CN105106318B - A kind of Chinese medicine composition and preparation method thereof for treating xerophthalmia - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating xerophthalmia Download PDFInfo
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Abstract
The present invention discloses a kind of Chinese medicine composition and preparation method thereof, which is made of the following raw material：Mulberry leaf, wild chrysanthemum, peppermint.Chinese medicine composition prepared by the present invention is used to prepare into common stifling pouch-type, and preparation process is simple, need to only smash the raw material of prescription into coarse powder, be distributed into stifling packet and sterilized.The Chinese medicine composition can be used for treating xerophthalmia, especially very effective to xerophthalmia caused by meibomian gland dysfunction, and therapeutic process is simple and practicable, works well.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, it is related to a kind of Chinese medicine composition that treating xerophthalmia and its preparation side
Method.
Background technology
Xerophthalmia is the exception or the caused tear film shakiness of the dynamic (dynamical) exception of tear of tear quality and quantity caused by any reason
Fixed and eye surface damage, so as to cause a kind of disease of eye discomfort symptoms.Patients with dry eye be mainly shown as eye sensation of dryness,
Foreign body sensation, asthenopia, eye are ached and burn feeling, and serious patient can cause being decreased obviously for eyesight and influence work and life.
With the development and the improvement of people's living standards of social economy, the incidence of dry eyes has increased trend, and has
The trend of rejuvenation.Due to people's reading method and the accelerating rhythm of life, incidence is in raised trend year by year.Xerophthalmia
It is common one of the eye surface diseases of ophthalmology, according to statistics, China's xerophthalmia incidence is 10.71%-12.91%.
Xerophthalmia belongs to the dry astringent eye, xerosis conjunctivitis scope of TCM Ophthalmology, and traditional Chinese medicine thinks that assertive evidence is the lack of lung-YIN since heat symptoms caused by an exopathgen are reluctant to leave,
Retention of heat in the spleen and stomach and liver-kidney Yin deficiency, YIN fluid being insufficient and cause caused by eyes losing nutrition.For modern medicine angle, according to teiology,
Xerophthalmia can be divided into：The imbalance dry eyes of Environmental dry eyes, sex hormone, meibomian gland dysfunction dry eyes, dry eye syndrome are (certainly
Body immunity), the dyskinetic dry eyes of nerve conduction (afferent and outflow obstacle), mixed type dry eyes.Although causing xerophthalmia
The cause of disease is different, but its pathophysiological change is similar, once into developing stage, inflammation becomes in xerophthalmia pathogenesis most
Crucial factor.
It is clinically mostly used eye drops etc. at present to treat xerophthalmia.Since the tissue of eye is more sensitive, these drugs pair
It is bigger in the injury of ocular tissue, and the problem of usually will produce drug resistance.
Western medical treatment is based on part, and a kind of common western medicine therapy such as supplements artificial tears, and this artificial tears can
It plays a protective role to normal eyes, eliminate ophthalmic uncomfortable, moisten eyeball alleviation local symptom, but this artificial tears couple
The potential cause of disease of xerophthalmia does not give treatment, plays palliative effect；When severe dry eye patients conventional treatments are treated
It imitates bad, and when being likely to result in eyesight and being badly damaged, generally uses operative treatment, be such as implanted into lacrimal passage stopper, puncta block technique
And the operative treatments such as salivary gland transplanting.
Chinese traditional treatment it is with a long history, therapy is various, as oral medicinal herb, acupuncture and moxibustion therapy, massaging and physiotherapeutical and Chinese medicine drip
Eye etc..The Chinese patent application of Publication No. 102145126A discloses a kind of profound wheat profit mesh of pharmaceutical composition that treating xerophthalmia
Particle, the composition are made of the bulk pharmaceutical chemicals of following mass parts：Radix Rehmanniae 6-30, radix scrophulariae 10-40, Radix Ophiopogonis 5-30, stem of noble dendrobium 5-30, know
This composition is made by female 10-20, root of Chinese trichosanthes 10-20, chrysanthemum 5-30, mulberry leaf 5-30, pipewort 5-20, windproof 10-30
Granula forms, and patient can carry out brewing for oral administration.The Chinese patent application of Publication No. 104367832A provides a kind for the treatment of
Compound stem of noble dendrobium eye drops of xerophthalmia and preparation method thereof, which is formulated by following raw material：Stem of noble dendrobium 80-120g, smallpox
Powder 80-120g, folium isatidis 80-120g, vitamin B1 50-100g and honey 10-20ml.It is first by the stem of noble dendrobium, root of Chinese trichosanthes, smalt
Leaf etc. is smashed to pieces and is boiled, and liquid is filtered to obtain, and preservative ethylparaben and vitamin B1 and bee first is added in backward gained liquid
Honey is equivalent to the osmotic pressure of 0.8-1.2 sodium chloride concentrations using distilled water regulating liquid medicine osmotic pressure, and drop is made in then filtering packing
Ocular fluid.Although these therapies also can Yin-nourishing and body fluid promoting, moisten eyes, treatment and improve dry eyes symptom, but still have Gu this mistake
That, if any larger side effect, treatment cycle is long, medicinal material type is various or preparation process very complicated etc., and effect is not
One.Modern life rhythm is fast, and conventional therapy condition is restricted, and patient Duo Yin cannot adhere to that giving up halfway causes
Influence its curative effect.Develop that a kind of therapeutic effect is more definite as a result, therapeutic process is simple and has the drug of less side effect to seem
It is particularly significant.
