CN101991520A - Washing-free bath cream with sleeping function and preparation method thereof - Google Patents
Washing-free bath cream with sleeping function and preparation method thereof Download PDFInfo
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- CN101991520A CN101991520A CN2010105280157A CN201010528015A CN101991520A CN 101991520 A CN101991520 A CN 101991520A CN 2010105280157 A CN2010105280157 A CN 2010105280157A CN 201010528015 A CN201010528015 A CN 201010528015A CN 101991520 A CN101991520 A CN 101991520A
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Abstract
The invention discloses a washing-free bath cream with a sleeping function and a preparation method thereof. The washing-free bath cream is prepared from the following components of 2-15 parts of anion surface activating agent, 1-10 parts of amphoterics, 5-10 parts of medicine extract liquid, 1-5 parts of wetting agent and 0.005-0.5 part of preservative. Effective components for treating insomnia are absorbed through the skin, which not only avoids the side effects of the traditional medicines for treating the insomnia to stomach, intestines and liver and overcomes the damage of digestive juice and liver detoxication to the medicine effect. Meanwhile, because of adopting the washing-free manner, the effective components of the medicines can attach on the surface of the skin for a long time, which is convenient for absorbing the effective components of the medicines by the skin, plays a role of moistening the skin, and solves the problem that the treatment can not be carried out continuously because of the influence of an objective environment.
Description
Technical field
The present invention relates to a kind of disposable bath gel of function and preparation method thereof of sleeping peacefully that has, belong to filed of daily-use chemical industry.
Background technology
In the middle of people's all one's life, have at least health time of 1/3rd all to spend in sleep, sleep is an extremely important physiological function of keeping human life, insomnia then is the formidable enemy of life and health, tend to after the insomnia cause the lassitude on daytime, feel dizzy tinnitus, forgetful, problems such as neurasthenia, and then cause inefficiency, nervous irritability, get along inharmonious with the people around, depressed, unhappy, serious also can cause pessimistic and worldweary emotion; The long-term easy harm of having a sleepless night is bigger, can cause emotions such as absent minded, ability of thinking decline, generation depression, anxiety, psychentonia, and the cerebral cortex functional disorder causes the autonomic nervous dysfunction, and severe patient forms psychosis, neurosis etc.Long-term in addition insomnia also can cause body immunity to descend, and causes hypertension, heart disease, hyperlipidemia, alzheimer disease, crosses presenility, shortens the life-span.Therefore insomnia is had a greatly reduced quality people's quality of life.Adopt the insomnia of traditional Drug therapy to exist a lot of hidden danger, medicine tends to the stomach, intestinal, liver to human body etc. and brings in various degree stimulation, and serious meeting produces the drug resistance reaction; In addition, medicine is through the destruction of the Detoxication of gastral Digestive system and liver and curative effect is reduced greatly.Therefore we need adopt other forms to remedy the deficiency of traditional treatment mode.Calculate according to medical science, the skin gross area of human body is big 1.5～2.0 square metres, and gross weight is about 16% of body weight, and its efficient that absorbs the drug is not second to oral.The well-known shower is cleaning and rest mode commonly used before people sleep, therefore can consider to adopt the method for shower to come Cure for insomnia, but some special occasions, shower is the comparison difficulty, such as patient, mountain-climbing, polar expedition, navigation etc., all because of the water supply bottleneck, environment badly makes the treatment of taking a shower be forced to interrupt, and has influenced whole curative effect.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of disposable bath gel of function and preparation method thereof of sleeping peacefully that has, the side effect that the present invention not only can avoid the conventional medicament Cure for insomnia to bring for stomach, intestinal, liver etc., overcome Digestive system and liver Detoxication destruction to drug effect, also solved the problem that can not continue to treat, thereby overcome the deficiencies in the prior art owing to the influence of objective environment.
For solving the problems of the technologies described above, the present invention adopts following technical scheme: a kind of disposable bath gel with the function of sleeping peacefully, calculate by weight, it is to be prepared from by 2～15 portions of anion surfactants, 1～10 part of amphoteric surfactant, 5～10 parts of drug extracts, 1～5 part of wetting agent and 0.005～0.5 portion of antiseptic.
