CN104546612B - A kind of hair-washing hair-care composition of Anti-hair loss - Google Patents
A kind of hair-washing hair-care composition of Anti-hair loss Download PDFInfo
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- CN104546612B CN104546612B CN201510025222.3A CN201510025222A CN104546612B CN 104546612 B CN104546612 B CN 104546612B CN 201510025222 A CN201510025222 A CN 201510025222A CN 104546612 B CN104546612 B CN 104546612B
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Abstract
This application discloses a kind of hair-washing hair-care composition of Anti-hair loss.The composition contains saw palmetto berry extract and lemon grass (Cymbopogon citratus) essential oil as active component.Wherein saw palmetto berry extract can effectively suppress 5Alpha reductase activities, and lemon grass (Cymbopogon citratus) essential oil can effectively suppress to cause Malassezia furfur caused by dandruff, and composition reduces the generation of alopecia in terms of two.The composition effectively can prevent or reduce alopecia.
Description
Technical field
The invention belongs to personal care field, the method for especially preventing or reducing alopecia.
Background technology
Male pattern baldness is also known as androgenetic alopecia or alopecia seborrheica etc..Androgen is a kind of important hormone, but such as
Fruit androgen surplus will produce various symptoms such as androgenetic alopecia, seborrhagia, acne and benign prostatauxe etc..5α-
Reductase is a kind of enzyme during male hormone metabolism, testosterone is changed into dihydrotestosterone (DHT), and DHT is to cause male is male to swash
The most important factor of disposition alopecia.
Malassezia furfur is the main reason for causing dandruff excessive, and one of inducement caused by alopecia.Work as horse traction
When distorted proliferation occurs in color bacterium, epidermal metabolic is caused to accelerate extremely, epidermal cell sheet comes off, and the recurrent exerbation of dandruff makes head
Skin cell layer is badly damaged, thinning scalp cells layer can not healthy hair follicle, consolidate root of hair, so as to cause alopecia.
Seek safe and reliable method and prevent or reduce alopecia to have carried out many years.Prior art discloses prevent or subtract
Many patents of few alopecia, as United States Patent (USP) US005750108 discloses a kind of method for delaying alopecia, the invention uses tea tree
Oil, chlorine dioxide and saw palmetto berry extract point three steps treatment, positive effect.United States Patent (USP) US006596266B2 reports one
The composition of kind hair growth, minoxidil is as active component combination saw palmetto berry extract and nettle extract, composition
Natural on-off cycles of hair growth ability can be strengthened.Chinese patent CN 103446563A are disclosed in a kind of Anti-hair loss for suppressing 5α-reductase activity
Herbal composition, for treating the seborrheic alopecia caused by the property of male androgen source.
In the market have many products declare can anti-alopecia-stopping, it is but most of expensive and with side effect, or only
It is being simply mixed for Multiple components, DeGrain.For example, minoxidil is a kind of common promotion natural on-off cycles of hair growth medicine, should
Medicine must daily be taken twice and can not be interrupted, will alopecia recurrence once disabling.It is reported that oral minoxidil can influence
The heart rate of some patients, therefore the patient with angiocardiopathy can not take.Finasteride is also the medicine for hair growth
Thing, can effectively suppress 5α-reductase activity, but study find the medicine may cause slight dysfunction of liver, sex dysfunction,
Middle severe depression, emotionally disturbed, sleep and eating habit exception etc., easily recur, it is difficult to maintain curative effect after drug withdrawal；Maternity dress meeting
Cause fetal anomaly.
The present invention relates to a kind of hair-washing hair-care composition of Anti-hair loss, on the one hand suppresses 5α-reductase activity, on the other hand
Effectively suppress chlosma, so as to prevent or reduce alopecia in terms of two, composition components are pure natural plant extract, can
Improve the using effect of chemical formulation product, have no side effect safely, health environment-friendly.
