CN106580791A - Antibacterial composition and private part care product - Google Patents
Antibacterial composition and private part care product Download PDFInfo
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- CN106580791A CN106580791A CN201611207178.9A CN201611207178A CN106580791A CN 106580791 A CN106580791 A CN 106580791A CN 201611207178 A CN201611207178 A CN 201611207178A CN 106580791 A CN106580791 A CN 106580791A
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- extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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Abstract
The invention provides an antibacterial composition, which comprises cactus extracts, rhizoma coptidis extracts and radix angelicae sinensis extracts. The invention provides a private part care product, which comprises the antibacterial composition. The active ingredients of the antibacterial composition provided by the invention are traditional Chinese medicine extracts, are mild and do not have irritation. The cactus extracts, the rhizoma coptidis extracts and the angelica sinensis extracts are mutually matched and achieve the synergistic effect, so that the antibacterial composition has a good sterilization effect. When the antibacterial composition provided by the invention is used for preparing the private part care product, the antibacterial composition contains no chemical bactericide, but has a good sterilization effect, so that the prepared private part care product is safe and mild and does not have irritation; the private part care product can be used for effectively cleaning the private part, balancing the acid-base and flora environment, and inhibiting the growth and the breeding of the private part pathogenic bacteria; meanwhile, the effects of sterilization, inflammation diminishing and peculiar smell elimination are achieved; the effect of beautifying the private part in an auxiliary way can be achieved after the long-time use; the occurrence and the recurrence of the private part diseases can be effectively prevented; the private part care product can be used by both men and women.
Description
Technical field
The present invention relates to technique in skin care field, more particularly to a kind of bactericidal composition and privates care product.
Background technology
The social responsibility of modern female and life stress increase severely, it has to allegro life style is faced, when most of
Between in office, the way on and off duty, in going on business, more times are in public place.And, external genital organs of female structure
Complexity is made, adjacent with urethra, anus, fragile privates easily infects various pathogenic bacterias, causes vaginitiss, cervicitises, pelvic inflammatory disease etc.
Gynaecopathia.Gynaecopathia threatens China's female body health, and in rejuvenation trend, hygiene department of China relevant information table
Bright, China women of child-bearing age gynaecopathia sickness rate is more than 70%, and prevalence is in obvious ascendant trend, and women is in life
Almost 100% suffered from different degrees of vaginitiss, and China has more than 400,000,000 women needs Amino-Cerv.Male be also thus, due to
The special physiological structure of its privates, easily shelters evil people and countenance evil practices, and also easily causes multiple dermatosis, tumor to itch, the symptom such as inflammation.Privates is scorching
Disease drastically influence the routine work and life of people, endanger the physical and mental health of people, or even some women therefore sterility and infertility,
So daily privates cleaning, nursing can not be ignored.
Many women are convenient for figure, and during cleaning pudendum the cleaning supplies such as common bath gel or fancy soap, life-time service are used
Pudendum sour environment can be caused to be destroyed, change the pH value of vagina, decline dysbacteriosiss, local resistance, induction gynecological disease
Disease.Therefore, private portion's care product is requisite cleaning product in female life, and in fact male also can use prophylactic
Occur.At present the sterilizing function of private portion articles for use mainly adds chemical bactericide to realize, such as bromination dodecyl dimethyl
Hexadecyldimethyl benzyl ammonium or Irgacare MP etc., these chemical productss are larger to the skin irritation of women privates, and long
Phase use can produce drug resistance, be easily destroyed women private portion physiological environment, cause bacterium colony disorderly, produce focus.Therefore develop
It is a kind of it is gentle it is non-stimulated, can effective cleaning privates, suppression kill harmful bacteria, the cleaning and nursing product of balance private portion physiological environment and have
Important meaning.
The content of the invention
In view of this, it is an object of the invention to provide a kind of bactericidal composition, the antibacterial combination provided using the present invention
Privates care product prepared by thing does not contain chemical bactericide, gentle non-stimulated and can effectively press down and kill harmful bacteria.
The invention provides a kind of bactericidal composition, including：
Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis extract and Radix Angelicae Sinensis extract.
Preferably, also include：
One or more in Hedyotidis Diffusae extract, Herba polygoni hydropiperis extract and Folium perillae extract.
Preferably, also include：
Hedyotidis Diffusae extract, Herba polygoni hydropiperis extract and Folium perillae extract.
Preferably, also include：
One or more in Radix Isatidis extract, Princepia utilis extract and Herba Violae extract.
Preferably, also include：
Radix Isatidis extract, Princepia utilis extract and Herba Violae extract.
Preferably, the bactericidal composition includes：
Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis extract, Radix Angelicae Sinensis extract, Hedyotidis Diffusae extract, Herba polygoni hydropiperis extract, Folium Perillae are extracted
Thing, Radix Isatidis extract, Princepia utilis extract and Herba Violae extract.
The invention provides a kind of privates care product, including the bactericidal composition described in above-mentioned technical proposal.
Preferably, also include：
One kind or several in thickening agent, solvent, surfactant, foam stabilizer, preservative, stabilizer and acid regulator
Kind.
Preferably, the surfactant is amino acid surfactant.
Preferably, also include：Pearlescent flake and/or anti-corrosion synergist.
