CN107519398A - 一种治疗烧烫伤的中药酊剂及其制备方法 - Google Patents
一种治疗烧烫伤的中药酊剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗烧烫伤的中药酊剂及其制备方法,包括如下重量份的组分:黄连1~5份、黄柏3~6份、黄芩4~8份、黄栀子4~8份、生大黄2~6份、苦参3~6份、虎杖2~8份、生地榆2~8份、紫草4~6份、白芨1~5份、五倍子2~8份、天花粉2~8份、冰片3~5份、75%的医用酒精溶液10~20份。本发明属于中药技术领域,通过选择合适的纯天然中药材及其配比,制备出一种无刺激,无毒副作用,患者易接受,安全度高,见效快,治疗烧烫伤效果好,能快速消除烧烫伤引起的疼痛、红肿等并发症,并防止烧烫伤面扩大、感染化脓,促使烧烫伤面快速愈合,不留疤痕的治疗烧烫伤的中药酊剂。
Description
技术领域
本发明属于中药技术领域,具体是指一种治疗烧烫伤的中药酊剂及其制备方法。
背景技术
烧伤主要指热力、化学物质、电能、放射线等引起的皮肤、粘膜,甚至深部组织的损害。其中皮肤热 力烧伤(如火焰、开水等)最为多见。据统计,每年因意外伤害的死亡人数,烧伤仅次于交通事故,排在 第二位,而且在交通事故伤害中也有大量伤员合并烧伤。
烧伤的严重程度取决于受伤组织的范围和深度,烧伤深度可分为Ⅰ度、Ⅱ度和Ⅲ度。Ⅰ度烧伤损伤最 轻,烧伤皮肤发红、疼痛、明显触痛、有渗出或水肿,轻压受伤部位时局部变白,但没有水疱。Ⅱ度烧伤 损伤较深,皮肤水疱,水疱底部呈红色或白色,充满了清澈、粘稠的液体,触痛敏感,压迫时变白。Ⅲ度 烧伤损伤最深,烧伤表面发白、***或者呈黑色、炭化皮革状,由于被烧皮肤变得苍白,在白皮肤人中常 被误认为正常皮肤,但压迫时不再变色,破坏的红细胞可使烧伤局部皮肤呈鲜红色,偶尔有水疱,烧伤区 的毛发很容易拔出,感觉减退。Ⅲ度烧伤区域因皮肤的神经末梢被破坏一般没有痛觉,烧伤后常常要经过 几天才能区分深Ⅱ度与Ⅲ度烧伤。
烫伤是日常生活中常见的疾患,主要是由沸水、沸油、摩托车排气管、太阳紫外线等接触人体表面, 而导致局部皮肤、组织损伤,造成人体功能障碍、疼痛、局部坏死等一系列临床症状,常伴潮红水肿,表 面大量液体渗出,以伤处红肿灼痛、起泡、结焦痂为主要表现症状。烫伤轻者损及皮毛,甚则伤及肌肉筋 内,严重者,火毒炽盛,伤津耗液,邪毒侵入营血,内攻脏腑而生诸症。临床上根据烫伤程度,将其分三 度:Ⅰ度烫伤:烫伤只损伤皮肤表层,局部轻度红肿、无水泡、疼痛明显;Ⅱ度烫伤:烫伤是真皮损伤, 局部红肿疼痛,有大小不等的水泡;Ⅲ度烫伤是皮下,脂肪、肌肉、骨骼都有损伤,并呈灰或红褐色。对 大面积烫伤,宜尽早送医院治疗。
中医学认为,烧烫伤是由于火热毒邪侵袭机体,导致肌表受损,脉络不通,热盛肉腐,肌表不全,津 液淋沥,机体阴液亏损,可出现局部红肿、水泡、疮疡等临床症状,故外用药以清热解毒、活血化瘀、收 敛止痛为主。