The Chinese medicine composition of the treatment xerophthalmia of the present invention is based on traditional Chinese medicine and pharmacy to the pathogenetic abundant of xerophthalmia
Understanding, is prepared by re-starting scientific composition to mulberry leaf, wild chrysanthemum and peppermint, is original with pure natural wild Chinese medicine
Material, has no toxic side effect, and preparation process and application method are simple, it dredging the channel, dispelling wind and heat from the body and can clear liver and improve vision, and reach and control
Treat the effect of xerophthalmia.
Invention content
The primary and foremost purpose of the present invention is to provide a kind of Chinese medicine composition that treating xerophthalmia and its preparation regarding to the issue above
Method.The Chinese medicine composition mutually cooperates with work for the cause of disease and the interpretation of the cause, onset and process of an illness of xerophthalmia formation using the active constituent of plurality of Chinese
With, wind-dispelling heat-dissipating, it is clearing heat and detoxicating, clear liver and improve vision, diminish inflammation, to achieve the purpose that treat xerophthalmia.
To achieve the purpose of the present invention, one aspect of the present invention provides a kind of Chinese medicine composition for treating xerophthalmia, main to wrap
Include the following raw material：Mulberry leaf, wild chrysanthemum and peppermint.
Wherein, the weight of the traditional Chinese medicine composite is：Mulberry leaf 0.5-2, wild chrysanthemum 0.5-2, peppermint
0.5-2。
In particular, the weight of the raw material is：Mulberry leaf 0.5-1.5, wild chrysanthemum 0.5-1.5, peppermint 0.5-1.5.
Especially, the weight of the raw material is preferably：Mulberry leaf 1, wild chrysanthemum 1, peppermint 1.
The Chinese medicine composition selection mulberry leaf of the present invention, wild chrysanthemum, peppermint are combined and are prepared, have wind-dispelling heat-dissipating,
Clearing heat and detoxicating, the effect of clearing liver and improving vision.For caused by wind-heat visitor's network eyelid and white of the eye Chi Mai it is indistinct, eye itch it is dry and astringent, mill pain burn
Heat, it is not durable to regard, long depending on aching.
Monarch drug in a prescription mulberry leaf bitter is cold in nature in the prescription of the present invention, has the effect of dispelling wind and heat from the body, clear liver and improve vision, the clear internal organs of interior energy
Lung is hot and suffocating, the heresy of external enwergy dispelling wind and heat from the body.Wind-heat is clear, stasis dissipate, then white of the eye, born of the same parents' eyelid it is red it is red move back, puckery shouting pain of itching can disappear.Fang Zhongchen
Medicine wild chrysanthemum toil is slightly cold, and enters the warp of lung liver two, clearing heat and detoxicating, there is the work(for moving back hot eyes, going itch；Ministerial drug peppermint nature and flavor are pungent in side
It is cool, enter liver lung channel, there is soothing the liver stagnant, the effect of removing stagnant heat, is antipruritic, the two is harmonious with monarch drug in a prescription, is aided with removing heat from the liver, moves back red screen, only
Itch puckery, bright eyes the effect of.
Mulberry leaf, be moraceae plants mulberry through white leaf, traditional Chinese medicine and pharmacy is thought, mulberry leaf are bitter in taste, sweet, cold, it is simultaneous enter Liver Channel, have
The benefits of pancake liver-yang, can gently evacuate clearly, external enwergy dispelling wind and heat from the body, interior energy clearing lung-heat, treatment liver-yang hyperactivity, improving eyesight, common to control wind-heat
Flu, dry-heat impairing lung, liver-yang hyperactivity and wind-heat or irascibility hot eyes flu, dry-heat impairing lung, liver-yang hyperactivity and wind-heat or irascibility hot eyes
Swelling and pain, the eyes of deficiecny of liver-YIN are dim-sighted；In addition, again can cooling blood and hemostasis.With the domination of clearing liver and improving vision such as chrysanthemum, Prunella vulgaris, plantain seed,
Available treatment wind-heat of liver channel such as attacks caused hot eyes, puckery pain, sheds tears in irascibility at the real examples；Coordinate the Semen sesami nigrum of nourishing essence-blood, i.e. mulberry fiber crops
Ball, and can be used for deficiecny of liver-YIN, the dim-sighted asthenic symptoms of eyes.
