CN108704040A - A kind of Chinese medicine composition and its application - Google Patents

A kind of Chinese medicine composition and its application Download PDF

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Publication number
CN108704040A
CN108704040A CN201810965365.6A CN201810965365A CN108704040A CN 108704040 A CN108704040 A CN 108704040A CN 201810965365 A CN201810965365 A CN 201810965365A CN 108704040 A CN108704040 A CN 108704040A
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parts
radix
root
radix paeoniae
honeysuckle
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CN108704040B (en
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苏效强
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Shandong Xiaoqiang Beauty Service Co Ltd
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Shandong Xiaoqiang Beauty Service Co Ltd
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/076Poria
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
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    • A61K36/88Liliopsida (monocotyledons)
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    • A61K36/894Dioscoreaceae (Yam family)
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
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    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The present invention provides a kind of Chinese medicine composition and its application, the composition includes following component in parts by weight:18-22 parts of 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of Radix Astragali, 33-38 parts of Radix Isatidis, 23-28 parts of raw hawthorn, 23-28 parts of Radix Salviae Miltiorrhizae, 23-28 parts of safflower, 23-28 parts of radix paeoniae rubra, 23-28 parts of Radix Notoginseng powder, 23-28 parts of bush, 23-28 parts of Sargent gloryvine, 18-22 parts of PORIA ALBA, 18-22 parts of Chinese yam rhizome, 18-22 parts of Radix Paeoniae Alba and the root of Dahurain angelica;The present invention is by science selection, and reasonably combined, Optimized Extraction Process, each step of each component is synergistic, finally obtains the product for resolving poxes with remarkable anti-acne effect, has broad application prospects and huge market value.

Description

A kind of Chinese medicine composition and its application
Technical field
The present invention relates to the field of Chinese medicines, it is related to a kind of Chinese medicine composition and its application.
Background technology
Loving beauty is part of human nature, with the improvement of living standards, people's demands for quality of life are getting higher and higher, more More pay attention to U.S. of skin, acne is a kind of chronic inflammatory conditions skin being metabolized related hair follicle, pilo-sebaceous unit with sebum Skin disease is more common in face, chest and back isocortex point modern medicine believes that, small pox is the inertia Lymph nodes of hair follicle, sebaceous glands Vigorous position is secreted, since acne is apt to occur in puberty, also commonly known as " whelk ", but due to oneself mistake of later stage patient Extruding, in addition after the irregular treatment in beauty parlor there are acne print, scar, local skin recess, skin color is in purplish red, secretly Red is not cured for a long time, and patient is very worried;
Although there are many anti-acne class Western medicine for being directed to acne on the market at present, essentially antibiotic, hormone etc., such as gram Woods mycin, vitamin A acid, ranitidine, first nitre file etc., most product side effects are big, easy to produce pharmacological dependence.Therefore many patients Seek the treatment of Chinese medicine, tcm therapy curative effect than more significant, but on the market treatment small pox tcm product be all mostly ointment, The product of face mask of traditional Chinese medicine etc, almost without the product of liquid, CN106667852A discloses a kind of Chinese medicine acne eliminating cream and its preparation Method, the Chinese medicine acne eliminating cream include base oil, emulsifier, thickener, polyalcohols moisturizer, hyaluronic acid, preservative, in Medicament extracting solution A, Chinese medicine extract B and water, the Chinese medicine extract A are made by Chinese medicine is extracted, and the Chinese medicine includes Radix Notoginseng, red Flower, the coptis, radix scutellariae and Cortex Phellodendri.CN105395717A discloses a kind of anti-acne and disappears the Chinese medicine Whelk-eliminating paste of acne print, is by following raw material Be prepared, by weight, the raw material include 5-10 parts of scutellaria, 5-10 parts of Poria cocos, 5-10 parts of kuh-seng, 5-10 parts of coptis root, 5-10 parts of Chinese violet, 1-5 parts of Salvia japonica, 1-5 parts of honeysuckle.CN108079270A discloses a kind of anti acne of traditional Chinese medicine composition, described Anti acne of traditional Chinese medicine composition by following parts by weight component extracting solution, add ecological nutrient liquid compatibility and form:Radix scutellariae 20-50 Part, 15-40 parts of rheum officinale, 8-30 parts of kuh-seng, 5-25 parts of Chinese gall, 3-10 parts of Radix Glycyrrhizae, 0-5 parts of rhizoma zingiberis, described in which also provides The preparation method of anti acne of traditional Chinese medicine composition, including ethyl alcohol heating and refluxing extraction, filtering, filtrate centrifugation, dissolving, membrane separation, The techniques such as ecological nutrient liquid are added.As these products have the drawbacks of continuing to block pore, preparation process complexity, and product effect Generally, make acne touching refractory, and seriously affect the physical and mental health of patient, it is impaired, awkward that patient is susceptible to self-esteem, self-confidence The social mentalities such as a word used for translation, depression, anxiety problem brings many worried and pain to patient mental, life and social activity.
