CN108853253A - A kind of Chinese medicine composition of invigorating kidney, promoting blood circulation and its preparation method and application - Google Patents
A kind of Chinese medicine composition of invigorating kidney, promoting blood circulation and its preparation method and application Download PDFInfo
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Abstract
The invention discloses Chinese medicine compositions of a kind of invigorating kidney, promoting blood circulation and its preparation method and application, belong to the technical field of Chinese medicine composition, and the composition is easy to use, and safely, effectively, side effect is smaller.Composition by Rehmannia glutinosa, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata, Radix Notoginseng and the fruit of Cherokee rose through over cleaning, decoction, extraction, concentration and etc. be made.Chinese medicine composition of the invention has kidney-supplementing liver-boosting, promoting qi circulation and removing obstruction in the collateral using several kinds of Chinese medicinal materials, relaxing tendons and activating collaterals, expelling wind and clearing away cold, blood-nourishing and blood, the effect of strengthening muscles and bones, it is reasonable to be formulated selected drug matching, to mend, dredge, lead to as big method, mutually there is synergistic effect, can heighten the effect of a treatment.Preparation method of the invention, technique is fine, and effective component extraction rate is high, and step is simple to operation, it avoids using organic solvent, it is safe and non-toxic, it is whole quality controllable, meet GMP requirement, the Chinese medicine composition being prepared can be used for the treatment medication of patient with cervical Spondylopathy caused by kidney deficiency blood stasis.
Description
Technical field
The present invention relates to the technical field of Chinese medicine composition more particularly to the Chinese medicine compositions and its system of a kind of invigorating kidney, promoting blood circulation
Preparation Method and application.
Background technique
Cervical spondylosis, cervical spondylosis are also known as cervical spine syndrome, are osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical nerve root synthesis
Sign, the general name of Cervical disc extrusion are a kind of illness that basis is changed into degeneration pathology.Mainly due to the long-term labor of cervical vertebra
Damage, osteoproliferation or Disc herniation, ligament thicken, and cervical vertebra spinal cord, nerve root or vertebral artery is caused to be pressurized, and occur a series of
The clinical syndrome of dysfunction.It shows as vertebra section unstability, loosen；Nucleus pulposus or abjection；Spur is formed；Ligament it is plump and after
The spinal canal stenosis etc. of hair stimulates or has oppressed the tissue such as neighbouring nerve root, spinal cord, vertebral artery and neck sympathetic nerve, causes
A series of symptoms and signs.
The clinical symptoms of cervical spondylosis are complex.Mainly have nape pain, upper myasthenia of limbs, finger is numb, lower limb are out of strength, row
Walk difficult, dizzy, Nausea and vomiting or even blurred vision, tachycardia and dysphagia etc..The clinical symptoms and disease of cervical spondylosis
Becoming position, tissue involved and individual difference has certain relationship.Cervical spondylosis caused by kidney deficiency blood stasis, common sympton have neck to swollen
Numb, movable unfavorable, dizziness and tinnitus of pain etc..Serious person can also cause vision disorder, hypertension cervical spondylosis, lower limb paralysis etc. simultaneously
Send out disease.Current treatment method mainly uses physiotherapy and anodyne, anti-inflammatory drug to alleviate, palliative, and the interpretation of the cause, onset and process of an illness is liver
Gradually void, insufficiency of vital energy and blood, Ying Wei's spleen kidney become estranged, the blood stasis of blood is stagnant, muscles and bones dystrophy, the injury of the tissues of being overworked for a very long period in addition, or the damp evil that is affected by the cold, and cause
Wind, phlegm, the stasis of blood are mutually tied, and the train of thought stasis of blood is stagnant, disorder of meridian-QI and become raw all diseases, kidney deficiency and liver is this, and the wind phlegm stasis of blood is mark.Chinese medicine is being treated
Effect in terms of cervical spondylosis is very significant, and Chinese medicine is globality to the treatment of cervical spondylosis, and doctor trained in Western medicine operation etc. is just for disease
Become position to be treated.Chinese medicine acts on each pathology level of cervical spondylosis by including specific drugs ingredient, whole to improve neck
The various pathological changes of vertebra disease come achieve the purpose that treat cervical spondylosis, and Chinese medicine treatment cervical spondylosis without doctor trained in Western medicine operation etc. exist damage
Wound, is used conveniently and safely, clinical efficacy is significant, and side effect is smaller.
Summary of the invention
The object of the present invention is to provide Chinese medicine composition of a kind of safe and effective invigorating kidney, promoting blood circulation and preparation method thereof and answer
With improving the pathological change of cervical spondylosis integrally by invigorating kidney, promoting blood circulation to achieve the purpose that treat cervical spondylosis, peace easy to use
Entirely, clinical efficacy is significant, and side effect is smaller.