Modern traditional Chinese and western medicine uses mulberry leaf and mulberry leaf biological agent as the drug for improving various difficult and complicated cases, it is believed that its
Drug effect is extremely wide.There is clearing away the lungheat and moisturizing, cough-relieving, reduces phlegm and internal heat, resolving sputum, controls night sweat；Tonifying liver clears liver and improve vision, treats dizzy, mistake
It sleeps, eliminates eye strain, subside a swelling, purify the blood；It treats dysentery, abdominal pain, weight-reducing, remove tinea pedis, the large and small intestines of profit；Resisting stress, cool blood, drop
Blood pressure, prevents myocardial infarction, cerebral hemorrhage, headache of dispelling, long hair at reducing blood lipid；Hypoglycemic, anti-sugared disease etc..
Wild chrysanthemum, property is pungent, and bitter is slightly cold, and Return liver, the heart channel of Hang-Shaoyin, primary efficacy are clearing heat and detoxicating.Cure mainly carbuncle swells, furunculosis, mesh
Red, scrofula, pemphigus, eczema etc..Since clearing heat and detoxicating power is contained in chrysanthemum, it is good at the disease for treating all kinds of furunculosis carbuncle swells.
Modern medicine finds wild chrysanthemum, and main component is yejuhua lactone, chrysanthemol, flavonoid glycoside etc., tool subdhing swelling and detoxicating,
Anti-infective, antiviral effect can prevent meningococal meningitis, prevent influenza, flu, treatment hypertension, liver
Inflammation, dysentery, carbuncle furuncle treatment sore have positive effect.The immersion liquid of wild chrysanthemum is also highly effective to killing wriggler and fly maggot.
Wild chrysanthemum has effects that clearing heat and detoxicating, dispelling wind soothing the liver.For treating anemopyretic cold, abscess of throat, red eye, swell pain,
Dizziness of having a headache and furunculosis carbuncle swells disease.Wild chrysanthemum water extract and volatile oil all have antiviral, antibacterial activity.Wild chrysanthemum water extract
To staphylococcus aureus, corynebacterium diphtheriae, typhoid bacillus, Escherichia coli, proteus, shigella dysenteriae, escherichia coli, green pus
Pseudomonad, Fu Shi he bacterium have stronger inhibiting effect.Flos Chrysanthemi Indici volatile oil is stronger to staphylococcus aureus effect, to white
Staphylococcus is effective.Wild chrysanthemum water extract and volatile oil have significant anti-inflammatory, immunosuppressive action, but volatile oil is to chemicals
Caused Inflammatory effects are preferable, and water extract is preferable to the inflammatory effect caused by foreign preteins pro-inflammatory cytokine；By in wild chrysanthemum
The chrysanthemol that lipophilic moieties are separated to has apparent anti-inflammatory effect.Wild chrysanthemum decoction, which has, promotes phagocytic activity of leukocytes
Effect, in vitro test shows 1:The wild chrysanthemum decoction of 1280 concentration has and promotes human leukocytes phagocytosis staphylococcus aureus
Effect, also have the function of resisting pathogenic microbes.
Peppermint is acrid flavour, cool in nature, nontoxic.Return lung, Liver Channel have diverging wind-heat, the general clearing throat of clear upperization, and promoting eruption removing toxic substances is dredged
Liver solution is strongly fragrant and antipruritic and other effects, itch suitable for cold, fever, headache, abscess of throat, lossless, wind-fire red eye, rubella, skin,
At diseases such as sore, diarrhea and scrofulas, external application has slight analgesic effect for colic, fiery poison, for neuralgia etc..Wind radiates, and can also draw
Heat is outgoing, thus control hectic fever due to yin consumptive disease (pulmonary tuberculosis), children shy under mad, big heat etc., often use it as priming.
Modern pharmacological research proves that dried peppermint leaf has following multiple functions：1, stimulate and inhibit nerve.Peppermint has stimulation
The effect of nervous centralis, acting on skin has bright sense and creeping chill simultaneously, it has sensory nerve ending in the work of inhibition and paralysis again
With.2, antiphlogistic antibacterial.Peppermint plays the role of desensitization, anti-inflammatory and antibacterial to bite by mosquitos skin；Also have to the infection of the upper respiratory tract bright
Aobvious cough-relieving, anti-inflammatory and bacteriostasis；There are swelling and pain relieving, antiphlogistic antibacterial to hemorrhoid, anal fissure.3. stomach invigorating wind-dispelling.Peppermint
There are big gun thermal sensation and stimulation to oral mucosa, oral cavity can be promoted to salivate, improve a poor appetite, increasing the amount of blood supply of gastric mucosa, improves
Digestive function.In addition, peppermint also has preferable wind dispelling to act in enteron aisle, intestines inflation can be mitigated, slow myenteron wriggling of speeding, have and subtract
The effect of slow enterocele pain.4. fragrance seasoning.Mainly using refrigerant throat-moistening specific to peppermint and fragrance pleasant smell is covered up
With improve some with peculiar smell and the sense of discomfort for being difficult to the drug swallowed.
Another aspect of the present invention provides a kind of preparation method of the Chinese medicine composition, includes the following steps：
1, prepare raw material according to following weight：
Wild chrysanthemum 0.5-2, mulberry leaf 0.5-2, peppermint 0.5-2
2, mulberry leaf, wild chrysanthemum, peppermint are crushed respectively, mulberry leaf, wild chrysanthemum, peppermint powder is made；
3, mulberry leaf, wild chrysanthemum, peppermint powder be uniformly mixed to get.