烧烫伤治疗中存在创面疼痛、进行性坏死、易感染、瘢痕愈合四大难题,因此,迫切需要寻找更为有 效的治疗药物。日常生活中,常会发生因行动不慎引起的皮肤烧伤或烫伤,轻者疼痛发红、重者起泡甚至 表皮剥脱坏死,伤至骨头。如不及时医治,病邪和细菌侵入,不仅会扩大创面,皮肤溃烂,甚至造成感染, 产生败血症,导致死亡。采用西药治疗烧烫伤虽然具有见效快、疗效确切的优点,但西药对人体有一定的 刺激性,并且在一定程度上能产生耐药性和副作用。现有技术中也有一些治疗烧烫伤的中药组合物,但是 这些组合物都存在下述问题,即见效慢,疗程长,效果差,不能自然愈合,甚至感染化脓,易留疤痕,且目前市面上常用的烧烫伤药物以湿润烧伤膏为主,该膏体外擦,一天5次,每次外擦时需先清除上一次涂 抹的药膏,这样造成患者痛苦不堪,而且费时费力,患者不易接受。那么如何对传统烧烫伤药剂的考察、 比较研究和不断改进,以期或得一种广谱性医用和家庭用治疗烧烫伤的药剂是目前亟待解决的问题。
发明内容
为解决上述现有难题,本发明通过选择合适的纯天然中药材及其配比,制备出一种无刺激,无毒副作 用,患者易接受,安全度高,见效快,治疗烧烫伤效果好,能快速消除烧烫伤引起的疼痛、红肿等并发症, 并防止烧烫伤面扩大、感染化脓,促使烧烫伤面快速愈合,不留疤痕的治疗烧烫伤的中药酊剂及其制备方 法。
本发明采用的技术方案如下:一种治疗烧烫伤的中药酊剂,包括如下重量份的组分:黄连1~5份、黄 柏3~6份、黄芩4~8份、黄栀子4~8份、生大黄2~6份、苦参3~6份、虎杖2~8份、生地榆2~8份、紫草 4~6份、白芨1~5份、五倍子2~8份、天花粉2~8份、冰片3~5份、75%的医用酒精溶液10~20份。
进一步地,一种治疗烧烫伤的中药酊剂,包括如下重量份的组分:黄连2~5份、黄柏4~6份、黄芩5~8 份、黄栀子5~8份、生大黄3~6份、苦参4~6份、虎杖3~8份、生地榆3~8份、紫草5~6份、白芨2~5 份、五倍子3~8份、天花粉3~8份、冰片4~5份、75%的医用酒精溶液15~20份。
进一步地,一种治疗烧烫伤的中药酊剂,包括如下重量份的组分:黄连4份、黄柏5份、黄芩6份、 黄栀子6份、生大黄5份、苦参5份、虎杖5份、生地榆5份、紫草6份、白芨4份、五倍子5份、天花 粉5份、冰片5份、75%的医用酒精溶液16份。
本发明配方所采用的各种药材的来源及功能主治如下:
黄连为毛茛科、黄连属多年生草本植物;清热燥湿,泻火解毒。用于湿热痞满,呕吐吞酸,泻痢,黄 疸,高热神昏,心火亢盛,心烦不寐,血热吐衄,目赤,牙痛,消渴,痈肿疔疮;外治湿疹,湿疮,耳道 流脓。酒黄连善清上焦火热,用于目赤,口疮。
黄柏为芸香科、黄檗属植物黄皮树或黄檗的干燥树皮;味苦,性寒;清热解毒,泻火燥湿。主治急性 细菌性痢疾、急性肠炎、急性黄疸型肝炎、泌尿***感染等炎症。外用治火烫伤、中耳炎、急性结膜炎等。
黄芩为唇形科黄芩属植物;味苦,性寒;归肺、胆、脾、胃、大肠、小肠经;能清热燥湿、泻火解毒、 止血、安胎;主治温热病、上呼吸道感染、肺热咳嗽、湿热黄胆、肺炎、痢疾、咳血、目赤、胎动不安、 高血压、痈肿疖疮等症。
黄栀子产于中国长江流域以南,果实味苦寒,用于清热、泻火、凉血。
生大黄性寒,味苦,归胃经,大肠经,肝经,脾经,清湿热;泻火,凉血,祛瘀,主治于跌打损伤, 热毒痈疡等。
苦参为豆科苦参属的变种,性寒,有清热燥湿,杀虫的功效,苦参浴能够清除下焦湿热,并且杀虫止 痒,对皮肤瘙痒有很好的缓解作用,植物中草药能够平衡油脂分泌,疏通并收敛毛孔,清除皮肤内毒素杂 质,丰富的本草营养,促进受损血管神经细胞的生长和修复,恢复皮下毛细血管细胞活力,肌肤重现紧致 细滑,起到美容护肤的作用。