In conclusion a kind of liquid product for resolving poxes with whitening of deoiling that will not block pore of research and development, in effectively removing The acne print of property and the long acne skin of oiliness, has broad application prospects and huge market value.
Invention content
In view of the deficiencies of the prior art and actual demand, the present invention provides a kind of Chinese medicine composition and its application, described The selected a variety of natural traditional Chinese medicines of Chinese medicine composition, progress is reasonably combined, and Optimized Extraction Process, each component is mutually promoted, synergistic, The effect of capable of realizing anti-inflammatory analgetic, promoting blood circulation and removing blood stasis, quick anti-acne.
For this purpose, the present invention uses following technical scheme:
In a first aspect, the present invention provides a kind of Chinese medicine composition, the composition includes following component in parts by weight:Toast 90-110 parts of Radix Glycyrrhizae, 30-40 parts of honeysuckle, 30-40 parts of purslane, 30-40 parts of Radix Astragali, 30-40 parts of Radix Isatidis, raw hawthorn 20- 30 parts, 20-30 parts of Radix Salviae Miltiorrhizae, 20-30 parts of safflower, 20-30 parts of radix paeoniae rubra, 20-30 parts of Radix Notoginseng powder, 20-30 parts of bush and Sargent gloryvine 20-30 parts.
In the present invention, inventor is by studying for a long period of time and verifying, selected a variety of natural traditional Chinese medicines, carries out reasonably combined, each group Divide and mutually promote, synergistic, Optimized Extraction Process adds and subtracts drug component and formula in clinical practice, and observation patient restores Situation finally determines optimal drug collocation, develops a kind of Chinese medicine acne-removing composition, the composition can realize anti-inflammatory analgetic, The effect of promoting blood circulation and removing blood stasis, quick anti-acne.
Wherein, the honey-fried licorice root is legume, is the Radix Glycyrrhizae baked with honey, is commonly called as processing, exactly sets honey in pot It is smelt middle honey, slow boiling is used instead and licorice piece is added to stir uniformly, 3-5min takes the dish out of the pot, and sets barn or when 60 DEG C of baking oven is dried to tack-free takes Go out, cool, honey-fried licorice root is similar round or oval section, and surface rufous or taupe brown, micro- glossy, section yellow is extremely Buff, cambium ring is apparent, ray irradiation shape.Zhigancao decoction has benefiting qi and nourishing yin, and activate yang multiple arteries and veins therapeutic efficiency.
The just entitled honeysuckle of the honeysuckle, " honeysuckle " one are come from《Compendium of Materia Medica》, it is white just to be opened due to honeysuckle flowers Color, after switch to yellow, hence obtain one's name honeysuckle.Honeysuckle be Caprifoliaceae woodbine honeysuckle and congener dry flower or The flower that band is just opened;Honeysuckle is known as clearing heat and detoxicating good medicine from ancient times.The sweet cold air fragrance of its property, clear heat with drugs of sweet flavour and cold nature is without injuring one's stomach, virtue It is fragrant thoroughly up to again can eliminating evil, honeysuckle can dispelling wind-heat, also kind removing summer-heat blood poison is used for various febrile diseases, such as body heat, dermexanthesis, hair The diseases such as spot, heat toxin sore carbuncle, abscess of throat, equal significant effect.
The purslane is annual herb, and complete stool is hairless, and stem lies down, and paving of throwing oneself on the ground dissipates, branch light green or with kermesinus.Leaf Alternate, blade is flat, plump, like dent shape, above dirty-green, below light green or with kermesinus;Petiole tubbiness.It spends without stalk, The period of the day from 11 a.m. to 1 p.m is in full bloom;Bract is lobate;Sepal green, helmet shape;Petal yellow, obovate;Stamen anther yellow;Ovary is hairless, capsule ovum It is spherical;Seed is tiny, and deflection is spherical, and dark brown is glossy.Chinese north and south various regions are produced, and property likes rich soil, drought-enduring also resistance to Flood, viability is strong, is born in vegetable garden, farmland, roadside, is field common weed, blazons whole world temperate zone and torrid areas.Herb supplies It is medicinal, there is clearing heat and promoting diuresis, removing toxicity for detumescence, anti-inflammatory, quench the thirst, diuresis;Seed improving eyesight;Veterinary drug and pesticide can also be made;Young stem and leaf It can make vegetables, sour and good feed.
The Radix Astragali is the root of legume astragalus mongolicus;Spring, autumn excavation, remove soil, fibrous root and root head, shine to six Seventy percent is dry, and reason is dried after directly lashing;Major function is:Invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis, myogenic.For treatment deficiency of vital energy weak, long Rush down the long disunion of rectal prolapse, spontaneous perspiration, oedema, sub-official prolapses, chronic rephrilis protinuria, diabetes, the open sore part.
The Radix Isatidis is a kind of Chinese medicine, bitter, is trembled with fear, and has the effect of clearing heat and detoxicating, cool blood relieving sore-throat.When being usually used in warm epidemic disease Poison, pharyngalgia of generating heat, febrile virulent maculae, mumps, scarlet fever, major part pestilence, erysipelas, carbuncle swells.