Aforesaid drug extract is prepared as follows: calculate by weight, accurately take by weighing 15～30 parts of Semen Ziziphi Spinosae (parched)s, 15～30 portions of Bulbus Liliies, 10～20 portions of Radix Scrophulariae, 15～30 parts of lavandula angustifoliaes, 5～10 parts of mustard, decoct with water 3 times, add for the first time 6 times of water gagings, second and third time respectively adds 5 times of water gagings, the each decoction 1 hour filters, and merging filtrate gets drug extract.
Aforesaid anion surfactant is one or more in sulfuric acid, lignosulfonates and the alkyl glyceryl ether sulfonate of polyoxyethylene alkyl ether sulfate salt, derivative of fatty acid.
Aforesaid amphoteric surfactant is one or more in imidazolidine derivatives, betanin derivative and the alanine derivatives.
Aforesaid wetting agent be in hyaluronic acid, chitosan, Aloe glue, glycerol and the propylene glycol one or more.
Aforesaid antiseptic is one or more in benzoic acid and sodium benzoate, sorbic acid and its esters and the P-hydroxybenzoic acid lipid.
A kind of preparation method with disposable bath gel of the function of sleeping peacefully comprises following steps:
(1) gets anion surfactant and amphoteric surfactant according to aforementioned weight, and be dissolved in 10～50 parts of water, stir, add drug extract then, continue stirring and make its mix homogeneously;
(2) according to aforementioned weight antiseptic is joined in the wetting agent, fully stir and make its dissolving;
(3) (1) and (2) two parts solution being mixed, and regulate pH=5～7 with citric acid, is to stir under 3000～10000rmp 30～60 minutes in homogenizing speed.
Add in 4～6 portions of skin protectant and 0.3～0.6 part of viscosifier one or both in the aforementioned preparation process (2).
Aforesaid skin protectant is one or more in stearic acid, olive oil, vaseline, lecithin and the liquid paraffin.
Aforesaid viscosifier are one or more in hydroxyethyl-cellulose, methylcellulose, sodium carboxymethyl cellulose and the polyvinylpyrrolidone.
Each medicine compatible combination of the present invention is taken into account prevention and treatment, is guidance with motherland's theory of medicine, and the traditional medicine theory is combined with modern science and technology and daily use chemicals technology, makes whole body hair key open by the warm power of bath water, promotes the dermal osmosis absorption.Chinese medicine ingredients prescription effect is as follows among the present invention:
Semen Ziziphi Spinosae (parched), property is sweet, flat, goes into the heart, spleen, liver, gallbladder meridian, has nourishing the liver, and mind calming is calmed the nerves, the arresting sweating effect; Cure mainly restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.Record in " book on Chinese herbal medicine converges and says ", it has astringing QI calms the nerves, and flourish muscle is supported marrow, the effect of stomach function regulating activating the spleen.
Bulbus Lilii, the sweet little hardship of property, flat, go into the heart, lung meridian, have nourishing the lung to arrest cough, the clearing away heart-fire for tranquillization curative effect is mainly used in behind the febrile disease that waste heat is unclear, restlessness of asrhenia type and insomnia, staring spells.Record in " Japan hanako materia medica ", it is felt at ease, and decides gallbladder, beneficial will, the effect of foster the five internal organs.
Radix Scrophulariae, bitter salty, cold, bitter in the mouth is salty, go into lung, kidney channel, have YIN nourishing, pathogenic fire reducing, relieving restlessness, detoxicating functions cures mainly consumption of YIN caused by febrile disease, and tongue is unraveled silk excessive thirst, sends out speckle, the hectic fever due to YIN-deficiency consumptive fever, it is not peaceful to sleep night, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula, diseases such as maculae caused by violent heat pathogen, conjunctival congestion, diphtheria, sore.Record in " medicine origin ", it controls vexed and insomnia is wild utterly confused, the stasis dysuria.
Lavandula angustifolia mainly contains linalyl acetate (about 60%), acetic acid lavandula angustifolia ester linalool, geraniol, Ingredients Such As Coumarin, so its fragrance is salubrious, fragrance is pleasant.At the treatment nervus centralis, alleviate anxiety, to improve nervous system disease effects such as insomnia better.In the present invention by introducing the renewal that lavandula angustifolia can promote the epithelial cell tissue, balance sebum secretion; Refreshment, sterilization, discharge of bacteria, toxin expelling also can be alleviated nerve, contribute to one's peace of mind of inner tranquility, and have the dormifacient effect of calming the nerves.
