CN102068498A - Chinese medicinal composition with acne treatment and anti-inflammation effects, preparation and preparation method thereof - Google Patents
Chinese medicinal composition with acne treatment and anti-inflammation effects, preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition with acne treatment and anti-inflammation effects. The composition is mainly prepared from the following raw materials in part by weight: 35 to 45 parts of root of red-rooted salvia, 15 to 20 parts of honeysuckle flower, 15 to 25 parts of clove, 10 to 15 parts of officinal magnolia bark and 10 to 15 parts of rhubarb. The raw materials contain natural soothing components, have low skin irritation and realize an acne treatment effect in various ways. Compared with the same type of products in the conventional market, the composition is safer, efficient and independent (without antibiotics or chemical medicament components); and raw materials are readily available, different dosage forms can be taken as carriers and a preparation method is convenient. The composition has low cost, good effect, good application prospect and market prospect, and is easily accepted by customers.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Chinese medicine composition that can effectively play anti-acne, anti-inflammatory efficacy, and by external preparation of said composition preparation and preparation method thereof.
Background technology
Comedo is a kind of pilosebaceous chronic inflammatory disease, is common in the youth of both sexes of adolescence, mainly occurs in face, shirtfront and omoplate position, forms pimple, and the traditional Chinese medical science claims " acne ", and the doctor trained in Western medicine name of disease is " acne ".The adolescence androgen increases, and smegma increases, and makes hair follicle, the different hyperkeratosis of sebaceous gland simultaneously, and the flat dead cell that horny layer comes off falls the hair follicle infundibulum, combines with sebum, produces mixture.If these mixture can not freely be discharged skin surface, in hair follicle, form the fat bolt and deposit.When these dyskeratosis cell aggregationes, lower hopper just forms sophisticated acne when expanding.The bacterial decomposition that sebum is existed in the hair follicle produces fatty acid, and latter's hair follicle stimulating causes inflammation, and causes the follicular wall damage to be broken, and the hair follicle content enters corium, thereby, cause the hair follicle inflammatory reaction of varying degree on every side.The genesis mechanism of comedo, relevant with following three big factors:
(1), causes sebum to produce and increase to the agnogenio property aggravation of androgen steroid (as testosterone, dehydroepiandros-sterone, hydroxyprogesterone) reaction.
(2) propionibacterium acnes hypertrophy.This bacterium is formed for the hair follicle normal flora, and it is its effect machine matter with sebum, and makes it partly to be converted into free fatty.But propionibacterium acnes is the activating complement path also, produces two kinds of chemotactic factors at least, impels inflammation to take place.
(3) the capsular epithelium cell quantity increases, and tackness is arranged, and it is excessive to form the hair follicle tetention keratosis.Latter's occurrence cause is undistinct yet.Propionibacterium acnes produces free fatty, may be the principal element that comedo forms.
Product for resolving poxes on the market is of a great variety, and the problem of existing product mainly is: 1, easily cause skin allergy, and big to skin irritation; 2,, add chemical antibacterial and destroy the skin normal flora in order to reach the purpose of antiinflammatory; 3, add hormones such as some banned substances such as chloromycetin, life-time service causes deeper injury to skin; 4, add heavy metal substance.
Summary of the invention
The purpose of this invention is to provide a kind of is the Chinese medicine composition that raw material has the anti-acne anti-inflammatory efficacy with Chinese medicine.
Another object of the present invention is to propose a kind of skin care formulation that utilizes the above-mentioned composition preparation.
A further object of the present invention is to propose the preparation method of above-mentioned skin care formulation.
The present invention is a primary raw material with Radix Salviae Miltiorrhizae, Flos Lonicerae, Flos Caryophylli, utilizes the method for the invention to be prepared, and produces synergism between the component, realizes good antiinflammatory acne-removing, has no side effect to skin is non-stimulated.Be aided with Cortex Magnoliae Officinalis and Radix Et Rhizoma Rhei, blood circulation promoting and blood stasis dispelling when can promote drug effect, pore is stopped up in mediation, makes the present invention have the effect of anti-acne seal concurrently.
