CN105663193A - Rice washing water prepared pseudo-ginseng powder as well as preparation and preparation method thereof - Google Patents

Abstract

The invention provides rice washing water prepared pseudo-ginseng powder as well as a preparation and a preparation method thereof. The rice washing water prepared pseudo-ginseng powder is prepared from the following ingredients in parts by weight: 5-100 parts of pseudo-ginseng and 5-100 parts of rice washing water, preferably 20-100 parts of pseudo-ginseng and 5-80 parts of rice washing water, more preferably 30-70 parts of pseudo-ginseng and 40-80 parts of rice washing water, and most preferably 40-70 parts of pseudo-ginseng and 50-70 parts of rice washing water. The rice washing water prepared pseudo-ginseng powder can improve the side effects of thirst, constipation, weakness of limbs, fever and the like caused by taking pseudo-ginseng, and can increase the effects of strengthening the middle-jiao, strengthening the spleen, harmonizing the stomach and lubricating the intestines.

Description

A kind of rice-washed water Radix Notoginseng powder and preparation thereof and preparation method

Technical field

The present invention relates to technical field of Chinese medicines, particularly relate to a kind of rice-washed water Radix Notoginseng powder and preparation thereof and preparation method.

Background technology

Radix Notoginseng has another name called Radix Notoginseng, the dry root of panax araliaceae plant Panaxnotoginseng (Burk.) F.H.Chen and rhizome, and main product is in Yunnan Wenshan Prefecture, therefore named mountain of papers Radix Notoginseng. Chinese crude drug Radix Notoginseng is using its root as medicinal effects, has dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain.

Sweet in the mouth, micro-hardship, temperature. Effect, dissipating blood stasis stops blooding, subduing swelling and relieving pain. Cure mainly for spitting blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.

A large amount of medical researches prove, Radix Notoginseng can be used for treating the various inside and outside hemorrhages such as traumatic hemorrhage, blood stasis, gastrorrhagia, hematuria; Expansion blood vessel, thrombus, improves microcirculation, the cardiovascular and cerebrovascular disease such as prevention and treatment hyperlipidemia, cholesterol increase, coronary heart diseases and angina pectoris, apoplexy sequela; The hepatopathy such as fatty liver, hepatic fibrosis and lose blood, body deficiency syndrome that puerperal, the reason such as prolonged illness cause. Radix Notoginseng, to cardiovascular system, to body material's metabolism, nervous system, auxiliary are suppressed anticancer, the antioxidation whitening colour of skin, slow down aging and tonification many-sided pharmacological action such as strong, makes it prevent and treat multiple disease, health care aspect extensive use.

But owing to Radix Notoginseng is warm in nature, most people easily consume impairment of body fluid liquid taking Radix Notoginseng, cause the disease of the deficiency of YIN, the side effect such as thirsty, constipation, myasthenia of limbs, heating occur.

Summary of the invention

In order to solve the technical problem existed in prior art, the invention provides a kind of rice-washed water Radix Notoginseng powder and preparation thereof, both can improve take produce after Radix Notoginseng thirsty, constipation, myasthenia of limbs, the aspect side effect such as heating, effect of invigorating middle warmer, spleen invigorating, stomach function regulating, laxation can be increased again. The present invention is realized by following technical scheme:

First, the invention provides a kind of rice-washed water Radix Notoginseng powder, it is made up by ratio of weight and the number of copies of following component:

Radix Notoginseng 5～100, rice-washed water 5～100; Preferred Radix Notoginseng 20～100 parts, rice-washed water 5～80 parts; More preferably Radix Notoginseng 30～70 parts, rice-washed water 40～80 parts; Most preferably Radix Notoginseng 40～70 parts, rice-washed water 50～70 parts.

The rice-washed water Radix Notoginseng powder of the present invention is prepared by the method comprised the steps:

1) Radix Notoginseng is cleaned smashing for coarse powder;

2) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby;

3) the Radix Notoginseng coarse powder after smashing is put into step 2) temperature controls 5～25 DEG C of leaching systems 2～48 hours in the rice-washed water prepared, and period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb rice-washed water;

4) by the notoginseng drying after leaching system to water content less than 15%;

5) Radix Notoginseng step 4) dried is pulverized as impalpable powder and get final product.