The raw hawthorn is stone fruit, and caryoplasm is hard, and pulp is thin, and taste is slightly sour puckery, and fruit is raw-eaten or makees preserved fruit fruitcake, is done It can be used as medicine after system, be the distinctive dual-purpose of drug and fruit seeds of China, have the effects that reducing blood lipid, blood pressure, cardiac stimulant, arrhythmia, together When be also spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting good medicine, the diseases such as, hernia, blood stasis full to chest diaphragm spleen, amenorrhoea have well Curative effect;Flavone compound Vitexin in hawthorn is a kind of stronger drug of antitumaous effect, and extract is to inhibiting internal cancer Cell growth, proliferation and infiltration metastasis have certain effect.
The Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Spring, the excavation of two season of autumn, remove silt, dry.Entirely The effect of state's most area is all distributed, and has promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness that clears away heart-fire, cool blood to disappear carbuncle, is used for the obstruction of qi in the chest heart Bitterly, gastral cavity abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea Amenorrhea, sore swell and ache curative.
The safflower is the drying column cap of irides safron, and there is cultivation on the ground such as existing Beijing, Shandong, Zhejiang, Sichuan Training has the effect of promoting blood circulation and removing blood stasis, removing pattogenic heat from the blood and toxic material from the body, resolving stagnation for tranquilization, is used for Amenorrhea abdominal mass, postpartum stasis, febrile virulent maculae, melancholy ruffian Bored, palpitation with fear is gone mad.
The radix paeoniae rubra is the dry root of ranunculaceae plant radix paeoniae rubra or river radix paeoniae rubra, and spring, the excavation of two season of autumn remove rhizome, palpus Root and silt, are dried, bitter, are slightly cold, return liver warp, and it is famous wild genuine Chinese medicine to have the effect of clearing heat and cooling blood, promoting blood circulation, radix paeoniae rubra Material, applicating history is long, and dosage is larger, widely used and demand is relatively stiff, there is a considerable amount of outlets every year.
The Radix Notoginseng powder is the rhizome product of plant Radix Notoginseng, is the powder broken into Radix Notoginseng main root, alias pseudo-ginseng powder, gold is not It changes;Warm-natured, sweet and slightly bitter taste enters liver, stomach, large intestine channel, there is title Radix Ginseng, southern Radix Notoginseng.Ginseng qi-tonifying first, Radix Notoginseng enrich blood first; The function of Radix Notoginseng originally can be used " hemostasis dissipates the stasis of blood, analgesic therapy " six words to summarize, so, it is always golden using Radix Notoginseng as traumatology Sore medicine, it is seldom edible as tonic.
The bush is the dry duramen of legume bush, is more than autumn, removes white sapwood, dry, distribution In TaiWan, China, Guangxi, Guangdong, Sichuan, Guizhou, Yunnan and other places, there is the effect of promoting blood circulation, swelling and pain relieving, be used for bruise Damage, the injury of tendon and muscle of fracturing, the stagnant swelling and pain of the stasis of blood, closed dysmenorrhea, postpartum stasis, chest and abdomen shouting pain, ulcer sore pain.
The Sargent gloryvine is the drying rattan of plants of Lardizabalaceae sargentodoxa cuneata.Autumn, the harvesting of two season of winter, remove side shoot, and intercept is done It is dry, be distributed in China Yellow River basin, the Qinling Mountains and on the south various regions, have clearing heat and detoxicating, promoting blood circulation, the effect of wind-expelling pain-stopping, be used for intestines Carbuncle abdominal pain, pathopyretic ulcer, Amenorrhea, dysmenorrhoea, tumbling and swelling, arthralgia pain due to rheumatism.
Preferably, the parts by weight of the honey-fried licorice root for example can be 90 parts, 93 parts, 95 parts, 97 parts, 99 parts, 100 parts, 103 parts, 105 parts, 107 parts or 110 parts, preferably 95-105 parts.
Preferably, the parts by weight of the honeysuckle for example can be 30 parts, 33 parts, 35 parts, 38 parts, 39 parts or 40 parts, Preferably 33-38 parts.
Preferably, the parts by weight of the purslane for example can be 30 parts, 33 parts, 35 parts, 38 parts, 39 parts or 40 parts, Preferably 33-38 parts.
Preferably, the parts by weight of the Radix Astragali for example can be 30 parts, 33 parts, 35 parts, 38 parts, 39 parts or 40 parts, excellent It is selected as 33-38 parts.
Preferably, the parts by weight of the Radix Isatidis for example can be 30 parts, 33 parts, 35 parts, 38 parts, 39 parts or 40 parts, Preferably 33-38 parts.
Preferably, the parts by weight of the raw hawthorn for example can be 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, Preferably 23-28 parts.
Preferably, the parts by weight of the Radix Salviae Miltiorrhizae for example can be 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, excellent It is selected as 23-28 parts.
Preferably, the parts by weight of the safflower for example can be 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, Preferably 23-28 parts.
