CN108066221A - A kind of composition for preventing alopecia - Google Patents
A kind of composition for preventing alopecia Download PDFInfo
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- CN108066221A CN108066221A CN201810046889.5A CN201810046889A CN108066221A CN 108066221 A CN108066221 A CN 108066221A CN 201810046889 A CN201810046889 A CN 201810046889A CN 108066221 A CN108066221 A CN 108066221A
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- composition
- extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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Abstract
The invention discloses a kind of compositions for preventing alopecia, include the component of 5 alpha reductase inhibitor of Chinese herbal medicine, antiseptic and Anti-hair loss agent, wherein 5 alpha reductase inhibitor of Chinese herbal medicine includes the one or more in Semen Myristicae extract, hawk carob element, red ginseng rhizome extract, Cuscuta reflexa extract.And applied in cosmetics, pass through restraining and sterilizing bacteria, the approach for inhibiting 5 alpha-reductases, promoting natural on-off cycles of hair growth so that scalp is more healthy, can effectively prevent alopecia.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of composition for preventing alopecia.
Background technology
Male pattern alopecia is the most common depilation phenomenon of adult male.The main reason for male pattern alopecia is caused to occur
It is that inherent cause and male hormone metabolism are not normal, the latter is mainly manifested in 5α-reductase increased activity, and testosterone is made to be converted into too much
Protona, the latter largely gather at scalp hair follicles position, cause natural on-off cycles of hair growth cycle time, and hair follicle regresses become smaller, and hair becomes
Carefully, soften, shorten, come off.On the other hand, it is subject to such as infection such as bacterium, virus, fungi, conveyor screw, parasite of various pathogen
It is serious to also result in alopecia.
In order to prevent alopecia, various formula for growing hair products are developed, but largely exists in terms of using effect and lacks
It falls into, and formula is unreasonable, and the cost performance for causing product is relatively low, and effective anti-hair loss products also have a vast market
Prospect.
The content of the invention
The composition of alopecia is prevented it is an object of the invention to provide a kind of, and is applied in cosmetics, is improved total
The scalp health of body, effectively prevents alopecia.
In order to achieve the above object, the present invention provides following technical solution：
A kind of composition for preventing alopecia includes the component of following mass parts：
Chinese herbal medicine 5- alpha reductase inhibitors 6~17
Antiseptic 2~6
Anti-hair loss agent 0.001~0.005
Wherein Chinese herbal medicine 5- alpha reductase inhibitors include Semen Myristicae extract, hawk carob element, red ginseng rhizome extract, greatly
One or more in flower Semen Cuscutae extract.
Further, the composition includes the component of following mass parts：
Chinese herbal medicine 5- alpha reductase inhibitors 8~16
Antiseptic 3~5
Anti-hair loss agent 0.002~0.004
Wherein Chinese herbal medicine 5- alpha reductase inhibitors include Semen Myristicae extract, hawk carob element, red ginseng rhizome extract, greatly
One or more in flower Semen Cuscutae extract.
Further, the composition includes the component of following mass parts：
Chinese herbal medicine 5- alpha reductase inhibitors 11
Antiseptic 4
Anti-hair loss agent 0.003
Wherein Chinese herbal medicine 5- alpha reductase inhibitors include Semen Myristicae extract, hawk carob element, red ginseng rhizome extract, greatly
One or more in flower Semen Cuscutae extract.
In addition, Anti-hair loss agent of the present invention is dihydrosphingosine；The antiseptic includes Artemisinin, kuh-seng
One or more in element, Ramulus Cinnamomi extract, resveratrol.
Composition of the present invention can be used as cosmetics, such as be used for Anti-hair loss class product as additive.
Compared with prior art, it is the device have the advantages that as follows：
(1) add antiseptic, can effective antibacterial, maintain scalp health, such as addition Artemisinin to all skin tineas
There is restraining and sterilizing bacteria effect, resveratrol not only can effectively prevent fungi invasion and attack, also have good antioxidation, can reduce oxidation
Damage, prevents alopecia indirectly；
(2) Chinese herbal medicine 5- alpha reductase inhibitors are added, hair caused by hawk carob element A can effectively improve testosterone is reduced
And the phenomenon that slow-growing, excessive androgen level caused by testosterone stimulates is reduced, and there is certain inhibition to 5- alpha-reductases
Effect；Red ginseng rhizome extract has 5- alpha-reductases inhibitory action, promotes hair growth, so as to effectively prevent alopecia；
(3) Anti-hair loss agent is added, anti-alopecia-stopping rebalances hair life cycle, makes scalp more healthy, promotes hair
With the formation of scalp basic substance, alopecia is effectively prevented.