Wherein, the weight of the raw material described in step 1 is preferably：It is wild chrysanthemum 0.5-1.5, mulberry leaf 0.5-1.5, thin
Lotus 0.5-1.5, further preferably：Wild chrysanthemum 1, mulberry leaf 1, peppermint 1.
In particular, the granularity of powder described in step 2 >=and 40 mesh, preferably 40-60 mesh, further preferred powder
Granularity is 50 mesh.
It should be noted that by the component of the composition being smashed using disintegrating machine, then blender is used to carry out
It stirs and evenly mixs, mixing is fully dispensed using filter paper bag (such as tea bag tea filter paper bag etc.) afterwards, every bag of packing 1-5g
Stifling packet is made, and carries out sterilization treatment.
In particular, by stifling packet obtained using the processing sterilizing of ethylene oxide sterilizing method.
Wherein, the conditional parameter being arranged in the sterilisation process is：Ethylene oxide concentration is 450mg/L, and temperature is
45 DEG C, sterilization time 5h.
The stifling packet application method of described the composition：The cup for taking a life common, cup is cleaned, and is put into stifling
Packet is subsequently poured into certain amount of boiling water until completely submerging stifling packet, cup is put near eyes, eye is smoked using hot steam and controls
It treats.Stifling number 1-3 times daily, fumigation treatment time are 10-30min/ times, use 1 bag every time, every bag of 3g.
In particular, will fumigate packet made from the Chinese medicine composition can have well in preventing or/and treating xerophthalmia
Application.
The Chinese medicine composition for the treatment of xerophthalmia prepared by the present invention has the following advantages that：
1, the source of each bulk pharmaceutical chemicals of composition in the present invention is easy, and preparation process is simple, it is easy to accomplish, pharmaceutical composition
Small toxicity, target user is extensive, curative for effect notable.
2, patient is simple for use, is heated using stainless-steel pan or fumigating instrument.
3, it fumigates packet to be convenient for storing, normal temperature environment, the term of validity is permanent.
4, present invention treatment xerophthalmia composition prescription compatibility science, it is curative for effect, it is safe, it is quality controllable.
5, present invention treatment xerophthalmia composition has effects that dispelling wind and heat, nourishing Yin and moistening dryness, clears liver and improve vision, and can be used for pre-
Anti- and treatment xerophthalmia, treats xerophthalmia, eliminates Meibomian gland inflammation.
Specific implementation mode
The invention will now be further described with reference to specific embodiments, the advantages and features of the present invention will be with description and
It is apparent.But examples are merely exemplary for these, and it is not intended to limit the scope of the present invention in any way.People in the art
Member it should be understood that without departing from the spirit and scope of the invention can to the details of technical solution of the present invention and form into
Row modifications or substitutions, but these modifications and replacement are each fallen in protection scope of the present invention.
Embodiment 1
1, prepare raw material (× 1000g) according to following weight
Wild chrysanthemum 1, mulberry leaf 1, peppermint 1
2, pulverizer is respectively adopted in mulberry leaf, wild chrysanthemum, peppermint and crushes processing, then crossed 50 mesh sieve, obtain respectively
Wild chrysanthemum powder, Mulberry Leaf, peppermint powder；
3, wild chrysanthemum powder, Mulberry Leaf, peppermint powder are added in blender and are stirred evenly, wild chrysanthemum-mulberry is made
Leaf-peppermint composition；
4, (example is sub-packed in packaging bag after weighing uniformly mixed wild chrysanthemum-mulberry leaf-peppermint composition by meter
The filter paper bag used such as common tea bag), every bag of 1-5g, preferably 3g；
5, the pack after packing is positioned over ethylene oxide sterilizing cabinet (ethylene oxide sterilizing cabinet, model ZMW-500L, Shen
Positive city's modern medical instrument research institute) disinfection, it is 450mg/L that the parameter of setting, which is ethylene oxide concentration, and temperature is 45 DEG C, sterilizing
Time 5h；
6, will sterilizing pack cool down post package in outer packaging bag to get.
The traditional Chinese medicine fumigating steamed bun of the treatment xerophthalmia of the present invention uses 1 bag every time, fumigates 2-3 times daily.
Embodiment 2
1, prepare raw material (× 1000g) according to following weight
Wild chrysanthemum 0.5, mulberry leaf 1.0, peppermint 1.0
2, pulverizer is respectively adopted in mulberry leaf, wild chrysanthemum, peppermint and crushes processing, then crossed 40 mesh sieve, obtain respectively
Wild chrysanthemum powder, Mulberry Leaf, peppermint powder；
3, wild chrysanthemum powder, Mulberry Leaf, peppermint powder are added in blender and are stirred evenly, wild chrysanthemum-mulberry is made
Leaf-peppermint composition；
4, (example is sub-packed in packaging bag after weighing uniformly mixed wild chrysanthemum-mulberry leaf-peppermint composition by meter
The filter paper bag used such as common tea bag), every bag of 1-5g, preferably 1g；
5, the pack after packing is positioned over ethylene oxide sterilizing cabinet (ethylene oxide sterilizing cabinet, model ZMW-500L, Shen
Positive city's modern medical instrument research institute) disinfection, it is 450mg/L that the parameter of setting, which is ethylene oxide concentration, and temperature is 45 DEG C, sterilizing
Time 5h；
6, will sterilizing pack cool down post package in outer packaging bag to get.