The brief introduction of five tastes medicine medical material effect is as follows:
Radix Salviae Miltiorrhizae: the nature and flavor hardship is slightly cold.GUIXIN, Liver Channel.Effect: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind.Cure mainly: menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris etc.
Flos Lonicerae: sweet in the mouth; Cold.Return lung; The stomach warp.Effect cures mainly: heat-clearing and toxic substances removing.The epidemic febrile disease heating; Toxic-heat and blood stasis; The carbuncle furuncle; Sore throat and multiple infectious disease etc.
Flos Caryophylli: the nature and flavor suffering, temperature is returned bright, the shaoyin channel of lunar, the sufficient sun of hands.Effect: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia and ringworm etc.
Cortex Magnoliae Officinalis: nature and flavor: hardship; Hot; Warm in nature.Return spleen channel; The stomach warp; Large intestine channel.Function: circulation of qi promoting removing food stagnancy; Dampness is removed full; Lowering the adverse QI to relieve asthma.Cure mainly: stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass are vomited and diarrhoea, expectorant is stopped up QI rising in reverse order and fullness in the chest is breathed with cough etc.
Radix Et Rhizoma Rhei: nature and flavor: hardship, cold.Return the stomach warp; Large intestine channel; Liver Channel; Spleen channel.Effect: attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Detoxifcation.Cure mainly: excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas and scald etc.
The present inventor carries out the above-mentioned five tastes medicine compatibility and finds out optimum amount.Discovery is remarkable with each flavor medicine combination external anti-acne anti-inflammatory efficacy.Wherein Radix Salviae Miltiorrhizae can play the effect of blood circulation promoting and blood stasis dispelling, removing heat from blood, and the Chinese medicine main component TANSHINONES that contains is goed deep into the hair follicle depths, eliminates skin oil and fat and dirt, kills the relevant flora with other acnes of corynebacterium acnes.The Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating; Flos Caryophylli helps the effect of Flos Lonicerae strong osmotic bactericidal antiphlogistic, the control local infection.Cortex Magnoliae Officinalis, regulating the flow of vital energy has the effect of dredging pore.Can dredge the pilosebaceous duct of obstruction, guarantee the eupnea of skin.Radix Et Rhizoma Rhei, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, blood circulation promoting and blood stasis dispelling.
Concrete technical scheme of the present invention is as follows:
A kind of Chinese medicine composition with anti-acne anti-inflammatory efficacy, described compositions are mainly made by following raw materials in weight portion medicine:
30～50 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Flos Loniceraes, 10～30 parts of Flos Caryophyllis.
Described compositions also comprises following raw materials in weight portion medicine:
5～15 parts of Cortex Magnoliae Officinalis, 5～15 parts of Radix Et Rhizoma Rhei.
The optimal components ratio of described each crude drug of compositions is:
35～45 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Flos Loniceraes, 15～25 parts of Flos Caryophyllis, 10～15 parts of Cortex Magnoliae Officinalis, 10～15 parts of Radix Et Rhizoma Rhei.
The best proportioning of described each crude drug of compositions is:
40 parts of Radix Salviae Miltiorrhizaes, 20 parts of Flos Loniceraes, 20 parts of Flos Caryophyllis, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Et Rhizoma Rhei.
A kind of method for preparing above-mentioned composition, concrete steps are as follows:
(1) takes by weighing each crude drug according to said components and consumption;
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 70%～85% the ethanol, soak time is more than 2 hours; (the ethanol use amount is as long as guarantee all to flood medical material)
(3) crude drug after step (2) is soaked and percentage by volume are that 70%～85% ethanol mixes stirring, and are heated to 55～70 ℃ of extractions 1～2 hour; Described crude drug and alcoholic acid mass volume ratio g/ml are 0.5～1: 10～20;
(4) filter, filtration residue adding percentage by volume is 70%～85% ethanol, is heated to 55～70 ℃ and carries out second extraction, and extraction time is 1～2 hour; Described filtration residue and alcoholic acid mass volume ratio g/ml are 0.5～1: 3～10;
(5) filter, the filtrate that step (3) and step (4) are obtained mixes and concentrates 16～18 times, and ethanol is steamed back collection concentrated solution;
(6) be that 1: 1～4 ratio adds propylene glycol in concentrated solution according to volume ratio, stirred 0.5～2 hour down at 30～50 ℃, cooled and filtered, sterilization promptly obtains activity extract.