Secondly, present invention also offers a kind of Chinese medicine preparation, it comprises above-mentioned rice-washed water Radix Notoginseng powder.

Further, the preparation method additionally providing rice-washed water Radix Notoginseng powder, comprise the steps:

1) Radix Notoginseng is cleaned smashing for coarse powder;

2) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby;

3) the Radix Notoginseng coarse powder after smashing is put into step 2) temperature controls 5～25 DEG C of leaching systems 2～48 hours in the rice-washed water prepared, and period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb rice-washed water;

4) by the notoginseng drying after leaching system to water content less than 15%;

5) Radix Notoginseng step 4) dried is pulverized as impalpable powder and get final product.

The pharmacological effect side of rice-washed water Radix Notoginseng powder of the present invention solves as follows:

Radix Notoginseng: nature and flavor hardship sweet, micro-, temperature, return through returning liver, stomach warp. There is dissipating blood stasis hemostasis, effect of subduing swelling and relieving pain. Cure mainly spitting of blood, spit blood, epistaxis, to have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling down swells and ache. Just it is acknowledged as since ancient times and there is significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, there is the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ". Cure mainly spitting of blood, spit blood, epistaxis, have blood in stool, metrorrhagia, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.

Rice-washed water: nature and flavor are sweet, cool, nontoxic. Can be used for concocting medicine, can go dry and in and laxation effect, function of spleen and stomach regulating, heat clearing away stops the effects such as excessive thirst, diuresis, removing heat from blood, removing toxic substances.

Present inventors have surprisingly found that, utilize the cool property of rice-washed water, go dry and in effect can reduce the dry property of warm of Radix Notoginseng, improve thirsty, constipation, etc. side effect. Therefore, the positive effect of the present invention is in that: the present invention is based on theory of Chinese medical science basis, utilizes said medicine compatibility, makes Radix Notoginseng and rice-washed water mutual restraint between two drugs, utilize the cool property of rice-washed water and go dry function to reduce the dry property of warm of Radix Notoginseng, improving the side effect such as thirsty, constipation, dysphoria with smothery sensation. And jointly prove effective, making Radix Notoginseng not raw heat not dryness-fire while dissipating blood stasis stops blooding, the bitterness mouthfeel simultaneously improving Radix Notoginseng makes people be easier to take.

Detailed description of the invention

Embodiments below and case application, be only for clearly demonstrating example of the present invention, and be not limitation of the invention. For those of ordinary skill in the field, other multi-form change or variations can also be made on the basis of the above description. And the apparent change thus amplified out or variation are still among protection scope of the present invention.

Embodiment 1:

The preparation method of rice-washed water Radix Notoginseng powder is as follows:

1, take 50g pseudo-ginseng, the removal of impurity, smash as coarse powder, through dry 1 hour of low temperature 30 DEG C, be dried to water content 20%;

2, choose 30g rice addition 300g clear water repeatedly to wash by rubbing with the hands, filter and obtain rice-washed water;

3, being placed in rice-washed water by the Radix Notoginseng raw material that step 1 is dry and stir soak system 8 hours constant temperature 25 DEG C, period stirred 1 time every 4 hours so that it is is evenly distributed, soaks into Radix Notoginseng and fully absorb rice-washed water;

4, step 3 is processed the Radix Notoginseng obtained and is placed in low-temperature vacuum drying case, dry 3 hours through low temperature 30 DEG C, be dried to water content 15%,

5, smash as impalpable powder and get final product.

Embodiment 2:

The preparation method of rice-washed water Radix Notoginseng powder is as follows:

1, take 300g pseudo-ginseng, the removal of impurity, smash as coarse powder, through dry 1 hour of low temperature 30 DEG C, be dried to water content 20%;

2, choose 150g rice to add 1000g clear water and repeatedly wash by rubbing with the hands, filter and rice-washed water;

3, being placed in rice-washed water by the Radix Notoginseng raw material that step 1 is dry and stir soak system 12 hours constant temperature 22 DEG C, period stirred 1 time every 4 hours so that it is is evenly distributed, soaks into Radix Notoginseng and fully absorb rice-washed water;

4, step 3 is processed the Radix Notoginseng obtained and be placed in low-temperature vacuum drying case, dry 5 hours through low temperature 23 DEG C, be dried to water content 13%;

5, smash as impalpable powder and get final product.