The traditional Chinese medicine fumigating steamed bun of the treatment xerophthalmia of the present invention uses 1 bag every time, fumigates 2-3 times daily.
Embodiment 3
1, prepare raw material (× 1000g) according to following weight
Wild chrysanthemum 1.5, mulberry leaf 0.5, peppermint 0.5
2, pulverizer is respectively adopted in mulberry leaf, wild chrysanthemum, peppermint and crushes processing, then crossed 60 mesh sieve, obtain respectively
Wild chrysanthemum powder, Mulberry Leaf, peppermint powder；
3, wild chrysanthemum powder, Mulberry Leaf, peppermint powder are added in blender and are stirred evenly, wild chrysanthemum-mulberry is made
Leaf-peppermint composition；
4, (example is sub-packed in packaging bag after weighing uniformly mixed wild chrysanthemum-mulberry leaf-peppermint composition by meter
The filter paper bag used such as common tea bag), every bag of 1-5g, preferably 5g；
5, the pack after packing is positioned over ethylene oxide sterilizing cabinet (ethylene oxide sterilizing cabinet, model ZMW-500L, Shen
Positive city's modern medical instrument research institute) disinfection, it is 450mg/L that the parameter of setting, which is ethylene oxide concentration, and temperature is 45 DEG C, sterilizing
Time 5h；
6, will sterilizing pack cool down post package in outer packaging bag to get.
The traditional Chinese medicine fumigating steamed bun of the treatment xerophthalmia of the present invention uses 1 bag every time, fumigates 2-3 times daily.
Embodiment 4
1, prepare raw material (× 1000g) according to following weight
Wild chrysanthemum 2, mulberry leaf 0.5, peppermint 2
2, pulverizer is respectively adopted in mulberry leaf, wild chrysanthemum, peppermint and crushes processing, then crossed 50 mesh sieve, obtain respectively
Wild chrysanthemum powder, Mulberry Leaf, peppermint powder；
3, wild chrysanthemum powder, Mulberry Leaf, peppermint powder are added in blender and are stirred evenly, wild chrysanthemum-mulberry is made
Leaf-peppermint composition；
4, (example is sub-packed in packaging bag after weighing uniformly mixed wild chrysanthemum-mulberry leaf-peppermint composition by meter
The filter paper bag used such as common tea bag), every bag of 1-5g, preferably 3g；
5, the pack after packing is positioned over ethylene oxide sterilizing cabinet (ethylene oxide sterilizing cabinet, model ZMW-500L, Shen
Positive city's modern medical instrument research institute) disinfection, it is 450mg/L that the parameter of setting, which is ethylene oxide concentration, and temperature is 45 DEG C, sterilizing
Time 5h；
6, will sterilizing pack cool down post package in outer packaging bag to get.
The traditional Chinese medicine fumigating steamed bun of the treatment xerophthalmia of the present invention uses 1 bag every time, fumigates 2-3 times daily.
Embodiment 5
1, prepare raw material (× 1000g) according to following weight
Wild chrysanthemum 0.5, mulberry leaf 1.5, peppermint 0.5
2, pulverizer is respectively adopted in mulberry leaf, wild chrysanthemum, peppermint and crushes processing, then crossed 40 mesh sieve, obtain respectively
Wild chrysanthemum powder, Mulberry Leaf, peppermint powder；
3, wild chrysanthemum powder, Mulberry Leaf, peppermint powder are added in blender and are stirred evenly, wild chrysanthemum-mulberry is made
Leaf-peppermint composition；
4, (example is sub-packed in packaging bag after weighing uniformly mixed wild chrysanthemum-mulberry leaf-peppermint composition by meter
The filter paper bag used such as common tea bag), every bag of 1-5g, preferably 3g；
5, the pack after packing is positioned over ethylene oxide sterilizing cabinet (ethylene oxide sterilizing cabinet, model ZMW-500L, Shen
Positive city's modern medical instrument research institute) disinfection, it is 450mg/L that the parameter of setting, which is ethylene oxide concentration, and temperature is 45 DEG C, sterilizing
Time 5h；
6, will sterilizing pack cool down post package in outer packaging bag to get.
The traditional Chinese medicine fumigating steamed bun of the treatment xerophthalmia of the present invention uses 1 bag every time, fumigates 2-3 times daily.
The clinical observation on the therapeutic effect of the traditional Chinese medicine composition for treating xerophthalmia of one present invention of test example
1, test objective
By studying the clinical observation of 80 patients with dry eye, the clinical efficacy of the traditional Chinese medicine fumigating steamed bun is verified.