To achieve the goals above, the present invention provides the following technical solutions：
A kind of Chinese medicine composition of invigorating kidney, promoting blood circulation, it is made of the raw material of following parts by weight：26~30 parts of Rehmannia glutinosa, what
36~40 parts of the tuber of multiflower knotweed, 16~20 parts of oyster, 16~20 parts of pyrola, 16~20 parts of the rhizome of davallia, 11~15 parts of Caulis Spatholobi, pueraria lobata 11
~15 parts, 6~10 parts of Radix Notoginseng and 11~15 parts of the fruit of Cherokee rose.
Further, the Chinese medicine composition of the invigorating kidney, promoting blood circulation, it is made of the raw material of following parts by weight：Rehmannia glutinosa
28 parts, 38 parts of the fleece-flower root, 18 parts of oyster, 17 parts of pyrola, 17 parts of the rhizome of davallia, 12 parts of Caulis Spatholobi, 13 parts of pueraria lobata, 8 parts of Radix Notoginseng and
13 parts of the fruit of Cherokee rose.
Further, the Chinese medicine composition of the invigorating kidney, promoting blood circulation, it is made of following steps：
(1) respectively by the non-of glutinous rehmannia, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata, Radix Notoginseng and the fruit of Cherokee rose
Medicinal effects remove, and cutting is spare after cleaning；
(2) fruit of Cherokee rose after cleaning, the rhizome of davallia and glutinous rehmannia is taken to be processed respectively；
(3) take Rehmannia glutinosa, the fleece-flower root, pueraria lobata, Radix Notoginseng and pyrola dry at 60~80 DEG C respectively；
(4) Radix Notoginseng powder for taking 1/2 parts by weight, at pressure 0.1MPa-0.2MPa, 115 DEG C of temperature, sterilization time 15 divides
Clock；60-80 DEG C heating, drying 20-30 minutes, cool after sterilizing；It is ground into fine powder again, sieves with 100 mesh sieve；
(5) by the Rehmannia glutinosa of the parts by weight, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata and Jin Ying
The Radix Notoginseng of son and 1/2 parts by weight is put into extraction tank, and decocts 2~3 times, and every time plus 4-6 times of water is measured, and decocts 1-3 every time
Hour, collecting decoction, filtration；Steam pressure 0.1-0.2Mpa, -90 DEG C of temperature 70 C are set, vacuum degree 0.04-0.08Mpa will
Filtrate is concentrated into the thick paste that relative density is 1.30~1.35, the density that the relative density is 60 DEG C；
(6) thick paste of the Radix Notoginseng powder of step (4) and step (5) is uniformly mixed, is dried at 60-80 DEG C of temperature,
100 mesh fine powders are ground into, the Chinese medicine composition of invigorating kidney, promoting blood circulation is obtained.
Further, the Chinese medicine composition of the invigorating kidney, promoting blood circulation is prepared into pharmaceutically acceptable dosage form.
Further, the dosage form is capsule.
Further, the preparation method of the Chinese medicine composition of the invigorating kidney, promoting blood circulation, includes the following steps：
(1) respectively by the non-of glutinous rehmannia, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata, Radix Notoginseng and the fruit of Cherokee rose
Medicinal effects remove, and cutting is spare after cleaning；
(2) fruit of Cherokee rose after cleaning, the rhizome of davallia and glutinous rehmannia is taken to be processed respectively；
(3) take Rehmannia glutinosa, the fleece-flower root, pueraria lobata, Radix Notoginseng and pyrola dry at 60~80 DEG C respectively；
(4) Radix Notoginseng powder for taking 1/2 parts by weight, at pressure 0.1MPa-0.2MPa, 115 DEG C of temperature, sterilization time 15 divides
Clock；60-80 DEG C heating, drying 20-30 minutes, cool after sterilizing；It is ground into fine powder again, sieves with 100 mesh sieve；
(5) by the Rehmannia glutinosa of the parts by weight, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata and Jin Ying
The Radix Notoginseng of son and 1/2 parts by weight is put into extraction tank, and decocts 2~3 times, and every time plus 5-7 times of water is measured, and decocts 1-3 every time
Hour, collecting decoction, filtration；Steam pressure 0.1-0.2Mpa, -90 DEG C of temperature 70 C are set, vacuum degree 0.04-0.08Mpa will
Filtrate is concentrated into the thick paste that relative density is 1.30~1.35, the density that the relative density is 60 DEG C；
(6) thick paste of the Radix Notoginseng powder of step (4) and step (5) is uniformly mixed, is dried at 60-80 DEG C of temperature,
100 mesh fine powders are ground into, the Chinese medicine composition of invigorating kidney, promoting blood circulation is obtained.
