CN105709060A - Application of traditional Chinese medicine preparation in preparing medicine for treating viral myocarditis - Google Patents

Application of traditional Chinese medicine preparation in preparing medicine for treating viral myocarditis Download PDF

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CN105709060A
CN105709060A CN201610271422.1A CN201610271422A CN105709060A CN 105709060 A CN105709060 A CN 105709060A CN 201610271422 A CN201610271422 A CN 201610271422A CN 105709060 A CN105709060 A CN 105709060A
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radix
parts
chinese medicine
medicine preparation
standby
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刘学键
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Yantai Lanyangzhicao Pharmaceutical Biotechnology Co Ltd
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Yantai Lanyangzhicao Pharmaceutical Biotechnology Co Ltd
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Abstract

The invention relates to an application of a traditional Chinese medicine preparation in preparing a medicine for treating viral myocarditis, belonging to the technical field of traditional Chinese medicines. The raw materials of the traditional Chinese medicine preparation comprise the following traditional Chinese medicine materials: cortex moutan, cassia twig, radix paeoniae rubra, colla corii asini, radix polygonati officinalis, radix pseudostellariae, salvia miltiorrhiza, herba portulacae, glossy privet fruit, herba ecliptae, folium isatidis, fingered citron, ligusticum wallichii, spina date seed, radix ophiopogonis, schisandra chinensis, radix sophorae subprostratae, safflower, lonicera japonica and liquorice. Compared with the prior art, the traditional Chinese medicine preparation has outstanding technical advantages of good curative effect, high cure rate, little toxic and side effects and the like in treatment of viral myocarditis and particularly realizes a remarkable curative effect on chronic viral myocarditis; and moreover, the traditional Chinese medicine preparation has the advantages of stable effect, cheap raw materials, simple technology and small investment and is suitable for promotion and application.

Description

A kind of Chinese medicine preparation purposes in the medicine of preparation treatment viral myocarditis
Technical field
The present invention relates to a kind of Chinese medicine preparation purposes in the medicine of preparation treatment viral myocarditis, belong to technical field of Chinese medicine.
Background technology
Viral myocarditis refers to the myocardium limitation or diffused acute or chronic inflammatory disorders that viral infection causes, and belongs to infectious cardiomyopathy.There are about 5% patient in viral prevalence infection period and myocarditis occurs, it is possible to be dispersed in morbidity.Clinical manifestation weight is different.Medical history is infected according to typical forerunner；Corresponding clinical manifestation；The myocardial damage evidence that electrocardiogram, myocardial injury markers, ultrasonic cardiography show considers this diagnosis, makes a definite diagnosis and depends on endomyocardial biopsy.At present without specificity therapeutic method, treatment is mainly for viral infection and myocardial inflammation.Most patients recovery from illness after suitably treatment, only a few patient in acute stage because severe arrhythmia, acute heart failure and cardiogenic shock are dead.Some patients can develop into dilated cardiomyopathy.
It has been recognised by the inventors that viral myocarditis is virus invades heart, based on the disease of cardiac muscle limitation or diffusivity pathological changes, what have can change with pericardium or endocarditis.With spiritlessness and weakness, pale complexion, shortness of breath and palpitation, cold extremities hyperhidrosis is Clinical symptoms.Its clinical manifestation weight differs, and the lighter without obvious subjective symptoms, ECG change, severe one arrhythmia, cardiac dilatation, minority generation cardiogenic shock or acute heart failure can only occur, even die suddenly.Viral myocarditis belongs to the traditional Chinese medical science " pathogenic wind-warm ", " cardiopalmus ", " palpitation with a distress feeling ", " thoracic obstruction " category.It is as follows that the Syndrome Differentiation of Chinese Medicine of inventor controls method:
1, the mind violated by evil poison
Disease sees that low grade fever prolongs silk floss, watery nasal discharge of having a stuffy nose, the red and swollen pain of pharynx, brings up phlegm when one coughs, or abdominal pain diarrhea, myalgia limb Chu, cardiopalmus of losing heart, feeling of oppression and pain in the chest, red tongue, yellow and thin fur, thready and rapid pulse or knot generation.Control suitable heat-clearing and toxic substances removing, Qi-benefiting and heart-nourishing.
2, damp and hot excessive heart arteries and veins is invaded
Disease sees alternative chill and fever, muscular soreness, nausea and vomiting, abdominal pain diarrhea, and nervous uncomfortable in chest, limbs are weak, red tongue, yellow and greasy fur, soft and rapid pulse or knot generation.Control suitable clearing away heat and eliminating dampness, expelling pathogenic factors from the exterior mind calming.
3, heart deficiency of qi and yin
Disease sees palpitation and uneasiness, dynamic then more so, deficiency of QI with disinclination to talk, tired, have a dizzy spell, dysphoria with smothery sensation is thirsty, uneasy sleeping at night, the few tongue of red tongue, thready and rapid pulse or short or knot generation.Control suitable supplementing QI and nourishing YIN, mind tranquilizing and the heart calming.
4, heart kidney deficient and weak YANG QI
Disease sees severe palpitation, spiritlessness and weakness, aversion to cold and cold limbs, pale complexion, dizzy hyperhidrosis, limbs edema, rapid breathing, and pale tongue is fat or pale purple, thready pulse without strength or knot generation.Controlling suitable temperature compensation heart kidney, diuretic is allayed excitement.