Compared with prior art, the effective ingredient of the bactericidal composition that the present invention is provided is Chinese medicine extract, without chemistry
Antibacterial, it is gentle non-stimulated, and also Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis extract and Radix Angelicae Sinensis extract cooperate and make with collaboration
With making this bactericidal composition that there is good bactericidal effect.
The bactericidal composition provided using the present invention prepares privates care product, because bactericidal composition does not contain chemical sterilization
Agent and with good bactericidal effect, makes the privates care product safety for preparing gentle non-stimulated, can effective cleaning it is private
Place, Balancing and flora environment suppress the growth and breeding of privates pathogenic bacterium, at the same have sterilization, antiinflammatory, it is antipruritic, dispel
The effect of abnormal flavour, life-time service not only has auxiliary beautification privates effect, moreover it is possible to the effectively generation and recurrence of prevention privates disease,
Men and women can use.
Specific embodiment
The technical scheme in the embodiment of the present invention will be clearly and completely described below, it is clear that described enforcement
Example is only a part of embodiment of the invention, rather than the embodiment of whole.Based on the embodiment in the present invention, this area is common
The every other embodiment that technical staff is obtained under the premise of creative work is not made, belongs to the model of present invention protection
Enclose.
The invention provides a kind of bactericidal composition, including：
Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis extract and Radix Angelicae Sinensis extract.
In the present invention, the mass ratio of the Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis extract and Radix Angelicae Sinensis extract is preferably (0.5
～2)：(1～3)：(1～4), more preferably (1～1.5)：(1.5～2.5)：(2～3), most preferably (1.2～1.3)：2：
2.5。
The bactericidal composition that the present invention is provided preferably also includes Hedyotidis Diffusae extract, Herba polygoni hydropiperis extract and Folium perillae extract
In one or more, more preferably also include it is several in Hedyotidis Diffusae extract, Herba polygoni hydropiperis extract and Folium perillae extract, it is optimum
Choosing also includes Hedyotidis Diffusae extract, Herba polygoni hydropiperis extract and Folium perillae extract.In the present invention, the Hedyotidis Diffusae extract,
The mass ratio of Herba polygoni hydropiperis extract and Folium perillae extract is preferably (0.5～2):(0.5～2)：(1～2.5), more preferably (1～
1.5):(1～1.5)：(1.5～2), most preferably (1.2～1.3):(1.2～1.3)：(1.7～1.8).In the present invention, institute
The mass ratio for stating Radix et Caulis Opuntiae Dillenii extract and Hedyotidis Diffusae extract is preferably (0.5～2)：(0.5～2), more preferably (1～
1.5)：(1～1.5), most preferably (1.2～1.3)：(1.2～1.3).In the present invention, the bactericidal composition is preferably wrapped
Include：Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis extract, Radix Angelicae Sinensis extract, Hedyotidis Diffusae extract, Herba polygoni hydropiperis extract and Folium perillae extract.
In the present invention, Serpentis grass extract, Herba polygoni hydropiperis extract and Folium perillae extract can further with the celestial being described in above-mentioned technical proposal
People's palm extract, Rhizoma Coptidis extract and Radix Angelicae Sinensis extract produce synergism, improve the bactericidal effect of bactericidal composition.
The bactericidal composition that the present invention is provided preferably also is carried including Radix Isatidis extract, Princepia utilis extract and Herba Violae
One or more in thing are taken, is more preferably also included in Radix Isatidis extract, Princepia utilis extract and Herba Violae extract
It is several, most preferably also include Radix Isatidis extract, Princepia utilis extract and Herba Violae extract.In the present invention, the plate
The mass ratio of blue root extract, Princepia utilis extract and Herba Violae extract is preferably (1～3):(1～2.5)：(1～3),
More preferably (1.5～2.5):(1.5～2)：(1.5～2.5), most preferably 2:(1.7～1.8)：2.In the present invention, it is described
The mass ratio of Radix et Caulis Opuntiae Dillenii extract and Radix Isatidis extract is preferably (0.5～2)：(1～3), more preferably (1～1.5)：(1.5
～2.5), most preferably (1.2～1.3)：2.In the present invention, Radix Isatidis extract, Princepia utilis extract and Herba Violae are extracted
Thing can further with the Radix et Caulis Opuntiae Dillenii extract described in above-mentioned technical proposal, Rhizoma Coptidis extract and Radix Angelicae Sinensis extract and Agkistrodon
Careless extract, Herba polygoni hydropiperis extract and Folium perillae extract produce synergism, further improve the bactericidal effect of bactericidal composition.
In the present invention, the bactericidal composition more preferably includes：Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis extract, Radix Angelicae Sinensis are extracted
Thing, Hedyotidis Diffusae extract, Herba polygoni hydropiperis extract, Folium perillae extract, Radix Isatidis extract, Princepia utilis extract and Herba Violae are carried
Take thing.In the present invention, the Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis extract, Radix Angelicae Sinensis extract, Hedyotidis Diffusae extract, Herba polygoni hydropiperis are carried
Take thing, Folium perillae extract, Radix Isatidis extract, Princepia utilis extract and Herba Violae extract mass ratio be preferably (0.5～
2)：(1～3)：(1～4)：(0.5～2):(0.5～2)：(1～2.5)：(1～3):(1～2.5)：(1～3), more preferably (1
～1.5)：(1.5～2.5)：(2～3)：(1～1.5):(1～1.5)：(1.5～2)：(1.5～2.5):(1.5～2)：(1.5
～2.5), most preferably (1.2～1.3)：2：2.5：(1.2～1.3):(1.2～1.3)：(1.7～1.8)：2:(1.7～
1.8)：2.