虎杖性微寒,味微苦,归肝、胆、肺经,具有清热解毒、祛风利湿、散火解毒之功效。
生地榆为蔷薇科地榆属植物;味苦、酸;性寒;归肝、肺、肾、大肠经;凉血止血,清热解毒,消肿 敛疮。
紫草为紫草科紫草属植物;味甘、咸,性寒;归心、肝经;功能主治凉血,活血,解毒透疹。用于血 热毒盛、斑疹紫黑、麻疹不透、疮疡、湿疹、水火烫伤。
白芨性微寒,味辛、苦、甘、涩,归肺、肝、胃经,具有活血化瘀、消肿止血、敛疮生肌之功效。
五倍子性寒,味酸、涩,归肺、大肠、肾经,具有凉血止血、敛肺降火之功效。
天花粉为葫芦科植物栝蒌的根,为清热泻火类药物,其具体功效是清热泻火,生津止渴,排脓消肿。 主治热病口渴、消渴、黄疸、肺燥咳血、痈肿、痔痿。
冰片为龙脑香科植物龙脑香的树脂和挥发油加工品提取获得的结晶;气清香,味苦辛、性微寒;入心、 肝、肺经;清香宣散,具有开窍醒神,清热散毒,清凉泻火的功效。
75%的医用酒精溶液,其中75%为体积分数,75%的医用酒精溶液具有下述作用:1)在涂药时杀灭伤 口细菌;2)有效清洁伤口;3)可有效浸泡出中药组分内的有效成分;4)可保证药物长期贮存不变质。 经实验证明,较其他体积分数的酒精溶液,75%的医用酒精溶液杀菌作用最强。
进一步地,所述治疗烧烫伤的中药酊剂在使用时,先摇晃使其内部组分混合均匀,再用药棉取用液体 涂擦伤口,每次1~2遍,每天4~5次至伤口痊愈。
本发明还公开了一种治疗烧烫伤的中药酊剂的制备方法,包括如下步骤:
1)按照组分的重量份比称取各组分;
2)将黄连、黄柏、黄芩、黄栀子、生大黄、苦参、虎杖、生地榆、紫草、白芨、五倍子、天花粉和 冰片经干燥后,按比例混合、粉粹、研磨、过80~100目筛后得中药粉末;
3)按重量份比将步骤2)所述的中药粉末和75%的医用酒精溶液置于药剂瓶内,盖上药剂瓶瓶盖, 摇晃30秒混合均匀,即得本发明治疗烧烫伤的中药酊剂。
采用上述方案本发明取得有益效果如下:本发明治疗烧烫伤的中药酊剂具有中草药酒精气味,是根据 祖传秘方,选合适的纯天然中药材及其配比,各组分之间相互配合,协同作用,在制备方法上力求简便易 操作,最大限度保持药物新鲜,尽量采用生药,药物炒用、蒸用都不如生用,外治用药,生用疗效最好。 本发明治疗烧烫伤的中药酊剂无刺激,无毒副作用,患者易接受,安全度高,见效快,治疗烧烫伤效果好, 能快速消除烧烫伤引起的疼痛、红肿等并发症,并防止烧烫伤面扩大、感染化脓,促使烧烫伤面快速愈合, 治疗Ⅰ度、浅Ⅱ度烧烫伤不留疤痕。本发明主治各种体表烫伤、带状疱疹、感染性皮肤病、皮肤瘙痒、蚊虫叮咬等,本发明治疗烧烫伤的中药酊剂成本低、效果好,是一种适合于广谱性医用和家庭用治疗烧烫伤 的药剂。另外,本发明提供的治疗烧烫伤的中药酊剂制备、使用及携带方便,对烧烫伤病症治疗效果显著, 经临床试验验证有效率为100%,完全治愈率不低于95%。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅是本发明的一 部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动 前提下所获得的所有其它实施例,都属于本发明保护的范围。