5, heart arteries and veins stagnation of blood stasis
Disease sees that palpitation and uneasiness, chest distress, pareordia aching as needle stabbing, dim complexion, cyanosis of the lips and nails, purplish tongue, or tongue limit point are shown in there is petechia, irregularly intermittent and regularly intermittent pulse.Control suitable promoting flow of QI and blood, mind tranquilizing and the heart calming.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine preparation purposes in the medicine of preparation treatment viral myocarditis.In order to solve above-mentioned technical problem, inventor is according to clinical practice experience, meticulous composition of prescription, inspection and adjustment then through clinical practice, develop a brand-new Chinese prescription, it is made to be applied to modern pharmaceutical technology when producing in batches, still keep excellent curative effect, this Chinese prescription is (with parts by weight): Cortex Moutan 8-27 part, Ramulus Cinnamomi 6-19 part, Radix Paeoniae Rubra 10-33 part, Colla Corii Asini 4-13 part, Rhizoma Polygonati Odorati 7-25 part, Radix Pseudostellariae 11-38 part, Radix Salviae Miltiorrhizae 9-30 part, Herba Portulacae 11-36 part, Fructus Ligustri Lucidi 7-23 part, Herba Ecliptae 8-25 part, Folium Isatidis 7-27 part, Fructus Citri Sarcodactylis 6-19 part, Rhizoma Chuanxiong 8-21 part, Semen Ziziphi Spinosae 7-20 part, Radix Ophiopogonis 8-25 part, Fructus Schisandrae Chinensis 6-17 part, Radix Sophorae Tonkinensis 7-20 part, Flos Carthami 4-13 part, Flos Lonicerae 11-37 part, Radix Glycyrrhizae 9-29 part.
In invention process, the preferred prescription proportioning with preferably curative effect out is (with parts by weight):
Proportioning 1: Cortex Moutan 18 parts, Ramulus Cinnamomi 12 parts, Radix Paeoniae Rubra 21 parts, 8 parts of Colla Corii Asini, Rhizoma Polygonati Odorati 15 parts, Radix Pseudostellariae 26 parts, Radix Salviae Miltiorrhizae 19 parts, Herba Portulacae 23 parts, Fructus Ligustri Lucidi 14 parts, Herba Ecliptae 16 parts, Folium Isatidis 16 parts, Fructus Citri Sarcodactylis 12 parts, Rhizoma Chuanxiong 14 parts, Semen Ziziphi Spinosae 13 parts, Radix Ophiopogonis 18 parts, Fructus Schisandrae Chinensis 11 parts, Radix Sophorae Tonkinensis 13 parts, 8 parts of Flos Carthami, Flos Lonicerae 24 parts, 18 parts of Radix Glycyrrhizae.
Proportioning 2: Cortex Moutan 20 parts, Ramulus Cinnamomi 14 parts, Radix Paeoniae Rubra 22 parts, 9 parts of Colla Corii Asini, Rhizoma Polygonati Odorati 14 parts, Radix Pseudostellariae 23 parts, Radix Salviae Miltiorrhizae 17 parts, Herba Portulacae 24 parts, Fructus Ligustri Lucidi 14 parts, Herba Ecliptae 18 parts, Folium Isatidis 14 parts, Fructus Citri Sarcodactylis 13 parts, Rhizoma Chuanxiong 14 parts, Semen Ziziphi Spinosae 15 parts, Radix Ophiopogonis 16 parts, Fructus Schisandrae Chinensis 12 parts, Radix Sophorae Tonkinensis 15 parts, 7 parts of Flos Carthami, Flos Lonicerae 22 parts, 17 parts of Radix Glycyrrhizae.
The method of a kind of Chinese medicine preparation preparing treatment viral myocarditis of disclosure, comprises the following steps:
(1) weigh ingredients respectively by Chinese prescription, pulverize respectively, standby；
(2) by the Colla Corii Asini distilled water molten of 5-14 times of weight, standby；
(3) Semen Ziziphi Spinosae, Radix Ophiopogonis, Radix Glycyrrhizae being put respectively in pot and fry to slightly yellow with slow fire, taking-up cools；Dry and grind, cross 90-180 mesh sieve, be mixed to get fine powder, standby；
(4) fresh Herba Portulacae pulverizing is squeezed the juice, filter, obtain filtrate, standby；
(5) by Cortex Moutan, Ramulus Cinnamomi, Radix Paeoniae Rubra, Rhizoma Polygonati Odorati, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Herba Ecliptae, Folium Isatidis, Fructus Citri Sarcodactylis, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Radix Sophorae Tonkinensis, Flos Carthami, Flos Lonicerae, add the distilled water of initial 5-17 times of weight of medical material, soak 4-24 hour, backflow decocts 1-6 hour, filters, adds the distilled water of 4-12 times of weight of initial weight, backflow decocts 1-5 hour, filter and retain filtering residue, merging filtrate, be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29 standby；
(6) filtering residue of step (5) is added the ethanol of the concentration 60-85% of 5-15 times of weight, reflux, extract, 2 times, each 1-6 hour, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29；
(7) Colla Corii Asini of molten, juice of Herba Portulacae are merged with the concentrated solution of step (5) and (6) gained, and step (3) gained mixing fine powders is added, keep 55 DEG C, be sufficiently mixed uniformly, continuing to be concentrated into 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.46-1.52, standby；
(8) traditional Chinese medicine thick paste of step (7) is added suitable adjuvant, utilize modern general Chinese medicine preparation technology to make the finished dosage forms of clinical needs.
Further, the dosage form of described Chinese medicine preparation is the dosage forms such as decoction, pill (containing concentrated pill, the watered pill, honeyed pill, wax pill), granule, powder, tincture, unguentum, medicated wine, colloid, sublimed preparation, tablet, capsule (containing soft capsule), syrup, electuary, oil preparation.
The raw material of Chinese medicine preparation of the present invention relates to 20 taste Chinese crude drugs, and the character feature of this 20 taste Chinese crude drug is described below:
Cortex Moutan: this product is the dry root bark of ranunculaceae peony.Bitter in the mouth, pungent, cold nature；GUIXIN, liver, kidney channel；Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.
Ramulus Cinnamomi: this product is the dry twig of canella Cortex Cinnamomi.Acrid in the mouth, sweet, warm in nature；GUIXIN, lung, bladder warp；Diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.