Crude drug described in the described step (3) and alcoholic acid mass volume ratio g/ml are that filtration residue described in 1: 15 and/or the step (4) and alcoholic acid mass volume ratio g/ml are 1: 5.
Filter in described step (4) and/or the step (5) is that 100～200 orders filter.
A kind of activity extract with anti-acne anti-inflammatory efficacy, described extract are to prepare through above-mentioned method.
The application of above-mentioned activity extract in the preparation skin care item.
A kind of skin care formulation with anti-acne anti-inflammatory efficacy, described preparation is made up of above-mentioned activity extract and skin care field acceptable auxiliary.
According to use approach difference, the present composition is made external preparation, as external facial cream, emulsion, cosmetic water, cleansing milk, spray or essence.But be not limited to above-mentioned dosage form, can be according to known method in the skin care item industrial circle, make various external preparation after the activity extract degerming that preparation of pharmaceutical compositions of the present invention is obtained.
The anti-acne preparation that the present invention makes, soft, the nonirritant abnormal flavour.Its usage and consumption are as follows:
Method: after clean of every day, on skin and the acne position smear preparation of the present invention, each is once sooner or later.
Consumption: for nursing usefulness on ordinary days, smear preparation of the present invention in right amount and get final product according to individual demand.For the multiple position of comedo and acne, can repeatedly smear, be as the criterion with whole coverings.
Beneficial effect of the present invention:
Raw material selection of the present invention is the natural composition of releiving, and the raw material gentleness is little to skin irritation, realizes treatment acne, acne-removing by number of ways.Relative like product in the market, safer, effective, nothing relies on (antibiotic-free and chemicals composition).Raw material of the present invention obtains simply, can be with different dosage forms as carrier, and preparation method is convenient, and good effect with low cost is easy to be accepted by consumers in general, has good application prospects and market prospect.
Foregoing invention content part of the present invention has been done detailed description to technical scheme of the present invention, and those skilled in the art can repeat the present invention and obtain technique effect of the present invention according to foregoing.Below by the specific embodiment the technology of the present invention content being further explained, understanding content of the present invention so that those skilled in the art are clearer, is not limitation of the present invention, and any being equal to replaces or known change all belongs to protection domain of the present invention.
Description of drawings
Describe the specific embodiment of the present invention in detail below in conjunction with accompanying drawing:
Fig. 1 be activity extract stock solution to P.acnes (P1), S.aureus (P2), S.epidermidis (P3), E.coli (P4), the fungistatic effect of the relevant pathogen of five kinds of acnes such as P.aeruginosa (P5);
Fig. 2 is activity extract stock solution and the 5% diluent fungistatic effect to P.acnes and S.aureus.
The specific embodiment
The used medical material of present embodiment all can be bought from China Medicament Group Corp. and obtain, and meets 2005 editions standards of Pharmacopoeia of People's Republic of China.Other compositions are the conventional adjuvant of skin care item and cosmetic field, all can obtain by commercially available purchase.Ethanol and propylene glycol are the commercially available prod.
The preparation of embodiment 1 activity extract of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Salviae Miltiorrhizae 40g, Flos Lonicerae 20g, Flos Caryophylli 10g.
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 70% the ethanol, soak time is 2.5 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 70% ethanol mixes stirring, and are heated to 55 ℃ of extractions 1 hour; Described crude drug and alcoholic acid mass volume ratio g/ml are 1:15; Be that the 70g crude drug adds 1050ml ethanol;
(4) 100 orders filter, and filtration residue adding percentage by volume is 70% ethanol, is heated to 55 ℃ and carries out second extraction, and extraction time is 1 hour; Described filtration residue and alcoholic acid mass volume ratio g/ml are 1: 5;
(5) 100 orders filter, and the filtrate that step (3) and step (4) are obtained mixes and concentrates 16 times, and ethanol under 50 ℃, is concentrated in the rotary evaporator and steams back collection concentrated solution fully;
(6) be that 1: 2 ratio adds propylene glycol in concentrated solution according to volume ratio, stirred 1 hour down at 30 ℃, cooled and filtered, sterilization promptly obtains activity extract.