Embodiment 3:

The preparation method of rice-washed water Radix Notoginseng powder is as follows:

1, take 100g pseudo-ginseng, the removal of impurity, smash as coarse powder, through dry 1 hour of low temperature 28 DEG C, be dried to water content 20%;

2, choose 60g rice to add 700g clear water and repeatedly wash by rubbing with the hands, filter and rice-washed water;

3, being placed in rice-washed water by the Radix Notoginseng raw material that step 1 is dry and stir soak system 8 hours constant temperature 18 DEG C, period stirred 1 time every 4 hours so that it is is evenly distributed, soaks into Radix Notoginseng and fully absorb rice-washed water;

4, step 3 is processed the Radix Notoginseng obtained and be placed in low-temperature vacuum drying case, dry 2 hours through low temperature 25 DEG C, be dried to water content 14%;

5, smash as impalpable powder and get final product.

Test example 1: pharmacodynamics

Effectiveness for proving this invention has carried out pharmacological evaluation from pharmacodynamics aspect, is reported as follows:

1, test material

1-1 medicine: primary Radix Notoginseng powder and rice-washed water Radix Notoginseng powder, territory, north, Jilin Province Radix Panacis Quinquefolii studying company limited provides, lot number 20151201. Dosage setting is by people and animal body surface area equivalent dosage conversions, and people's daily maximum dose level (9g/60kg) is equivalent to mice 1.2g/kg. Therefore this test set the primary Radix Notoginseng powder of mice and rice-washed water Radix Notoginseng powder dosage be 0.6,1.2,2.4g/kg group, be all configured to desired concn with 0.5% sodium carboxymethyl cellulose during test.

1-2 animal ICR mice, body weight 18～22g, the quality certification number: SCXK(is lucky) 2015-0003, Jilin University Bethune medical college animal experimental center supply. Raise ground: Jilin University Bethune medical college animal experimental center.

2, test method

ICR mice 140,18～22g, male and female half and half. It is randomly divided into 7 groups, it may be assumed that matched group, primary Radix Notoginseng powder basic, normal, high dosage group and the basic, normal, high dosage group of rice-washed water Radix Notoginseng powder, often each 10 of male and female of group by sex, body weight. Gavage capacity is 20ml/kg, every day 1 time, continuous 30 days. In administration 30 days, respectively organize the equal lumbar injection pentobarbital sodium 50mg/kg of mice, the incubation period slept in recording 30 minutes and the length of one's sleep.

3, observation index

Each group all observes lower index for 10,20,30 days respectively in administration:

(1) 10 minutes interior autonomic activities situations of mice;

(2) mice symptom and sign: the expression of animal, activity (grabbing nose, pruritus etc.) situation;

(3) the mice amount of drinking water of 24 hours, urine volume and color, feces shape etc. change.

4, result of the test

Within 10,20,30 days, mice autonomic activities is observed respectively in administration, compare with matched group, the middle and high dosage group of primary Radix Notoginseng powder all can substantially increase mice autonomic activities number of times (p<0.05), and the basic, normal, high dosage group of rice-washed water Radix Notoginseng powder has no notable difference (p>0.05), in Table 1.

Within 10,20,30 days, mice amount of drinking water and urine volume situation of change is observed respectively in administration, compare with matched group, the middle and high dosage group of primary Radix Notoginseng powder all can substantially increase mice amount of drinking water and urine volume (p<0.05) for 20,30 days in administration, the basic, normal, high dosage group of rice-washed water Radix Notoginseng powder has no notable difference (p>0.05), in Table 2.

Within 10,20,30 days, mice urine volume color, feces shape, the expression of animal, activity (grabbing nose, pruritus etc.) situation is observed respectively in administration, compare with matched group, the visible mice expression of primary Radix Notoginseng powder middle and high dosage group is irritated, movable increase, hydrouria, darken, feces gets rid of minimizing, shape is hard, and the basic, normal, high dosage group of rice-washed water Radix Notoginseng powder has no notable difference, in Table 3.

Compare with matched group, * p < 0.05

Compare with matched group, * p < 0.05.