The invention provides a kind of privates care product, including the bactericidal composition described in above-mentioned technical proposal.At this
In bright, the privates care product preferably also include thickening agent, solvent, surfactant, foam stabilizer, preservative, stabilizer and
One or more in acid regulator, more preferably also include thickening agent, solvent, surfactant, foam stabilizer, preservative, steady
Determine several in agent and acid regulator, most preferably also include thickening agent, solvent, surfactant, foam stabilizer, preservative, steady
Determine agent and acid regulator.In the present invention, the privates care product preferably also includes pearlescent flake and/or anti-corrosion synergist,
More preferably also include pearlescent flake and anti-corrosion synergist.
In the present invention, the privates care product is preferably included：Bactericidal composition, thickening agent, solvent, surface activity
Agent, foam stabilizer, preservative, stabilizer, acid regulator, pearlescent flake, anti-corrosion synergist and water.
In the present invention, mass content of the bactericidal composition in privates care product is preferably 7.5～24%, more
Preferably 10～20%, more preferably 12～18%, most preferably 14～16%.In the present invention, the bactericidal composition with
Bactericidal composition in above-mentioned technical proposal is consistent, will not be described here.
In the present invention, mass content of the thickening agent in privates care product is preferably 1～3%, more preferably
1.5～2.5%, most preferably 2%.In the present invention, the thickening agent has thickening power, can make Surfactants
Grow up, viscosity is improved.In the present invention, the thickening agent is preferably selected from Sodium Chloride and/or potassium chloride, more preferably chlorination
Sodium.
In the present invention, mass content of the solvent in privates care product is preferably 6～12%, more preferably 8
～10%, most preferably 9%.In the present invention, the solvent is preferably selected from glycerol and/or Sorbitol, more preferably glycerol.
In the present invention, mass content of the surfactant in privates care product is preferably 20～35%, more
Preferably 25～30%, most preferably 27～28%.In the present invention, the surfactant is preferably amino acid surface activity
Agent, more preferably sodium lauroyl glutamate and/or cocamido propyl betaine, most preferably sodium lauroyl glutamate and cocos nucifera oil
Amido propyl betaine.In the present invention, the mass ratio of the sodium lauroyl glutamate and cocamido propyl betaine is preferred
For (8～19)：(10～16), more preferably (10～16)：(12～14), most preferably 18:10,19:16 or 8:12.
In the present invention, mass content of the foam stabilizer in privates care product is preferably 1.5～2.5%, more excellent
Elect 1.8～2.2%, most preferably 2% as.In the present invention, the foam stabilizer is preferably selected from lauric acid, tetradecylic acid, hexadecylic acid
With one or more in stearic acid, more preferably lauric acid.
In the present invention, mass content of the preservative in privates care product is preferably 0.2～0.5%, more excellent
Elect 0.3～0.4% as.In the present invention, the preservative be preferably selected from phenoxyethanol, chlorphenesin, decoyl hydroximic acid, to hydroxyl
One or more in benzoylformaldoxime and hydroxy phenylpropionyl amine benzoic acid, more preferably phenoxyethanol and chlorphenesin.At this
In bright, the mass ratio of the phenoxyethanol and chlorphenesin is preferably (0.1～0.3)：(0.1～0.2), more preferably (0.15
～0.25)：(0.12～0.18), most preferably 0.2：(0.14～0.16).
In the present invention, mass content of the stabilizer in privates care product is preferably 0.5～2.5%, more excellent
Elect 1～2%, more preferably 1.2～1.8%, most preferably 1.4～1.6 as.In the present invention, the stabilizer has and suspends
Stable effect.In the present invention, the stabilizer is preferably acrylic acid (ester) analog copolymer, is acrylic acid, methacrylic acid
And (or) the copolymer of their one or more simple esters, it is that this area prepares the conventional additive of skin nursing products, can
Obtained by market purchase.
In the present invention, mass content of the acid regulator in privates care product is preferably 0.4～0.8%,
More preferably 0.5～0.7%, most preferably 0.6%.In the present invention, the acid regulator is preferably citric acid or lactic acid.
In the present invention, mass content of the pearlescent flake in privates care product is preferably 1～3%, more preferably
1.5～2.5%, most preferably 2%.In the present invention, the pearlescent flake being capable of the obvious pearly-lustre effect of privates care product generation
Really.In the present invention, the pearlescent flake is preferably one kind in glycol distearate and stearic acid ethylene glycol ester or several
Plant, more preferably glycol distearate.
In the present invention, mass content of the anti-corrosion synergist in privates care product is preferably 0.1～0.3%,
More preferably 0.15～0.25%, most preferably 0.2%.In the present invention, the anti-corrosion synergist is preferably selected from ethylhexyl
One or more in glycerol, caprylyl glycol, 1,2- pentanediols and 1,2- hexanediol, more preferably Sensiva SC50.
The present invention does not have special restriction, preferably deionized water to the water.In the present invention, the consumption of the water
For the total mass content of each composition is 100% in privates care product, removes bactericidal composition, thickening agent, solvent, surface work
Property agent, foam stabilizer, preservative, stabilizer, acid regulator, pearlescent flake, the summation of anti-corrosion synergist mass content, as water
Mass content.