Extracting solution is the bright thick liquid of peony, measures electrical conductivity, pH, solid content, flavones content, and measurement result is: solid content 40～46%, electrical conductivity 200～500 μ s/cm
2, pH value 4～6, flavones content 0.2～0.5mg/ml.
The preparation of embodiment 2 activity extracts of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Salviae Miltiorrhizae 30g, Flos Lonicerae 30g, Flos Caryophylli 10g.
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 85% the ethanol, soak time is 2 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 85% ethanol mixes stirring, and are heated to 60 ℃ of extractions 1.5 hours; Described crude drug and alcoholic acid mass volume ratio g/ml are 0.5: 10; Be that the 70g crude drug adds 1400ml ethanol.
(4) 200 orders filter, and filtration residue adding percentage by volume is 80% ethanol, is heated to 60 ℃ and carries out second extraction, and extraction time is 1.5 hours; Described filtration residue and alcoholic acid mass volume ratio g/ml are 0.5: 10;
(7) 200 orders filter, and the filtrate that step (3) and step (4) are obtained mixes and concentrates 18 times, and ethanol under 50 ℃, is concentrated in the rotary evaporator, steams back collection concentrated solution fully;
(5) be that 1: 3 ratio adds propylene glycol in concentrated solution according to volume ratio, stirred 2 hours down at 40 ℃, cooled and filtered, sterilization promptly obtains activity extract.
Extracting solution is the bright thick liquid of peony, measures electrical conductivity, pH, solid content, flavones content, and measurement result is: solid content 45～50%, electrical conductivity 200～500 μ s/cm
2, pH value 4～6, flavones content 0.2～0.4mg/ml.
The preparation of embodiment 3 activity extracts of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Salviae Miltiorrhizae 50g, Flos Lonicerae 10g, Flos Caryophylli 30g.
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 80% the ethanol, soak time is 4 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 80% ethanol mixes stirring, and are heated to 70 ℃ of extractions 2 hours; Described crude drug and alcoholic acid mass volume ratio g/ml are 1: 20; Be that the 90g crude drug adds 1800ml ethanol.
(4) 200 orders filter, and filtration residue adding percentage by volume is 80% ethanol, is heated to 70 ℃ and carries out second extraction, and extraction time is 2 hours; Described filtration residue and alcoholic acid mass volume ratio g/ml are 0.5: 3;
(5) 200 orders filter, and the filtrate that step (3) and step (4) are obtained mixes and concentrates 16 times, and ethanol under 50 ℃, is concentrated in the rotary evaporator and steams back collection concentrated solution fully;
(6) be that 1: 4 ratio adds propylene glycol in concentrated solution according to volume ratio, stirred 2 hours down at 50 ℃, cooled and filtered, sterilization promptly obtains activity extract.
Extracting solution is the bright thick liquid of peony, measures electrical conductivity, pH, solid content, flavones content, and measurement result is: solid content 40～44%, electrical conductivity 200～500 μ s/cm
2, pH value 4～6, flavones content 0.3～0.5mg/ml.
The preparation of embodiment 4 activity extracts of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Salviae Miltiorrhizae 40g, Flos Lonicerae 20g, Flos Caryophylli 20g, Cortex Magnoliae Officinalis 10g, Radix Et Rhizoma Rhei 10g.
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 80% the ethanol, soak time is 2 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 80% ethanol mixes stirring, and are heated to 60 ℃ of extractions 1 hour; Described crude drug and alcoholic acid mass volume ratio g/ml are 1: 15; Be that the 100g crude drug adds 1500ml ethanol;
(4) 200 orders filter, and filtration residue adding percentage by volume is 80% ethanol, is heated to 60 ℃ and carries out second extraction, and extraction time is 1 hour; Described filtration residue and alcoholic acid mass volume ratio g/ml are 1: 5; Promptly add 500ml ethanol;
(5) 200 orders filter, and the filtrate that step (3) and step (4) are obtained mixes and concentrates 16 times, and ethanol under 50 ℃, is concentrated in the rotary evaporator and steams back collection concentrated solution fully;
(6) be that 1: 2 ratio adds propylene glycol in concentrated solution according to volume ratio, stirred 1 hour down at 50 ℃, cooled and filtered, sterilization promptly obtains activity extract.