2, traditional Chinese and western medicine diagnostic criteria and its foundation
Xerophthalmia belongs to the scope of " dry astringent eye, xerosis conjunctivitis " in ophthalmology of traditional Chinese medicine, is edited with reference to Zeng Qinghua《Ophthalmology of traditional Chinese medicine》It is related
CM syndrome differentiation criterion.Its Symptoms is：It is dry and astringent not well to suffer from eye, twinkles again and again or micro- photophobia；White of the eye Chi Mai is indistinct, or can look into see it is black
The dotted star an ancient unit of weight equal to 20 or 24 *taels of silver of eyeball；Tongue is red.Tongue is thin, rapid pulse or counts accurately.Diagnosing and treating of the Western medicine diagnostic criteria with reference to national xerophthalmia in 2004
Be in progress the diagnostic criteria formulated.The diagnostic criteria is：1, patient has apparent subjective symptoms, such as foreign body sensation, sensation of dryness, burns
Sense, photophobia, is envious at eye is swollen sense, wherein using 3 asthenopia, foreign body sensation, sensation of dryness symptoms as leading indicator；2, tear film is shown as
Unstability, breakup time of tear film, which shortens, to be less than 10 seconds；3, lacrimal secretion is reduced, and Schimer's test is less than or equal to
10mm/5min；4, eye surface is damaged, and is dyed using corneal fluorescein and is reinforced diagnosis.
3, case inclusion criteria
Meet traditional Chinese and western medicine diagnostic criteria, and the age in 70 one full year of life hereinafter, gender is without limitation.
4, case exclusion criteria
A is accompanied with the glaucoma that seriously affects other eye disease of visual function and cannot such as cure simultaneously, cataract disease.
B has apparent organic eye disease (hypophasis；Eyelid malposition；Thyroid gland correlation immunity eye disease；Angle
Film scar；Conjunctiva trace etc.).
C has this disease the eye disease (anaphylaxis keratoconjunctivitis sicca etc.) interfered strongly
D has the decorum disease such as serious connective tissue disease, rheumatoid arthritis, chorionitis, erythematosus lupus.
E merges the severe primaries diseases such as the heart, liver, kidney, hemopoietic system, mental patient.
F allergic constitution persons.
5, criterion of therapeutical effect and its foundation
With reference to State Administration of Traditional Chinese Medicine's publication《Disease of tcm Standardization of diagnosis and curative effect》It drafts
A is cured：Symptom disappears, and corneal dyeing subsides, and lacrimal secretion experiment, which repeatedly measures, is more than 10mm/5min.
B improves：Symptom mitigates, and corneal dyeing is reduced, and lacrimal secretion experiment repeatedly measures lacrimal secretion and increased.
C is not cured：For symptom without improvement, corneal dyeing is unchanged or increases, and lacrimal secretion experiment repeatedly measures lacrimal secretion
Without increase.
6, test method
(1) all Eligible subjects for meeting case diagnosis standard, inclusion criteria and exclusion criteria use " table of random number
Method " is assigned randomly to herbal fumigation packet treatment group A (40) and control group B (40).
(2) medicine
A treatment groups use：The stifling packet of Chinese medicine composition prepared by the embodiment of the present invention 1
The auspicious droplet ocular fluid of choice of drug that b control groups use (Hubei Grand Everyday Bright Eyes Pharmaceutical Co., Ltd., 0.8 milliliter：
11.2 milligrams (with polyvinyl alcohols))
(3) medication
The cup that a takes a life common, cup is cleaned, and is put into stifling packet, is subsequently poured into certain amount of boiling water to will smoke completely
Until steamed bun submerges, cup is put near eyes, eye is smoked using hot steam and is treated, uses 1 bag every time, stifling daily time
Number 2-3 times, fumigation treatment time are 10-30min/ times.It is 1 course for the treatment of to treat 4 weeks.Medication is checked after 2 weeks, carries out tear
Basal secretion is tested and the measurement of breakup time of tear film.
B control groups give control drug auspicious droplet ocular fluid, when eyes feel dry and astringent, auspicious droplet ocular fluid are added dropwise to eye is suffered from, often
Secondary 1 drop, 4 times a day.It is 1 course for the treatment of to treat 4 weeks.Medication is checked after 2 weeks, carries out the experiment of tear basal secretion and tear film is broken
Split the measurement of time.
(4) clinical observation content
A, eye symptom；B, ocular signs (corneal fluorescein dyeing, lacrimal secretion)；C, tongue fur, pulse condition.
(5) result is observed in clinical trial
| Group | It cures | It improves | It is not cured | Total effective rate (%) |
| Treatment group | 8 | 31 | 1 | 97.5 |
| Control group | 2 | 25 | 13 | 67.5 |
The result shows that：
On inspection, total effective rate reaches 97.5% to 40 patients for the treatment of group after the treatment.Patient symptom disappears, corneal dyeing
Subside, lacrimal secretion is more than patient's number 8 of 10mm/5min, and cure rate reaches 20%；Symptom mitigates, and corneal dyeing is reduced,
The patient that lacrimal secretion increased has 31, and improvement effective percentage reaches 77.5%；Patient symptom does not have clear improvement, and tear
The patient that liquid secretory volume does not obviously increase has 1, and more rate is not 2.5%.