Further, the preparation method of the Chinese medicine composition of the invigorating kidney, promoting blood circulation, includes the following steps：
(1) respectively by the non-of glutinous rehmannia, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata, Radix Notoginseng and the fruit of Cherokee rose
Medicinal effects remove, and cutting is spare after cleaning；
(2) fruit of Cherokee rose after cleaning, the rhizome of davallia and glutinous rehmannia is taken to be processed respectively；
(3) take Rehmannia glutinosa, the fleece-flower root, pueraria lobata, Radix Notoginseng and pyrola dry at 70 DEG C respectively；
(4) Radix Notoginseng powder for taking 1/2 parts by weight, at pressure 0.1MPa, 115 DEG C of temperature, sterilization time 15 minutes；After sterilizing
70 DEG C heating, drying 25 minutes, cool；It is ground into fine powder again, sieves with 100 mesh sieve；
(5) by the Rehmannia glutinosa of the parts by weight, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata and Jin Ying
The Radix Notoginseng of son and 1/2 parts by weight is put into extraction tank, and decocts 2 times, and for the first time plus 7 times of water are measured, decoction 3 hours, and first
Secondary plus 5 times of water amounts, decoct 1.5 hours, collecting decoction, filtration；Set steam pressure 0.2Mpa, 80 DEG C of temperature, vacuum degree
0.06Mpa concentrates the filtrate to the thick paste that relative density is 1.32, the density that the relative density is 60 DEG C；
(6) thick paste of the Radix Notoginseng powder of step (4) and step (5) is uniformly mixed, is dried at 60-80 DEG C of temperature,
100 mesh fine powders are ground into, the Chinese medicine composition of invigorating kidney, promoting blood circulation is obtained.
Further, the Chinese medicine composition of the invigorating kidney, promoting blood circulation is preparing the application in removing blood stasis and hemostasis drug, using side
Method is that the Chinese medicine composition of the removing blood stasis and hemostasis is made to granule or capsule, and granule takes orally twice, every time daily
The Chinese medicine composition of 1.2g invigorating kidney, promoting blood circulation；Capsule takes orally twice daily, 3 tablets each time, every capsule invigorating kidney, promoting blood circulation containing 0.4g
Chinese medicine composition.In addition, the Chinese medicine composition of invigorating kidney, promoting blood circulation also can be applicable to dosage form described in any pharmacy, such as ball
Agent, powder, tablet, capsule, granule, syrup, oral solution etc..
Compared with prior art, beneficial effects of the present invention are：
The Chinese medicine composition of invigorating kidney, promoting blood circulation of the invention has kidney-supplementing liver-boosting using several kinds of Chinese medicinal materials, and promoting qi circulation and removing obstruction in the collateral relaxes
Muscle promoting blood circulation, expelling wind and clearing away cold, blood-nourishing and blood, the effect of strengthening muscles and bones, it is big to mend, dredge, lead to that the selected drug matching of formula is reasonable
Method mutually has synergistic effect, can heighten the effect of a treatment.Prove that there is safety and validity, can be used for kidney by zoopery
The treatment medication of patient with cervical Spondylopathy caused by empty blood stasis.
The preparation method of the Chinese medicine composition of invigorating kidney, promoting blood circulation of the invention, technique is fine, and effective component extraction rate is high, step
It is simple to operation, it avoids using organic solvent, it is safe and non-toxic, it is whole quality controllable, meet GMP requirement, the kidney tonifying being prepared
The Chinese medicine composition of promoting blood circulation can be used for the treatment medication of patient with cervical Spondylopathy caused by kidney deficiency blood stasis.
Specific embodiment
The present invention provides a kind of Chinese medicine compositions of invigorating kidney, promoting blood circulation, it is made of the raw material of following parts by weight：Radix rehmanniae preparata
Yellow 26~30 parts, 36~40 parts of the fleece-flower root, 16~20 parts of oyster, 16~20 parts of pyrola, 16~20 parts of the rhizome of davallia, Caulis Spatholobi 11
~15 parts, 11~15 parts of pueraria lobata, 6~10 parts of Radix Notoginseng and 11~15 parts of the fruit of Cherokee rose.
And the preparation method of the Chinese medicine composition of above-mentioned invigorating kidney, promoting blood circulation, include the following steps：
(1) respectively by the non-of glutinous rehmannia, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata, Radix Notoginseng and the fruit of Cherokee rose
Medicinal effects remove, and cutting is spare after cleaning；
(2) fruit of Cherokee rose after cleaning, the rhizome of davallia and glutinous rehmannia is taken to be processed respectively；
(3) take Rehmannia glutinosa, the fleece-flower root, pueraria lobata, Radix Notoginseng and pyrola dry at 60~80 DEG C respectively；
(4) Radix Notoginseng powder for taking 1/2 parts by weight, at pressure 0.1MPa-0.2MPa, 115 DEG C of temperature, sterilization time 15 divides
Clock；60-80 DEG C heating, drying 20-30 minutes, cool after sterilizing；It is ground into fine powder again, sieves with 100 mesh sieve；
(5) by the Rehmannia glutinosa of the parts by weight, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata and Jin Ying
The Radix Notoginseng of son and 1/2 parts by weight is put into extraction tank, and decocts 2~3 times, and every time plus 5-7 times of water is measured, and decocts 1-3 every time
Hour, collecting decoction, filtration；Steam pressure 0.1-0.2Mpa, -90 DEG C of temperature 70 C are set, vacuum degree 0.04-0.08Mpa will
Filtrate is concentrated into the thick paste that relative density is 1.30~1.35, the density that the relative density is 60 DEG C；
(6) thick paste of the Radix Notoginseng powder of step (4) and step (5) is uniformly mixed, is dried at 60-80 DEG C of temperature,
100 mesh fine powders are ground into, the Chinese medicine composition of invigorating kidney, promoting blood circulation is obtained.