实施例1,本发明治疗烧烫伤的中药酊剂,包括如下重量份的组分:黄连4份、黄柏5份、黄芩6份、 黄栀子6份、生大黄5份、苦参5份、虎杖5份、生地榆5份、紫草6份、白芨4份、五倍子5份、天花 粉5份、冰片5份、75%的医用酒精溶液16份。
本发明治疗烧烫伤的中药酊剂的制备方法,包括如下步骤:
1)按照组分的重量份比称取各组分;
2)将黄连、黄柏、黄芩、黄栀子、生大黄、苦参、虎杖、生地榆、紫草、白芨、五倍子、天花粉和 冰片经干燥后,按比例混合、粉粹、研磨、过80~100目筛后得中药粉末;
3)按重量份比将步骤2)所述的中药粉末和75%的医用酒精溶液置于药剂瓶内,盖上药剂瓶瓶盖,摇 晃30秒混合均匀,即得本发明治疗烧烫伤的中药酊剂。
实施例2,本发明治疗烧烫伤的中药酊剂,包括如下重量份的组分:黄连3份、黄柏6份、黄芩7份、 黄栀子7份、生大黄6份、苦参4份、虎杖7份、生地榆8份、紫草6份、白芨3份、五倍子4份、天花 粉5份、冰片4份、75%的医用酒精溶液19份。
本发明治疗烧烫伤的中药酊剂的制备方法,包括如下步骤:
1)按照组分的重量份比称取各组分;
2)将黄连、黄柏、黄芩、黄栀子、生大黄、苦参、虎杖、生地榆、紫草、白芨、五倍子、天花粉和 冰片经干燥后,按比例混合、粉粹、研磨、过80~100目筛后得中药粉末;
3)按重量份比将步骤2)所述的中药粉末和75%的医用酒精溶液置于药剂瓶内,盖上药剂瓶瓶盖,摇 晃30秒混合均匀,即得本发明治疗烧烫伤的中药酊剂。
实施例3,本发明治疗烧烫伤的中药酊剂,包括如下重量份的组分:黄连2份、黄柏6份、黄芩8份、 黄栀子5份、生大黄6份、苦参4份、虎杖7份、生地榆5份、紫草5份、白芨5份、五倍子7份、天花 粉8份、冰片4份、75%的医用酒精溶液17份。
本发明治疗烧烫伤的中药酊剂的制备方法,包括如下步骤:
1)按照组分的重量份比称取各组分;
2)将黄连、黄柏、黄芩、黄栀子、生大黄、苦参、虎杖、生地榆、紫草、白芨、五倍子、天花粉和 冰片经干燥后,按比例混合、粉粹、研磨、过80~100目筛后得中药粉末;
3)按重量份比将步骤2)所述的中药粉末和75%的医用酒精溶液置于药剂瓶内,盖上药剂瓶瓶盖,摇 晃30秒混合均匀,即得本发明治疗烧烫伤的中药酊剂。
下面结合临床数据进一步说明本发明的有益效果,但本发明并不局限于以下临床数据:
一般资料:发明人于2015年3月~2017年5月间共收集了多例烧烫伤患者,年龄3~70岁。
诊断标准:皮肤经热液、热气、化学药品烧烫伤后,烧烫伤面疼痛、红肿、起水泡,甚至伤及肌肉、 骨骼,呈灰色或红褐色。
观察指标:观察治疗前后烧烫伤面有哪些变化,治疗后症状,体征是否消失或减轻。
临床痊愈:临床症状、体征消失,烫伤面恢复正常。
显效:临床症状、体征基本消失,烫伤面基本恢复正常。
有效:临床症状、体征有所改善,烫伤面情况有一定改善。
无效:临床症状、体征均无改善或加重,烫伤面无改善。
试验结果如下:
疗效评定:烧烫伤的临床试验中,患者外用由本发明治疗烧烫伤的中药酊剂,有效率100%、治愈率 95.4%;而对照组外用市面常用的湿润烧伤膏,有效率83.3%、治愈率60%。治疗组与对照组的效果比较 表明,本发明治疗烧烫伤的中药酊剂治疗有效率和治愈率较高,治愈率达95.4%,且治疗周期短。