The present invention medicinal fuming steamed bun in use subject without any allergic reaction and other adverse reactions, explanation
The composition of the treatment xerophthalmia of the present invention has no adverse effects to human body.
To subject using there is no rebound phenomena in observation in 6 months after product of the present invention.
The Chinese medicine composition of two present invention of test example fumigates packet toxicological test
Traditional Chinese medicine fumigating steamed bun is made in embodiment 1, toxicity test is carried out to mouse：Stifling packet is placed in boiling water and is fully impregnated,
Oral gastric infusion and by the Chinese medicine composition by ultrasonic atomizatio administration, observe day by day, and record each group animal poisoning
As a result performance and dead animal number showed that the equal LD50 ＞ 5000ml/kg (weight) of two kinds of medications, true border were nontoxic to 14 days
Substance.
Toxicity test of the stifling packet to lagophthalmos nose：The traditional Chinese medicine fumigating steamed bun prepared according to embodiment 1 is placed in cup, using opening
After being completely soaked in water, then cup is placed in semi-enclosed rabbit-hutch of opening, the other side is with boiled distillation of boiling
Water is control.Then 1,6,24,48h and 4 day observer's rabbit conjunctival, iris and cornea and schneiderian membrane reaction (whether there is or not
The symptoms such as eye nasal congestion, rhinorrhea, cough), acquired results reaction integral is 0, is belonged to without compared with strong and stimulating and toxicity.
Case 1
Patient Lee, man, 32 years old, people from Baoding；Private prosecution eyes sense of discomfort and eyes pain 3 years, eye is itched, and eye is dry, eyesight
Before being much worse than, to check double eyeball conjunctival congestion, breakup time of tear film (BUT) right eye 4S, left eye 5S, Schimmer when going to a doctor
I test right eye 3mm/5min, left eye 2mm/5min, corneal fluorescein dye right eye+, left eye ++ be diagnosed as xerophthalmia (liver kidney yin
Deficiency), it is guaranteed to cure by this herbal fumigation and treats 2 courses for the treatment of, wherein each course for the treatment of 4 weeks, conjunctiva of both eyes hyperemia recession, feel eye
Dry to be clearly better, eyes moisten, and dry itch with eye of eye disappears after 1 course for the treatment of, and Dual-eyelid chemosis is rechecked after two courses for the treatment of
Subside, Schimmer I experiments check tear 15mm/5min (double), breakup time of tear film (BUT) 20S.
Case 2
Patient Chen, female, 57 years old, people from Beijing；Readme eye is dry, puckery 1 year of eye, is paid no attention to sodium hyaluronate eye drops effect
Think.The hyperemia of inspection conjunctiva of both eyes, corneal transparency when medical, pupil 3mm, breakup time of tear film (BUT) right eye 3S, left eye 4S,
Schimmer I experiment inspection tear 2mm/5min (double), corneal fluorescein dyeing right eye+, left eye ++, it is diagnosed as xerophthalmia (liver
Kidney yin deficiency type), after traditional Chinese medicine fumigating steamed bun using the present invention carries out 2 courses for the treatment of of fumigation treatment, wherein each course for the treatment of 4 weeks, eyelid, eye
Ball, conjunctival congestion are subsided, eye is dry and eye is itched disappearance, breakup time of tear film (BUT) 15s.Schimmer I experiments check tear
14mm/5min (double), all inadaptations are eliminated and are fully recovered.
Case 3
Patient Lee, female, 40 years old, people from Heilungkiang, dry and astringent 1 year of eyes distending pain was envious sometimes.Checked when medical Dual-eyelid without
Abnormal, conjunctiva mild hyperaemia, corneal transparency, deep in anterior chamber, pupil 3mm, sensitive to light reflection, breakup time of tear film (BUT) is right
Eye 3S, left eye 2S, Schimmer I experiments check that tear eyes are 0, and corneal fluorescein dyes right eye ++, left eye+, it is diagnosed as
Xerophthalmia (liver-kidney yin deficiency).By two course for the treatment of fumigation treatments of this traditional Chinese medicine fumigating steamed bun, wherein each course for the treatment of surrounding, dry eye condition
All disappear, the undeliverable dye of corneal fluorescein dyeing, breakup time of tear film (BUT) right eye 12s, left eye 15s.Schimmer I experiments
Right eye 13mm/5min, left eye 14mm/5min.
Case 4
Patient Zhao, man, 38 years old, people from Liaoning, eyes were dry and astringent, cannot regard more than 2 years long.The conjunctival congestion of inspection double eyeball+, it is double
Cornea is transparent, and deep in anterior chamber, pupil 3mm, light reflection is sensitive, breakup time of tear film (BUT) right eye 3S, left eye 2S,
Schimmer I test right eye 1mm/5min, left eye 4mm/5min, and corneal fluorescein dyes right eye ++, left eye ++, it is diagnosed as doing
Eye disease (liver-kidney yin deficiency).By the fumigation treatment of three courses for the treatment of of this traditional Chinese medicine fumigating steamed bun, each course for the treatment of surrounding, eyes dry eye condition
It all disappears, conjunctiva of both eyes is without hyperemia, corneal transparency, deep in anterior chamber, pupil 3mm, breakup time of tear film sensitive to light reflection
(BUT) right eye 18s, left eye 16s.Schimmer I test right eye 25mm/5min, left eye 20mm/5min, cornea of both eyes fluorescein
The undeliverable dye of dyeing, dry eye condition all disappear.
