CN105705172A - 用于组织再生的亲水性静电纺生物复合支架材料及其制法与应用 - Google Patents

用于组织再生的亲水性静电纺生物复合支架材料及其制法与应用 Download PDF

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CN105705172A
CN105705172A CN201380079743.6A CN201380079743A CN105705172A CN 105705172 A CN105705172 A CN 105705172A CN 201380079743 A CN201380079743 A CN 201380079743A CN 105705172 A CN105705172 A CN 105705172A
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biological composite
composite scaffold
scaffold material
hydrophily
static spinning
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CN105705172B (zh
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何红兵
苏岭
刘章
杨莉
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Shanghai P & P Biotech Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/043—Proteins; Polypeptides; Degradation products thereof
    • A61L31/046—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F1/00—General methods for the manufacture of artificial filaments or the like
    • D01F1/02—Addition of substances to the spinning solution or to the melt
    • D01F1/10—Other agents for modifying properties
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
    • D01F6/62—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters
    • D01F6/625—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyesters derived from hydroxy-carboxylic acids, e.g. lactones
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
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    • D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
    • D01F6/78—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products
    • D01F6/84—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from copolycondensation products from copolyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/22—Materials or treatment for tissue regeneration for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus
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    • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2401/00—Physical properties
    • D10B2401/02—Moisture-responsive characteristics
    • D10B2401/022—Moisture-responsive characteristics hydrophylic
    • D—TEXTILES; PAPER
    • D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
    • D10B2509/00—Medical; Hygiene
    • D10B2509/06—Vascular grafts; stents

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Abstract

一种用于组织再生的亲水性静电纺生物复合支架材料及其制法与应用，所述的生物复合材料是由纤维蛋白原、L-精氨酸或其盐酸盐的水溶液与P(LLA-CL)溶液共混，采用静电纺技术制备而得到的。该生物复合支架材料的平衡接触角达55℃以下，具有亲水性，在修复机体组织缺损中具有良好应用前景。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201380079743.6A 2013-11-19 2013-11-19 用于组织再生的亲水性静电纺生物复合支架材料及其制法与应用 Active CN105705172B (zh)

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CN112251912A (zh) * 2020-10-19 2021-01-22 新疆大学 一种刺山柑载药纳米纤维膜及其制备方法和应用
CN114177342A (zh) * 2021-12-10 2022-03-15 四川大学华西医院 一种纳米纤维抗菌敷料及其制备方法
CN114425102A (zh) * 2022-01-30 2022-05-03 上海松力生物技术有限公司 一种诱导皮肤组织再生的亲水性静电纺植入物
CN114452442A (zh) * 2022-01-30 2022-05-10 上海松力生物技术有限公司 一种原位诱导子宫壁组织再生的植入物
WO2023143337A1 (zh) * 2022-01-30 2023-08-03 上海松力生物技术有限公司 一种肩袖补片及其制备方法
WO2023143334A1 (zh) * 2022-01-30 2023-08-03 上海松力生物技术有限公司 一种预防吻合口瘘的植入物
CN117462755A (zh) * 2023-11-24 2024-01-30 北京康派特医疗器械有限公司 生物修补材料及其制备方法和应用

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CN105568557B (zh) * 2015-12-22 2019-01-18 青岛大学 一种氯化钴湿敏电纺微纳米纤维膜及其制备方法和应用
CN106581777A (zh) * 2017-02-08 2017-04-26 袁峰 一种聚己内酯‑氧化石墨烯复合多孔支架材料的制备方法
AU2018268713B2 (en) 2017-05-16 2024-04-18 Embody Inc. Biopolymer compositions, scaffolds and devices
CN107510520B (zh) * 2017-09-21 2020-08-11 上海松力生物技术有限公司 十字交叉韧带再生性植入物及其制备方法与应用
CN108676769B (zh) * 2018-04-24 2022-09-23 武汉仝干医疗科技股份有限公司 一种促进肝细胞生长的无纺布支架材料及其制备方法
WO2020160491A1 (en) 2019-02-01 2020-08-06 Embody, Inc. Microfluidic extrusion
CN109847104B (zh) * 2019-03-07 2022-05-03 宁波光远致信生物科技有限公司 一种神经修复膜及其制备方法和应用
CN113413488B (zh) * 2021-06-09 2022-10-18 济南大学 一种可降解压电纤维支架的制备方法及其产品
CN113583224A (zh) * 2021-07-13 2021-11-02 川北医学院 Ala-Gln-PPDO/PLGA/PLCA/庆大霉素静电纺丝膜
CN114288476B (zh) * 2022-01-05 2022-08-12 奥精医疗科技股份有限公司 一种人工硬脑膜及其制备方法
CN114438782B (zh) * 2022-03-24 2023-05-02 新疆师范大学 一种快速抗菌/抗氧化活性的聚乳酸/单宁酸/铁/半胱氨酸骨诱导复合纤维膜的制备方法
CN114984311B (zh) * 2022-05-11 2023-05-26 上海市第六人民医院 一种压电导电复合支架及其制备方法
CN115804867B (zh) * 2022-12-29 2023-12-05 深圳市拉菲尔生物医药有限公司 纤维化iii型胶原蛋白纳米膜、制备方法及其在皮肤再生中的应用

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112251912A (zh) * 2020-10-19 2021-01-22 新疆大学 一种刺山柑载药纳米纤维膜及其制备方法和应用
CN114177342A (zh) * 2021-12-10 2022-03-15 四川大学华西医院 一种纳米纤维抗菌敷料及其制备方法
CN114177342B (zh) * 2021-12-10 2022-09-20 四川大学华西医院 一种纳米纤维抗菌敷料及其制备方法
CN114425102A (zh) * 2022-01-30 2022-05-03 上海松力生物技术有限公司 一种诱导皮肤组织再生的亲水性静电纺植入物
CN114452442A (zh) * 2022-01-30 2022-05-10 上海松力生物技术有限公司 一种原位诱导子宫壁组织再生的植入物
WO2023143336A1 (zh) * 2022-01-30 2023-08-03 上海松力生物技术有限公司 一种原位诱导子宫壁组织再生的植入物
WO2023143335A1 (zh) * 2022-01-30 2023-08-03 上海松力生物技术有限公司 一种诱导皮肤组织再生的亲水性静电纺植入物
WO2023143337A1 (zh) * 2022-01-30 2023-08-03 上海松力生物技术有限公司 一种肩袖补片及其制备方法
WO2023143334A1 (zh) * 2022-01-30 2023-08-03 上海松力生物技术有限公司 一种预防吻合口瘘的植入物
CN117462755A (zh) * 2023-11-24 2024-01-30 北京康派特医疗器械有限公司 生物修补材料及其制备方法和应用

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EP3072536A4 (en) 2017-08-23
WO2015074176A1 (zh) 2015-05-28
US10245353B2 (en) 2019-04-02
CN105705172B (zh) 2021-12-03
US20160279301A1 (en) 2016-09-29
EP3072536B1 (en) 2020-06-03
EP3072536A1 (en) 2016-09-28

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