The raw material pharmacological action used in the present invention is as follows：
Rehmannia glutinosa：
【Nature and flavor and channel tropism】It is sweet, tepor.Return liver and kidney channel.
【Function with cure mainly】It enriches blood enriching yin, beneficial to spirit and marrow.For blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, under metrorrhagia and metrostaxis
Blood, the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat spermatorrhea, Heat Diabetes, dizziness, tinnitus, poliosis.
The fleece-flower root：
【Nature and flavor and channel tropism】It is bitter, sweet, puckery, tepor.Return liver, the heart, kidney channel.
【Function with cure mainly】Removing toxic substances, disappear carbuncle, preventing malaria, relax bowel and defecation.For sore carbuncle, scrofula, rubella itch, chronic malaria body void,
Dry constipation of intestines.
Oyster：
【Nature and flavor and channel tropism】It is salty, it is slightly cold.Return liver, gallbladder, kidney channel.
【Function with cure mainly】It is transquilization with heavy material, checking exuberance of yang and tonifying yin, resolving hard lump.For insomnia of palpitating with fear, dizziness and tinnitus, scrofula addiction phlegm
He , abdominal mass and lump.Calcined oyster shell astringency inducing, hyperacidity and pain relief.For spontaneous sweating, emission and spermatorrhea, metrorrhagia and metrostaxis leukorrhagia, acid regurgitation of having a stomachache.
Pyrola：
【Nature and flavor and channel tropism】It is sweet, bitter, temperature.Return liver and kidney channel.
【Function with cure mainly】Wind-damp dispelling, strengthening the bones and muscles, hemostasis, cough-relieving.For rheumatic arthralgia, lumbago due to the kidney deficiency, waist-leg weakness, the moon
Through excessive, chronic cough due to asthenia of viscera.
The rhizome of davallia (boiling hot)：
【Nature and flavor and channel tropism】Hardship, temperature.Return liver and kidney channel.
【Function with cure mainly】It cures the wound analgesic, The strong bone of kidney tonifying；External application disappears wind nti-freckle.For falling winks frustrates, injured bone, kidney deficiency
Pain in the loins, muscles and bones impotence, Hiccough and deaf, tooth mobility；Control outward alopecia areata, leucoderma.
Caulis Spatholobi：
【Nature and flavor and channel tropism】Bitter, sweet, warm.Return liver and kidney channel.
【Function with cure mainly】Blood circulation promoting and enriching, menstruction regulating and pain relieving, relaxing tendons and activating collaterals.For irregular menstruation, dysmenorrhea, menostasis, rheumatism numbness
Bitterly, paralysis and numbness, blood deficiency chlorosis.
Pueraria lobata：
【Nature and flavor and channel tropism】It is sweet, pungent, it is cool.Returns spleen, stomach, lung channel.
【Function with cure mainly】Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid to quench thirst, promoting eruption, Shengyang Zhixie, clearing and activating the channels and collaterals, relieving alcoholism.For exogenous disease
Fever and headache, stiff nape and back is thirsty, quenches one's thirst, measles without adequate eruption, hot dysentery, diarrhea, dizziness and headache, hemiplegia, chest impediment and cardialgia, wine
In poison wound.
Radix Notoginseng：
【Nature and flavor and channel tropism】Sweet, slight bitter, temperature.Return liver, stomach meridian.
【Function with cure mainly】Dissipating stasis and stanching bleeding, detumescence ding-tong.For spitting blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage,
Chest and abdomen shouting pain, tumbling and swelling.
The fruit of Cherokee rose
【Nature and flavor and channel tropism】It is sour, sweet, puckery, it puts down.Return kidney, bladder, large intestine channel.
【Function with cure mainly】Astringent sperm contracting urine, curing metrorrhagia and leukorrhagia, relieving diarrhea with astringents.For emission and spermatorrhea, enuresis frequent micturition, metrorrhagia and metrostaxis band
Under, protracted dysentery and diarrhea.
In order to make those skilled in the art more fully understand technical solution of the present invention, below in conjunction with embodiment to this
Invention is further detailed.
It is prepared by the Chinese medicine composition of 1 invigorating kidney, promoting blood circulation of embodiment
(1) it cleans
Glutinous rehmannia is placed on station, glutinous rehmannia medicinal part is dried root, removes impurity, foreign matter, dis-medicinal part；
The fleece-flower root is placed on station, fleece-flower root medicinal part is dried root, and it is non-to remove silt, foreign matter, fibrous root etc.
Medicinal part；
Oyster is placed on station, oyster medicinal part is dry bark, removes impurity, foreign matter, dis-medicinal part；
Pyrola is placed on station, pyrola medicinal part is dry herb, removes impurity, foreign matter, non-medicinal portion
Position；
The rhizome of davallia is placed on station, rhizome of davallia medicinal part is dry tuber, and it is non-to remove impurity, foreign matter, fine hair etc.
