CN103751073B - Compound traditional Chinese medicine extract with function of removing dandruff, and application - Google Patents
Compound traditional Chinese medicine extract with function of removing dandruff, and application Download PDFInfo
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- CN103751073B CN103751073B CN201410065848.2A CN201410065848A CN103751073B CN 103751073 B CN103751073 B CN 103751073B CN 201410065848 A CN201410065848 A CN 201410065848A CN 103751073 B CN103751073 B CN 103751073B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses a compound traditional Chinese medicine extract with a function of removing dandruff, and an application. A compound traditional Chinese medicine composite comprises the following components by weight percentage: 1-45% of ginger, 1-40% of adenophora stricta, 1-35% of aloe and 1-35% of cactus. The compound traditional Chinese medicine extract can effectively restrain fungi such as malassezia furfur and escherichia coli, and bacteria, has the good function of removing the dandruff, and can be used for preparing a hair article with the function of removing the dandruff.
Description
Technical field
The present invention relates to a kind of compound Chinese medicine extract, specifically a kind of compound Chinese medicine extract with dandruff removing function, this compound Chinese medicine extract has the function dispelling dandruff, can be applied to preparation hair cosmetic.
Background technology
Under normal circumstances, the epidermis cell at scalp place, because the cell of those basal layeres is ceaselessly bred, and releases to surface, finally these cell maturations, become and do not have lived horny layer and come off.When scalp is very healthy, the cell come off is the powder that we not easily discover, and also just can't see the dandruff.But when scalp goes wrong, epidermal area just can not be ripe well, so peel off large stretch ofly, the dandruff that Here it is.
Dandruff Producing reason mainly contains two aspects: one is that microorganism (as fungus and bacteriums such as Malassezia furfurs) infection causes hypodermal cell to divide quickening; Two is that sebum secretion is too vigorous, and sebum is attached on scalp together with the cell come off, and just becomes the dandruff in small, broken bits after drying.So dandruff removing the best way suppresses microbial growth exactly and suppresses sebum secretion.
Dandruff removing agent conventional in current dandruff removing cosmetics mainly contains salicylic acid, pyrithione zinc (ZPT), ketoconazole, climbazole (climbazole) and pyridone ethanolamine (Octopirox) etc.These dandruff removing agent reach dandruff removing object mainly through suppressing microorganism.These dandruff removing agent are the material of chemosynthesis, comparatively large to the zest of human body, are cosmetics regulated substance.Along with the development of society, the raising of people's living standard, require also more and more higher to cosmetics safety, particularly there is many safety issues in cosmetic industry in recent years, impel people more and more higher to green, safe, healthy cry, thus advance the Application and Development of natural dandruff removing agent.Patent of invention CN201110199356.9 discloses natural plant anti-dandruff moisture retention water and preparation method thereof, and this spray is primarily of Herba Schizonepetae, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae or wherein a part of compositions composition; Patent of invention ZL201110398845.7 discloses a kind of dandruff-removing itching-relieve Chinese medicine composition and uses thereof, described a kind of dandruff-removing itching-relieve Chinese medicine composition, by first Radix Paeoniae Rubra extract 0.02 ~ 0.2g/ml, first Fructus Xanthii extract 0.02 ~ 0.2g/ml, Semen Sesami Nigrum extract 0.02 ~ 0.2g/ml, said extracted thing proportionally 1 ~ 5: 1 ~ 5: 1 volume ratio be mixed with the first Chinese medicine composition; Second Radix Paeoniae Rubra extract 0.02 ~ 0.2g/ml, second Fructus Xanthii extract 0.02 ~ 0.2g/ml, Folium Artemisiae Argyi extract 0.01 ~ 0.2g/ml, said extracted thing is mixed with the second Chinese medicine composition according to the volume ratio of 1 ~ 5: 1 ~ 5: 1; First Chinese medicine composition and the second Chinese medicine composition are prepared according to the ratio of 1: 10 ~ 10: 1, namely obtain dandruff-removing itching-relieve Chinese medicine composition, and said composition can be used for all kinds ofly washing in hair products, has effect of bactericidal, removing scurf and relieving itching.The present invention then adopts low to human body zest, that toxicity is low herbal mixture as fungus and bacterium inhibitor such as Malassezia furfurs, reaches the object of dandruff removing.
Summary of the invention
The object of the invention is the defect in order to overcome chemosynthesis dandruff removing agent, providing a kind of herbal mixture, the extract of this herbal mixture can suppress the fungus and bacteriums such as Malassezia furfur, has good dandruff removing function.
