnadiene-3, 20-diones |
US3419582A (en) * | 1965-08-23 | 1968-12-31 | Warner Lambert Pharmaceutical | Pentacyclic steroids and process |
US3960842A (en) * | 1973-07-14 | 1976-06-01 | Schering Aktiengesellschaft | Process for the preparation of 17β-oxalyl steroids |
US4110326A (en) * | 1975-07-15 | 1978-08-29 | Richter Gedeon Vegyeszeti Gyar Rt | Acylated diepoxy-androstane and a process for the preparation thereof |
US4257948A (en) * | 1978-04-19 | 1981-03-24 | Roussel Uclaf | Novel epoxidation agent and process |
US4600538A (en) * | 1984-08-02 | 1986-07-15 | The Upjohn Company | Corticosteroids from 17-keto steroids via 20-cyano-Δ17 (20)-pregnanes |
EP0515264A2 (fr) * | 1991-05-23 | 1992-11-25 | Roussel Uclaf | Nouveaux dérivés stéroides du pregna-4,9(11),17(20)-triène-3-one, leur préparation, leur préparation, leur application à la préparation de composés stéroides de type pregna-4,9(11),16-trièn-3,20-dione et nouveaux intermédiaires |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2123217A (en) * | 1937-07-15 | 1938-07-12 | Merck & Co Inc | Process for the production of hormones |
US2541439A (en) * | 1949-02-18 | 1951-02-13 | Merck & Co Inc | Osmate esters of 20-cyanopregnanes and process |
US2648688A (en) * | 1950-12-23 | 1953-08-11 | Merck & Co Inc | Process for peparing 21-alkyl ethers of cortisone |
US2813860A (en) * | 1954-12-31 | 1957-11-19 | Upjohn Co | Steroids |
US2744108A (en) * | 1955-01-13 | 1956-05-01 | Searle & Co | 3-ethylene mercaptoles of 11-oxygenated derivatives of 17, 21-dihydroxy-4-pregnene-3, 20-diones |
US3234246A (en) * | 1955-01-14 | 1966-02-08 | Merck & Co Inc | delta1-3, 11, 20-triketo-17alpha-hydroxy-21-lower alkanoyloxy-4-bromo-pregnene |
US2844600A (en) * | 1955-10-10 | 1958-07-22 | Upjohn Co | 22-cyanohydrins of bis-nor cholen-al compounds |
US3074979A (en) * | 1961-05-08 | 1963-01-22 | Merck & Co Inc | 3-mono-oxime derivatives of c-4 unsaturated steroids |
DE2330581A1 (de) * | 1973-06-15 | 1975-01-16 | Warner Lambert Co | Steroidyloestratriene, ihre verwendung und verfahren zur herstellung derselben |
FR2691968B1 (fr) * | 1992-06-04 | 1994-07-29 | Roussel Uclaf | Nouveau procede de preparation d'un derive sterouide 11-ceto. |
-
1993
- 1993-01-14 FR FR9300290A patent/FR2700339B1/fr not_active Expired - Fee Related
- 1993-12-29 YU YU82293A patent/YU49025B/sh unknown
-
1994
- 1994-01-12 UA UA94005054A patent/UA40574C2/uk unknown
- 1994-01-12 PL PL94301862A patent/PL181805B1/pl unknown
- 1994-01-13 KR KR1019940000454A patent/KR100312268B1/ko not_active IP Right Cessation
- 1994-01-13 AU AU53161/94A patent/AU667413B2/en not_active Expired
- 1994-01-13 JP JP01411294A patent/JP3356525B2/ja not_active Expired - Lifetime
- 1994-01-13 AT AT94400082T patent/ATE151435T1/de active
- 1994-01-13 RU RU94000724A patent/RU2125060C1/ru active
- 1994-01-13 ES ES94400082T patent/ES2100023T3/es not_active Expired - Lifetime
- 1994-01-13 HU HU9400094A patent/HU217632B/hu unknown
- 1994-01-13 CN CN94100614A patent/CN1057304C/zh not_active Expired - Lifetime
- 1994-01-13 DE DE69402441T patent/DE69402441T2/de not_active Expired - Lifetime
- 1994-01-13 CA CA002113404A patent/CA2113404C/fr not_active Expired - Lifetime
- 1994-01-13 EP EP94400082A patent/EP0607088B1/fr not_active Expired - Lifetime
- 1994-01-13 DK DK94400082.7T patent/DK0607088T3/da active
-
1995
- 1995-03-09 US US08/401,426 patent/US5504203A/en not_active Expired - Lifetime
-
1997
- 1997-04-11 GR GR960402707T patent/GR3023106T3/el unknown