Medicinal part；
Caulis Spatholobi is placed on station, Caulis Spatholobi medicinal part is dry buckle stem branch, removes impurity, foreign matter, leaf etc.
Dis-medicinal part；
Pueraria lobata is placed on station, pueraria lobata medicinal part is dry root, removes the non-medicinal portions such as silt, foreign matter, fibrous root
Position；
Radix Notoginseng is placed on station, Radix Notoginseng medicinal part is dry root and rhizome, removes impurity, foreign matter etc.；
The fruit of Cherokee rose is placed on station, fruit of Cherokee rose medicinal part is dry mature seed, removes impurity, foreign matter etc..
(2) it cleans
The fleece-flower root after cleaning, oyster, pueraria lobata, Radix Notoginseng and glutinous rehmannia are respectively placed in tumbling-box type medicine-washing machine, drunk with flowing
It is cleaned with water, is washed till wash clarification of water, hydraulic pressure 0.3MPa, medicine-washing machine revolving speed 12r/min；Pyrola after cleaning is put into
It is eluted in wash pond with the drinking water of flowing, is washed till wash clarification of water.
(3) cutting
The fleece-flower root, oyster, pueraria lobata and Radix Notoginseng are respectively placed in progress cutting crushing in medicine cutter, are ground into 2-4mm size；
Pyrola is placed in medicine cutter and carries out cutting, cuts into 10-15mm sections.
(4) it processes
The fruit of Cherokee rose after cleaning is taken to set in cylinder type medicine roasting machine, with being fried with slow fire micro- heave to get surface is micro- to heave, color
Pool is deepened, and matter is crisp, gas micro-perfume；
Clean river sand is taken to set in cylinder type medicine roasting machine, when being heated to sliding sharp state with high heat, the investment rhizome of davallia is fried to drum
It rises, hits unhairing, shaped like the rhizome of davallia or piece, body expands to be heaved this product, light, crisp；
It takes glutinous rehmannia that clear water is added to moisturize, sets in medicine processing device, steam to black profit, take out, slice is dry to get Rehmannia glutinosa.
(5) dry
Rehmannia glutinosa, the fleece-flower root, pueraria lobata, Radix Notoginseng and pyrola are respectively placed in heated-air circulation oven and are dried, it is dry
Temperature 60 C.
(6) sterilizing crushes
It takes 3 parts by weight Radix Notoginseng to be put into the sterilizing of Chinese herbal medicine sterilizing cabinet, controls pressure：Pressure is 0.1MPa, sterilising temp：115
DEG C, sterilization time 15 minutes；60 DEG C of heating, drying materials of interlayer are used after sterilizing, drying time 30 minutes, are cooled；Pulverizer is used again
Group is ground into fine powder, sieves with 100 mesh sieve, and crushes yield >=94%.
(7) concentration is extracted
By 26 parts by weight Rehmannia glutinosas, the 36 parts by weight fleece-flowers root, 20 parts by weight oysters, 16 parts by weight pyrolas, 20 parts by weight
The rhizome of davallia, 11 parts by weight Caulis Spatholobis, 15 parts by weight pueraria lobatas, 3 parts by weight Radix Notoginseng and the 11 parts by weight fruits of Cherokee rose put into multi-functional extraction
It in tank, decocts 2 times, for the first time plus 7 times of water amounts, decoction 3 hours, second plus 6 times of water amounts are decocted 2 hours, collecting decoction, filtered
It crosses；It is placed in single-effect vacuum evaporator to be concentrated, sets steam pressure 0.1Mpa, 90 DEG C of temperature, vacuum degree 0.04Mpa, filtrate
It is concentrated into the thick paste that relative density is 1.30 (60 DEG C).
(8) cream powder combination drying
The thick paste of the Radix Notoginseng powder and step (7) that take step (6) is set in trough type mixing machine and is uniformly mixed, and vacuum drying is placed into
In baking oven, temperature 60 C is dried.
(9) it crushes
Dry cream after drying is set and is crushed in unit, 100 mesh fine powders is ground into, obtains the Chinese medicine composition of invigorating kidney, promoting blood circulation.
It is prepared by the Chinese medicine composition of 2 invigorating kidney, promoting blood circulation of embodiment
Step (1)~(4) with embodiment 1, other steps the difference is that,
The drying temperature of step (5) is 70 DEG C.
(6) sterilizing crushes
It takes 4 parts by weight Radix Notoginseng to be put into the sterilizing of Chinese herbal medicine sterilizing cabinet, controls pressure：Pressure is 0.1MPa, sterilising temp：115
DEG C, sterilization time 15 minutes；70 DEG C of heating, drying materials of interlayer are used after sterilizing, drying time 25 minutes, are cooled；Pulverizer is used again
Group is ground into fine powder, sieves with 100 mesh sieve, and crushes yield >=94%.