Radix Paeoniae Rubra: this product is ranunculaceae plant Radix Paeoniae or the dry root of river Radix Paeoniae Rubra.Bitter in the mouth, cold nature；Return Liver Channel；Clearing away heat and cooling blood, eliminating stasis to stop pain.
Colla Corii Asini: this product is the skin of the equine species donkey solid gum through decocting, concentration is made.Sweet in the mouth, property is put down；Return lung, liver, kidney channel；Enrich blood YIN nourishing, moisturize, hemostasis.
Rhizoma Polygonati Odorati: this product is the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati.Sweet in the mouth, cold nature；Attach to the lung and stomach meridians；Nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.
Radix Pseudostellariae: this product is the dried root of pinkwort Radix Ginseng.Sweet in the mouth, micro-hardship, property is put down；Return spleen, lung meridian；Replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.
Radix Salviae Miltiorrhizae: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Bitter in the mouth, cold nature；GUIXIN, Liver Channel；Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
Herba Portulacae: this product is portulacaceous plant Herba Portulacae, with all herbal medicine.Sour in the mouth, cold in nature；Enter large intestine, liver, spleen channel；Heat-clearing and toxic substances removing, dissipates blood detumescence.
Fructus Ligustri Lucidi: this product is the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi.Sweet in the mouth, hardship, cool in nature；Return liver, kidney channel；Nourishing the liver and kidney, improving eyesight black hair.
Herba Ecliptae: be the plant of Compositae Eclipta prostrata genus.All herbal medicine.Sweet in the mouth acid, cool in nature；Enter Liver and kidney two warp, nontoxic；The diseases such as nourishing the liver and kidney, cooling blood for hemostasis, can control various haematemesis, enterorrhagia.Smashing juice painting eyebrow to send out, can promote hair growth, for oral administration have black hair, hair color effect.
Folium Isatidis: this product is the dried leaves of cruciferae isatis.In the summer, divide 2-3 time in season in autumn two and gather, remove impurity, dry.Bitter in the mouth, cold in nature；GUIXIN, stomach warp；Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Join the army for pathogenic warmth, unconsciousness due to high fever, send out speckle dermexanthesis, jaundice, hematodiarrhoea, mumps, sore throat, erysipelas, carbuncle.
Fructus Citri Sarcodactylis: this product is the dry fruit of Rutaceae citrus plant Fructus Citri Sarcodactylis.Autumn, fruit was gathered when not yet turning yellow or turn yellow, and rip cutting flakiness dries or cold drying.Acrid in the mouth, hardship, acid, warm in nature；Return liver, spleen, lung meridian；Liver-smoothing, qi-regulating, and stomach and alleviating pain.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite is vomitted.
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong.Acrid in the mouth, warm in nature；Return liver, gallbladder, pericardium channel；Blood-activating and qi-promoting, wind-expelling pain-stopping.
Semen Ziziphi Spinosae: this product is the dry mature seed of Rhamnaceae plant Ziziphi Spinosae.Sweet in the mouth, acid, property is put down；Return liver, gallbladder, heart channel；Tonifying liver, mind calming, arresting sweating, promotes the production of body fluid.
Radix Ophiopogonis: this product is the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf).Sweet in the mouth, micro-hardship, cold nature；GUIXIN, lung, stomach warp；YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Fructus Schisandrae Chinensis: this product is the dry mature fruit of magnoliaceae schisandra or schisandra chinensis.Sour in the mouth, sweet, warm in nature；Return lung, the heart, kidney channel；Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.
Radix Sophorae Tonkinensis: crude drug source is the root of menispermaceous plants Sichuan Radix Stephaniae Japonicae.Bitter in the mouth, cold in nature；Return lung, the heart, large intestine channel；Heat-clearing and toxic substances removing, pain relieving, parasite killing.Main laryngopharynx swelling and pain, toothache, stomachache, swelling and pain of hemorrhoid, snake bite and insect sting, enterobiasis.
Flos Carthami: call red blue flower, thorn Flos Carthami, Compositae, Flos Carthami platymiscium.Acrid in the mouth, warm in nature；Enter the heart, Liver Channel；Promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.
Flos Lonicerae: this product is caprifoliaceae plant Radix Ophiopogonis, Flos Lonicerae, Flos Lonicerae (hair calyx Radix Ophiopogonis) or the dry flower of hair style Radix Ophiopogonis or the first flower opened of band.Sweet in the mouth, cold in nature；Return lung, the heart, stomach warp；Heat-clearing and toxic substances removing, wind-heat dissipating.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down；GUIXIN, lung, spleen, stomach warp；Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
This Chinese prescription is with Radix Pseudostellariae, Herba Portulacae, Radix Paeoniae Rubra, Flos Lonicerae, Radix Salviae Miltiorrhizae, Cortex Moutan for monarch drug, replenishing QI to invigorate the spleen, scattered blood detumescence, eliminating stasis to stop pain, heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow, blood circulation promoting and blood stasis dispelling；With Radix Ophiopogonis, Herba Ecliptae, Folium Isatidis, Rhizoma Polygonati Odorati, Radix Sophorae Tonkinensis for ministerial drug, lung moistening clears away heart-fire, nourishing the liver and kidney, heat-clearing and toxic substances removing, nourishing YIN to relieve dryness, pain relieving parasite killing；With Flos Carthami, Semen Ziziphi Spinosae, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis for adjuvant drug, blood stasis removing pain relieving, mind calming arresting sweating, blood-activating and qi-promoting, supplementing QI for promoting the production of body fluid；With Ramulus Cinnamomi, Colla Corii Asini, Fructus Ligustri Lucidi, Fructus Citri Sarcodactylis for making medicine, promoting the flow of QI-blood by warming the meridian, YIN nourishing of enriching blood, nourishing the liver and kidney, liver-smoothing, qi-regulating；Effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing is played with Radix Glycyrrhizae, coordinating the actions of various ingredients in a prescription simultaneously, the all medicines of monarch are made to coordinate, the exterior and the interior is used mutually, negative and positive are taken mutually, thus reach replenishing QI to invigorate the spleen, dissipate blood detumescence, the effect such as eliminating stasis to stop pain, heat-clearing and toxic substances removing, promoting blood circulation to restore menstrual flow, blood circulation promoting and blood stasis dispelling, lung moistening clear away heart-fire, pain relieving parasite killing, mind calming arresting sweating, blood-activating and qi-promoting, promoting the flow of QI-blood by warming the meridian, liver-smoothing, qi-regulating, viral myocarditis is shown very excellent curative effect.