Preferably, the parts by weight of the radix paeoniae rubra for example can be 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, excellent It is selected as 23-28 parts.
Preferably, the parts by weight of the Radix Notoginseng powder for example can be 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, Preferably 23-28 parts.
Preferably, the parts by weight of the bush for example can be 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, excellent It is selected as 23-28 parts.
Preferably, the parts by weight of the Sargent gloryvine for example can be 20 parts, 23 parts, 25 parts, 28 parts, 29 parts or 30 parts, excellent It is selected as 23-28 parts.
Preferably, the composition includes following component in parts by weight:95-105 parts of honey-fried licorice root, honeysuckle 33-38 Part, 33-38 parts of purslane, 33-38 parts of Radix Astragali, 33-38 parts of Radix Isatidis, 23-28 parts of raw hawthorn, 23-28 parts of Radix Salviae Miltiorrhizae, safflower 23-28 parts of 23-28 parts, 23-28 parts of radix paeoniae rubra, 23-28 parts of Radix Notoginseng powder, 23-28 parts of bush and Sargent gloryvine.
Preferably, the composition further includes 15-25 parts of PORIA ALBA, 15-25 parts of Chinese yam rhizome, Radix Paeoniae Alba 15- in parts by weight 25 parts and 15-25 parts of the root of Dahurain angelica.
Wherein, the PORIA ALBA is that medicinal material Poria cocos block cuts the white portion after poria cocos, usually the prepared slices of Chinese crude drugs, its work( Effect is very extensive, regardless of the four seasons, by it and various compatibility of drugs, no matter cold, temperature, wind, wet all diseases, can play its unique work( Effect.Poria cocos is sweet in flavor, light, mild-natured, is used as medicine with clearing damp and promoting diuresis, beneficial spleen and stomach, the function of antitoxic heart-soothing and sedative;Modern medicine study:Fu Siberian cocklebur can enhance body's immunity, and pachymaran has apparent antitumor and liver protecting effect, but cold of insufficiency type essence cunning or collapse from qi deficiency Person avoids clothes.
The Chinese yam rhizome is the stem tuber of Dioscoreaceae plant Chinese yam, and major function is:Invigorating the spleen, tonifying lung are reinforced the kidney, and strengthening the essence controls spleen Empty diarrhea, protracted dysentery, cough due to consumptive disease are quenched one's thirst, under seminal emission, band, frequent urination.Tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence of kidney tonifying are used for Spleen eating less, endless diarrhea, the deficiency syndrome of the lung breath with cough, under emission due to the kidney deficiency, band, frequent micturition, abnormal heat quench one's thirst.
Wherein, the Radix Paeoniae Alba is Ranunculaceae Radix Paeoniae Alba platymiscium, is the dry root of cohosh Chinese herbaceous peony, adopts in summer, two season of autumn It digs, cleans, remove end to end and radicula, set and boiled again after removing crust or peeling after being boiled in boiling water, dried, chief value is stopped for soothing the liver Bitterly, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, abdominal pain, four limbs contraction pain, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, Night sweat.
The root of Dahurain angelica is perennial tall and big draft, 1-2.5 meters high, and root is cylindrical, 2-5 centimetres of basal part of stem diameter, basal leaf one Return pinnation, universal umbel basidixed or side life, fruit oblong to oval;It is used as medicine with root, the dehumidifying that gets rid of illness, apocenosis life The functions such as flesh, promoting blood circulation and stopping pain;Cure mainly anemofrigid cold, headache, rhinitis, toothache.The diseases such as leukorrhea with reddish discharge, pain furuncle poison, can also make perfume (or spice) Material, there are cultivation in some northern provinces and regions, market one's own products more, and minority is adjusted outside the province, be generally born in hayashishita, border, by small stream, shrubbery and mountain Millet straw.
Preferably, the parts by weight of the PORIA ALBA for example can be 15 parts, 18 parts, 20 parts, 22 parts or 25 parts, preferably It is 18-22 parts.
Preferably, the parts by weight of the Chinese yam rhizome for example can be 15 parts, 18 parts, 20 parts, 22 parts or 25 parts, preferably It is 18-22 parts.
Preferably, the parts by weight of the Radix Paeoniae Alba for example can be 15 parts, 18 parts, 20 parts, 22 parts or 25 parts, preferably 18-22 parts.
Preferably, the parts by weight of the root of Dahurain angelica for example can be 15 parts, 18 parts, 20 parts, 22 parts or 25 parts, preferably 18-22 parts.
Preferably, the composition further includes 18-22 parts of PORIA ALBA, 18-22 parts of Chinese yam rhizome, Radix Paeoniae Alba 18- in parts by weight 22 parts and 18-22 parts of the root of Dahurain angelica.