To achieve the object of the present invention, present invention employs following technical scheme:
There is a herbal mixture for dandruff removing function, it is characterized in that the component comprising following percentage by weight: Rhizoma Zingiberis Recens 1-45%; Radix Adenophorae (Radix Glehniae) 1-40%; Aloe 1-35%; Radix et Caulis Opuntiae Dillenii 1-35%.
For obtaining the extract of above-mentioned herbal mixture, present invention employs following technical scheme: the Rhizoma Zingiberis Recens in above-mentioned herbal mixture, Aloe, Radix et Caulis Opuntiae Dillenii, Radix Adenophorae (Radix Glehniae) are pulverized, mix homogeneously after sieving, add Extraction solvent, soak 1 ~ 2h together with Extraction solvent after, extract with high pressure homogenization method machine under room temperature, extracting solution is through centrifugalize, after concentrating under reduced pressure, go up macroporous resin column purification again, collect the ethanol elution part that mass fraction is 30%-80%, being evaporated to extracting solution with quality of medicinal material ratio is 1: 0.5 ~ 1: 2, obtained compound Chinese medicine extract; Extraction solvent is water, ethanol, alcohol-water mixed solution.
The second object of the present invention is used in hair cosmetic by the extract of above-mentioned herbal mixture, makes stable in properties, respond well hair cosmetic.
For realizing the second object of the present invention, present invention employs following technical scheme: be used for preparing hair cosmetic by the extract of above-mentioned herbal mixture, it is characterized in that the extract containing above-mentioned herbal mixture in hair cosmetic, its consumption is 0.05-30%, and preferable amount is 0.5-15%.Except containing except above-mentioned compound Chinese medicine extract, the usual composition that applicable hair cosmetic uses suitably can be added as required, as matrix components such as wetting agent, conditioner, water, surfactants.
The dosage form of hair cosmetic is not particularly limited, and can be solution, emulsion, cream frost, spray etc.
Beneficial effect of the present invention: the present invention carries out the design of herbal mixture according to the theory of Chinese medical science of monarch, and the Rhizoma Zingiberis Recens in herbal mixture of the present invention is warm in nature, the effect of have dispeling the wind, inducing sweat, has obviously antipyretic, antibacterial, antiinflammation, as monarch drug; Radix Adenophorae (Radix Glehniae) sweetness and bitterness is lightly seasoned, has effect of clearing away heat and nourishing YIN, to obvious antifungic action, as ministerial drug; Aloe nature and flavor bitter cold, have under rushing down, liver heat removing, parasite killing effect, containing abundant vitamin, aminoacid, trace element, there is blood circulation promoting, promote cell regeneration and improve the effect of immunity, there is control head skin fat secretion and moisture-keeping functions simultaneously, as adjuvant drug; Radix et Caulis Opuntiae Dillenii has effect of the detumescence of heat-clearing and toxic substances removing, scattered silt, toxin expelling granulation promoting, promoting flow of QI and blood, has extraordinary irritation function simultaneously, as making medicine, and coordinating the actions of various ingredients in a prescription.The extract of herbal mixture of the present invention has very strong suppression and suppresses the effect of the fungus and bacterium such as Malassezia furfur, escherichia coli, has removal dandruff function, simultaneously energy blood circulation promoting, promotes effect of cell regeneration and raising skin immunization power.
Detailed description of the invention
Below by way of specific embodiment, the present invention is further illustrated, but these embodiments are just in order to illustrate, are not limitations of the present invention.
embodiment 1 compound Chinese medicine extract (I) and preparation method
Get Rhizoma Zingiberis Recens, Aloe, Radix et Caulis Opuntiae Dillenii, each 100g of Radix Adenophorae (Radix Glehniae), pulverize, excessively mix homogeneously after 40 mesh sieves, add the ethanol 4L that mass fraction is 50%, after soaking 2h, extract with high pressure homogenization method machine under room temperature, extracting solution is through centrifugalize, after concentrating under reduced pressure, going up macroporous resin column purification again, is the ethanol elution of 70% with mass fraction, collects eluent, being evaporated to extracting solution with quality of medicinal material ratio is 1: 1, obtained compound Chinese medicine extract (I).