(4) composition by the prevention alopecia of the present invention is applied in cosmetics, is acted synergistically between ingredient, assigns cosmetics
Good Anti-hair loss effect.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Prevent the preparation of alopecia composition：
By 4 grams of hawk carob elements, 7 grams of red ginseng rhizome extracts, 0.003 gram of dihydrosphingosine, 4 grams of kushenins and 84.997 grams
Deionized water is placed in mixer, is uniformly mixed, you can obtains the prevention alopecia composition.
Embodiment 2
Inhibit 5α-reductase active effect evaluation test
By evaluating inhibitory action of the prevention alopecia composition to 5α-reductase activity, it may be determined that prevention alopecia composition
To the suppression level of protona (abbreviation DHT) synthesis, so that it is determined that the effect of its Anti-hair loss.Evaluation method is as follows：
Blank test group (5α-reductase, dependence dihydrocoenzyme (NADPH), Tris buffer solutions).
Blank control group (stosterone of series concentration, 5α-reductase, dependence dihydrocoenzyme (NADPH), Tris bufferings
Solution).
Finasteride group (Finasteride solution, the stosterone of series concentration, 5α-reductase, dependence dihydrocoenzyme
(NADPH), Tris buffer solutions).
Prevent alopecia composition group (prevention alopecia composition, the stosterone of series concentration, 5α-reductase, dependence reduction
Coenzyme (NADPH), Tris buffer solutions).
By more than each group reaction system respectively at being continuously incubated at 37 DEG C, with ultraviolet grating spectrophotometer at 340nm
The time changing curve of the characteristic absorption wavelength OD values of METHOD FOR CONTINUOUS DETERMINATION NADPH, is converted into according to NADPH standard curves as zymetology
Concentration fall off rate in reaction substrate NADPH 10min deducts the fall off rate of blank test pipe, is enzymatic activity.It measures
It the results are shown in Table shown in 1.
Table 1
Table 1 the result shows that, prevention alopecia composition of the invention to 5α-reductase activity have apparent inhibitory action,
Show that it has good inhibitory action to protona (abbreviation DHT) synthesis, have effects that well to prevent alopecia.
Embodiment 3
Prevent the experiment of alopecia effect assessment
The prevention alopecia composition prepared using embodiment 1 selects 20-45 Sui alopecia seborrheica patient 50 as sample on probation
Example, wherein 40 people of male, 10 people of women, as crowd on probation.
Therapy：Sample on probation is gently embrocated affected part by patient with absorbent cotton, with finger at coating gently knocking 5min,
Daily morning and evening respectively with 1 time, 30 as a treatment course, continuously treats 4 courses for the treatment of.The pretherapy and post-treatment follow-ups record of all patients as a result,
Curative effect is evaluated after drug withdrawal.
Curative effect determinate standard：Recovery from illness (alopecia recovers normal, no scratchiness)；Effective (alopecia significantly reduces or recovers normal,
Dandruff, itch disappear, and affected part has the long or former fine, soft fur sample of apparent kainogenesis send out thicker, is black, is hard, is long, and appearance is obviously improved)；Effectively
(alopecia, dandruff are reduced, and itch mitigates, and affected part has kainogenesis long, and appearance makes moderate progress)；It is invalid that (alopecia, dandruff slightly reduce or nothing
Variation, itch is slightly clear or the same, and no kainogenesis is long, appearance investigation unobvious).Efficacy result is shown in Table 2.
Table 2
| Curative effect grade | Recovery from illness | It is effective | Effectively | It is invalid |
| Number | 8 | 20 | 19 | 3 |
| Ratio | 16% | 40% | 38% | 6% |
Table 2 the result shows that, prevention alopecia composition of the invention to treatment alopecia seborrheica have more apparent effect, show
Effect more than ratio reaches 56%, and effective Yi Shang ratio reaches 94%.
Embodiment 4
The preparation of anticreep hair conditioner：
According to mass percent, 5% INCROQUAT TMC-80,0.1% disodium ethylene diamine tetraacetate are added in
In 76.1% deionized water, 80 DEG C are heated to, is water phase.2.5% glycerin monostearate, 3% cetostearyl alcohol, 3% are gathered
Dimethyl siloxane mixes, and is heated to 80 DEG C, is oil phase.Oil phase and water are added in emulsification pot, stirred evenly, emulsifying homogeneous
After five minutes, when stirring is cooled to 50 DEG C, 0.1% essence, 0.2% Phenoxyethanol and 10% above-mentioned prevention alopecia combination are added in
Object stirs evenly, and is cooled to 38 DEG C.
Embodiment 5
The preparation of anticreep shampoo：
According to mass percent, 57% deionized water is heated to 80 DEG C, adds in 0.5% cationic cellulose, heat preservation is molten
After solution is uniform, 0.1% disodium ethylene diamine tetraacetate, 0.1% citric acid, 0.5% sodium chloride, stirring and dissolving are added in.Then, add in
18% Dodecyl Polyoxyethylene Ether sodium sulfovinate, stirring and dissolving.Add in 2% cetostearyl alcohol, 1% olive oil, stirring and dissolving.Add
Enter 2.5% Coconut Fatty Acid Monoethanolamide, 6% Cocoamidopropyl betaine and 10% prevention alopecia composition, stir evenly, lead to
Enter cooling and be water-cooled to 50 DEG C, 0.2% Phenoxyethanol, 2% silicone emulsion and 0.1% essence are added in, when continuing cool to 40 DEG C
.
