CN109362222A - 选择性***受体降解物及其用途 - Google Patents
选择性***受体降解物及其用途 Download PDFInfo
- Publication number
- CN109362222A CN109362222A CN201780008535.5A CN201780008535A CN109362222A CN 109362222 A CN109362222 A CN 109362222A CN 201780008535 A CN201780008535 A CN 201780008535A CN 109362222 A CN109362222 A CN 109362222A
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- Prior art keywords
- substituted
- compound
- unsubstituted
- pharmaceutically acceptable
- acceptable salt
- Prior art date
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07—ORGANIC CHEMISTRY
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
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- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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Abstract
Description
Claims (53)
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CN108329311A (zh) * | 2017-01-11 | 2018-07-27 | 南京圣和药业股份有限公司 | 作为选择性***受体下调剂的三环类化合物及其应用 |
CN109311870A (zh) * | 2016-04-01 | 2019-02-05 | 芝诺罗耶尔蒂里程碑有限责任公司 | ***受体调节剂 |
WO2020238733A1 (zh) * | 2019-05-24 | 2020-12-03 | 浙江海正药业股份有限公司 | 丙烯酸类衍生物的晶型及其制备方法和用途 |
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CN113164467B (zh) * | 2018-12-24 | 2023-12-26 | 益方生物科技(上海)股份有限公司 | 选择性***受体降解剂的新型盐 |
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CN107428758A (zh) * | 2015-11-12 | 2017-12-01 | 浙江海正药业股份有限公司 | 丙烯酸类衍生物、其制备方法及其在医药上的用途 |
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US11065233B2 (en) | 2016-04-01 | 2021-07-20 | Recurium Ip Holdings, Llc | Estrogen receptor modulators |
US11065234B2 (en) | 2016-04-01 | 2021-07-20 | Recurium Ip Holdings, Llc | Estrogen receptor modulators |
CN109311870B (zh) * | 2016-04-01 | 2021-09-21 | 里科瑞尔姆Ip控股有限责任公司 | ***受体调节剂 |
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CN108329311B (zh) * | 2017-01-11 | 2022-02-22 | 南京圣和药业股份有限公司 | 作为选择性***受体下调剂的三环类化合物及其应用 |
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US11278532B2 (en) | 2019-08-06 | 2022-03-22 | Recurium Ip Holdings, Llc | Estrogen receptor modulators for treating mutants |
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CA3012078C (en) | 2024-01-30 |
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AU2017213614A1 (en) | 2018-08-09 |
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RU2018128318A (ru) | 2020-03-05 |
MX2018009496A (es) | 2018-12-11 |
EP3411034B1 (en) | 2020-11-25 |
BR112018015419A2 (pt) | 2018-12-18 |
US20210253592A1 (en) | 2021-08-19 |
JP2019504890A (ja) | 2019-02-21 |
KR102479822B1 (ko) | 2022-12-21 |
CA3012078A1 (en) | 2017-08-10 |
BR112018015419B1 (pt) | 2024-01-30 |
US11014936B2 (en) | 2021-05-25 |
IL260789B (en) | 2021-03-25 |
CN109362222B (zh) | 2021-03-19 |
US20240043442A1 (en) | 2024-02-08 |
EP3411034A4 (en) | 2019-08-28 |
CN113004273A (zh) | 2021-06-22 |
AU2017213614B2 (en) | 2022-09-01 |
US20200040001A1 (en) | 2020-02-06 |
ES2842579T3 (es) | 2021-07-14 |
ZA201805573B (en) | 2020-12-23 |
WO2017136688A1 (en) | 2017-08-10 |
RU2734501C2 (ru) | 2020-10-19 |
RU2018128318A3 (zh) | 2020-04-02 |
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