Compared with prior art, in treatment viral myocarditis, Chinese medicine preparation of the present invention has technical advantage highlighted below:
1, good effect, cure rate is high, and chronic viral myocarditis particularly has prominent curative effect；
2, toxic and side effects is minimum, and conditioning and treatment are wanted to combine, it is possible to strengthen the resistance against diseases of patient；
3, the efficacy stability of preparation, preparation raw material is cheap, the simple less investment of preparation process, is suitable for popularization and application.
Detailed description of the invention
In order to verify the feasibility of Chinese medicine preparation of the present invention further, and being follow-up series of experiments pilot production medicine, inventor chooses the preferred process parameter of several groups of representational prescription proportionings and preparation method and carries out practice and produce, and the Chinese medicine preparation of production is electuary.
Embodiment 1
(1) weigh respectively by Chinese prescription Cortex Moutan 2700g, Ramulus Cinnamomi 1900g, Radix Paeoniae Rubra 3300g, Colla Corii Asini 1300g, Rhizoma Polygonati Odorati 2500g, Radix Pseudostellariae 3800g, Radix Salviae Miltiorrhizae 3000g, Herba Portulacae 3600g, Fructus Ligustri Lucidi 2300g, Herba Ecliptae 2500g, Folium Isatidis 2700g, Fructus Citri Sarcodactylis 1900g, Rhizoma Chuanxiong 2100g, Semen Ziziphi Spinosae 2000g, Radix Ophiopogonis 2500g, Fructus Schisandrae Chinensis 1700g, Radix Sophorae Tonkinensis 2000g, Flos Carthami 1300g, Flos Lonicerae 3700g, Radix Glycyrrhizae 2900g, pulverize respectively, standby；
(2) by the Colla Corii Asini distilled water molten of 10 times of weight, standby；
(3) Semen Ziziphi Spinosae, Radix Ophiopogonis, Radix Glycyrrhizae being put respectively in pot and fry to slightly yellow with slow fire, taking-up cools；Dry and grind, cross 130 mesh sieves, be mixed to get fine powder, standby；
(4) fresh Herba Portulacae pulverizing is squeezed the juice, filter, obtain filtrate, standby；
(5) by Cortex Moutan, Ramulus Cinnamomi, Radix Paeoniae Rubra, Rhizoma Polygonati Odorati, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Herba Ecliptae, Folium Isatidis, Fructus Citri Sarcodactylis, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Radix Sophorae Tonkinensis, Flos Carthami, Flos Lonicerae, add the distilled water of initial 13 times of weight of medical material, soak 12 hours, backflow decocts 3 hours, filters, adds the distilled water of 8 times of weight of initial weight, backflow decocts 2 hours, filter and retain filtering residue, merging filtrate, be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29 standby；
(6) filtering residue of step (5) is added the ethanol of the concentration 75% of 11 times of weight, reflux, extract, 2 times, each 2 hours, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29；
(7) Colla Corii Asini of molten, juice of Herba Portulacae are merged with the concentrated solution of step (5) and (6) gained, and step (3) gained mixing fine powders is added, keep 55 DEG C, be sufficiently mixed uniformly, continuing to be concentrated into 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.46-1.52, standby；
(8) traditional Chinese medicine thick paste of step (7) being added suitable adjuvant, utilize modern general Chinese medicine preparation technology to make electuary, specification is: 0.72g crude drug/g electuary.
Embodiment 2
(1) weigh respectively by Chinese prescription Cortex Moutan 800g, Ramulus Cinnamomi 600g, Radix Paeoniae Rubra 1000g, Colla Corii Asini 400g, Rhizoma Polygonati Odorati 700g, Radix Pseudostellariae 1100g, Radix Salviae Miltiorrhizae 900g, Herba Portulacae 1100g, Fructus Ligustri Lucidi 700g, Herba Ecliptae 800g, Folium Isatidis 700g, Fructus Citri Sarcodactylis 600g, Rhizoma Chuanxiong 800g, Semen Ziziphi Spinosae 700g, Radix Ophiopogonis 800g, Fructus Schisandrae Chinensis 600g, Radix Sophorae Tonkinensis 700g, Flos Carthami 400g, Flos Lonicerae 1100g, Radix Glycyrrhizae 900g, pulverize respectively, standby；
(2) by the Colla Corii Asini distilled water molten of 10 times of weight, standby；
(3) Semen Ziziphi Spinosae, Radix Ophiopogonis, Radix Glycyrrhizae being put respectively in pot and fry to slightly yellow with slow fire, taking-up cools；Dry and grind, cross 130 mesh sieves, be mixed to get fine powder, standby；
(4) fresh Herba Portulacae pulverizing is squeezed the juice, filter, obtain filtrate, standby；
(5) by Cortex Moutan, Ramulus Cinnamomi, Radix Paeoniae Rubra, Rhizoma Polygonati Odorati, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Herba Ecliptae, Folium Isatidis, Fructus Citri Sarcodactylis, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Radix Sophorae Tonkinensis, Flos Carthami, Flos Lonicerae, add the distilled water of initial 13 times of weight of medical material, soak 12 hours, backflow decocts 3 hours, filters, adds the distilled water of 8 times of weight of initial weight, backflow decocts 2 hours, filter and retain filtering residue, merging filtrate, be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29 standby；
(6) filtering residue of step (5) is added the ethanol of the concentration 75% of 11 times of weight, reflux, extract, 2 times, each 2 hours, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29；
(7) Colla Corii Asini of molten, juice of Herba Portulacae are merged with the concentrated solution of step (5) and (6) gained, and step (3) gained mixing fine powders is added, keep 55 DEG C, be sufficiently mixed uniformly, continuing to be concentrated into 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.46-1.52, standby；
(8) traditional Chinese medicine thick paste of step (7) being added suitable adjuvant, utilize modern general Chinese medicine preparation technology to make electuary, specification is: 0.72g crude drug/g electuary.