Case 5
Patient fiber crops certain, female, 70 years old, people from Beijing, the dry and astringent shouting pain of eyes, cannot long regard 3 months.Check conjunctiva of both eyes without filling
Blood, corneal transparency is deep in anterior chamber, pupil 3mm, breakup time of tear film (BUT) right eye 4S, left eye 4S sensitive to light reflection,
Schimmer I test right eye 7mm/5min, left eye 8mm/5min, and corneal fluorescein dyeing has no dye, is diagnosed as eyes dry eyes
Disease (liver-kidney yin deficiency).By one course for the treatment of fumigation treatment of this traditional Chinese medicine fumigating steamed bun, wherein each course for the treatment of surrounding, patient's dry eye condition
It disappears, breakup time of tear film (BUT) right eye 15s, left eye 17s.Schimmer I test right eye 13mm/5min, left eye 15mm/
5min。
Claims (9)
1. a kind of Chinese medicine composition for treating xerophthalmia, characterized in that be made of the raw material of following weight：Mulberry leaf 0.5-
2, wild chrysanthemum 0.5-2, peppermint 0.5-2.
2. Chinese medicine composition as described in claim 1, characterized in that the weight of the raw material is：Mulberry leaf 0.5-
1.5, wild chrysanthemum 0.5-1.5, peppermint 0.5-1.5.
3. Chinese medicine composition as described in claim 1, characterized in that the weight of the raw material is：Mulberry leaf 1, mother chrysanthemum
Spend 1, peppermint 1.
4. a kind of preparation method of Chinese medicine composition that treating xerophthalmia, characterized in that carry out step in the following order：
1）Prepare raw material according to following weight：
Wild chrysanthemum 0.5-2, mulberry leaf 0.5-2, peppermint 0.5-2
2）Mulberry leaf, wild chrysanthemum, peppermint are crushed respectively, mulberry leaf, wild chrysanthemum, peppermint powder is made；
3）Mulberry leaf, wild chrysanthemum, peppermint powder be uniformly mixed to get.
5. preparation method as claimed in claim 4, characterized in that step 1）Described in the weight of raw material be：Mulberry leaf
0.5-1.5, wild chrysanthemum 0.5-1.5, peppermint 0.5-1.5.
6. preparation method as claimed in claim 4, characterized in that step 1）Described in the weight of raw material be：Mulberry leaf
1, wild chrysanthemum 1, peppermint 1.
7. preparation method as claimed in claim 4, characterized in that step 2）Described in mulberry leaf, wild chrysanthemum, peppermint powder grain
Spend >=40 mesh.
8. preparation method as claimed in claim 7, characterized in that step 2）Described in mulberry leaf, wild chrysanthemum, peppermint powder grain
Degree ranging from 40-60 mesh.
9. the Chinese medicine composition as described in claim 1-3 is arbitrary is preparing the application in preventing or/and treating dry eye drugs.
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| CN112933163A (en) * | 2021-02-05 | 2021-06-11 | 广州新锐视光学科技有限公司 | Method for classifying traditional Chinese medicine composition for treating asthenopia by external application and traditional Chinese medicine eye patch |
| CN112704705A (en) * | 2021-02-05 | 2021-04-27 | 广州新锐视光学科技有限公司 | Traditional Chinese medicine eye patch for relieving visual fatigue and preparation method thereof |
| CN116211916B (en) * | 2023-05-05 | 2023-12-15 | 广州白云山星群(药业)股份有限公司 | Application of grass mulberry chrysanthemum extract in preparing medicament for treating hypertonic xerophthalmia |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100953A (en) * | 1994-06-14 | 1995-04-05 | 咸阳市第三制药厂 | Eyedrops |
| CN101612199A (en) * | 2008-06-28 | 2009-12-30 | 孙斌 | The flushing liquor of treatment eyes redness and the distinguished and admirable tear of chance |
| CN103211869A (en) * | 2013-05-13 | 2013-07-24 | 陕西立众制药有限公司 | Traditional Chinese medicine eye drops used for treating acute conjunctivitis and preparation method thereof |
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2015
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100953A (en) * | 1994-06-14 | 1995-04-05 | 咸阳市第三制药厂 | Eyedrops |
| CN101612199A (en) * | 2008-06-28 | 2009-12-30 | 孙斌 | The flushing liquor of treatment eyes redness and the distinguished and admirable tear of chance |
| CN103211869A (en) * | 2013-05-13 | 2013-07-24 | 陕西立众制药有限公司 | Traditional Chinese medicine eye drops used for treating acute conjunctivitis and preparation method thereof |
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