Mustard, property suffering, heat have the effect of warming spleen and stomach for dispelling cold, promoting the circulation of QI eliminating phlegm, the meridian dredging, detumescence poison.
Semen Ziziphi Spinosae (parched) has the effect of good nourishing blood to tranquillize the mind among the present invention, and Bulbus Lilii invigorating the spleen and replenishing QI, strong, the peaceful gas of nourishing are calmed the nerves; Radix Scrophulariae can nourish pathogenic fire reducing, and the two is associated with, and makes cloudy blood abundance, and the deficiency-heat sleeplessness is a monarch drug from removing altogether.Be aided with lavandula angustifolia and promote epithelial cell tissue to upgrade, regulate the cortex balance, be aided with the mustard detumescence of stimulating the menstrual flow, so be more conducive to the absorption of skin effective ingredient.
The present invention is by a large amount of animal experiments and clinical observation, proves that it improves sleep significantly, and curative effect is fast, wide accommodation,, and the agitation that because of insomnia cause, forgetful, dreaminess etc. not good to sleep state, and health care and evident in efficacy, and human body had no side effect.
One, prolongs the inductive mouse sleep time test of long pentobarbital sodium
One-level Kunming kind female mice spinal column diamond wool is cut, do not damage epidermis, and be divided into four groups at random, it is matched group of three dosage combination of the present invention, three dosage groups are respectively 10,20,30 times of human body use amount, use every day the present invention to wash and soaked mice 30 minutes, continuously around, matched group adopts distilled water to wash and soaks.Observe and the record mice sleep persistent period, calculate the average length of one's sleep of respectively organizing mice respectively, checkout result is as shown in the table:
The result shows: the mice of three dosage groups of the present invention all is higher than matched group the average length of one's sleep, and the every body index to mice is measured, and for noting abnormalities, especially dosage of the present invention is equivalent to mice average length of one's sleep of two dosage groups of human dose 20 and 30 times apparently higher than matched group, the free movable number of times of mice obviously reduces, be the effect that the present invention has obvious improvement sleep, and without any toxic and side effects.
In the clinical trial in nearly 3 years simultaneously, 120 examples are the insomniac in various degree, uses product of the present invention in shower every day process, and its sleep quality is carried out tracing observation, and observed result is as follows:
| The course of treatment | 4 weeks | 8 weeks | 12 weeks | 16 weeks |
| Effective percentage | 33.7％ | 59.5％ | 85.9％ | 91.8％ |
The result shows, through using the invention product, 91.8% patient is in 16 weeks, and effective sleep time every day has all surpassed 8 hours, and after prolonging the length of one's sleep, dreaminess and forgetful problem also be improved significantly, reflect that generally attention concentrates, work efficiency improves.As seen shower of the present invention is responded well to treatment soon, improves sleep significantly, wide accommodation, and all have the patient of insomnia all can take, and is applicable to the sleep state gastrointestinal disease patient, and the agitation that causes because of insomnia, forgetful, dreaminess etc., health care and evident in efficacy.And human body is had no side effect.
Two, bath gel directly contacts with skin, and will be detained a period of time at skin surface, so need three groups of tests are carried out in its safety and toxicology:
1 acute irritation tuerculoderma
8 rabbit spinal column diamond wools are cut, do not damaged epidermis, left and right each the about 3cm * 3cm of unhairing scope.8 rabbit are divided into A, B group at random, get and tried the about 0.5ml of thing and directly be coated on the skin that (the A group is coated with bath gel, the B group is coated with 10 times of concentration bath gel), (2.5cm * 2.5cm) cover with 1 layer of cellophane, reuse nonirritant adhesive plaster and binder are fixed to use 2 layers of gauze then.Opposite side skin in contrast.Adopt blocking test, the application time is 4h.After removing is tried thing 1,24,48,72h observes and to smear the position dermoreaction, carry out the dermoreaction scoring by " cosmetics health standard " (2007) specified standard, meansigma methods with the animal subject integration is carried out overall merit, top average according to 24,48, during 72h is judged skin irritation intensity.