In the present invention, the privates care product is preferably included：Sodium Chloride, glycerol, amino acid surfactant, second two
Alcohol distearate, lauric acid, acid regulator, acrylic acid (ester) analog copolymer, Radix et Caulis Opuntiae Dillenii extract, Herba polygoni hydropiperis extract, purple
It is Soviet Union's extract, Hedyotidis Diffusae extract, Radix Isatidis extract, Princepia utilis extract, Rhizoma Coptidis extract, Radix Angelicae Sinensis extract, pale reddish brown
Herba Violae extract, Sensiva SC50, phenoxyethanol, chlorphenesin and water；More preferably include：1～3wt% of Sodium Chloride, glycerol 6
～12wt%, 20～35wt% of amino acid surfactant, glycol distearate 2wt%, 1.5～2.5wt% of lauric acid,
0.4～0.8wt% of acid regulator, acrylic acid (ester) 0.5～2.5wt% of analog copolymer, 0.5～2wt% of Radix et Caulis Opuntiae Dillenii extract,
0.5～2wt% of Herba polygoni hydropiperis extract, 1～2.5wt% of Folium perillae extract, Hedyotidis Diffusae 0.5～2wt% of extract, Radix Isatidis are extracted
It is 1～3wt% of thing, Princepia utilis 1～2.5wt% of extract, 1～3wt% of Rhizoma Coptidis extract, 1～4wt% of Radix Angelicae Sinensis extract, pale reddish brown
Herba Violae 1～3wt% of extract, 0.1～0.3wt% of Sensiva SC50,0.1～0.3wt% of phenoxyethanol, chlorphenesin 0.1
～0.2wt%, balance of water.
The present invention does not have special restriction to the preparation method of the privates care product, and those skilled in the art can basis
It is actually needed the privates nursing added as antimicrobial component using above-mentioned bactericidal composition needed for suitable component is prepared to produce
Product dosage form.In the present invention, the preparation method of the privates care product preferably includes following steps：
(1) by water, surfactant, thickening agent, solvent mixing, the first mixture is obtained；
(2) surfactant, pearlescent flake, stabilizer, acid regulator and the first mixture are mixed, obtains the second mixing
Thing；
(3) bactericidal composition and the second mixture are mixed, obtains mixed liquor；
(4) stabilizer is dissolved in the water and mix with above-mentioned mixed liquor, obtain the 3rd mixture；
(5) by the 3rd mixture and anti-corrosion synergist, preservative mixing, privates care product is obtained.
In the present invention, the bactericidal composition, thickening agent, solvent, surfactant, foam stabilizer, preservative, stable
Agent, acid regulator, pearlescent flake, anti-corrosion synergist and water and its bactericidal composition, thickening described in consumption and above-mentioned technical proposal
Agent, solvent, surfactant, foam stabilizer, preservative, stabilizer, acid regulator, pearlescent flake, anti-corrosion synergist and water and its
Consumption is consistent, will not be described here.
In the present invention, the temperature of mixing is preferably 80～85 DEG C in the step (1), and the time is preferably 10～15min.
In the present invention, the surfactant in the step (1) is preferably sodium lauroyl glutamate.In the present invention, the step
(2) surfactant in is preferably cocamido propyl betaine.In the present invention, the mixing temperature in the step (3)
Preferably 60～65 DEG C.In the present invention, the mixing temperature in the step (5) is preferably 40～45 DEG C.
In the present invention, the Herba polygoni hydropiperis extract, Hedyotidis Diffusae extract, Radix Angelicae Sinensis extract, Herba Violae extract
Preparation method is preferably：
Dry Herba polygoni hydropiperis, Hedyotidis Diffusae, Radix Angelicae Sinensis, Herba Violae are crushed, above-mentioned medicinal powder is weighed respectively, add medical material
The mass concentration that 6～10 times of powder quality is 50～80% ethanol waters, 30～60min is soaked, then at 60～75 DEG C
Backflow 2～3 times, every time 2～3h, united extraction liquid, reclaim ethanol, are evaporated to 1～1.05g (crude drug)/mL, as each medicine
Material extract, cold preservation is standby at 4 DEG C.
In the present invention, the Folium perillae extract, Radix Isatidis extract, Princepia utilis extract, the preparation of Rhizoma Coptidis extract
Method：
Dry Folium Perillae, Radix Isatidis, Princepia utilis, Rhizoma Coptidis are crushed, above-mentioned medicinal powder is weighed, medicinal powder quality is added
6～10 times of distilled water, soaks 30～60min, decocts at 60～85 DEG C 2～3 times, and every time 1～2h, filters, and merging filtrate subtracts
Press and be concentrated into 1～1.05g (crude drug)/mL, as each medicinal substances extract, cold preservation is standby at 4 DEG C.