- 1997-10-08 US US08/946,970 patent/US5892028A/en not_active Expired - Lifetime
- 1997-11-05 CN CN97122440A patent/CN1095847C/zh not_active Expired - Lifetime
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3285940A (en) * | 1959-06-04 | 1966-11-15 | Merck & Co Inc | 16-methyl-delta-1, 4, 16-pregnatriene-3, 20-dione compounds |
US3118882A (en) * | 1961-02-16 | 1964-01-21 | American Home Prod | Preparation of 17alpha-fluoroprogesterone and intermediates therein |
US3419582A (en) * | 1965-08-23 | 1968-12-31 | Warner Lambert Pharmaceutical | Pentacyclic steroids and process |
US3378574A (en) * | 1966-03-30 | 1968-04-16 | Merck & Co Inc | Process of hydrolyzing 16beta-alkyl-16alpha, 17alpha-oxido-11, 20 bis-oxygenated-1, 4-pregnadiene-3, 20-diones |
US3960842A (en) * | 1973-07-14 | 1976-06-01 | Schering Aktiengesellschaft | Process for the preparation of 17β-oxalyl steroids |
US4110326A (en) * | 1975-07-15 | 1978-08-29 | Richter Gedeon Vegyeszeti Gyar Rt | Acylated diepoxy-androstane and a process for the preparation thereof |
US4257948A (en) * | 1978-04-19 | 1981-03-24 | Roussel Uclaf | Novel epoxidation agent and process |
US4600538A (en) * | 1984-08-02 | 1986-07-15 | The Upjohn Company | Corticosteroids from 17-keto steroids via 20-cyano-Δ17 (20)-pregnanes |
EP0515264A2 (fr) * | 1991-05-23 | 1992-11-25 | Roussel Uclaf | Nouveaux dérivés stéroides du pregna-4,9(11),17(20)-triène-3-one, leur préparation, leur préparation, leur application à la préparation de composés stéroides de type pregna-4,9(11),16-trièn-3,20-dione et nouveaux intermédiaires |
Also Published As
Publication number | Publication date |
---|---|
CA2113404C (fr) | 2004-10-19 |
CN1096790A (zh) | 1994-12-28 |
CN1182092A (zh) | 1998-05-20 |
FR2700339A1 (fr) | 1994-07-13 |
CA2113404A1 (fr) | 1994-07-15 |
KR940018395A (ko) | 1994-08-16 |
YU49025B (sh) | 2003-07-07 |
YU82293A (sh) | 1996-07-24 |
HU217632B (hu) | 2000-03-28 |
EP0607088B1 (fr) | 1997-04-09 |
RU2125060C1 (ru) | 1999-01-20 |
EP0607088A1 (fr) | 1994-07-20 |
JP3356525B2 (ja) | 2002-12-16 |
US5892028A (en) | 1999-04-06 |
PL181805B1 (pl) | 2001-09-28 |
KR100312268B1 (ko) | 2002-06-20 |
DK0607088T3 (da) | 1997-10-06 |
AU667413B2 (en) | 1996-03-21 |
HUT67551A (en) | 1995-04-28 |
US5504203A (en) | 1996-04-02 |
FR2700339B1 (fr) | 1995-03-03 |
DE69402441T2 (de) | 1997-10-30 |
ES2100023T3 (es) | 1997-06-01 |
PL301862A1 (en) | 1994-07-25 |
JPH06279486A (ja) | 1994-10-04 |
CN1057304C (zh) | 2000-10-11 |
UA40574C2 (uk) | 2001-08-15 |
HU9400094D0 (en) | 1994-05-30 |
ATE151435T1 (de) | 1997-04-15 |
GR3023106T3 (en) | 1997-07-30 |
AU5316194A (en) | 1994-07-21 |
DE69402441D1 (de) | 1997-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: VENTIS PHARMA S.A. Free format text: FORMER NAME OR ADDRESS: HOECHST MARION ROUSSEL INC. Owner name: HOECHST MARION ROUSSEL INC. Free format text: FORMER NAME OR ADDRESS: LUSUO ROUSSEL UCLAF CO., LTD. Owner name: LUSUO ROUSSEL UCLAF CO., LTD. Free format text: FORMER NAME OR ADDRESS: ROUSSEL-UCLAF |
|
CP03 | Change of name, title or address |
Address after: French Anthony Patentee after: AVENTIS PHARMA S.A. Address before: French AUX Patentee before: Hoechst Marion Roussel Address after: French Roman Patentee after: Roussel-Uclaf Address before: Paris France Patentee before: ROUSSEL UCLAF Address after: French AUX Patentee after: Hoechst Marion Roussel Address before: French Roman Patentee before: Roussel-Uclaf |
|
CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Expiration termination date: 20140113 Granted publication date: 20021211 |