典型病例1
何某,男,40岁。在氧焊切割油箱时,不慎点燃油箱内汽油,致面部、颈部Ⅱ度浅烧伤,烧伤面积占 体表6%左右,用本发明治疗烧烫伤的中药酊剂外擦5次/日,连用一周,共用本发明中药酊剂100ml/瓶规 格的两瓶,并配合服用阿莫西林胶囊,2粒/次,连服5天,一周后痊愈,伤口无疤痕无色素沉着。
典型病例2
赵某,女,45岁。使用压力锅煮粥时***,造成面部、颈部、胸部烫伤Ⅰ度,占体表面积8%左右, 用本发明治疗烧烫伤的中药酊剂外擦4~5次/日,一周痊愈,共用本发明中药酊剂100ml/瓶规格的两瓶, 愈后创口不留疤痕。
典型病例3
王某,女,37岁。炒菜时沸油烫伤面部和双上肢,用本发明治疗烧烫伤的中药酊剂外擦4次/日,连 用一周痊愈,共用本发明中药酊剂100ml/瓶规格的半瓶,愈后创口不留疤痕。
典型病例4
刘某,男,35岁。骑摩托车摔倒,摩托车排气管烫伤小腿,用本发明治疗烧烫伤的中药酊剂外擦4~5 次/日,一周痊愈,愈后创口不留疤痕,有少量红色色素沉着,3个月后色素消失。
以上所述仅为本发明的实施例,并非因此限制本发明的专利范围,凡是利用本发明说明书内容所作的 等效结构或等效流程变换,或直接或间接运用在其它相关的技术领域,均同理包括在本发明的专利保护范 围内。
Claims (5)
1.一种治疗烧烫伤的中药酊剂,其特征在于,包括如下重量份的组分:黄连1~5份、黄柏3~6份、黄芩4~8份、黄栀子4~8份、生大黄2~6份、苦参3~6份、虎杖2~8份、生地榆2~8份、紫草4~6份、白芨1~5份、五倍子2~8份、天花粉2~8份、冰片3~5份、75%的医用酒精溶液10~20份。
2.根据权利要求1所述的一种治疗烧烫伤的中药酊剂,其特征在于,包括如下重量份的组分:黄连2~5份、黄柏4~6份、黄芩5~8份、黄栀子5~8份、生大黄3~6份、苦参4~6份、虎杖3~8份、生地榆3~8份、紫草5~6份、白芨2~5份、五倍子3~8份、天花粉3~8份、冰片4~5份、75%的医用酒精溶液15~20份。
3.根据权利要求1所述的一种治疗烧烫伤的中药酊剂,其特征在于,包括如下重量份的组分:黄连4份、黄柏5份、黄芩6份、黄栀子6份、生大黄5份、苦参5份、虎杖5份、生地榆5份、紫草6份、白芨4份、五倍子5份、天花粉5份、冰片5份、75%的医用酒精溶液16份。
4.根据权利要求1所述的一种治疗烧烫伤的中药酊剂,其特征在于,所述治疗烧烫伤的中药酊剂在使用时,先摇晃使其内部组分混合均匀,再用药棉取用液体涂擦伤口,每次1~2遍,每天4~5次至伤口痊愈。
5.一种治疗烧烫伤的中药酊剂的制备方法,其特征在于,包括如下步骤:
1)按照组分的重量份比称取各组分;
2)将黄连、黄柏、黄芩、黄栀子、生大黄、苦参、虎杖、生地榆、紫草、白芨、五倍子、天花粉和冰片经干燥后,按比例混合、粉粹、研磨、过80~100目筛后得中药粉末;
3)按重量份比将步骤2)所述的中药粉末和75%的医用酒精溶液置于药剂瓶内,盖上药剂瓶瓶盖,摇晃30秒混合均匀,即得本发明治疗烧烫伤的中药酊剂。
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