More than 2 skin irritation test
Back part of animal spinal column both sides are cut each 3cm * 3cm of unhairing scope, application area 2.5cm * 2.5cm by hair before the test.Get and tried the about 0.5ml of thing and spread upon on the side skin (the A group is coated with bath gel, and the B group is coated with 10 times of concentration bath gel), opposite side is coated with deionized water in contrast, smears every day 1 time, smears 14d continuously.Since the 2nd day, smear preceding cropping at every turn, remove the residual thing that tried with deionized water.Observed result behind the 1h, by the scoring of " cosmetics health standard " (2007) specified standard, check plot and trial zone are handled equally.
The test of 3 eye irritations
8 rabbit are divided into A, B group at random, open the palpebra inferior of rabbit one branch hole eyeball gently, will be tried thing 0.1ml (100mg) and splash into (the A group is coated with bath gel, and the B group is coated with 10 times of concentration bath gel) in (or being coated with) conjunctival sac, make the passive closed 1s of upper and lower eyelid, to prevent that being tried thing loses.The opposite side eyes are not handled, and make own control.Splash into and tried not wash eyes in the 24h behind the thing.Clinical examination and scoring: splash into tried thing after 1,24,48,72h and animal eyes being checked in the 4th day and the 7th day.If irritant reaction does not appear in 72h, get final product termination test.If find to involve cornea or not recuperator arranged in other stimulations 7d, be reversibility or the irreversibility of determining this infringement, need to prolong observing time, generally be no more than 21d, and the 7th, 14,21 day visual report is provided.Except corneal, iris, conjunctiva were observed, other detrimental effects were all noted down and are reported.All write down the integration of eye irritant reaction in each the inspection by the standards of grading of eye infringement.Use handheld slit lamp to carry out an irritant reaction inspection.After 24h observation and record end, with fluorescein sodium the eyes of all animals are done further to check, with give tried animal corneal behind the thing, iris or conjunctiva 24,48h or 72h the top and recovery time of observing the irritant reaction of time point estimate, judge the stimulation degree of thing to eye of being tried.
Test result shows: no matter be acute skin irritation test or repeatedly the skin irritation test there is no zest and corrosivity reaction, integration is 0.Illustrate that product of the present invention to the skin nonirritant, can not damage skin.In the test of acute eye irritation, only there is 1 rabbit conjunctiva when 1h observes that slight hyperemia is arranged, slight temporary transient zest is described, but recover normal during the 24h observation; All the other do not observe any irritant reaction in 72h, integration is 0, illustrate that product of the present invention to the eyes nonirritant, can not damage eyes, but will avoid pleasing to the eye when using, and prevent to cause of short duration zest.
Compared with prior art, the present invention adopts simple process and equipment, deficiency at existing Cure for insomnia method, prepare a kind of disposable bath gel of the function of sleeping peacefully, with the form of taking a shower, absorb the effective ingredient of Cure for insomnia by skin, not only avoid the conventional medicament Cure for insomnia to stomach, intestinal, liver brings side effect, overcome Digestive system and liver Detoxication destruction to drug effect, simultaneously owing to adopt disposable mode to make the effective ingredient of medicine can be attached to skin surface for a long time, both be convenient to the effective ingredient of skin absorbs medicine, the effect of playing skin moisturizing again and preserving moisture has also solved the problem that can not continue to treat owing to the influence of objective environment.
The specific embodiment
Embodiment 1: drug extract preparation: calculate by weight, accurately take by weighing 15 parts of Semen Ziziphi Spinosae (parched)s, 15 portions of Bulbus Liliies, 10 portions of Radix Scrophulariae, 15 parts of lavandula angustifoliaes, 5 parts of mustard, decoct with water 3 times, add for the first time 6 times of water gagings, second and third time respectively adds 5 times of water gagings, the each decoction 1 hour filters, and merging filtrate gets drug extract.
Disposable bath gel preparation method with the function of sleeping peacefully:
(1) gets 2 portions of polyoxyethylene alkyl ether sulfate salt and 1 part of imidazolidine derivatives is dissolved in 10 parts of water, stir, add 5 parts of aforesaid drug extracts then, continue to stir and make its mix homogeneously;
(2) 0.005 part of benzoic acid is joined in 1 part of hyaluronic acid, fully stir and make its dissolving;
(3) (1) and (2) two parts solution being mixed, and regulate pH=5 with citric acid, is to stir 30 minutes under the 3000rmp in homogenizing speed, promptly.