In the present invention, sodium lauroyl glutamate, foam performance is strong, with gentle cleaning and moisturizing effect, using peace
Entirely, environment is had no effect.Cocamido propyl betaine, zest is little, biodegradable, with good cleaning, sends out
Bubble, opsonic action, compatibility and thickening properties it is excellent, and with certain bacteriostasis antibiosis effect.Radix et Caulis Opuntiae Dillenii extract, has
The effects such as heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, stomach invigorating, pain relieving, antitussive, being capable of antiinflammatory antiallergic, blood sugar lowering, blood fat reducing, blood pressure lowering, antioxygen
Change, antitumor, increase immunity.Herba polygoni hydropiperis extract, with removing toxic substances, removing dampness, hemostasis, row stagnant, wind-dispelling, relieving itching and eliminating swelling the effect of,
Control the dirty stomachache of acute diseases such as cholera and sunstroke, vomiting and diarrhoea have a cramp, have loose bowels, dysentery, rheumatism, tinea pedis, carbuncle, scabies moss, traumatic injury.Folium perillae extract, with solution
Table cold expelling, the therapeutic method to keep the adverse QI flowing downwards, expectorant, lung moistening, wide intestinal, diuresis, the function such as only cholera, resolving depression be antiabortive, can adjust blood fat, antioxidation, antibacterial
Deng.Spend diffusa extract in vain, there is heat clearing away, dampness removing, removing toxic substances, for dyspnea and cough due to lung-heat, tonsillitiss, pharyngolaryngitis, vermiform appendix
The diseases such as inflammation, dysentery, jaundice, pelvic inflammatory disease, adnexitis, carbuncle swells furunculosis.Radix Isatidis extract, with heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving it
Effect, for the disease such as maculae caused by violent heat pathogen, dark reddish purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.Princepia utilis are extracted
Thing, with heat clearing away, removing toxic substances, promoting blood circulation, blood stasis dispelling, qi-restoratives, antiinflammatory, detumescence, pain relieving, help digestion, the effect such as stomach invigorating.Rhizoma Coptidis extract, clearly
Hot dampness, eliminating fire and detoxication, for damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, blood
Heat tell nosebleed, conjunctival congestion, have a toothache, quench one's thirst, carbuncle swells furunculosis etc., external treatment eczema, eczema, auditory meatus are suppurated.Radix Angelicae Sinensis extract, work of enriching blood
Blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation, blood deficiency and yellow complexion, dizziness palpitaition, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, wind
The effects such as pain of dampness syndrome, injury from falling down, ulcer sores, be that doctor commonly uses, and have a title of " ten side's rules for doing division with a one-digit divisor on the abacus ", Radix Angelicae Sinensis have blood pressure lowering,
Analgesia, antiinflammatory, antibacterial, radioprotective, and antibody Monoclonal, strengthen immunologic function, antioxidation and remove the effect such as free radical.Pale reddish brownly
Fourth extract, heat-clearing and toxic substances removing, cool blood detumescence antiinflammatory, for furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom, jaundice due to damp-heat etc.
Disease.
The present invention carries out rational collocation and prepares privates shield from gentle amino acid surfactant and Chinese medicine extract
Reason product, this privates care product energy effective cleaning privates, and it is safe and non-stimulating, privates skin mucosa will not be damaged, while
Scalable private portion's soda acid and flora environmental balance, suppress staphylococcus aureuses, escherichia coli, Candida albicans to grow, and have
Play the role of sterilization, antiinflammatory, it is antipruritic, go to eliminate the unusual smell, life-time service will not produce drug resistance, not only with auxiliary beautification privates work(
Effect, moreover it is possible to the effectively generation and recurrence of prevention privates disease.The present invention is preferably prepared privates care product becomes ointment preparation,
It is easy to use, can be used for daily private portion's cleaning, men and women can use.
Raw material used in following examples of the present invention is commercial goods, and acrylic acid (ester) analog copolymer is bought in Guangzhou
Million weighing apparatus Trade Development company limiteies.
Embodiment 1
Herba polygoni hydropiperis extract, Hedyotidis Diffusae extract, Radix Angelicae Sinensis extract, the preparation method of Herba Violae extract：By drying
Herba polygoni hydropiperis, Hedyotidis Diffusae, Radix Angelicae Sinensis, Herba Violae crush, weigh the above-mentioned medicinal powders of 100g respectively, add medicinal powder quality 8
Mass concentration again is 65% ethanol water, soaks 45min, is then flowed back 2 times at 70 DEG C, each 3h, united extraction
Liquid, reclaims ethanol, is evaporated to 1g (crude drug)/mL, as each medicinal substances extract, and cold preservation is standby at 4 DEG C.
Folium perillae extract, Radix Isatidis extract, Princepia utilis extract, the preparation method of Rhizoma Coptidis extract：By dry purple
Soviet Union, Radix Isatidis, Princepia utilis, Rhizoma Coptidis are crushed, and the above-mentioned medicinal powders of 100g are weighed respectively, add the distillation of 6 times of medicinal powder quality
Water, soaks 60min, decocts 3 times at 60 DEG C, each 1h, filters, and merging filtrate is evaporated to 1.03g (crude drug)/mL, as
Each medicinal substances extract, cold preservation is standby at 4 DEG C.
The formula of privates care product：Sodium Chloride 2wt%, glycerol 9wt%, sodium lauroyl glutamate 18wt%, cocos nucifera oil acyl
Amine CAB 10wt%, glycol distearate 2wt%, lauric acid 2wt%, lactic acid 0.4wt%, acrylic acid (ester) class
Copolymer 2wt%, Radix et Caulis Opuntiae Dillenii extract 1.25wt%, Herba polygoni hydropiperis extract 1.25wt%, Folium perillae extract 1.75wt%, Agkistrodon
Careless extract 1.25wt%, Radix Isatidis extract 2wt%, Princepia utilis extract 1.75wt%, Rhizoma Coptidis extract 2wt%, Radix Angelicae Sinensis
Extract 2.5wt%, Herba Violae extract 2wt%, Sensiva SC50 0.2wt%, phenoxyethanol 0.2wt%, chlorobenzene are sweet
Ether 0.15wt%, balance of water.