Preferably, the composition includes following component in parts by weight:95-105 parts of honey-fried licorice root, honeysuckle 33-38 Part, 33-38 parts of purslane, 33-38 parts of Radix Astragali, 33-38 parts of Radix Isatidis, 23-28 parts of raw hawthorn, 23-28 parts of Radix Salviae Miltiorrhizae, safflower 23-28 parts, 23-28 parts of radix paeoniae rubra, 23-28 parts of Radix Notoginseng powder, 23-28 parts of bush, 23-28 parts of Sargent gloryvine, 18-22 parts of PORIA ALBA, Chinese yam 18-22 parts of 18-22 parts of medicine, 18-22 parts of Radix Paeoniae Alba and the root of Dahurain angelica.
Second aspect, the present invention provide the application that a kind of composition as described in relation to the first aspect is used to prepare product for resolving poxes.
Preferably, the product for resolving poxes includes drug and/or cosmetics.
Preferably, the cosmetics include cleansing cream, facial cleanser, face cream, soothing oil, essential oils, Cleansing Foam or clarifying lotion In any one or at least two combination.
Preferably, the dosage form of the product for resolving poxes is liquor.
The product for resolving poxes of the liquor is not easy to plug pore, further promotes grease discharge, enhances anti-acne effect.
The third aspect, the present invention provide a kind of method preparing product for resolving poxes, include the following steps:
(1) honey-fried licorice root, honeysuckle, Herba portulacae, Radix Astragali, Radix Isatidis, raw hawthorn, Radix Salviae Miltiorrhizae, safflower, red is weighed in proportion Chinese herbaceous peony, Radix Notoginseng powder, bush, Sargent gloryvine, PORIA ALBA, Chinese yam rhizome, Radix Paeoniae Alba and the root of Dahurain angelica, are mixed to get raw mixture;
(2) extractant is added in the raw mixture obtained to step (1) to be impregnated and filtered, obtains leachate;
(3) appropriate moisturizer is added in the leachate for obtaining step (2), obtains the product for resolving poxes.
Preferably, step (1) described ratio is:95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of Radix Astragali, 33-38 parts of Radix Isatidis, 23-28 parts of raw hawthorn, 23-28 parts of Radix Salviae Miltiorrhizae, 23-28 parts of safflower, radix paeoniae rubra 23-28 Part, 23-28 parts of Radix Notoginseng powder, 23-28 parts of bush, 23-28 parts of Sargent gloryvine, 18-22 parts of PORIA ALBA, 18-22 parts of Chinese yam rhizome, Radix Paeoniae Alba 18- 22 parts and 18-22 parts of the root of Dahurain angelica;
Preferably, described (2) extractant is organic solvent, and preferably ethanol solution, further preferably volume is dense Degree is the ethanol solution of 70-80%.
Preferably, the volumetric concentration of the ethanol solution for example can be 70%, 73%, 75%, 77%, 79% or 80%.
Preferably, the time of step (2) described immersion be 60-80h, such as can be 60h, 65h, 68h, 70h, 72h, 75h, 78h or 80h.
Preferably, any one in step (3) the moisturizer including collagen, hyaluronic acid or glycerine or at least Two kinds of combination, preferably glycerine.
As optimal technical scheme, a method of product for resolving poxes is prepared, is specifically comprised the following steps:
(1) 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, Radix Astragali 33-38 are weighed in parts by weight Part, 33-38 parts of Radix Isatidis, 23-28 parts of raw hawthorn, 23-28 parts of Radix Salviae Miltiorrhizae, 23-28 parts of safflower, 23-28 parts of radix paeoniae rubra, Radix Notoginseng powder 23-28 parts, 23-28 parts of bush, 23-28 parts of Sargent gloryvine, 18-22 parts of PORIA ALBA, 18-22 parts of Chinese yam rhizome, 18-22 parts of Radix Paeoniae Alba and white 18-22 parts of the root of Dahurian angelica, is mixed to get raw mixture;
(2) ethanol solution that volumetric concentration is 70-80% is added in the raw mixture obtained to step (1) to be impregnated Then 70-80h is filtered, obtain leachate;
(3) qs glycerin is added in the leachate for obtaining step (2), obtains the product for resolving poxes.
Compared with prior art, the present invention has the advantages that:
Chinese medicine composition selection science provided by the invention, formula is reasonable, and preparation process is succinctly efficient, and what is be prepared dispels There is acne product anti-inflammatory analgetic, promoting blood circulation and removing blood stasis, quick anti-acne prints, deoil, whitening effect, be particularly suitable for neutral and oiliness The skin of long small pox, the treatment rate counted to get according to skin lesion is quick more than 90%, does not stimulate skin, does not stay pigment deposition And acne print, it has broad application prospects and huge market value.
Description of the drawings
Fig. 1 is patient facial region's figure before the treatment of the present invention;
Fig. 2 is patient facial region's figure after the treatment of the present invention.
Specific implementation mode
Further to illustrate the technological means and its effect of the invention taken, below in conjunction with attached drawing and by specific real The technical solution for applying mode to further illustrate the present invention, but the present invention is not limited in scope of embodiments.