The content of the invention
It is an object of the invention to provide a kind of hair-washing hair-care composition of Anti-hair loss, effectively can prevent or reduce alopecia.This
Inventive composition contains saw palmetto berry extract and lemon grass (Cymbopogon citratus) essential oil, overcomes the difficulty of prior art, with pure plant group
It is divided into main component, effectively can prevents or reduce alopecia, maintain scalp health, while reduce the addition of chemical composition, changes
The using effect of kind product, prevents the generation of side effect.
The present invention technical characteristic be：Saw palmetto berry extract addition 0.01%-20%；Lemon grass (Cymbopogon citratus) essential oil addition
0.01%-20%.
The present composition is characterised by：The hair-washing hair-care composition can also contain other additives, such as bacteriostatic agent
ZPT, OCT, peppermint, resorcinol, salicylic acid etc..
The present composition is characterised by：The hair-washing hair-care composition can also contain surfactant, fatty alcohol, season
Ammonium salt, cationic polymer, silicone compounds and glyceride type etc..
Saw palmetto fruit is the berry of babassu saw palmetto, and saw palmetto berry extract contains the change for suppressing 5α-reductase
Study point, therefore dihydrotestosterone DHT generation can be prevented, so as to prevent or reduce androgenetic alopecia.Saw palmetto fruit is extracted
Thing contains aliphatic acid, fatty alcohol and phytosterol.Wherein aliphatic acid main component is laurate, myristic acid, palmitic acid, oil
Acid, linoleic acid etc., fatty alcohol main component are octacosanol, hexacosyl alcohol etc., and phytosterol is mainly cupreol.
The extracting method of saw palmetto berry extract：Supercritical CO will be passed through after fruit drying, crushing2Extraction, extraction pressure
Power is not less than 500bar, and temperature is less than 80 DEG C.Pressure is reduced after extraction by extract from CO2Middle sub-argument comes out.Supercritical CO2Extraction
Whole process is taken without using organic solvent, noresidue solvent, it is therefore prevented that murder by poisoning of the extraction process to human body and the pollution to environment, be
100% it is pure natural.
Lemon grass (Cymbopogon citratus) scientific name lemongrass, also known as lemon grass, grass tree section Cymbopogon herbaceos perennial, are widely used in and cook
Prepare food, household articles and traditional medicine.The main component of lemon grass (Cymbopogon citratus) essential oil is citral (3,7- dimethyl -2,6- octadiene aldehyde),
World Health Organization's essential drugs standard regulation is classified as a kind of external skin medicine and is used for antimycotic special shampoo and goes
Seborrhea is treated in keratose.Research finds that lemon grass (Cymbopogon citratus) essential oil can effectively suppress to cause chaff horse caused by dandruff
Color bacterium is drawn, and then prevents or reduce alopecia.In addition, lemon grass (Cymbopogon citratus) essential oil has a powerful antibacterial action, and can anti-depression, carry
Shake spirit, stimulate energy to recover.
Lemon grass (Cymbopogon citratus) method of extraction of essential oil：Essential oil is obtained by steam distillation.Concrete operations are selection lemon grass blade sheath,
Its chip section is put into round-bottomed flask, adds deionized water, solid-liquid ratio 1:10, it is connected to distilling apparatus, institute after extraction
Obtain oil water mixture to be separated with separatory funnel, gained essential oil is stored in closed container and carries out light protection, standby.
Compared with prior art, composition of the invention is using pure plant component as principle active component, reducing
The addition of additive is learned, improves product using effect, prevents the generation of side effect, maintains effectively to subtract while scalp health
Less or anti-alopecia-stopping.
The present composition can be made into a variety of formulations such as liquid dosage form, cream formulation, paste formulation and solid dosage forms.Will be normal
The various hair care products enabled in said composition applied to anti-alopecia-stopping, such as shampoo, hair care are added to additive
Element, scalp tonic liquid, hair jelly, pomade, send out film, hair spraying, brilliantine etc..Particularly preferred product form produces for leave
Product, such as hair conditioner (leave), hair Essence, scalp tonic liquid, hair spraying etc..