Embodiment 3
(1) weigh respectively by Chinese prescription Cortex Moutan 800g, Ramulus Cinnamomi 1900g, Radix Paeoniae Rubra 1000g, Colla Corii Asini 1300g, Rhizoma Polygonati Odorati 2500g, Radix Pseudostellariae 1100g, Radix Salviae Miltiorrhizae 900g, Herba Portulacae 1100g, Fructus Ligustri Lucidi 2300g, Herba Ecliptae 2500g, Folium Isatidis 700g, Fructus Citri Sarcodactylis 1900g, Rhizoma Chuanxiong 800g, Semen Ziziphi Spinosae 2000g, Radix Ophiopogonis 2500g, Fructus Schisandrae Chinensis 600g, Radix Sophorae Tonkinensis 700g, Flos Carthami 1300g, Flos Lonicerae 1100g, Radix Glycyrrhizae 2900g, pulverize respectively, standby；
(2) by the Colla Corii Asini distilled water molten of 10 times of weight, standby；
(3) Semen Ziziphi Spinosae, Radix Ophiopogonis, Radix Glycyrrhizae being put respectively in pot and fry to slightly yellow with slow fire, taking-up cools；Dry and grind, cross 130 mesh sieves, be mixed to get fine powder, standby；
(4) fresh Herba Portulacae pulverizing is squeezed the juice, filter, obtain filtrate, standby；
(5) by Cortex Moutan, Ramulus Cinnamomi, Radix Paeoniae Rubra, Rhizoma Polygonati Odorati, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Herba Ecliptae, Folium Isatidis, Fructus Citri Sarcodactylis, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Radix Sophorae Tonkinensis, Flos Carthami, Flos Lonicerae, add the distilled water of initial 13 times of weight of medical material, soak 12 hours, backflow decocts 3 hours, filters, adds the distilled water of 8 times of weight of initial weight, backflow decocts 2 hours, filter and retain filtering residue, merging filtrate, be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29 standby；
(6) filtering residue of step (5) is added the ethanol of the concentration 75% of 11 times of weight, reflux, extract, 2 times, each 2 hours, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29；
(7) Colla Corii Asini of molten, juice of Herba Portulacae are merged with the concentrated solution of step (5) and (6) gained, and step (3) gained mixing fine powders is added, keep 55 DEG C, be sufficiently mixed uniformly, continuing to be concentrated into 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.46-1.52, standby；
(8) traditional Chinese medicine thick paste of step (7) being added suitable adjuvant, utilize modern general Chinese medicine preparation technology to make electuary, specification is: 0.72g crude drug/g electuary.
Embodiment 4
(1) weigh respectively by Chinese prescription Cortex Moutan 1800g, Ramulus Cinnamomi 1200g, Radix Paeoniae Rubra 2100g, Colla Corii Asini 800g, Rhizoma Polygonati Odorati 1500g, Radix Pseudostellariae 2600g, Radix Salviae Miltiorrhizae 1900g, Herba Portulacae 2300g, Fructus Ligustri Lucidi 1400g, Herba Ecliptae 1600g, Folium Isatidis 1600g, Fructus Citri Sarcodactylis 1200g, Rhizoma Chuanxiong 1400g, Semen Ziziphi Spinosae 1300g, Radix Ophiopogonis 1800g, Fructus Schisandrae Chinensis 1100g, Radix Sophorae Tonkinensis 1300g, Flos Carthami 800g, Flos Lonicerae 2400g, Radix Glycyrrhizae 1800g, pulverize respectively, standby；
(2) by the Colla Corii Asini distilled water molten of 10 times of weight, standby；
(3) Semen Ziziphi Spinosae, Radix Ophiopogonis, Radix Glycyrrhizae being put respectively in pot and fry to slightly yellow with slow fire, taking-up cools；Dry and grind, cross 130 mesh sieves, be mixed to get fine powder, standby；
(4) fresh Herba Portulacae pulverizing is squeezed the juice, filter, obtain filtrate, standby；
(5) by Cortex Moutan, Ramulus Cinnamomi, Radix Paeoniae Rubra, Rhizoma Polygonati Odorati, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Herba Ecliptae, Folium Isatidis, Fructus Citri Sarcodactylis, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Radix Sophorae Tonkinensis, Flos Carthami, Flos Lonicerae, add the distilled water of initial 13 times of weight of medical material, soak 12 hours, backflow decocts 3 hours, filters, adds the distilled water of 8 times of weight of initial weight, backflow decocts 2 hours, filter and retain filtering residue, merging filtrate, be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29 standby；
(6) filtering residue of step (5) is added the ethanol of the concentration 75% of 11 times of weight, reflux, extract, 2 times, each 2 hours, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29；
(7) Colla Corii Asini of molten, juice of Herba Portulacae are merged with the concentrated solution of step (5) and (6) gained, and step (3) gained mixing fine powders is added, keep 55 DEG C, be sufficiently mixed uniformly, continuing to be concentrated into 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.46-1.52, standby；
(8) traditional Chinese medicine thick paste of step (7) being added suitable adjuvant, utilize modern general Chinese medicine preparation technology to make electuary, specification is: 0.72g crude drug/g electuary.