Preparation method is：1) by the water of 34.3wt%, sodium lauroyl glutamate, Sodium Chloride, glycerol mixing, 80 are heated to
DEG C, and be stirred continuously, 15min is incubated, obtain the first mixture；2) it is and then cocamido propyl betaine, ethylene glycol bisthioglycolate is hard
Fat acid ester, lauric acid, citric acid are added in the first mixture, are stirred, and are lowered the temperature, and obtain the second mixture；3) treat that temperature drops
During to 60 DEG C, in the second mixture add Radix et Caulis Opuntiae Dillenii extract, Herba polygoni hydropiperis extract, Folium perillae extract, Hedyotidis Diffusae extract,
Radix Isatidis extract, Princepia utilis extract, Rhizoma Coptidis extract, Radix Angelicae Sinensis extract, Herba Violae extract, stir, and obtain
Mixed liquor；4) acrylic acid (ester) analog copolymer is dissolved in remaining water in advance, is then added to step 3) in mixed liquor,
Stir, lower the temperature, obtain the 3rd mixture；5) when temperature is down to 40 DEG C, add ethylhexyl sweet in the 3rd mixture
Oil, phenoxyethanol, chlorphenesin, stirs the privates care product that be obtained.
Embodiment 2
Herba polygoni hydropiperis extract, Hedyotidis Diffusae extract, Radix Angelicae Sinensis extract, the preparation method of Herba Violae extract are：Will be dry
Dry Herba polygoni hydropiperis, Hedyotidis Diffusae, Radix Angelicae Sinensis, Herba Violae crushing, weighs respectively the above-mentioned medicinal powders of 100g, adds medicinal powder quality
6 times of mass concentration is 80% ethanol water, soaks 60min, is then flowed back 2 times at 75 DEG C, each 2h, united extraction
Liquid, reclaims ethanol, is evaporated to 1.05g (crude drug)/mL, as each medicinal substances extract, and cold preservation is standby at 4 DEG C.
Folium perillae extract, Radix Isatidis extract, Princepia utilis extract, the preparation method of Rhizoma Coptidis extract：By dry purple
Soviet Union, Radix Isatidis, Princepia utilis, Rhizoma Coptidis are crushed, and the above-mentioned medicinal powders of 100g are weighed respectively, add the distillation of 8 times of medicinal powder quality
Water, soaks 45min, decocts 2 times at 85 DEG C, each 2h, filters, and merging filtrate is evaporated to 1g (crude drug)/mL, as respectively
Medicinal substances extract, cold preservation is standby at 4 DEG C.
The formula of privates care product is：Sodium Chloride 1wt%, glycerol 12wt%, sodium lauroyl glutamate 19wt%, cocos nucifera oil
Acyl CAB 16wt%, glycol distearate 3wt%, lauric acid 1.5wt%, citric acid 0.8wt%, acrylic acid
(ester) analog copolymer 0.5wt%, Radix et Caulis Opuntiae Dillenii extract 0.5wt%, Herba polygoni hydropiperis extract 2wt%, Folium perillae extract 1wt%, spend in vain
Magnoliacoco extract 2wt%, Radix Isatidis extract 1wt%, Princepia utilis extract 1wt%, Rhizoma Coptidis extract 3wt%, Radix Angelicae Sinensis are extracted
Thing 1wt%, Herba Violae extract 1wt%, Sensiva SC50 0.3wt%, phenoxyethanol 0.1wt%, chlorphenesin
0.2wt%, balance of water.
The preparation method of privates care product is：1) by the water of 32.1wt%, sodium lauroyl glutamate, Sodium Chloride, glycerol
Mixing, is heated to 85 DEG C, and is stirred continuously, and is incubated 10min, obtains the first mixture；2) and then by cocamidopropyl propyl amide Radix Betae
Alkali, glycol distearate, lauric acid, citric acid are added in the first mixture, are stirred, and are lowered the temperature, and obtain the second mixing
Thing；3) when temperature is down to 65 DEG C, Radix et Caulis Opuntiae Dillenii extract, Herba polygoni hydropiperis extract, Folium perillae extract, white is added in the second mixture
Serpentis grass extract, Radix Isatidis extract, Princepia utilis extract, Rhizoma Coptidis extract, Radix Angelicae Sinensis extract, Herba Violae extract,
Stir, obtain mixed liquor；4) acrylic acid (ester) analog copolymer is dissolved in remaining water in advance, is then added to step
3) in mixed liquor, stir, lower the temperature, obtain the 3rd mixture；5) when temperature is down to 40 DEG C, add in the 3rd mixture
Enter Sensiva SC50, phenoxyethanol, chlorphenesin, stirs the privates care product that be obtained.
