CN109311865A - 抗乙肝病毒的吡唑-噁唑烷酮类化合物 - Google Patents

抗乙肝病毒的吡唑-噁唑烷酮类化合物 Download PDF

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CN109311865A
CN109311865A CN201780035186.6A CN201780035186A CN109311865A CN 109311865 A CN109311865 A CN 109311865A CN 201780035186 A CN201780035186 A CN 201780035186A CN 109311865 A CN109311865 A CN 109311865A
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base
fluorophenyl
pyrazoles
bromophenyl
ketone
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CN109311865B (zh
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陈焕明
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Shanghai Zhimeng Biopharma Inc
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Shanghai Zhimeng Biopharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

本发明公开了一类具有抗乙肝病毒活性的吡唑‑噁唑烷酮化合物，其具有式(I)的结构，其中各变量如本文所定义。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN201780035186.6A 2016-04-06 2017-04-06 抗乙肝病毒的吡唑-噁唑烷酮类化合物 Active CN109311865B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016102104220 2016-04-06
CN201610210422 2016-04-06
PCT/CN2017/079552 WO2017173999A1 (zh) 2016-04-06 2017-04-06 抗乙肝病毒的吡唑-噁唑烷酮类化合物

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CN109311865A true CN109311865A (zh) 2019-02-05
CN109311865B CN109311865B (zh) 2021-08-31

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US (1) US10519145B2 (zh)
EP (1) EP3441389B1 (zh)
JP (1) JP6581745B2 (zh)
KR (1) KR102083818B1 (zh)
CN (1) CN109311865B (zh)
CY (1) CY1124671T1 (zh)
DK (1) DK3441389T3 (zh)
ES (1) ES2893208T3 (zh)
HR (1) HRP20211907T1 (zh)
LT (1) LT3441389T (zh)
PL (1) PL3441389T3 (zh)
PT (1) PT3441389T (zh)
RS (1) RS62597B1 (zh)
SI (1) SI3441389T1 (zh)
WO (1) WO2017173999A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023001298A1 (zh) * 2021-07-23 2023-01-26 上海挚盟医药科技有限公司 一种乙肝病毒核衣壳抑制剂的制备方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3138380A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel oxalyl piperazines active against the hepatitis b virus (hbv)
CA3138643A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indole-2-carboxamides active against the hepatitis b virus (hbv)
CU20210089A7 (es) 2019-04-30 2022-06-06 Aicuris Gmbh & Co Kg Compuestos derivados de fenil y piridil ureas activas contra el virus de la hepatitis b (vhb)
AU2020265392A1 (en) 2019-04-30 2021-12-23 Aicuris Gmbh & Co. Kg Novel indolizine-2-carboxamides active against the hepatitis B virus (HBV)
CN112574188B (zh) * 2019-09-29 2022-05-06 苏州爱科百发生物医药技术有限公司 一种吡唑类化合物及其应用
CN114685473A (zh) * 2020-12-25 2022-07-01 杭州百新生物医药科技有限公司 5-烷基-2-吡唑-恶唑烷-4-酮类衍生物及其用途
CN115677680A (zh) * 2021-07-23 2023-02-03 上海挚盟医药科技有限公司 式i化合物的晶型及其制备和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006033995A2 (en) * 2004-09-16 2006-03-30 Valeant Research And Development Thiazolidin-4-ones having anti-hepatitis b activity
WO2007014023A1 (en) * 2005-07-21 2007-02-01 Valeant Research & Development Thiazolidinones, oxazolidinones, and pyrrolidinones for hbv

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006033995A2 (en) * 2004-09-16 2006-03-30 Valeant Research And Development Thiazolidin-4-ones having anti-hepatitis b activity
WO2007014023A1 (en) * 2005-07-21 2007-02-01 Valeant Research & Development Thiazolidinones, oxazolidinones, and pyrrolidinones for hbv

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023001298A1 (zh) * 2021-07-23 2023-01-26 上海挚盟医药科技有限公司 一种乙肝病毒核衣壳抑制剂的制备方法

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ES2893208T3 (es) 2022-02-08
SI3441389T1 (sl) 2022-01-31
EP3441389A4 (en) 2019-09-04
JP6581745B2 (ja) 2019-09-25
CY1124671T1 (el) 2022-07-22
WO2017173999A1 (zh) 2017-10-12
PT3441389T (pt) 2021-11-11
LT3441389T (lt) 2021-10-11
JP2019513830A (ja) 2019-05-30
DK3441389T3 (da) 2021-11-08
EP3441389B1 (en) 2021-09-08
KR102083818B1 (ko) 2020-03-03
PL3441389T3 (pl) 2022-01-24
KR20180128953A (ko) 2018-12-04
US10519145B2 (en) 2019-12-31
HRP20211907T1 (hr) 2022-03-18
US20190152963A1 (en) 2019-05-23
EP3441389A1 (en) 2019-02-13
RS62597B1 (sr) 2021-12-31
CN109311865B (zh) 2021-08-31

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