Embodiment 1
(1) honey-fried licorice root 100g, honeysuckle 35g, purslane 35g, Radix Astragali 35g, Radix Isatidis 35g, life are weighed in parts by weight Hawthorn 25g, Radix Salviae Miltiorrhizae 25g, safflower 25g, radix paeoniae rubra 25g, Radix Notoginseng powder 25g, bush 25g, Sargent gloryvine 25g, PORIA ALBA 20g, Chinese yam rhizome 20g, Radix Paeoniae Alba 20g and root of Dahurain angelica 20g, are mixed to get raw mixture;
(2) ethanol solution that volumetric concentration is 75% is added in the raw mixture obtained to step (1) to be impregnated Then 72h is filtered, obtain leachate;
(3) 100 milliliters of glycerine are added in the leachate for obtaining step (2), obtain the product for resolving poxes.
Embodiment 2
(1) honey-fried licorice root 90g, honeysuckle 30g, purslane 30g, Radix Astragali 30g, Radix Isatidis 30g, raw mountain are weighed in parts by weight Short, bristly hair or beard 20g, Radix Salviae Miltiorrhizae 20g, safflower 20g, radix paeoniae rubra 20g, Radix Notoginseng powder 20g, bush 20g, Sargent gloryvine 20g, PORIA ALBA 15g, Chinese yam rhizome 15g, Radix Paeoniae Alba 15g and root of Dahurain angelica 15g, are mixed to get raw mixture;
(2) ethanol solution that volumetric concentration is 70% is added in the raw mixture obtained to step (1) to be impregnated Then 70h is filtered, obtain leachate;
(3) 80 milliliters of glycerine are added in the leachate for obtaining step (2), obtain the product for resolving poxes.
Embodiment 3
(1) honey-fried licorice root 110g, honeysuckle 40g, purslane 40g, Radix Astragali 40g, Radix Isatidis 40g, life are weighed in parts by weight Hawthorn 30g, Radix Salviae Miltiorrhizae 30g, safflower 30g, radix paeoniae rubra 30g, Radix Notoginseng powder 30g, bush 30g, Sargent gloryvine 30g, PORIA ALBA 25g, Chinese yam rhizome 25g, Radix Paeoniae Alba 25g and root of Dahurain angelica 25g, are mixed to get raw mixture;
(2) ethanol solution that volumetric concentration is 80% is added in the raw mixture obtained to step (1) to be impregnated Then 80h is filtered, obtain leachate;
(3) 120 milliliters of glycerine are added in the leachate for obtaining step (2), obtain the product for resolving poxes.
Embodiment 4
(1) honey-fried licorice root 95g, honeysuckle 33g, purslane 33g, Radix Astragali 33g, Radix Isatidis 33g, raw mountain are weighed in parts by weight Short, bristly hair or beard 23g, Radix Salviae Miltiorrhizae 23g, safflower 23g, radix paeoniae rubra 23g, Radix Notoginseng powder 23g, 23 g of bush, Sargent gloryvine 23g, PORIA ALBA 18g, Chinese yam rhizome 18g, Radix Paeoniae Alba 18g and root of Dahurain angelica 18g, are mixed to get raw mixture;
(2) ethanol solution that volumetric concentration is 78% is added in the raw mixture obtained to step (1) to be impregnated Then 78h is filtered, obtain leachate;
(3) 100 milliliters of glycerine are added in the leachate for obtaining step (2), obtain the product for resolving poxes.
Embodiment 5
(1) honey-fried licorice root 105g, honeysuckle 38g, purslane 38g, Radix Astragali 38g, Radix Isatidis 38g, life are weighed in parts by weight Hawthorn 28g, Radix Salviae Miltiorrhizae 28g, safflower 28g, radix paeoniae rubra 28g, Radix Notoginseng powder 28g, bush 28g, Sargent gloryvine 28g, PORIA ALBA 22g, Chinese yam rhizome 22g, Radix Paeoniae Alba 22g and root of Dahurain angelica 22g, are mixed to get raw mixture;
(2) ethanol solution that volumetric concentration is 75% is added in the raw mixture obtained to step (1) to be impregnated Then 72h is filtered, obtain leachate;
(3) 100 milliliters of glycerine are added in the leachate for obtaining step (2), obtain the product for resolving poxes.
Comparative example 1
Compared with Example 1, in addition to not adding honey-fried licorice root, other conditions are same as Example 1.
Comparative example 2
Compared with Example 1, in addition to honey-fried licorice root additive amount is changed to 150g, other conditions are same as Example 1.
Comparative example 3
Compared with Example 1, other than not adding honeysuckle, Radix Astragali, Radix Isatidis and purslane, other conditions and embodiment 1 is identical.
Comparative example 4
Compared with Example 1, other than the additive amount of honeysuckle, Radix Astragali, Radix Isatidis and purslane is changed to 50g, other Condition is same as Example 1.
Comparative example 5
Compared with Example 1, other than not adding raw hawthorn, Radix Salviae Miltiorrhizae, safflower, radix paeoniae rubra, Radix Notoginseng powder, bush and Sargent gloryvine, Other conditions are same as Example 1.
Comparative example 6
Compared with Example 1, in addition to raw hawthorn, Radix Salviae Miltiorrhizae, safflower, radix paeoniae rubra, Radix Notoginseng powder, bush and the additive amount of Sargent gloryvine are equal It is changed to outside 40g, other conditions are same as Example 1.