Embodiment 3
Herba polygoni hydropiperis extract, Hedyotidis Diffusae extract, Radix Angelicae Sinensis extract, the preparation method of Herba Violae extract are：Will be dry
Dry Herba polygoni hydropiperis, Hedyotidis Diffusae, Radix Angelicae Sinensis, Herba Violae crushing, weighs respectively the above-mentioned medicinal powders of 100g, adds medicinal powder quality
10 times of mass concentration is 50% ethanol water, soaks 30min, is then flowed back 3 times at 60 DEG C, each 2h, united extraction
Liquid, reclaims ethanol, is evaporated to 1.03g (crude drug)/mL, as each medicinal substances extract, and cold preservation is standby at 4 DEG C.
Folium perillae extract, Radix Isatidis extract, Princepia utilis extract, the preparation method of Rhizoma Coptidis extract are：Will be dry
Folium Perillae, Radix Isatidis, Princepia utilis, Rhizoma Coptidis are crushed, and the above-mentioned medicinal powders of 100g are weighed respectively, add the steaming of 10 times of medicinal powder quality
Distilled water, soaks 30min, decocts 3 times at 75 DEG C, each 2h, filters, and merging filtrate is evaporated to 1.05g (crude drug)/mL, i.e.,
For each medicinal substances extract, cold preservation is standby at 4 DEG C.
The formula of privates care product is：Sodium Chloride 3wt%, glycerol 6wt%, sodium lauroyl glutamate 8wt%, cocos nucifera oil acyl
CAB 12wt%, glycol distearate 1wt%, lauric acid 2.5wt%, lactic acid 0.6wt%, acrylic acid (ester) class
Copolymer 2.5wt%, Radix et Caulis Opuntiae Dillenii extract 2wt%, Herba polygoni hydropiperis extract 0.5wt%, Folium perillae extract 2.5wt%, Hedyotidis Diffusae
Extract 0.5wt%, Radix Isatidis extract 3wt%, Princepia utilis extract 2.5wt%, Rhizoma Coptidis extract 1wt%, Radix Angelicae Sinensis are extracted
Thing 4wt%, Herba Violae extract 3wt%, Sensiva SC50 0.1wt%, phenoxyethanol 0.3wt%, chlorphenesin
0.1wt%, balance of water.
The preparation method of privates care product is：1) by the water of 39.4wt%, sodium lauroyl glutamate, Sodium Chloride, glycerol
Mixing, is heated to 85 DEG C, and is stirred continuously, and is incubated 10min, obtains the first mixture；2) and then by cocamidopropyl propyl amide Radix Betae
Alkali, glycol distearate, lauric acid, citric acid are added in the first mixture, are stirred, and are lowered the temperature, and obtain the second mixing
Thing；3) when temperature is down to 65 DEG C, Radix et Caulis Opuntiae Dillenii extract, Herba polygoni hydropiperis extract, Folium perillae extract, white is added in the second mixture
Serpentis grass extract, Radix Isatidis extract, Princepia utilis extract, Rhizoma Coptidis extract, Radix Angelicae Sinensis extract, Herba Violae extract,
Stir, obtain mixed liquor；4) acrylic acid (ester) analog copolymer is dissolved in remaining water in advance, is then added to step
3) in mixed liquor, stir, lower the temperature, obtain the 3rd mixture；5) when temperature is down to 40 DEG C, add in the 3rd mixture
Enter Sensiva SC50, phenoxyethanol, chlorphenesin, stirs the privates care product that be obtained.
Embodiment 4
The formula of privates care product is same as Example 1 with preparation method, and difference is not use Hedyotidis Diffusae to extract
Thing, Herba polygoni hydropiperis extract, Folium perillae extract, Radix Isatidis extract, Princepia utilis extract and Herba Violae extract, and Radix et Caulis Opuntiae Dillenii carries
The consumption for taking thing is 4.25wt%, the consumption of Rhizoma Coptidis extract is 5.5wt%, and the consumption of Radix Angelicae Sinensis extract is 6wt%.
Embodiment 5
The formula of privates care product is same as Example 1 with preparation method, difference be do not use Radix Isatidis extract,
Princepia utilis extract and Herba Violae extract, and the consumption of Radix et Caulis Opuntiae Dillenii extract is 2.25wt%, the consumption of Rhizoma Coptidis extract
For 3wt%, the consumption of Radix Angelicae Sinensis extract is 3.5wt%, and the consumption of Hedyotidis Diffusae extract is 2.25wt%, Herba polygoni hydropiperis extract
Consumption is 2.25wt%, and the consumption of Folium perillae extract is 2.5wt%.
Comparative example 1
The formula of privates care product is same as Example 4 with preparation method, and difference is not use Radix et Caulis Opuntiae Dillenii extract
And Rhizoma Coptidis extract, the consumption of Radix Angelicae Sinensis extract is 15.75wt%.
Comparative example 2
The formula of privates care product is same as Example 4 with preparation method, difference be do not use Radix Angelicae Sinensis extract and
Rhizoma Coptidis extract, the consumption of Radix et Caulis Opuntiae Dillenii extract is 15.75wt%.
Comparative example 3
The formula of privates care product is same as Example 4 with preparation method, difference be do not use Radix Angelicae Sinensis extract and
Radix et Caulis Opuntiae Dillenii extract, the consumption of Rhizoma Coptidis extract is 15.75wt%.