Embodiment 2: drug extract preparation: calculate by weight, accurately take by weighing 30 parts of Semen Ziziphi Spinosae (parched)s, 30 portions of Bulbus Liliies, 20 portions of Radix Scrophulariae, 30 parts of lavandula angustifoliaes, 10 parts of mustard, decoct with water 3 times, add for the first time 6 times of water gagings, second and third time respectively adds 5 times of water gagings, the each decoction 1 hour filters, and merging filtrate gets drug extract.
Disposable bath gel preparation method with the function of sleeping peacefully:
(1) sulfuric acid and 10 parts of betanin derivative of getting 15 parts of derivative of fatty acid are dissolved in 50 parts of water, stir, and add 10 parts of aforesaid drug extracts then, continue to stir to make its mix homogeneously;
(2) 0.5 part of sorbic acid, 6 parts of stearic acid and 0.6 part of hydroxyethyl-cellulose are joined in 5 parts of chitosans, fully stir and make its dissolving;
(3) (1) and (2) two parts solution being mixed, and regulate pH=7 with citric acid, is to stir 60 minutes under the 10000rmp in homogenizing speed, promptly.
Embodiment 3: drug extract preparation: calculate by weight, accurately take by weighing 20 parts of Semen Ziziphi Spinosae (parched)s, 20 portions of Bulbus Liliies, 15 portions of Radix Scrophulariae, 20 parts of lavandula angustifoliaes, 8 parts of mustard, decoct with water 3 times, add for the first time 6 times of water gagings, second and third time respectively adds 5 times of water gagings, the each decoction 1 hour filters, and merging filtrate gets drug extract.
Disposable bath gel preparation method with the function of sleeping peacefully:
(1) gets 10 parts of alkyl glyceryl ether sulfonates and 5 parts of alanine derivatives are dissolved in 30 parts of water, stir, add 8 parts of aforesaid drug extracts then, continue to stir and make its mix homogeneously;
(2) 0.3 part of P-hydroxybenzoic acid fat is joined in 3 parts of propylene glycol, fully stir and make its dissolving;
(3) (1) and (2) two parts solution being mixed, and regulate pH=6 with citric acid, is to stir 45 minutes under the 6000rmp in homogenizing speed, promptly.
Embodiment 4:
Drug extract preparation: calculate by weight, accurately take by weighing 25 parts of Semen Ziziphi Spinosae (parched)s, 25 portions of Bulbus Liliies, 18 portions of Radix Scrophulariae, 25 parts of lavandula angustifoliaes, 6 parts of mustard, decoct with water 3 times, add for the first time 6 times of water gagings, second and third time respectively adds 5 times of water gagings, the each decoction 1 hour filters, and merging filtrate gets drug extract.
Disposable bath gel preparation method with the function of sleeping peacefully:
(1) gets 8 parts of lignosulfonates and 8 parts of betanin derivative are dissolved in 40 parts of water, stir, add 6 parts of aforesaid drug extracts then, continue to stir and make its mix homogeneously;
(2) 0.1 part of benzoate, 5 parts of vaseline and 0.5 part of polyvinylpyrrolidone are joined in 4 parts of Aloe glues, fully stir and make its dissolving;
(3) (1) and (2) two parts solution being mixed, and regulate pH=7 with citric acid, is to stir 40 minutes under the 8000rmp in homogenizing speed, promptly.
The using method of above product is: extrude an amount of shower and be exposed on the centre of the palm or the moistening bubble cottonrose hibiscus, evenly wipe and rub whole body.
Claims (9)
1. disposable bath gel with the function of sleeping peacefully, it is characterized in that: calculate by weight, it is to be prepared from by 2～15 portions of anion surfactants, 1～10 part of amphoteric surfactant, 5～10 parts of drug extracts, 1～5 part of wetting agent and 0.005～0.5 portion of antiseptic, and wherein: drug extract prepares with 15～30 parts of Semen Ziziphi Spinosae (parched)s, 15～30 portions of Bulbus Liliies, 10～20 portions of Radix Scrophulariae, 15～30 parts of lavandula angustifoliaes and 5～10 parts of mustard.