embodiment 2 compound Chinese medicine extract (II) and preparation method
Get Rhizoma Zingiberis Recens 150g, Aloe 150 g, Radix et Caulis Opuntiae Dillenii 60g, Radix Adenophorae (Radix Glehniae) 40g, pulverize, excessively mix homogeneously after 60 mesh sieves, add the ethanol 6L that mass fraction is 30%, after soaking 2h, extract with high pressure homogenization method machine under room temperature, extracting solution is through centrifugalize, after concentrating under reduced pressure, going up macroporous resin column purification again, is the ethanol elution of 60% with mass fraction, collects eluent, being evaporated to extracting solution with quality of medicinal material ratio is 1: 1, obtained compound Chinese medicine extract (II).
embodiment 3 compound Chinese medicine extract (III) and preparation method
Get Rhizoma Zingiberis Recens 100g, Aloe 120 g, Radix et Caulis Opuntiae Dillenii 80g, Radix Adenophorae (Radix Glehniae) 100g, pulverize, excessively mix homogeneously after 40 mesh sieves, add the ethanol 4.8L that mass fraction is 40%, after soaking 2h, extract with high pressure homogenization method machine under room temperature, extracting solution is through centrifugalize, after concentrating under reduced pressure, going up macroporous resin column purification again, is the ethanol elution of 70% with mass fraction, collects eluent, being evaporated to extracting solution with quality of medicinal material ratio is 1: 1, obtained compound Chinese medicine extract (III).
embodiment 4 minimal inhibitory concentration (MIC) is tested
Get the culture dish containing different extract concentrations gradient, be added drop-wise in above-mentioned culture dish with the examination bacterium that supplies that aseptic straw draws 0.1 mL corresponding, smoothen with aseptic L-type Glass rod, at 37 DEG C, cultivate 24h, compare with sterilized water, blank extracting solution and extract diluent, record observed result.Be the MIC of this extract there is no the least concentration of thalli growth completely.And using pyrithione zinc as positive control.Test procedure reference [Zheng Jiaqi, Li Jiahong. clinical bacteriology. Beijing: People's Health Publisher, 1986,11-12,367-368].Testing result is shown in Table 1.
The MIC (mg/L) of the various bacterium of table 1
As can be seen from Table 1, compound Chinese medicine extract prepared by the present invention has good inhibition to causing the various bacteria such as the Malassezia furfur of the dandruff and escherichia coli and fungus, suitable with the effect of pyrithione zinc.
embodiment 5 dandruff removing shampoo and preparation method thereof
Table 2 provides the dandruff removing shampoo formula containing compound Chinese medicine extract, and the consumption of each material represents with mass fraction.
Table 2 dandruff removing shampoo formula
Preparation method: deionized water is heated to 80 DEG C, adds cation guar gum, after insulation is uniformly dissolved, adds disodiumedetate, citric acid, sodium chloride, stirring and dissolving.Then, lauryl alcohol sulfuric ester ammonium and Dodecyl Polyoxyethylene Ether sodium sulfovinate is added, stirring and dissolving.Add pearlescent flake, cetostearyl alcohol, stirring and dissolving.Add lauric acid amide of ethanol, cocamido propyl betaine and compound Chinese medicine extract, stir, pass into water quench to 50 DEG C, add KF88 antiseptic, emulsified silicone oil and essence, stir, when continuing to be cooled to 40 DEG C, be dandruff removing shampoo.
embodiment 6 dandruff removing moisture retention water and preparation method thereof
Table 3 provides the dandruff removing moisture retention water formula containing compound Chinese medicine extract, and the consumption of each material represents with mass fraction.
Table 3 dandruff removing moisture retention water formula
Preparation method: be dissolved in deionized water by all the components in formula, stirring and dissolving is even, is dandruff removing moisture retention water.
common shampoo of comparative example 1 and preparation method thereof
Table 4 provides common shampoo formula, and the consumption of each material represents with mass fraction.
The common shampoo formula of table 4
Preparation method: deionized water is heated to 80 DEG C, adds cation guar gum, after insulation is uniformly dissolved, adds disodiumedetate, citric acid, sodium chloride, stirring and dissolving.Then, lauryl alcohol sulfuric ester ammonium and Dodecyl Polyoxyethylene Ether sodium sulfovinate is added, stirring and dissolving.Add pearlescent flake, cetostearyl alcohol, stirring and dissolving.Add lauric acid amide of ethanol, cocamido propyl betaine, stir, pass into water quench to 50 DEG C, add KF88 antiseptic, emulsified silicone oil and essence, when continuing to be cooled to 40 DEG C, be common shampoo.
embodiment 7 dandruff removing effect assessment is tested
Test specimen: common shampoo prepared by the dandruff removing shampoo prepared by embodiment 5 and comparative example 1, as sample on probation.