Extracting solution is the bright thick liquid of peony, measures electrical conductivity, pH, solid content, flavones content, and measurement result is: solid content 40～44%, electrical conductivity 200～500 μ s/cm
2, pH value 4～6, flavones content 0.2～0.5mg/ml.
The preparation of embodiment 5 activity extracts of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Salviae Miltiorrhizae 30g, Flos Lonicerae 30g, Flos Caryophylli 10g, Cortex Magnoliae Officinalis 5g, Radix Et Rhizoma Rhei 15g.
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 70% the ethanol, soak time is 5 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 70% ethanol mixes stirring, and are heated to 70 ℃ of extractions 2 hours; Described crude drug and alcoholic acid mass volume ratio g/ml are 1: 10; Be that the 90g crude drug adds 900ml ethanol.
(4) 100 orders filter, and filtration residue adding percentage by volume is 70% ethanol, is heated to 70 ℃ and carries out second extraction, and extraction time is 2 hours; Described filtration residue and alcoholic acid mass volume ratio g/ml are 1: 8; Promptly add 720ml ethanol.
(5) 100 orders filter, and the filtrate that step (3) and step (4) are obtained mixes and concentrates 18 times, and ethanol under 50 ℃, is concentrated in the rotary evaporator and steams back collection concentrated solution fully;
(6) be that 1: 1 ratio adds propylene glycol in concentrated solution according to volume ratio, stirred 2 hours down at 30 ℃, cooled and filtered, sterilization promptly obtains activity extract.
Extracting solution is the bright thick liquid of peony, measures electrical conductivity, pH, solid content, flavones content, and measurement result is: solid content 40～44%, electrical conductivity 200～500 μ s/cm
2, pH value 4～6, flavones content 0.2～0.5mg/ml.
The preparation of embodiment 6 activity extracts of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Radix Salviae Miltiorrhizae 50g, Flos Lonicerae 10g, Flos Caryophylli 30g, Cortex Magnoliae Officinalis 15g, Radix Et Rhizoma Rhei 5g.
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 85% the ethanol, soak time is 2.5 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 85% ethanol mixes stirring, and are heated to 55 ℃ of extractions 2 hours; Described crude drug and alcoholic acid mass volume ratio g/ml are 1: 5; Be that the 110g crude drug adds 550ml ethanol;
(4) 200 orders filter, and filtration residue adding percentage by volume is 85% ethanol, is heated to 60 ℃ and carries out second extraction, and extraction time is 1 hour; Described filtration residue and alcoholic acid mass volume ratio g/ml are 1: 5; Promptly add 500ml ethanol.
(5) 200 orders filter, and the filtrate that step (3) and step (4) are obtained mixes and concentrates 16 times, and ethanol under 50 ℃, is concentrated in the rotary evaporator and steams back collection concentrated solution fully.
(6) be that 1: 2 ratio adds propylene glycol in concentrated solution according to volume ratio, stirred 1 hour down at 45 ℃, cooled and filtered, sterilization promptly obtains activity extract.
Extracting solution is the bright thick liquid of peony, measures electrical conductivity, pH, solid content, flavones content, and measurement result is: solid content 40～44%, electrical conductivity 200～500 μ s/cm
2, pH value 4～6, flavones content 0.2～0.5mg/ml.
The preparation of embodiment 7 facial creams of the present invention
Component A: Cera Flava 3g, lanoline 4g, stearic acid 2g, white oil 6g, vitamin E 8g
Activity extract 15g, distilled water 57.4g, Margarita powder 1g, the chitosan 3g of B component: embodiment 4 preparations;
Component C: vitamin C 0.15g, essence 0.25g, antiseptic 0.2g
Concrete preparation method: component A is mixed and heated to 75 ℃; The B group is mixed and heated to 75 ℃; Under 45 rev/mins of mixing speeds, component A is joined in the B component evenly, carry out emulsifying.Add the C group when cooling the temperature to 50 ℃, stir, finished product is promptly made in packing.