Compare with matched group, * p < 0.05

5, conclusion (of pressure testing)

Primary Radix Notoginseng powder can substantially increase mice autonomic activities number of times, substantially increase mice amount of drinking water and urine volume, mice expression can be made irritated, movable increase, hydrouria, darken, feces gets rid of minimizing, shape is hard, points out primary Radix Notoginseng powder continuous oral 1 month, and animal can be made thirsty, dysphoria with smothery sensation, constipation side effect occur. Continuous oral of the present invention 1 month, has no obvious animal and thirsty, dysphoria with smothery sensation, constipation side effect occurs.

Test example 2: typical case

1, certain man, 57 years old, tcm diagnosis: the thoracic obstruction, tongue with ecchymosis, angina pectoris.

Treatment: take primary Radix Notoginseng powder after 1 week symptom be obviously improved, but dysphoria with smothery sensation, thirsty, constipation symptom occur. The rice-washed water Radix Notoginseng powder of the rear use embodiment of the present invention 1 preparation, often takes 3 grams, every day 3 times.

Effect: improve the symptom of dysphoria with smothery sensation, thirsty, constipation after using present invention Radix Notoginseng powder instead, more any side effect does not occur yet after taking 21 days continuously, Angina rate significantly reduces.

2, certain female, 49 years old, diagnosis: shank traumatic injury, bone splits with subcutaneous hemorrhage.

Treatment: grind with Radix Notoginseng powder and take, compatibility Rhizoma Corydalis, Flos Carthami, Semen Armeniacae Amarum. Taking 2 doses, rear blood stasis substantially disappears, pain relief, but occurs in that thirsty, constipation side effect that Radix Notoginseng causes.

Effect: primary Radix Notoginseng powder is used instead the rice-washed water Radix Notoginseng powder of 2 preparations subsequently in the embodiment of the present invention, and thirsty after 2 doses, constipation symptom disappears. Take check recovery from illness in March continuously.

3, certain man, diagnosis in 16 years old: often epistaxis.

Treatment: individually taking Radix Notoginseng powder, every day 3 times, each 3g, after taking 2 weeks continuously, serious constipation occur, simultaneously with thirsty, dysphoria with smothery sensation side reaction increases the weight of particularly evening.

Effect: after by primary Radix Notoginseng powder this with the rice-washed water Radix Notoginseng powder in embodiment of the present invention 3, constipation, dysphoria with smothery sensation, thirsty side reaction disappear, and do not occur any side effect yet, and nose is not hemorrhage after taking 21 days continuously, fully recover.

Claims (4)

1. a rice-washed water Radix Notoginseng powder, it is characterised in that be made up by ratio of weight and the number of copies of following component:

Radix Notoginseng 5～100 parts, rice-washed water 5～100 parts; Preferred Radix Notoginseng 20～100 parts, rice-washed water 5～80 parts; More preferably Radix Notoginseng 30～70 parts, rice-washed water 40～80 parts; Most preferably Radix Notoginseng 40～70 parts, rice-washed water 50～70 parts.

2. rice-washed water Radix Notoginseng powder as claimed in claim 1, it is characterised in that prepared by the method comprised the steps:

1) Radix Notoginseng is cleaned smashing for coarse powder;

2) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby;

3) the Radix Notoginseng coarse powder after smashing is put into step 2) temperature controls 5～25 DEG C of leaching systems 2～48 hours in the rice-washed water prepared, and period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb rice-washed water;

4) by the notoginseng drying after leaching system to water content less than 15%;

5) Radix Notoginseng step 4) dried is pulverized as impalpable powder and get final product.

3. a Chinese medicine preparation, it is characterised in that comprise rice-washed water Radix Notoginseng powder as claimed in claim 1 or 2.

4. the preparation method of rice-washed water Radix Notoginseng powder as claimed in claim 1, comprises the steps:

1) Radix Notoginseng is cleaned smashing for coarse powder;

2) choose rice clear water and eluriate that to obtain the rice-washed water of white opacity standby;

3) the Radix Notoginseng coarse powder after smashing is put into step 2) temperature controls 5～25 DEG C of leaching systems 2～48 hours in the rice-washed water prepared, and period stirred 1 time every 6 hours so that it is is evenly distributed, soaks into Radix Notoginseng granule and fully absorb rice-washed water;

4) by the notoginseng drying after leaching system to water content less than 15%;

5) Radix Notoginseng step 4) dried is pulverized as impalpable powder and get final product.