(7) concentration is extracted
By 28 parts by weight Rehmannia glutinosas, the 38 parts by weight fleece-flowers root, 18 parts by weight oysters, 17 parts by weight pyrolas, 17 parts by weight
The rhizome of davallia, 12 parts by weight Caulis Spatholobis, 13 parts by weight pueraria lobatas, 4 parts by weight Radix Notoginseng and the 13 parts by weight fruits of Cherokee rose put into multi-functional extraction
In tank, decoct 2 times, for the first time plus 7 times of water amounts, decoction 3 hours, second plus 5 times of water amounts decoct 1.5 hours, collecting decoction,
Filtration；It is placed in single-effect vacuum evaporator to be concentrated, sets steam pressure 0.2Mpa, 80 DEG C of temperature, vacuum degree 0.06Mpa, filter
Liquid is concentrated into the thick paste that relative density is 1.32 (60 DEG C).
(8) cream powder combination drying
The thick paste of the Radix Notoginseng powder and step (7) that take step (6) is set in trough type mixing machine and is uniformly mixed, and vacuum drying is placed into
In baking oven, temperature 70 C is dried.
(9) it crushes
Dry cream after drying is set and is crushed in unit, 100 mesh fine powders is ground into, obtains the Chinese medicine composition of invigorating kidney, promoting blood circulation.
It is prepared by the Chinese medicine composition of 3 invigorating kidney, promoting blood circulation of embodiment
Step (1)~(4) with embodiment 1, other steps the difference is that,
The drying temperature of step (5) is 80 DEG C.
(6) sterilizing crushes
It takes 5 parts by weight Radix Notoginseng to be put into the sterilizing of Chinese herbal medicine sterilizing cabinet, controls pressure：Pressure is 0.2MPa, sterilising temp：115
DEG C, sterilization time 15 minutes；80 DEG C of heating, drying materials of interlayer are used after sterilizing, drying time 20 minutes, are cooled；Pulverizer is used again
Group is ground into fine powder, sieves with 100 mesh sieve, and crushes yield >=94%.
(7) concentration is extracted
By 30 parts by weight Rehmannia glutinosas, the 40 parts by weight fleece-flowers root, 16 parts by weight oysters, 20 parts by weight pyrolas, 16 parts by weight
The rhizome of davallia, 15 parts by weight Caulis Spatholobis, 11 parts by weight pueraria lobatas, 5 parts by weight Radix Notoginseng and the 15 parts by weight fruits of Cherokee rose put into multi-functional extraction
It in tank, decocts 3 times, for the first time plus 7 times of water amounts, decoction 2 hours, second plus 6 times of water amounts decoct 1.5 hours, first time plus water
5 times of amounts, decoct 1 hour, collecting decoction, filtration；Single-effect vacuum evaporator is placed in be concentrated, setting steam pressure 0.2Mpa,
Temperature 70 C, vacuum degree 0.08Mpa, filtrate are concentrated into the thick paste that relative density is 1.35 (60 DEG C).
(8) cream powder combination drying
The thick paste of the Radix Notoginseng powder and step (7) that take step (6) is set in trough type mixing machine and is uniformly mixed, and vacuum drying is placed into
In baking oven, 80 DEG C of temperature are dried.
(9) it crushes
Dry cream after drying is set and is crushed in unit, 100 mesh fine powders is ground into, obtains the Chinese medicine composition of invigorating kidney, promoting blood circulation.
The granule preparation of the Chinese medicine composition of 4 invigorating kidney, promoting blood circulation of embodiment
The 1/10 of starch dosage is taken, sets and rushes in paddle tank plus purified water is boiled, starch slurry, starch is made：Water ratio (1:15)；
Take starch, embodiment 2 invigorating kidney, promoting blood circulation Chinese medicine composition elder generation postposition spray-drying pelleting machine hopper in, mixing be heated up to material
Temperature 70 C, spray into starch slurry, start to pelletize, 75 DEG C of inlet air temperature, 70 DEG C of temperature of charge or so, spouting velocity 0.6m/s it
Between, it is pumped 2MPa, fan speed 40 watches temperature of charge, granularity in hopper at any time, surveys particle aqueous 3.5%, stop heating,
It puts into oscillating granulator, crosses 18 meshes and carry out whole grain, obtain the granule of the Chinese medicine composition of invigorating kidney, promoting blood circulation.
The capsule preparation of the Chinese medicine composition of 5 invigorating kidney, promoting blood circulation of embodiment
Granule is made in embodiment 4 to be filled with fully-automatic capsule filling machine, 800-1000/minute of filling speed, often
Grain dress particle 0.4g, content uniformity control in ± 7.5% range of 0.4g, obtain the capsule of the Chinese medicine composition of invigorating kidney, promoting blood circulation
Agent.
1 safety testing of experimental example
Test method：The healthy kunming mice for taking 18~20g of weight is divided into 4 groups, and every group 5, half male and half female is right respectively
The mouse of group 1~3 takes the Chinese medicinal composition granules of the removing blood stasis and hemostasis of the preparation of embodiment 4, and group 4 is blank control.Group 1~3
At 24 hours medicine for oral administration 3 times, each 120g/kg, 30 times of people's dosage are equivalent to, observe mouse survival situation.