The preparation of embodiment 8 essences of the present invention
(1) prepares each raw material according to following proportioning;
Embodiment 1 preparation Chinese medicine extract 10wt%
Phyto-hyaluronic acid 2wt%
Allantoin 0.6wt%
Water solublity Jojoba oil 2wt%
Pantothenylol 3wt%
EDTA-2Na?0.05wt％
Glycerol 8wt%
Ammonium acryloyldime-thyltaurate// VP copolymer (thickening agent) 0.5wt%
The deionized water surplus.
(2) will join except the composition antiseptic and the thickening agent and be heated to 60 ℃ in the deionized water and mix 300 rev/mins of stir speed (S.S.)s;
(3) behind the mix homogeneously, be cooled to 30 ℃ and add thickening agent and the packing of antiseptic mix homogeneously.
The activity extract efficacy test
Suppress the growth (to the inhibition effect of the relevant pathogen of acne) of the relevant cause of disease flora of acne in the hair follicle sebum
Adopt the filter paper method, observing samples is to the inhibition zone size of pathogen on flat board.Sample liquid and 20 times of diluents are adopted in experiment respectively, contrast the liquid (propylene glycol) into sample dissolution.And be positioned over dull and stereotyped central.Each handles 3 repetitions.Sample liquid is the activity extract of embodiment 5 preparations.
This experimental result: Fig. 1 be extract stock solution to P.acnes (P1), S.aureus (P2), S.epidermidis (P3), E.coli (P4), the fungistatic effect figure of the relevant pathogen of five kinds of acnes of P.aeruginosa (P5); The result of Fig. 1 shows that this extract stock solution all has the obvious suppression effect to five kinds of relevant pathogen that are separated to from patient's acne.Fig. 2 is extract stock solution (left figure) and the fungistatic effect figure of 5% diluent (right figure) to P.acnes and S.aureus.The result of Fig. 2 shows that this extract of variable concentrations all has the ability of the relevant pathogen of obvious suppression acne.
Clinical experiment of the present invention and result
Adopt embodiment 7 to carry out clinic trial and observe 90 examples, pimple and acne appear in the clinical face that mainly shows as, majority darkly, hoary hair's acne sample, color is red, pimple or cyst appear in the top, conscious slight pruritus or pain are difficult repeatedly.To be tried the patient and be divided into three groups at random.
Usage: group 1: after clean of every day, on acne and easily send out a position to smear the embodiment of the invention 7 preparations an amount of, each is once sooner or later.Group 2: after clean of every day, on acne and easily send out a position to smear the embodiment of the invention 8 preparations an amount of, each is once sooner or later.Group 3: after clean of every day, on acne and easily send out a position to smear commercially available certain brand anti-acne emulsion an amount of, each is once sooner or later.3 days, 7 days, 1 month, 3 months each statistics once.
Evaluation criterion: (1) cures: clinical symptom disappearance, erythra acne disappear; (2) effective: clinical symptom relief, erythra acne partly disappear or disappear, and reduce or reduce; (3) invalid: the commentaries on classics of not getting better of clinical symptoms, erythra acne.
Experimental result: (1) group 1 and organize 2 instant effects, effective percentage all can reach more than 93% in 3 days, 7 days, and certain cure rate is arranged, and 3 months cure rate is more than 96%.Organize 3,3 days and 7 days effective percentage are that 46%, 3 month cure rate is 13%.(2) group 1 and organize 2 pairs of pimples and the acne treatment effect all remarkable.(3) group 1 and organize 2 and do not have an example reaction phenomenons such as allergy, skin discomfort to occur.There is 1 example irritated erythra phenomenon to occur in the group 3.
Claims (10)
1. the Chinese medicine composition with anti-acne anti-inflammatory efficacy is characterized in that, described compositions is mainly made by following raw materials in weight portion medicine:
30～50 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Flos Loniceraes, 10～30 parts of Flos Caryophyllis.