Above example is merely to illustrate embodiment of the present invention, and there is no the limits having to the present invention in any form
System；It is any to be engaged in professional and technical personnel, it all has the ability using the technology contents having revealed that, some is made to it and changes or repaiies
Decorations become the equivalent embodiment of equivalent variations.Technical spirit according to the present invention carries out the present invention simply modification, equivalent variations
With modification, belong in the range of technical solution of the present invention.
Claims (10)
1. a kind of composition for preventing alopecia, it is characterised in that component and content are：
Chinese herbal medicine 5- alpha reductase inhibitors 6~17
Antiseptic 2~6
Anti-hair loss agent 0.001~0.005
It is mass parts above；
Wherein Chinese herbal medicine 5- alpha reductase inhibitors include Semen Myristicae extract, hawk carob element, red ginseng rhizome extract, great Hua Tu
It is one or more of in silk seed extract.
2. composition as described in claim 1, it is characterised in that component and content are：
Chinese herbal medicine 5- alpha reductase inhibitors 8~16
Antiseptic 3~5
Anti-hair loss agent 0.002~0.004
It is mass parts above；
Wherein Chinese herbal medicine 5- alpha reductase inhibitors include Semen Myristicae extract, hawk carob element, red ginseng rhizome extract, great Hua Tu
It is one or more of in silk seed extract.
3. composition as claimed in claim 2, it is characterised in that component and content are：
Chinese herbal medicine 5- alpha reductase inhibitors 11
Antiseptic 4
Anti-hair loss agent 0.003
It is mass parts above；
Wherein Chinese herbal medicine 5- alpha reductase inhibitors include Semen Myristicae extract, hawk carob element, red ginseng rhizome extract, great Hua Tu
It is one or more of in silk seed extract.
4. composition as described in claim 1, it is characterised in that：
The Anti-hair loss agent is dihydrosphingosine；
The antiseptic includes one or more of in Artemisinin, kushenin, Ramulus Cinnamomi extract, resveratrol.
5. composition as claimed in claim 2, it is characterised in that：
The Anti-hair loss agent is dihydrosphingosine；
The antiseptic includes one or more of in Artemisinin, kushenin, Ramulus Cinnamomi extract, resveratrol.
6. composition as claimed in claim 3, it is characterised in that：
The Anti-hair loss agent is dihydrosphingosine；
The antiseptic includes one or more of in Artemisinin, kushenin, Ramulus Cinnamomi extract, resveratrol.
7. composition as described in claim 1, it is characterised in that can be used as cosmetics.
8. composition as claimed in claim 2, it is characterised in that can be used as cosmetics.
9. composition as claimed in claim 3, it is characterised in that can be used as cosmetics.
10. such as claims 1 to 3 any one of them composition, it is characterised in that additive can be used as to be produced for Anti-hair loss class
Product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810046889.5A CN108066221A (en) | 2018-01-16 | 2018-01-16 | A kind of composition for preventing alopecia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810046889.5A CN108066221A (en) | 2018-01-16 | 2018-01-16 | A kind of composition for preventing alopecia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108066221A true CN108066221A (en) | 2018-05-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810046889.5A Pending CN108066221A (en) | 2018-01-16 | 2018-01-16 | A kind of composition for preventing alopecia |
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| Country | Link |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110104251A1 (en) * | 2004-01-07 | 2011-05-05 | Goldstein Mindy S | Cosmetic Composition And Method For Retarding Hair Growth |
| CN104546612A (en) * | 2015-01-19 | 2015-04-29 | 广州市科能化妆品科研有限公司 | Anti-hair-loss hairdressing and hair care composition |
| CN106166118A (en) * | 2016-07-28 | 2016-11-30 | 王玉艳 | A kind of Anti-hair loss, germinal preparation |
-
2018
- 2018-01-16 CN CN201810046889.5A patent/CN108066221A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110104251A1 (en) * | 2004-01-07 | 2011-05-05 | Goldstein Mindy S | Cosmetic Composition And Method For Retarding Hair Growth |
| CN104546612A (en) * | 2015-01-19 | 2015-04-29 | 广州市科能化妆品科研有限公司 | Anti-hair-loss hairdressing and hair care composition |
| CN106166118A (en) * | 2016-07-28 | 2016-11-30 | 王玉艳 | A kind of Anti-hair loss, germinal preparation |
Non-Patent Citations (1)
| Title |
|---|
| 唐青涛: ""中草药来源的5α-还原酶抑制剂的研究进展"", 《华西药学杂志》 * |
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