Embodiment 5
(1) weigh respectively by Chinese prescription Cortex Moutan 2000g, Ramulus Cinnamomi 1400g, Radix Paeoniae Rubra 2200g, Colla Corii Asini 900g, Rhizoma Polygonati Odorati 1400g, Radix Pseudostellariae 2300g, Radix Salviae Miltiorrhizae 1700g, Herba Portulacae 2400g, Fructus Ligustri Lucidi 1400g, Herba Ecliptae 1800g, Folium Isatidis 1400g, Fructus Citri Sarcodactylis 1300g, Rhizoma Chuanxiong 1400g, Semen Ziziphi Spinosae 1500g, Radix Ophiopogonis 1600g, Fructus Schisandrae Chinensis 1200g, Radix Sophorae Tonkinensis 1500g, Flos Carthami 700g, Flos Lonicerae 2200g, Radix Glycyrrhizae 1700g, pulverize respectively, standby；
(2) by the Colla Corii Asini distilled water molten of 10 times of weight, standby；
(3) Semen Ziziphi Spinosae, Radix Ophiopogonis, Radix Glycyrrhizae being put respectively in pot and fry to slightly yellow with slow fire, taking-up cools；Dry and grind, cross 130 mesh sieves, be mixed to get fine powder, standby；
(4) fresh Herba Portulacae pulverizing is squeezed the juice, filter, obtain filtrate, standby；
(5) by Cortex Moutan, Ramulus Cinnamomi, Radix Paeoniae Rubra, Rhizoma Polygonati Odorati, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Herba Ecliptae, Folium Isatidis, Fructus Citri Sarcodactylis, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Radix Sophorae Tonkinensis, Flos Carthami, Flos Lonicerae, add the distilled water of initial 13 times of weight of medical material, soak 12 hours, backflow decocts 3 hours, filters, adds the distilled water of 8 times of weight of initial weight, backflow decocts 2 hours, filter and retain filtering residue, merging filtrate, be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29 standby；
(6) filtering residue of step (5) is added the ethanol of the concentration 75% of 11 times of weight, reflux, extract, 2 times, each 2 hours, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29；
(7) Colla Corii Asini of molten, juice of Herba Portulacae are merged with the concentrated solution of step (5) and (6) gained, and step (3) gained mixing fine powders is added, keep 55 DEG C, be sufficiently mixed uniformly, continuing to be concentrated into 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.46-1.52, standby；
(8) traditional Chinese medicine thick paste of step (7) being added suitable adjuvant, utilize modern general Chinese medicine preparation technology to make electuary, specification is: 0.72g crude drug/g electuary.
Test example 1
For verifying Chinese medicine preparation safety of the present invention further, inventor has carried out toxicity test with the embodiment 1-5 electuary produced.
1, acute toxicity test data
Mice presses 1g crude drug/ml, 40ml/kg dosage gavage gives instant particles as Chinese medicine of the present invention, one day 3 times, Continuous Observation 14d after medicine, all test mice skins, hair color are normal, and nose, eye, oral cavity be normal and secretions without exception, without vomiting phenomenon, body weight increases, movable, diet drinking-water and two is just normal, and unfavorable condition and death does not occur in animal.Within 15th day, putting to death and dissect animal, perusal main organs is no abnormal.Rat presses 1g crude drug/ml, 40ml/kg dosage gavage gives instant particles as Chinese medicine of the present invention, one day 3 times, Continuous Observation 14d after medicine, all tested rat skins, hair color are normal, and nose, eye, oral cavity be normal and secretions without exception, without vomiting phenomenon, body weight increases, movable, diet drinking-water and two is just normal, and unfavorable condition and death does not occur in animal.Within 15th day, putting to death and dissect animal, perusal main organs is no abnormal.This product mice, one day of rat administration total amount are 333.3 times of adult, point out instant particles as Chinese medicine drug safety of the present invention higher.
2, long term toxicity test data
Select SD rat, male and female half and half, random packet: blank group and the high, medium and low dosage group of instant particles as Chinese medicine of the present invention.High, medium and low for instant particles as Chinese medicine of the present invention dosage is respectively set to Coming-of-Age Day clinic and intends the 80 of consumption, 40,20 times, adopt gastric infusion, once a day, successive administration 6 months, and drug withdrawal does restorative observation for 1 month.Observe the outward appearance of animal, general behavior, body weight, the change of diet amount of drinking water during test, each group is carried out hemanalysis, blood biochemical analysis and organ coefficient, blank group and high dose group and carries out histopathology index checking.Result of the test shows: blank group and in instant particles as Chinese medicine of the present invention, low dose group animal general state good, outward appearance sign, behavioral activity, glandular secretion, breathing, two just, body weight increase, administration reaction and the change all without exception of drinking water diet amount.Reducing occurs in high dose group the weight of animals, accidental soft stool, but recovers after drug withdrawal.In hemanalysis, having indivedual index to compare variant with blank group, blood biochemical analysis indexes no abnormality seen changes.Be administered 3 months, each administration group organ coefficient compares no significant difference with blank group after drug withdrawal 1 month.Be administered 3 months, administration 6 months, the color and luster of each treated animal main organs after drug withdrawal 1 month, quality normal, naked eyes are there are no obvious change.Pathological examination, blank group has no the Pathologic changes relevant with medicine to high dose group main organs tissue.Result shows that rat oral gavage administration is had no significant effect by instant particles as Chinese medicine of the present invention administration in continuous 6 months, and without clear and definite toxicity target organ and sensitive indicator, convalescent period observes and also has no retardance toxic reaction, and the dose safety of prompting this product clinical practice is significantly high.
Test example 2
Effectiveness of the invention pharmacodynamic experiment is inventors performed in order to verify further.
1, laboratory animal
Kunming mouse, body weight 21g ± 4g, male and female half and half, female mice is all without pregnant.