Comparative example 7
Compared with Example 1, other than not adding PORIA ALBA, Chinese yam rhizome, Radix Paeoniae Alba and the root of Dahurain angelica, other conditions and embodiment 1 It is identical.
Comparative example 8
Compared with Example 1, other than the additive amount of PORIA ALBA, Chinese yam rhizome, Radix Paeoniae Alba and the root of Dahurain angelica is changed to 30g, other Part is same as Example 1.
Comparative example 9
Compared with Example 1, other than ethanol solution is changed to water, other conditions are same as Example 1.
Comparative example 10
Compared with Example 1, other than the time of immersion is changed to 50h, other conditions are same as Example 1.
Experiment detection:
Choose 150 experimental subjects, men and women is fifty-fifty, average age be 20-30 Sui, face have apparent papule, useless fellow and The long acne patient of middle severe skin of acne print is randomly divided into 15 groups, and every group of 10 people, the skin lesion before record experimental subjects treatment counts, Experimental method is the product for resolving poxes that experimental subjects uses embodiment and comparative example every night respectively, and service life is 4 weeks, is united after four weeks Skin lesion number is counted, according to the following formula calculating treatment rate=(preceding skin of (skin lesion counts after skin lesion counting-treatment before treatment)/treatment Damage counts × 100%, and the pigmentation and acne print situation of observation experiment subject face, the results are shown in Table 1;
Table 1
As shown in Table 1, embodiment 1-5 has brilliance according to the product for resolving poxes that technical solution provided by the invention is prepared Treatment rate, be all higher than 90%, and non-pigment is calm and acne print, wherein the effect of embodiment 1 is best, and treatment rate reaches 95.6%, and the formula of comparative example 1-8 technical solution not according to the invention, lack component or component addition excess, comparative example 9 Extraction process provided by the invention is not used with comparative example 10, the treatment rate for finally extracting obtained product for resolving poxes is decreased obviously, And there are pigmentation and acne print.
Antibiotics susceptibility test:
Subjects:Product for resolving poxes prepared by embodiment 1-5.
Tested crowd:50 people, men and women is fifty-fifty, and age 15-35 Sui is randomly divided into five groups;
Health status:Subject meets subject and volunteers inclusion criteria without skin disease allergies;
Patch method:It selects qualified spot to try device, with closed patch experiment method, appropriate product for resolving poxes is taken to be put into spot examination In device, external application special adhesive tape is covered on subject back, and tested material is removed after 12 hours, respectively 24 hours skin after observation removal Reaction, according to《Cosmetics health specification》Middle dermoreaction grade scale records result.
Human skin patch result is shown:The patch examination of 50 subjects product for resolving poxes through the invention It tests, dermoreaction was observed at 24 hours, wherein 0 skin adverse reaction occurs, experimental subjects does not show during the experiment Any reaction has no adverse reaction, such as erythema, burn feeling or itch symptom, shows that anti acne of traditional Chinese medicine composition is non-stimulated to skin Property, wherein it chooses the result figure before the treatment of certain women experimental subjects of the experimental group of embodiment 1 and sees Fig. 1, the result after treatment Figure is shown in Fig. 2;
By Fig. 1 and Fig. 2 it is found that the therapeutic effect of Chinese medicine composition provided by the invention is notable, acne print obviously disappears after four weeks It loses, non-pigment is calm.
In conclusion Chinese medicine composition selection science provided by the invention, formula is reasonable, and preparation process is succinctly efficient, system There is standby obtained product for resolving poxes anti-inflammatory analgetic, promoting blood circulation and removing blood stasis, quick anti-acne prints, deoil, whitening effect, be particularly suitable for neutral It is quick with the skin of the long small pox of oiliness, skin is not stimulated, pigment deposition and acne print are not stayed, is had broad application prospects With huge market value.
Applicant states that the present invention illustrates the method detailed of the present invention, but the present invention not office by above-described embodiment It is limited to above-mentioned method detailed, that is, does not mean that the present invention has to rely on above-mentioned method detailed and could implement.Technical field Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention Addition, the selection etc. of concrete mode, all fall within protection scope of the present invention and the open scope.

Claims (10)

1. a kind of Chinese medicine composition, which is characterized in that the composition includes following component in parts by weight:Honey-fried licorice root 90-110 Part, 30-40 parts of honeysuckle, 30-40 parts of purslane, 30-40 parts of Radix Astragali, 30-40 parts of Radix Isatidis, 20-30 parts of raw hawthorn, Radix Salviae Miltiorrhizae 20-30 parts of 20-30 parts, 20-30 parts of safflower, 20-30 parts of radix paeoniae rubra, 20-30 parts of Radix Notoginseng powder, 20-30 parts of bush and Sargent gloryvine.