Embodiment
Embodiment 1：Anticreep hair-care shampoo
| Composition | Scheme 1：Addition (%) | Scheme 2：Addition (%) |
| Poly alkyl alcohol ether sodium sulfovinate | 12 | 12 |
| Laruyl alcohol sodium sulfovinate | 9 | 9 |
| Cocoamidopropyl betaine | 1 | 3 |
| Coconut oleoyl amine MEA | 2 | 1.5 |
| Glycol distearate | 1.5 | 1.5 |
| EDTA- disodiums | 0.1 | 0.1 |
| Sodium chloride | 0.6 | 0.6 |
| Saw palmetto berry extract | 0.01 | 0.5 |
| Guar hydroxypropyltrimonium ammonium chloride | 0.5 | 0.1 |
| Citric acid | 0.007 | 0.007 |
| Methylchloroisothiazandnone | 0.0006 | 0.0006 |
| Methylisothiazolinone | 0.0002 | 0.0002 |
| Dimethyl silicone polymer | 1.0 | 1.0 |
| Sodium lauroyl sarcosine | 3.0 | 1.5 |
| Lemon grass (Cymbopogon citratus) essential oil | 0.2 | 0.01 |
| Deionized water | Surplus | Surplus |
Embodiment 2：Anti-hair loss hair conditioner
| Composition | Scheme 1：Addition (%) | Scheme 2：Addition (%) |
| 16/octadecyl alcolol | 8.0 | 5.5 |
| SAPDMA | 2 | 1.5 |
| Cyclomethicone | 1 | 1 |
| Glycerin monostearate | 0.8 | 0.8 |
| Guar hydroxypropyltrimonium ammonium chloride | 0.35 | 0.15 |
| Dimethyl silicone polymer | 2 | 2 |
| Saw palmetto berry extract | 5 | 15 |
| Propane diols | 2 | 2 |
| Lemon grass (Cymbopogon citratus) essential oil | 0.3 | 0.3 |
| Lactic acid | 0.4 | 0.3 |
| EDTA- disodiums | 0.1 | 0.1 |
| Methyl hydroxybenzoate | 0.15 | 0.15 |
| Nipasol | 0.1 | 0.1 |
| Phenoxyethanol | 0.4 | 0.4 |
| Deionized water | Surplus | Surplus |
Embodiment 3：Anticreep hair essence
Testing example 1：
The radical method of testing of epilation：Alopecia during hair washing is collected, determines its radical, every 10 day early morning counts alopecia
Quantity.Further, since alopecia is big with seasonal variations, particularly from the increase of summer-to-fall alopecia quantity, therefore 6 need to be continued
Month.Method of testing is had one's hair wash on the 30cm square adhesive-bonded fabrics of opening, and the hair adhered on adhesive-bonded fabric is dried, received with tweezers
Collection, hair is placed on clean paper, calculates hair radical.The radical of epilation and visual method are carried out when being had one's hair wash by counting
Evaluation, is as a result divided into following five levels, and is scored, and the final judgement to effect is expressed as the average value of fraction, when flat
Average is judged to effectively, as a result see the table below 1 when being 3.0 or higher
The alopecia criterion of table 1
| It is horizontal | The radical of epilation during hair washing | Range estimation |
| 5 | Significantly reduce | Significantly improve |
| 4 | Moderate reduces | Moderate improves |
| 3 | It is slight to reduce | It is slight to improve |
| 2 | It is constant | It is constant |
| 1 | Increase | Difference |
Subject chooses condition：25-45 one full year of life males, daily alopecia radical are 100 or more.
Effect experiment is carried out to Example formulations.Application method：Dry, will implement after being had one's hair wash using embodiment 1 (scheme 1)
Example 2 (scheme 1) is uniformly applied to hair and scalp, stops 5-10 minutes, embodiment 3 (scheme 1) is bestowed into head after rinsing well
Epidermis face is simultaneously massaged, and promotes to absorb, without cleaning.Use 2-3 times, by a definite date 6 months weekly.