2, Experimental agents
(1) comparison medicine: Metronidazole Tablet, the quasi-word H44020769 of traditional Chinese medicines, manufacturer: GuangDong HuaNan Pharmacy Group Co., Ltd.
(2) experimental drug: the electuary (specification is: 0.72g crude drug/g electuary) that the embodiment of the present invention 4, embodiment 5 produce, is numbered electuary 4, electuary 5 respectively.
3, experimental technique and result
(1) xylol causes the impact of mice ear
Taking mice 40, be randomly divided into 4 groups, every day is administered once, gastric infusion 7d, after last is administered 1h, in the positive and negative topcoating dimethylbenzene 0.05ml of mouse right ear, to 2h after dimethylbenzene, put to death animal, cut ear, sweep away auricle in corresponding site 8mm steel drift, weigh, with the difference of left and right ear weight for swelling degree, result is in Table 1.
Table 1 xylol cause mice ear impact (± SD, n=10)
Note: compare with saline control group,**P < 0.01；Compare with Metronidazole Tablet,△P < 0.05.
From table 1 result, impact on mice ear, compared with normal saline group, Chinese medicine preparation of the present invention and the equal highly significant of metronidazole group (P < 0.01) inhibit swelling, the inhibitory action of two kinds of preparations of Chinese medicine of the present invention notable (P < 0.05) is better than Metronidazole Tablet, and electuary 4 shows more excellent.
(2) impact on mouse skin capillary permeability
Taking mice 40, be randomly divided into 4 groups, every day is administered once, gastric infusion 7d, after last is administered 1h, and tail vein injection 1% Azo-Blue normal saline 0.1ml/10g body weight, and inject histamine 5ug(0.1ml in abdominal part depilation place Intradermal immediately).After 20min, putting to death animal, cut blue dye skin graft, be soaked in acetone normal saline (7:3) mixed liquor, after 24min, centrifuging and taking supernatant is in 721 type spectrophotometer wavelength 610nm colorimetrics, and result is in Table 2.
Table 2 on the impact of mouse skin capillary permeability (± SD, n=10)
Note: compare with saline control group,**P < 0.01；Compare with Metronidazole Tablet,△P < 0.05.
From table 2 result, impact on mouse skin capillary permeability, compared with normal saline group, Chinese medicine preparation of the present invention and the equal highly significant of metronidazole group (P < 0.01) inhibit permeability, the inhibitory action of two kinds of preparations of Chinese medicine of the present invention notable (P < 0.05) is better than Metronidazole Tablet, and electuary 4 shows more excellent.
(3) impact on mice granuloma induced by implantation of cotton pellets
Implanting each 1 of 5mg sterilized cotton ball, packet administration, every day 1 time, altogether 7d in oxter, mice left and right, put to death animal, take granuloma induced by implantation of cotton pellets after last is administered 1h, weigh (weight in wet base), result is in Table 3.
Table 3 on the impact of mice granuloma induced by implantation of cotton pellets (± SD, n=10)
Note: compare with saline control group,*P < 0.05,**P < 0.01；Compare with Metronidazole Tablet,△P < 0.05.
From table 3 result, impact on mice granuloma induced by implantation of cotton pellets, Chinese medicine preparation of the present invention and the equal highly significant of metronidazole group (P < 0.01) or notable (P < 0.05) suppress granuloma, the inhibitory action of two kinds of preparations of Chinese medicine of the present invention notable (P < 0.05) is better than Metronidazole Tablet, and electuary 4 shows more excellent.
In sum, every pharmacodynamics test of mice being shown, Chinese medicine preparation of the present invention has the therapeutical effect such as stronger antiinflammatory, analgesia, detumescence, and its action effect is significantly better than Metronidazole Tablet, is numbered the preparation better effects if of electuary 4.
Test example 3
In order to verify the clinical effectiveness of reality, the electuary that inventor chooses the embodiment of the present invention 4, embodiment 5 produces has carried out clinical trial.
Patients with Viral Myocarditis 272 people is collected in this clinical trial altogether, age 21-58 year, female 122 example, male 150 examples, all patients are equally divided into two groups by statistics standard, oral electuary (specification is: 0.72g crude drug/g electuary) manufactured by the embodiment of the present invention 4, embodiment 5 respectively, every day 3 times, each 10g, at least 4 hours, interval, within 3 weeks, it is a course for the treatment of, 4 courses for the treatment of of treatment continuously.Two groups are respectively arranged with 3 people because the reason beyond medicine drops by the wayside clinical trial, and therefore, two groups are respectively arranged with 133 people and complete clinical trial, and untoward reaction all do not occur in all patients.Therapeutic outcome statistical analysis such as table 4.
Table 4 clinical test results
Therapeutic outcome shows, the embodiment of the present invention 4, embodiment 5 Chinese medicine preparation to the cure rate of viral myocarditis respectively up to 58.6%, 57.9%, total effective rate respectively up to 91.0%, 90.2%, and untoward reaction does not occur, illustrate that Chinese medicine preparation of the present invention achieves breakthrough technical progress in the treatment field of viral myocarditis, filled up the blank of oral medication viral myocarditis, it is thus achieved that beyond thought technological achievement, therefore, the creativeness of the present invention is apparent from.

Claims (4)

1. a Chinese medicine preparation treats the purposes in the medicine of viral myocarditis in preparation, it is characterized in that, the raw material of described Chinese medicine preparation is prepared by the Chinese crude drug composition of weight portion: Cortex Moutan 8-27 part, Ramulus Cinnamomi 6-19 part, Radix Paeoniae Rubra 10-33 part, Colla Corii Asini 4-13 part, Rhizoma Polygonati Odorati 7-25 part, Radix Pseudostellariae 11-38 part, Radix Salviae Miltiorrhizae 9-30 part, Herba Portulacae 11-36 part, Fructus Ligustri Lucidi 7-23 part, Herba Ecliptae 8-25 part, Folium Isatidis 7-27 part, Fructus Citri Sarcodactylis 6-19 part, Rhizoma Chuanxiong 8-21 part, Semen Ziziphi Spinosae 7-20 part, Radix Ophiopogonis 8-25 part, Fructus Schisandrae Chinensis 6-17 part, Radix Sophorae Tonkinensis 7-20 part, Flos Carthami 4-13 part, Flos Lonicerae 11-37 part, Radix Glycyrrhizae 9-29 part.