2. composition according to claim 1, which is characterized in that the composition includes following component in parts by weight: 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of Radix Astragali, 33-38 parts of Radix Isatidis, raw hawthorn 23-28 parts, 23-28 parts of Radix Salviae Miltiorrhizae, 23-28 parts of safflower, 23-28 parts of radix paeoniae rubra, 23-28 parts of Radix Notoginseng powder, 23-28 parts of bush and Sargent gloryvine 23-28 parts.
3. composition according to claim 1 or 2, which is characterized in that the composition further includes white Fu in parts by weight 15-25 parts of 15-25 parts of Siberian cocklebur, 15-25 parts of Chinese yam rhizome, 15-25 parts of Radix Paeoniae Alba and the root of Dahurain angelica.
4. composition according to claim 3, which is characterized in that the composition further includes PORIA ALBA in parts by weight 18-22 parts of 18-22 parts, 18-22 parts of Chinese yam rhizome, 18-22 parts of Radix Paeoniae Alba and the root of Dahurain angelica.
5. according to the composition described in any one of claim 1-4, which is characterized in that the composition includes in parts by weight Following component:95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of Radix Astragali, Radix Isatidis 33-38 Part, 23-28 parts of raw hawthorn, 23-28 parts of Radix Salviae Miltiorrhizae, 23-28 parts of safflower, 23-28 parts of radix paeoniae rubra, 23-28 parts of Radix Notoginseng powder, bush 23- 18-22 parts of 28 parts, 23-28 parts of Sargent gloryvine, 18-22 parts of PORIA ALBA, 18-22 parts of Chinese yam rhizome, 18-22 parts of Radix Paeoniae Alba and the root of Dahurain angelica.
6. a kind of composition as described in any one of claim 1-5 is used to prepare the application of product for resolving poxes.
7. application according to claim 6, which is characterized in that the product for resolving poxes includes drug and/or cosmetics;
Preferably, the cosmetics include in cleansing cream, facial cleanser, face cream, soothing oil, essential oils, Cleansing Foam or clarifying lotion Any one or at least two combination;
Preferably, the dosage form of the product for resolving poxes is liquor.
8. a kind of method preparing product for resolving poxes, which is characterized in that include the following steps:
(1) honey-fried licorice root, honeysuckle, Herba portulacae, Radix Astragali, Radix Isatidis, raw hawthorn, Radix Salviae Miltiorrhizae, safflower, radix paeoniae rubra, three are weighed in proportion Seven powder, bush, Sargent gloryvine, PORIA ALBA, Chinese yam rhizome, Radix Paeoniae Alba and the root of Dahurain angelica, are mixed to get raw mixture;
(2) extractant is added in the raw mixture obtained to step (1) to be impregnated and filtered, obtains leachate;
(3) appropriate moisturizer is added in the leachate for obtaining step (2), obtains the product for resolving poxes.
9. according to the method described in claim 8, it is characterized in that, step (1) described ratio is:95-105 parts of honey-fried licorice root, gold 33-38 parts of honeysuckle flower, 33-38 parts of purslane, 33-38 parts of Radix Astragali, 33-38 parts of Radix Isatidis, 23-28 parts of raw hawthorn, Radix Salviae Miltiorrhizae 23-28 Part, 23-28 parts of safflower, 23-28 parts of radix paeoniae rubra, 23-28 parts of Radix Notoginseng powder, 23-28 parts of bush, 23-28 parts of Sargent gloryvine, PORIA ALBA 18- 18-22 parts of 22 parts, 18-22 parts of Chinese yam rhizome, 18-22 parts of Radix Paeoniae Alba and the root of Dahurain angelica;
Preferably, described (2) extractant is organic solvent, and preferably ethanol solution, further preferably volumetric concentration is The ethanol solution of 70-80%;
Preferably, the time of step (2) described immersion is 60-80h;
Preferably, any one in step (3) the moisturizer including collagen, hyaluronic acid or glycerine or at least two Combination, preferably glycerine.
10. method according to claim 8 or claim 9, which is characterized in that specifically comprise the following steps:
(1) weigh in parts by weight 95-105 parts of honey-fried licorice root, 33-38 parts of honeysuckle, 33-38 parts of purslane, 33-38 parts of Radix Astragali, 33-38 parts of Radix Isatidis, 23-28 parts of raw hawthorn, 23-28 parts of Radix Salviae Miltiorrhizae, 23-28 parts of safflower, 23-28 parts of radix paeoniae rubra, Radix Notoginseng powder 23-28 Part, 23-28 parts of bush, 23-28 parts of Sargent gloryvine, 18-22 parts of PORIA ALBA, 18-22 parts of Chinese yam rhizome, 18-22 parts of Radix Paeoniae Alba and root of Dahurain angelica 18-22 Part, it is mixed to get raw mixture;
(2) ethanol solution that volumetric concentration is 70-80% is added in the raw mixture obtained to step (1) and carries out immersion 70- Then 80h is filtered, obtain leachate;
(3) qs glycerin is added in the leachate for obtaining step (2), obtains the product for resolving poxes.
CN201810965365.6A 2018-08-23 2018-08-23 Traditional Chinese medicine composition and application thereof Active CN108704040B (en)

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