Test result：The present invention is all survived through acute toxicity test, mouse, it was demonstrated that its good security.
2 safety testing of experimental example
Test method：The healthy white rat for taking 200~240g of weight is divided into 4 groups, and every group 10, half male and half female is right respectively
The mouse of group 1~3 takes the Chinese medicinal composition granules of the removing blood stasis and hemostasis of the preparation of embodiment 4, and group 4 is blank control.Group 1~3
Successive administration 6 months, 1 daily administration 80g/kg is organized, organizes 2 daily administration 40g/kg, organizes 3 daily administration 20g/kg, observes mouse
Survival.
Test result：The present invention is through long term toxicity test, large dosage of 80g/kg (20 times that are equivalent to people's dosage)；Middle dosage
40g/kg (be equivalent to people with dosage 10 times)；Low dose of 20g/kg (5 times that are equivalent to people's dosage) successive administration 6 months, greatly
There was no significant difference compared with the control group for part index number；Histopathological examination result has no significantly related with test medicine
Pathological change.
3 efficiency assay of experimental example
Test method：Accepting tcm diagnosis for medical treatment is average age 48 years old patient with cervical Spondylopathy 32 caused by kidney deficiency blood stasis, male
21, women 11, clinical symptoms are neck to distending pain numbness, neck limitation of activity, accessible strip scleroma, dizziness and tinnitus.
The capsule of 32 patient's embodiments 5 preparation is given, it is 2 times oral daily, 3 tablets each time, successive administration 45 days, observe clinical symptoms
Eliminate situation.
Index of assessment of curative effect：
It cures：Original clinical symptoms disappear, and shoulder neck movable function restores；
Alleviate：Original clinical symptom relief, shoulder neck movable function part are restored；
In vain：Original clinical symptoms are without improvement.
Total effective rate=(curing patient's number of cases+reduction of patient number of cases)/total patient's number of cases × 100%
Experimental result：One 32 patients cure 19 after the course for the treatment of 45 days, improve 10, invalid 3, total effective rate reaches
To 90.6%.
It is above that certain exemplary embodiments of the invention are only described by way of explanation, undoubtedly, for ability
The those of ordinary skill in domain without departing from the spirit and scope of the present invention can be with a variety of different modes to institute
The embodiment of description is modified.Therefore, above-described embodiment and description are regarded as illustrative in nature, and should not be construed as to this hair
The limitation of bright claims.
Claims (8)
1. a kind of Chinese medicine composition of invigorating kidney, promoting blood circulation, which is characterized in that it is made of the raw material of following parts by weight：Rehmannia glutinosa 26
~30 parts, 36~40 parts of the fleece-flower root, 16~20 parts of oyster, 16~20 parts of pyrola, 16~20 parts of the rhizome of davallia, Caulis Spatholobi 11~15
Part, 11~15 parts of pueraria lobata, 6~10 parts of Radix Notoginseng and 11~15 parts of the fruit of Cherokee rose.
2. the Chinese medicine composition of invigorating kidney, promoting blood circulation according to claim 1, which is characterized in that it is by the original of following parts by weight
Material is made：28 parts of Rehmannia glutinosa, 38 parts of the fleece-flower root, 18 parts of oyster, 17 parts of pyrola, 17 parts of the rhizome of davallia, 12 parts of Caulis Spatholobi, pueraria lobata 13
Part, 8 parts of Radix Notoginseng and 13 parts of the fruit of Cherokee rose.
3. the Chinese medicine composition of invigorating kidney, promoting blood circulation according to claim 1 or 2, which is characterized in that it is by following steps system
At：
(1) respectively by the non-medicinal of glutinous rehmannia, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata, Radix Notoginseng and the fruit of Cherokee rose
Part removes, and cutting is spare after cleaning；
(2) fruit of Cherokee rose after cleaning, the rhizome of davallia and glutinous rehmannia is taken to be processed respectively；
(3) take Rehmannia glutinosa, the fleece-flower root, pueraria lobata, Radix Notoginseng and pyrola dry at 60~80 DEG C respectively；
(4) Radix Notoginseng powder for taking 1/2 parts by weight, at pressure 0.1MPa-0.2MPa, 115 DEG C of temperature, sterilization time 15 minutes；It goes out
60-80 DEG C heating, drying 20-30 minutes, cool after bacterium；It is ground into fine powder again, sieves with 100 mesh sieve；
(5) by the Rehmannia glutinosa of the parts by weight, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata and the fruit of Cherokee rose, with
And 1/2 the Radix Notoginseng of the parts by weight be put into extraction tank, decoct 2~3 times, every time plus 4-6 times of water is measured, decoct 1-3 hours every time,
Collecting decoction, filtration；Set steam pressure 0.1-0.2Mpa, -90 DEG C of temperature 70 C, vacuum degree 0.04-0.08Mpa, by filtrate
It is concentrated into the thick paste that relative density is 1.30~1.35, the density that the relative density is 60 DEG C；
(6) thick paste of the Radix Notoginseng powder of step (4) and step (5) is uniformly mixed, is dried at 60-80 DEG C of temperature, crushed
At 100 mesh fine powders, the Chinese medicine composition of invigorating kidney, promoting blood circulation is obtained.
