CY1124671T1 - Ενωση πυραζολο-οξαζολιδινονης για αντι-ηπατιτιδας β ιο - Google Patents

Ενωση πυραζολο-οξαζολιδινονης για αντι-ηπατιτιδας β ιο

Info

Publication number
CY1124671T1
CY1124671T1 CY20211100903T CY211100903T CY1124671T1 CY 1124671 T1 CY1124671 T1 CY 1124671T1 CY 20211100903 T CY20211100903 T CY 20211100903T CY 211100903 T CY211100903 T CY 211100903T CY 1124671 T1 CY1124671 T1 CY 1124671T1
Authority
CY
Cyprus
Prior art keywords
pyrazole
hepatitis
bio
oxazolidinone compound
oxazolidinone
Prior art date
Application number
CY20211100903T
Other languages
English (en)
Inventor
Huanming Chen
Original Assignee
Shanghai Zhimeng Biopharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Zhimeng Biopharma, Inc. filed Critical Shanghai Zhimeng Biopharma, Inc.
Publication of CY1124671T1 publication Critical patent/CY1124671T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αποκάλυψε μία ένωση πυραζολο-οξαζολιδινόνης που έχει δραστικότητα κατά του ιού ηπατίτιδας Β, η οποία έχει τη σύνταξη του τύπου (I), όπου εκάστη μεταβλητή είναι όπως ορίζεται στο παρόν.
CY20211100903T 2016-04-06 2021-10-19 Ενωση πυραζολο-οξαζολιδινονης για αντι-ηπατιτιδας β ιο CY1124671T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610210422 2016-04-06
PCT/CN2017/079552 WO2017173999A1 (zh) 2016-04-06 2017-04-06 抗乙肝病毒的吡唑-噁唑烷酮类化合物

Publications (1)

Publication Number Publication Date
CY1124671T1 true CY1124671T1 (el) 2022-07-22

Family

ID=60000897

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100903T CY1124671T1 (el) 2016-04-06 2021-10-19 Ενωση πυραζολο-οξαζολιδινονης για αντι-ηπατιτιδας β ιο

Country Status (15)

Country Link
US (1) US10519145B2 (el)
EP (1) EP3441389B1 (el)
JP (1) JP6581745B2 (el)
KR (1) KR102083818B1 (el)
CN (1) CN109311865B (el)
CY (1) CY1124671T1 (el)
DK (1) DK3441389T3 (el)
ES (1) ES2893208T3 (el)
HR (1) HRP20211907T1 (el)
LT (1) LT3441389T (el)
PL (1) PL3441389T3 (el)
PT (1) PT3441389T (el)
RS (1) RS62597B1 (el)
SI (1) SI3441389T1 (el)
WO (1) WO2017173999A1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3962909B1 (en) 2019-04-30 2023-10-04 AiCuris GmbH & Co. KG Novel oxalyl piperazines active against the hepatitis b virus (hbv)
JP2022531199A (ja) 2019-04-30 2022-07-06 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト Ｂ型肝炎ウイルス（ｈｂｖ）に対し活性な新規のフェニル及びピリジル尿素
WO2020221826A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indole-2-carboxamides active against the hepatitis b virus (hbv)
SG11202111198QA (en) 2019-04-30 2021-11-29 Aicuris Gmbh & Co Kg Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv)
CN112574188B (zh) * 2019-09-29 2022-05-06 苏州爱科百发生物医药技术有限公司 一种吡唑类化合物及其应用
CN114685473A (zh) * 2020-12-25 2022-07-01 杭州百新生物医药科技有限公司 5-烷基-2-吡唑-恶唑烷-4-酮类衍生物及其用途
CN115677680A (zh) * 2021-07-23 2023-02-03 上海挚盟医药科技有限公司 式i化合物的晶型及其制备和应用
CN115677681A (zh) * 2021-07-23 2023-02-03 上海挚盟医药科技有限公司 一种乙肝病毒核衣壳抑制剂的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006033995A2 (en) * 2004-09-16 2006-03-30 Valeant Research And Development Thiazolidin-4-ones having anti-hepatitis b activity
WO2007014023A1 (en) * 2005-07-21 2007-02-01 Valeant Research & Development Thiazolidinones, oxazolidinones, and pyrrolidinones for hbv

Also Published As

Publication number Publication date
DK3441389T3 (da) 2021-11-08
WO2017173999A1 (zh) 2017-10-12
JP2019513830A (ja) 2019-05-30
ES2893208T3 (es) 2022-02-08
JP6581745B2 (ja) 2019-09-25
SI3441389T1 (sl) 2022-01-31
EP3441389B1 (en) 2021-09-08
LT3441389T (lt) 2021-10-11
EP3441389A4 (en) 2019-09-04
HRP20211907T1 (hr) 2022-03-18
US10519145B2 (en) 2019-12-31
US20190152963A1 (en) 2019-05-23
CN109311865A (zh) 2019-02-05
EP3441389A1 (en) 2019-02-13
RS62597B1 (sr) 2021-12-31
PL3441389T3 (pl) 2022-01-24
KR102083818B1 (ko) 2020-03-03
PT3441389T (pt) 2021-11-11
KR20180128953A (ko) 2018-12-04
CN109311865B (zh) 2021-08-31

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