Object on probation: select 20-45 year dandruff patient 50 example, wherein male 30 people, women 20 people, as crowd on probation, be divided at random two groups (often organizing 25 people, male 15 people, women 10 people), one group of dandruff removing shampoo of trying out embodiment 5 and preparing, common shampoo prepared by another group comparative example 1 on probation.
Evaluation methodology: when patient washes hair every day, gets sample 5mL on probation, for washing hair and massaging scalp 2min by rubbing with the hands, then rinses well with water, and using continuously 7th is a course for the treatment of.Follow up a case by regular visits to record result before and after all patients use, try out post-evaluation curative effect.
Curative effect determinate standard: recovery from illness (dandruff disappears, without scratchiness); Effective (dandruff obviously reduces, and pruritus disappears); Effectively (dandruff reduces, and pruritus alleviates); Invalid (dandruff is minimizing or unchanged slightly, and pruritus is slightly clear or the same).Efficacy result is shown in Table 5.
Table 5 therapeutic evaluation result
Table 5 result shows, the shampoo containing compound Chinese medicine extract of the present invention has obviously effect to treatment dandruff, and effective above ratio reaches 84%, and effectively above ratio reaches 92%.
Claims (2)
1. there is a herbal mixture for dandruff removing function, it is characterized in that being made up of following weight percent composition: Rhizoma Zingiberis Recens 25-45%, Radix Adenophorae (Radix Glehniae) 20-40%, Aloe 10-25%, Radix et Caulis Opuntiae Dillenii 10-25%; The preparation method of this herbal mixture is: above-mentioned Rhizoma Zingiberis Recens, Aloe, Radix et Caulis Opuntiae Dillenii, Radix Adenophorae (Radix Glehniae) are pulverized, mix homogeneously after sieving, add Extraction solvent, soak 1 ~ 2h together with Extraction solvent after, extract with high pressure homogenization method machine under room temperature, extracting solution is through centrifugalize, after concentrating under reduced pressure, upper macroporous resin column purification, collect the ethanol elution part that mass fraction is 30%-80%, being evaporated to extracting solution with quality of medicinal material ratio is 1: 0.5 ~ 1: 2, obtained herbal mixture; Extraction solvent is water, ethanol, ethanol-water mixed solution.
2. the hair cosmetic containing the herbal mixture described in claim 1, is characterized in that its consumption is 0.05-30% containing above-mentioned herbal mixture in hair cosmetic.
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| CN107308060A (en) * | 2017-07-28 | 2017-11-03 | 佛山实瑞先导材料研究院（普通合伙） | A kind of plant residue composition with conditioning hair quality effect and its application |
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| CN102451128A (en) * | 2010-10-28 | 2012-05-16 | 曹晶晶 | Ginger shampoo |
| CN102670735A (en) * | 2012-05-28 | 2012-09-19 | 龚盛昭 | Anti-dandruff Chinese medicinal composition and application thereof to anti-dandruff external application agent |
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| TWI290469B (en) * | 2000-07-12 | 2007-12-01 | Medical & Pharm Ind Tech & Dev | Method for manufacturing product with component capable of efficiently preventing inflammation and platelets agglutination form ginger and medical composition with the efficient component |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102451128A (en) * | 2010-10-28 | 2012-05-16 | 曹晶晶 | Ginger shampoo |
| CN102670735A (en) * | 2012-05-28 | 2012-09-19 | 龚盛昭 | Anti-dandruff Chinese medicinal composition and application thereof to anti-dandruff external application agent |
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| 大孔吸附树脂对芦荟有效成分纯化工艺研究;张翠利等;《广东化工》;20131231;第40卷(第18期);第35-36页 * |
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Effective date of registration: 20201217 Address after: No.5, area 1, community 8, Xinke village, JUNHE street, Baiyun District, Guangzhou City, Guangdong Province 510000 Patentee after: Guangzhou Biotechnology Co.,Ltd. Address before: 510300 No. 152 West Xingang Road, Guangzhou, Guangdong, Haizhuqu District Patentee before: Guangdong Industry Technical College Patentee before: GUANGZHOU BAIYUN DISTRICT FANGQI COSMETICS FACTORY |