The in-vitro antibacterial performance test of embodiment 6
Clinical isolation staphylococcus aureuses, escherichia coli and Candida albicans are taken, are incubated at respectively in culture medium,
Example 1～5 and privates care product obtained in comparative example 1～3 as subjects, according to standard GB/T 15979-
2002 are operated, and as shown in table 1, table 1 resists in vitro testing result for the privates care product that the embodiment of the present invention is prepared
Bacterium the performance test results.
The privates care product in-vitro antibacterial the performance test results that the embodiment of the present invention of table 1 is prepared
As shown in Table 1, the privates care product that the present invention is provided is to private portion's common pathogen-staphylococcus aureuses, big
Enterobacteria and Candida albicans have significant antibacterial activity, can safeguard private portion's colony balance.
Irritant test of the embodiment 7 to vaginal mucosa
Regular grade Female New Zealand rabbit 12 is taken, 2～2.5kg of body weight is randomly divided into 4 groups, and experimental group is present invention enforcement
The privates care product that example 1～3 is prepared, matched group is sterilized normal saline, and each 3, pretest inspection animal is cloudy
Road junction whether there is secretions, hyperemia, edema and other situations.Animal is faced upward fixation, vaginal orifice is exposed, by conduit physiology salt
Vagina (4～5cm) is gently inserted after water-wet, and 2mL tested materials are slowly injected into syringe, extract conduit out, complete contamination.
After 24 hours, animal is put to death using air tap inserting method, completely cut longitudinally slit after vagina, whether perusal has hyperemia, water
The phenomenon such as swollen.Testing result is：Each group experimental animal vaginal mucosa has no hyperemia, edema, erosion, vaginal mucosa irritation index<
1, thus illustrate, the privates care product that the present invention is provided is non-stimulated to vaginal mucosa.
The clinical effectiveness of embodiment 8 is tested
360 women are chosen, 25～55 years old, is divided into 4 groups, wherein per group includes the people of bacterial vaginitiss 30, trichomonas the moon
Road 30 people of inflammation, the people of comprehensive vaginitiss 30,4 groups of privates care products for being prepared using the embodiment of the present invention 1～3 respectively,
Using method is to take appropriate in the palm of the hand, plus little water, and both hands rub out abundant foam, is then applied to private portion, 2～3 minutes
Afterwards, rinsed well with clear water, another set then uses metronidazole cleanout fluid as a control group, continuous to use 30 days, detection
As a result as shown in table 2, the clinical effectiveness test result of the privates care product that table 2 is prepared for the embodiment of the present invention.
The clinical effectiveness test result of the privates care product that the embodiment of the present invention of table 2 is prepared
As can be seen from Table 2, the effect is significant of the privates care product that the present invention is provided, hence it is evident that higher than matched group, can be effective
The generation and recurrence of prevention privates disease.
As seen from the above embodiment, the invention provides a kind of bactericidal composition, including：Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis carry
Take thing and Radix Angelicae Sinensis extract.The invention provides a kind of privates care product, including described bactericidal composition.The present invention is provided
The effective ingredient of bactericidal composition be Chinese medicine extract, gentle non-stimulated, Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis extract and Radix Angelicae Sinensis are carried
Take thing to cooperate with synergism, make this bactericidal composition that there is good bactericidal effect.There is provided using the present invention
Bactericidal composition prepares privates care product, because bactericidal composition is imitated without chemical bactericide and with good sterilization
Really, the privates care product safety for making to prepare is gentle non-stimulated, can effective cleaning privates, Balancing and flora environment,
Suppress the growth and breeding of privates pathogenic bacterium, while with sterilization, antiinflammatory, antipruritic, dispelling abnormal flavor effect, life-time service is not only
With auxiliary beautification privates effect, moreover it is possible to which effectively prevention privates disease occurs and recurs, and men and women can use.
Claims (10)
1. a kind of bactericidal composition, including：
Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis extract and Radix Angelicae Sinensis extract.
2. bactericidal composition according to claim 1, it is characterised in that also include：
One or more in Hedyotidis Diffusae extract, Herba polygoni hydropiperis extract and Folium perillae extract.
3. bactericidal composition according to claim 1, it is characterised in that also include：
Hedyotidis Diffusae extract, Herba polygoni hydropiperis extract and Folium perillae extract.
4. bactericidal composition according to claim 2, it is characterised in that also include：
One or more in Radix Isatidis extract, Princepia utilis extract and Herba Violae extract.
5. bactericidal composition according to claim 2, it is characterised in that also include：
Radix Isatidis extract, Princepia utilis extract and Herba Violae extract.
6. bactericidal composition according to claim 1, it is characterised in that the bactericidal composition includes：
Radix et Caulis Opuntiae Dillenii extract, Rhizoma Coptidis extract, Radix Angelicae Sinensis extract, Hedyotidis Diffusae extract, Herba polygoni hydropiperis extract, Folium perillae extract,
Radix Isatidis extract, Princepia utilis extract and Herba Violae extract.
7. a kind of privates care product, including the bactericidal composition in claim 1～6 described in any one.
8. privates care product according to claim 7, it is characterised in that also include：
One or more in thickening agent, solvent, surfactant, foam stabilizer, preservative, stabilizer and acid regulator.
9. privates care product according to claim 8, it is characterised in that the surfactant is that amino acid surface is lived
Property agent.
10. privates care product according to claim 8, it is characterised in that also include：Pearlescent flake and/or anti-corrosion potentiation
Agent.
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