2. Chinese medicine composition according to claim 1 is characterized in that, described compositions also comprises following raw materials in weight portion medicine:
5～15 parts of Cortex Magnoliae Officinalis, 5～15 parts of Radix Et Rhizoma Rhei.
3. skin care compositions according to claim 2 is characterized in that, described compositions is made by following raw materials in weight portion medicine:
35～45 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Flos Loniceraes, 15～25 parts of Flos Caryophyllis, 10～15 parts of Cortex Magnoliae Officinalis, 10～15 parts of Radix Et Rhizoma Rhei.
4. skin care compositions according to claim 3 is characterized in that, described compositions is made by following raw materials in weight portion medicine:
40 parts of Radix Salviae Miltiorrhizaes, 20 parts of Flos Loniceraes, 20 parts of Flos Caryophyllis, 10 parts of Cortex Magnoliae Officinalis, 10 parts of Radix Et Rhizoma Rhei.
5. one kind prepares claim 1,2,3 or 4 described method for compositions, it is characterized in that concrete steps are as follows:
(1) takes by weighing each crude drug according to claim 1,2,3 or 4 described components and consumption;
(2) each crude drug is mixed to be incorporated in percentage by volume be to soak in 70%～85% the ethanol, soak time is more than 2 hours;
(3) crude drug after step (2) is soaked and percentage by volume are that 70%～85% ethanol mixes stirring, and are heated to 55～70 ℃ of extractions 1～2 hour; Described crude drug and alcoholic acid mass volume ratio g/ml are 0.5～1: 10～20;
(4) filter, filtration residue adding percentage by volume is 70%～85% ethanol, is heated to 55～70 ℃ and carries out second extraction, and extraction time is 1～2 hour; Described filtration residue and alcoholic acid mass volume ratio g/ml are 0.5～1: 3～10;
(5) filter, the filtrate that step (3) and step (4) are obtained mixes and concentrates 16～18 times, and ethanol is steamed back collection concentrated solution;
(6) be that 1: 1～4 ratio adds propylene glycol in concentrated solution according to volume ratio, stirred 0.5～2 hour down at 30～50 ℃, cooled and filtered, sterilization promptly obtains activity extract.
6. method according to claim 5 is characterized in that, filtering in described step (4) and/or the step (5) is that 100～200 orders filter.
7. method according to claim 6 is characterized in that, crude drug described in the described step (3) and alcoholic acid mass volume ratio g/ml are that filtration residue described in 1: 15 and/or the step (4) and alcoholic acid mass volume ratio g/ml are 1: 5.
8. the activity extract with anti-acne anti-inflammatory efficacy is characterized in that, described extract prepares through claim 5,6 or 7 described methods.
9. the application of the described activity extract of claim 8 in the preparation skin care item.
10. the skin care formulation with anti-acne anti-inflammatory efficacy is characterized in that, described preparation is made up of described activity extract of claim 8 and skin care field acceptable auxiliary.
