CN107759712B - 羊来源的低分子肝素及其制备方法与应用 - Google Patents
羊来源的低分子肝素及其制备方法与应用 Download PDFInfo
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- CN107759712B CN107759712B CN201610695072.1A CN201610695072A CN107759712B CN 107759712 B CN107759712 B CN 107759712B CN 201610695072 A CN201610695072 A CN 201610695072A CN 107759712 B CN107759712 B CN 107759712B
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- sheep
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- heparin
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
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- Animal Behavior & Ethology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
项目 | 重均分子量(Da) | <3000Da | 3000-8000Da | >8000Da |
组别 | APTT | PT | TT |
羊达肝素钠样品 | 114.1±9.5s | 13.2±0.6s | 157.3±47.4s |
羊那曲肝素钙样品 | 105.3±12.1s | 13.9±0.4s | 145.9±43.6s |
羊亭扎肝素钠样品 | 102.5±9.8s | 13.4±0.5s | 134.4±52.3s |
羊帕肝素钠样品 | 97.3±10.3s | 12.8±0.5s | 124.6±49.1s |
羊贝米肝素钠样品 | 95.8±9.8s | 13.2±0.5s | 132.5±44.3s |
依诺肝素钠标准品 | 104.6±10.2s | 13.8±0.3s | 140.4±54.7s |
空白对照 | 38.1±1.4s | 12.7±0.6s | 16.6±0.7s |
组别 | 纤维蛋白原 | 复钙时间 |
羊达肝素钠样品 | 2.91±0.51g/L | 31.00±0.00s* |
羊那曲肝素钙样品 | 2.66±0.43g/L | 31.00±0.00s* |
羊亭扎肝素钠样品 | 2.64±0.37g/L | 31.00±0.00s* |
羊帕肝素钠样品 | 2.76±0.53g/L | 31.00±0.00s* |
羊贝米肝素钠样品 | 2.71±0.72g/L | 31.00±0.00s* |
依诺肝素钠标准品 | 2.89±0.44g/L | 31.00±0.00s* |
空白对照 | 2.57±0.25g/L | 9.95±0.40s |
Claims (5)
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CN201610695072.1A CN107759712B (zh) | 2016-08-19 | 2016-08-19 | 羊来源的低分子肝素及其制备方法与应用 |
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CN201610695072.1A CN107759712B (zh) | 2016-08-19 | 2016-08-19 | 羊来源的低分子肝素及其制备方法与应用 |
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CN107759712A CN107759712A (zh) | 2018-03-06 |
CN107759712B true CN107759712B (zh) | 2020-03-24 |
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Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110885386A (zh) * | 2019-12-23 | 2020-03-17 | 天津生物化学制药有限公司 | 一种利用那屈肝素钙废料提取超低分子量肝素钠的方法 |
CN114072430B (zh) * | 2020-04-27 | 2023-07-28 | 罗威制药股份有限公司 | 低分子量肝素获取程序以及由此获得的低分子量肝素 |
CN114230688B (zh) * | 2021-12-24 | 2022-12-13 | 武汉瑞法医疗器械有限公司 | 简单高效的血液净化用肝素钠回收方法 |
CN115436542B (zh) * | 2022-09-29 | 2023-04-25 | 东营天东制药有限公司 | 一种鉴别猪肠粘膜肝素中羊来源肝素掺杂比例的方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2003197A6 (es) * | 1987-01-05 | 1988-10-16 | Rovi Lab Farmaceut Sa | Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica |
CN1111171C (zh) * | 2000-09-07 | 2003-06-11 | 上海惠海生化制品厂 | 一种肝素及其制备方法 |
CN101831009A (zh) * | 2010-05-11 | 2010-09-15 | 新疆立实生物科技有限公司 | 一种浓缩纯化肝素的生产工艺 |
CN105131153A (zh) * | 2015-08-21 | 2015-12-09 | 苏州融析生物科技有限公司 | 绵羊依诺肝素钠化合物的制备方法及其化合物与应用 |
CN105343890B (zh) * | 2015-11-18 | 2018-02-13 | 山东大学 | 一种肝素或其盐修饰的氧化石墨烯及其制备方法与应用 |
CN105294885A (zh) * | 2015-11-23 | 2016-02-03 | 山东大学 | 一种新来源亚硝酸降解低分子肝素的制备方法 |
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Application publication date: 20180306 Assignee: SUZHOU ERYE PHARMACEUTICAL Co.,Ltd. Assignor: SUZHOU RONNSI PHARMA Co.,Ltd. Contract record no.: X2020980009006 Denomination of invention: Preparation and application of low molecular weight heparin from sheep Granted publication date: 20200324 License type: Common License Record date: 20201209 |
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