Using alopecia volunteer totally 15 people of above-described embodiment formula, test uses the series of products 6 totally months, experiment knot
Fruit is shown in Table 2.Can substantially it be found from the data of table 2, the series of products can effectively reduce alopecia, effective percentage 73%, anticreep after application
Positive effect.
The test result of table 2
Testing example 2：
Effect experiment is carried out to Example formulations.Application method：Dry, will implement after being had one's hair wash using embodiment 1 (scheme 2)
Example 2 (scheme 2) is uniformly applied to hair and scalp, stops 5-10 minutes, embodiment 3 (scheme 2) is bestowed into head after rinsing well
Epidermis face is simultaneously massaged, and promotes to absorb, without cleaning.Use 2-3 times, by a definite date 6 months weekly.
Using alopecia volunteer totally 15 people of above-described embodiment formula, test uses the series of products 6 totally months experiment knots
Fruit is shown in Table 3.Can substantially it be found from the data of table 3, the series of products can effectively reduce alopecia, effective percentage 80%, anticreep after application
Positive effect.
Claims (3)
1. a kind of hair-washing hair-care composition of Anti-hair loss, contains saw palmetto berry extract and lemon grass (Cymbopogon citratus) essential oil, it is characterised in that：Press
Weight meter, the addition of saw palmetto berry extract is 0.01%-20%, wherein lemon grass (Cymbopogon citratus) essential oil addition 0.01%-20%, saw palmetto
Berry extract contains aliphatic acid, fatty alcohol and phytosterol, and wherein aliphatic acid main component is laurate, myristic acid, palm
Acid, oleic acid, linoleic acid, fatty alcohol main component are octacosanol, hexacosyl alcohol, and phytosterol is mainly cupreol.
2. hair-washing hair-care composition as claimed in claim 1, it is characterised in that：The hair-washing hair-care composition is also containing antibacterial
Agent ZPT, OCT, peppermint, salicylic acid.
3. hair-washing hair-care composition as claimed in claim 1, it is characterised in that：The hair-washing hair-care composition also contains surface
Activating agent, fatty alcohol, quaternary ammonium salt, cationic polymer, siloxanes and glyceride type.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510025222.3A CN104546612B (en) | 2015-01-19 | 2015-01-19 | A kind of hair-washing hair-care composition of Anti-hair loss |
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| CN201510025222.3A CN104546612B (en) | 2015-01-19 | 2015-01-19 | A kind of hair-washing hair-care composition of Anti-hair loss |
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| CN104546612A CN104546612A (en) | 2015-04-29 |
| CN104546612B true CN104546612B (en) | 2017-12-19 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107334894A (en) * | 2016-12-14 | 2017-11-10 | 北京福纳康生物技术有限公司 | A kind of composition for treating alopecia seborrheica |
| CN108066221A (en) * | 2018-01-16 | 2018-05-25 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of composition for preventing alopecia |
| CN112603861A (en) * | 2021-01-14 | 2021-04-06 | 澳美制药厂有限公司 | Head detergent and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150546A (en) * | 1995-11-21 | 1997-05-28 | 王云潮 | Hair regrowth liquid medicine |
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2015
- 2015-01-19 CN CN201510025222.3A patent/CN104546612B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150546A (en) * | 1995-11-21 | 1997-05-28 | 王云潮 | Hair regrowth liquid medicine |
Non-Patent Citations (2)
| Title |
|---|
| 23种中草药及其14种单体抗马拉色菌体外药敏试验;朱敏，等;《临床皮肤科杂志》;20031231;第32卷(第4期);第193-195页 * |
| 美国佛罗里达州的锯叶棕;汪开治;《植物杂志》;19991231(第5期);第42-43页 * |
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