2. the Chinese medicine preparation as claimed in claim 1 purposes in the medicine of preparation treatment viral myocarditis, it is characterized in that, the raw material of described Chinese medicine preparation is prepared by the Chinese crude drug composition of weight portion: Cortex Moutan 18 parts, Ramulus Cinnamomi 12 parts, Radix Paeoniae Rubra 21 parts, 8 parts of Colla Corii Asini, Rhizoma Polygonati Odorati 15 parts, Radix Pseudostellariae 26 parts, Radix Salviae Miltiorrhizae 19 parts, Herba Portulacae 23 parts, Fructus Ligustri Lucidi 14 parts, Herba Ecliptae 16 parts, Folium Isatidis 16 parts, Fructus Citri Sarcodactylis 12 parts, Rhizoma Chuanxiong 14 parts, Semen Ziziphi Spinosae 13 parts, Radix Ophiopogonis 18 parts, Fructus Schisandrae Chinensis 11 parts, Radix Sophorae Tonkinensis 13 parts, 8 parts of Flos Carthami, Flos Lonicerae 24 parts, 18 parts of Radix Glycyrrhizae.
3. the Chinese medicine preparation as claimed in claim 1 or 2 purposes in the medicine of preparation treatment viral myocarditis, it is characterised in that the preparation method of described Chinese medicine preparation is following steps:
(1) weigh ingredients respectively by Chinese prescription, pulverize respectively, standby；
(2) by the Colla Corii Asini distilled water molten of 5-14 times of weight, standby；
(3) Semen Ziziphi Spinosae, Radix Ophiopogonis, Radix Glycyrrhizae being put respectively in pot and fry to slightly yellow with slow fire, taking-up cools；Dry and grind, cross 90-180 mesh sieve, be mixed to get fine powder, standby；
(4) fresh Herba Portulacae pulverizing is squeezed the juice, filter, obtain filtrate, standby；
(5) by Cortex Moutan, Ramulus Cinnamomi, Radix Paeoniae Rubra, Rhizoma Polygonati Odorati, Radix Pseudostellariae, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Herba Ecliptae, Folium Isatidis, Fructus Citri Sarcodactylis, Rhizoma Chuanxiong, Fructus Schisandrae Chinensis, Radix Sophorae Tonkinensis, Flos Carthami, Flos Lonicerae, add the distilled water of initial 5-17 times of weight of medical material, soak 4-24 hour, backflow decocts 1-6 hour, filters, adds the distilled water of 4-12 times of weight of initial weight, backflow decocts 1-5 hour, filter and retain filtering residue, merging filtrate, be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29 standby；
(6) filtering residue of step (5) is added the ethanol of the concentration 60-85% of 5-15 times of weight, reflux, extract, 2 times, each 1-6 hour, to filter, merging filtrate, decompression is distilled off ethanol, and it is standby to be concentrated into the concentrated solution that 55 DEG C of relative densities are 1.24-1.29；
(7) Colla Corii Asini of molten, juice of Herba Portulacae are merged with the concentrated solution of step (5) and (6) gained, and step (3) gained mixing fine powders is added, keep 55 DEG C, be sufficiently mixed uniformly, continuing to be concentrated into 55 DEG C of relative densities is the traditional Chinese medicine thick paste of 1.46-1.52, standby；
(8) traditional Chinese medicine thick paste of step (7) is added suitable adjuvant, utilize modern general Chinese medicine preparation technology to make the finished dosage forms of clinical needs.
4. the Chinese medicine preparation as claimed in claim 1 or 2 purposes in the medicine of preparation treatment viral myocarditis, it is characterised in that: described Chinese medicine preparation is decoction, pill, granule, powder, tincture, unguentum, medicated wine, colloid, sublimed preparation, tablet, capsule, syrup, electuary or oil preparation.
CN201610271422.1A 2016-04-28 2016-04-28 Application of traditional Chinese medicine preparation in preparing medicine for treating viral myocarditis Withdrawn CN105709060A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105943938A (en) * 2016-07-18 2016-09-21 甄建民 Medicine for treating viral myocarditis and preparing method of medicine

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103120791A (en) * 2013-03-25 2013-05-29 华梅 Traditional Chinese medicine composition for treating vital myocarditis and preparation method thereof
CN104667158A (en) * 2013-12-02 2015-06-03 李雨泽 Medicine for treating viral myocarditis
CN105412884A (en) * 2015-12-25 2016-03-23 青岛华之草医药科技有限公司 Method for preparing Chinese herbal preparation for treating pulmonary emphysema
CN105435180A (en) * 2015-12-25 2016-03-30 青岛华之草医药科技有限公司 Traditional Chinese medicine preparation for treating emphysema

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103120791A (en) * 2013-03-25 2013-05-29 华梅 Traditional Chinese medicine composition for treating vital myocarditis and preparation method thereof
CN104667158A (en) * 2013-12-02 2015-06-03 李雨泽 Medicine for treating viral myocarditis
CN105412884A (en) * 2015-12-25 2016-03-23 青岛华之草医药科技有限公司 Method for preparing Chinese herbal preparation for treating pulmonary emphysema
CN105435180A (en) * 2015-12-25 2016-03-30 青岛华之草医药科技有限公司 Traditional Chinese medicine preparation for treating emphysema

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105943938A (en) * 2016-07-18 2016-09-21 甄建民 Medicine for treating viral myocarditis and preparing method of medicine

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Application publication date: 20160629