2. the disposable bath gel with the function of sleeping peacefully according to claim 1 is characterized in that: described anion surfactant is one or more in sulfuric acid, lignosulfonates and the alkyl glyceryl ether sulfonate of polyoxyethylene alkyl ether sulfate salt, derivative of fatty acid.
3. the disposable bath gel with the function of sleeping peacefully according to claim 1 is characterized in that: described amphoteric surfactant is one or more in imidazolidine derivatives, betanin derivative and the alanine derivatives.
4. the disposable bath gel with the function of sleeping peacefully according to claim 1 is characterized in that: described wetting agent be in hyaluronic acid, chitosan, Aloe glue, glycerol and the propylene glycol one or more.
5. the disposable bath gel with the function of sleeping peacefully according to claim 1 is characterized in that: described antiseptic is one or more in benzoic acid and sodium benzoate, sorbic acid and its esters and the P-hydroxybenzoic acid lipid.
6. as the arbitrary described preparation method with disposable bath gel of the function of sleeping peacefully of claim 1～5, it is characterized in that: described method comprises following steps:
(1) drug extract is prepared as follows: calculate by weight, accurately taking by weighing 15～30 parts of Semen Ziziphi Spinosae (parched)s, 15～30 portions of Bulbus Liliies, 10～20 portions of Radix Scrophulariae, 15～30 parts of lavandula angustifoliaes and 5～10 parts of mustard decocts with water 3 times, add for the first time 6 times of water gagings, second and third time respectively adds 5 times of water gagings, the each decoction 1 hour, filter, merging filtrate gets drug extract.
(2) get anion surfactant and amphoteric surfactant according to aforementioned weight, and be dissolved in 10～50 parts of water, stir, add drug extract then, continue stirring and make its mix homogeneously;
(3) according to aforementioned weight antiseptic is joined in the wetting agent, fully stir and make its dissolving;
(4) (2) and (3) two parts solution being mixed, and regulate pH=5～7 with citric acid, is to stir under 3000～10000rmp 30～60 minutes in homogenizing speed.
7. the preparation method with disposable bath gel of the function of sleeping peacefully according to claim 6 is characterized in that: add in 4～6 portions of skin protectant and 0.3～0.6 part of viscosifier one or both in described preparation process (3).
8. the preparation method with disposable bath gel of the function of sleeping peacefully according to claim 7 is characterized in that: described skin protectant is one or more in stearic acid, olive oil, vaseline, lecithin and the liquid paraffin.
9. the preparation method with disposable bath gel of the function of sleeping peacefully according to claim 7 is characterized in that: described viscosifier are one or more in hydroxyethyl-cellulose, methylcellulose, sodium carboxymethyl cellulose and the polyvinylpyrrolidone.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105280157A CN101991520A (en) | 2010-11-01 | 2010-11-01 | Washing-free bath cream with sleeping function and preparation method thereof |
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| CN2010105280157A CN101991520A (en) | 2010-11-01 | 2010-11-01 | Washing-free bath cream with sleeping function and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655434A (en) * | 2013-04-28 | 2014-03-26 | 钱臻 | Biological fermentation bath cream and preparation method thereof |
| CN104905997A (en) * | 2015-04-24 | 2015-09-16 | 南通蛇类治疗研究所 | Fresh flower medicinal herb functional bath lotion |
| CN106176431A (en) * | 2016-08-16 | 2016-12-07 | 南通蛇类治疗研究所 | Natural medicinal stone plant nanometer milk bath liquid |
| CN106389272A (en) * | 2016-08-16 | 2017-02-15 | 南通蛇类治疗研究所 | Natural plant effective bath lotion |
-
2010
- 2010-11-01 CN CN2010105280157A patent/CN101991520A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655434A (en) * | 2013-04-28 | 2014-03-26 | 钱臻 | Biological fermentation bath cream and preparation method thereof |
| CN104905997A (en) * | 2015-04-24 | 2015-09-16 | 南通蛇类治疗研究所 | Fresh flower medicinal herb functional bath lotion |
| CN106176431A (en) * | 2016-08-16 | 2016-12-07 | 南通蛇类治疗研究所 | Natural medicinal stone plant nanometer milk bath liquid |
| CN106389272A (en) * | 2016-08-16 | 2017-02-15 | 南通蛇类治疗研究所 | Natural plant effective bath lotion |
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Application publication date: 20110330 |