4. the Chinese medicine composition of described in any item removing blood stasis and hemostasis according to claim 1~3, which is characterized in that be prepared into
Pharmaceutically acceptable dosage form.
5. the Chinese medicine composition of invigorating kidney, promoting blood circulation according to claim 4, which is characterized in that the dosage form is capsule.
6. the preparation method of the Chinese medicine composition of invigorating kidney, promoting blood circulation according to claim 1 or 2, which is characterized in that including such as
Lower step：
(1) respectively by the non-medicinal of glutinous rehmannia, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata, Radix Notoginseng and the fruit of Cherokee rose
Part removes, and cutting is spare after cleaning；
(2) fruit of Cherokee rose after cleaning, the rhizome of davallia and glutinous rehmannia is taken to be processed respectively；
(3) take Rehmannia glutinosa, the fleece-flower root, pueraria lobata, Radix Notoginseng and pyrola dry at 60~80 DEG C respectively；
(4) Radix Notoginseng powder for taking 1/2 parts by weight, at pressure 0.1MPa-0.2MPa, 115 DEG C of temperature, sterilization time 15 minutes；It goes out
60-80 DEG C heating, drying 20-30 minutes, cool after bacterium；It is ground into fine powder again, sieves with 100 mesh sieve；
(5) by the Rehmannia glutinosa of the parts by weight, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata and the fruit of Cherokee rose, with
And 1/2 the Radix Notoginseng of the parts by weight be put into extraction tank, decoct 2~3 times, every time plus 5-7 times of water is measured, decoct 1-3 hours every time,
Collecting decoction, filtration；Set steam pressure 0.1-0.2Mpa, -90 DEG C of temperature 70 C, vacuum degree 0.04-0.08Mpa, by filtrate
It is concentrated into the thick paste that relative density is 1.30~1.35, the density that the relative density is 60 DEG C；
(6) thick paste of the Radix Notoginseng powder of step (4) and step (5) is uniformly mixed, is dried at 60-80 DEG C of temperature, crushed
At 100 mesh fine powders, the Chinese medicine composition of invigorating kidney, promoting blood circulation is obtained.
7. the preparation method of the Chinese medicine composition of invigorating kidney, promoting blood circulation according to claim 6, which is characterized in that including walking as follows
Suddenly：
(1) respectively by the non-medicinal of glutinous rehmannia, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata, Radix Notoginseng and the fruit of Cherokee rose
Part removes, and cutting is spare after cleaning；
(2) fruit of Cherokee rose after cleaning, the rhizome of davallia and glutinous rehmannia is taken to be processed respectively；
(3) take Rehmannia glutinosa, the fleece-flower root, pueraria lobata, Radix Notoginseng and pyrola dry at 70 DEG C respectively；
(4) Radix Notoginseng powder for taking 1/2 parts by weight, at pressure 0.1MPa, 115 DEG C of temperature, sterilization time 15 minutes；70 DEG C after sterilizing
It heating, drying 25 minutes, cools；It is ground into fine powder again, sieves with 100 mesh sieve；
(5) by the Rehmannia glutinosa of the parts by weight, the fleece-flower root, oyster, pyrola, the rhizome of davallia, Caulis Spatholobi, pueraria lobata and the fruit of Cherokee rose, with
And 1/2 the Radix Notoginseng of the parts by weight be put into extraction tank, decoct 2 times, for the first time plus 7 times of water amounts, decoct 3 hours, for the first time plus
5 times of water amounts, decoct 1.5 hours, collecting decoction, filtration；Set steam pressure 0.2Mpa, 80 DEG C of temperature, vacuum degree 0.06Mpa,
Concentrate the filtrate to the thick paste that relative density is 1.32, the density that the relative density is 60 DEG C；
(6) thick paste of the Radix Notoginseng powder of step (4) and step (5) is uniformly mixed, is dried, is ground under temperature 70 C
100 mesh fine powders, obtain the Chinese medicine composition of invigorating kidney, promoting blood circulation.
8. the Chinese medicine composition of described in any item invigorating kidney, promoting blood circulations is in preparing removing blood stasis and hemostasis drug according to claim 1~3
Using.
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| CN101773561A (en) * | 2009-01-13 | 2010-07-14 | 北京亚东生物制药有限公司 | Chinese medicine composition with functions of tonifying kidney, invigorating blood circulation and relieving pain and preparation method thereof |
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| CN101773561A (en) * | 2009-01-13 | 2010-07-14 | 北京亚东生物制药有限公司 | Chinese medicine composition with functions of tonifying kidney, invigorating blood circulation and relieving pain and preparation method thereof |
Cited By (1)
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