Priority Applications (1)
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| CN102018646A (en) * | 2010-11-26 | 2011-04-20 | 新时代健康产业（集团）有限公司 | Skin-care composition and skin-care preparation with acne-removing effect and preparation method thereof |
| CN102247442A (en) * | 2011-06-13 | 2011-11-23 | 北京华夏众芳生物科技有限公司 | Traditional Chinese medicine composition and preparation with mosquito repelling and itching relieving efficacies, and preparation method thereof |
| CN102727611A (en) * | 2012-07-02 | 2012-10-17 | 北京华夏众芳生物科技有限公司 | Topical Chinese medicinal composition/preparation with antibacterial, antipruritic and repairing effects, and preparation method thereof |
| CN102949461A (en) * | 2012-10-25 | 2013-03-06 | 北京华夏众芳生物科技有限公司 | External traditional Chinese medicine composition and preparation for treating nodular type acnes and preparation method thereof |
| CN103271855A (en) * | 2013-05-23 | 2013-09-04 | 苏州谷力生物科技有限公司 | Skincare water for removing acnes and preparation method thereof |
| CN104434685A (en) * | 2014-12-10 | 2015-03-25 | 唯美度科技（北京）有限公司 | Light facial cleanser and preparation method of light facial cleanser |
| CN104523473A (en) * | 2014-12-03 | 2015-04-22 | 广州市尚医生物科技有限公司 | Anti-acne microemulsion system and preparation method thereof |
| CN104622763A (en) * | 2015-03-06 | 2015-05-20 | 谢妮妮 | Acne-preventing herbal essence composition, acne-preventing herbal essence extract, acne-preventing herbal facial cleanser and production method of acne-preventing herbal facial cleanser |
| CN105497479A (en) * | 2015-12-17 | 2016-04-20 | 济南舜祥医药科技有限公司 | Acne ointment applied to female chin and preparation method thereof |
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| CN109498536A (en) * | 2018-12-15 | 2019-03-22 | 横琴智库转化医学有限公司 | A kind of cosmetic composition containing Chinese medicine extract |
| CN113081933A (en) * | 2021-04-12 | 2021-07-09 | 建昌帮药业有限公司 | Acne-removing composition and preparation method and application thereof |
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| CN102018646A (en) * | 2010-11-26 | 2011-04-20 | 新时代健康产业（集团）有限公司 | Skin-care composition and skin-care preparation with acne-removing effect and preparation method thereof |
| CN102018646B (en) * | 2010-11-26 | 2013-08-21 | 新时代健康产业（集团）有限公司 | Skin-care composition and skin-care preparation with acne-removing effect and preparation method thereof |
| CN102247442A (en) * | 2011-06-13 | 2011-11-23 | 北京华夏众芳生物科技有限公司 | Traditional Chinese medicine composition and preparation with mosquito repelling and itching relieving efficacies, and preparation method thereof |
| CN102247442B (en) * | 2011-06-13 | 2013-04-03 | 北京华夏众芳生物科技有限公司 | Traditional Chinese medicine composition and preparation with mosquito repelling and itching relieving efficacies, and preparation method thereof |
| CN102727611B (en) * | 2012-07-02 | 2014-01-01 | 北京华夏众芳生物科技有限公司 | Topical Chinese medicinal composition/preparation with antibacterial, antipruritic and repairing effects, and preparation method thereof |
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| CN103271855A (en) * | 2013-05-23 | 2013-09-04 | 苏州谷力生物科技有限公司 | Skincare water for removing acnes and preparation method thereof |
| CN103271855B (en) * | 2013-05-23 | 2014-10-15 | 苏州谷力生物科技有限公司 | Skincare water for removing acnes and preparation method thereof |
| CN104523473A (en) * | 2014-12-03 | 2015-04-22 | 广州市尚医生物科技有限公司 | Anti-acne microemulsion system and preparation method thereof |
| CN104523473B (en) * | 2014-12-03 | 2017-11-28 | 广州市尚医生物科技有限公司 | A kind of anti-acne microemulsion system and preparation method thereof |
| CN104434685A (en) * | 2014-12-10 | 2015-03-25 | 唯美度科技（北京）有限公司 | Light facial cleanser and preparation method of light facial cleanser |
| CN104622763A (en) * | 2015-03-06 | 2015-05-20 | 谢妮妮 | Acne-preventing herbal essence composition, acne-preventing herbal essence extract, acne-preventing herbal facial cleanser and production method of acne-preventing herbal facial cleanser |
| CN105497479A (en) * | 2015-12-17 | 2016-04-20 | 济南舜祥医药科技有限公司 | Acne ointment applied to female chin and preparation method thereof |
| CN108704040A (en) * | 2018-08-23 | 2018-10-26 | 山东效强美容服务有限公司 | A kind of Chinese medicine composition and its application |
| CN108704040B (en) * | 2018-08-23 | 2021-09-17 | 山东效强美容服务有限公司 | Traditional Chinese medicine composition and application thereof |
| CN109498536A (en) * | 2018-12-15 | 2019-03-22 | 横琴智库转化医学有限公司 | A kind of cosmetic composition containing Chinese medicine extract |
| CN113081933A (en) * | 2021-04-12 | 2021-07-09 | 建昌帮药业有限公司 | Acne-removing composition and preparation method and application thereof |
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