CN105031439A - Pharmaceutic preparation for treating chronic periodontitis - Google Patents
Pharmaceutic preparation for treating chronic periodontitis Download PDFInfo
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- CN105031439A CN105031439A CN201510578695.6A CN201510578695A CN105031439A CN 105031439 A CN105031439 A CN 105031439A CN 201510578695 A CN201510578695 A CN 201510578695A CN 105031439 A CN105031439 A CN 105031439A
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Abstract
The invention belongs to the field of traditional Chinese medicine preparations, and particularly provides a pharmaceutic preparation for treating chronic periodontitis. The pharmaceutic preparation for treating the chronic periodontitis is prepared from 25 parts of raspberries, 20 parts of purple flower holly leaves, 25 parts of lysimachia fortunei maxim, 18 parts of common wedgelet fern leaves, 10 parts of flos eriocauli, 15 parts of unprocessed rehmannia roots, 20 parts of fructus forsythiae, 20 parts of radix ophiopogonis, 25 parts of milkvetch roots, 25 parts of roots of bidentate achyranthes, 20 parts of glabrous greenbrier rhizome, 15 parts of Chinese wolfberry fruit, 18 parts of cowherb seeds, 15 parts of radix paeoniae rubra, 20 parts of flos chrysanthemi, 15 parts of honeysuckle flowers and 5 parts of liquorice. The pharmaceutic preparation can treat the chronic periodontitis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of chronic periodontitis and its preparation method and application.
Background technology
Chronic periodontitis is a modal class periodontitis, accounts for 95% of patients with periodontitis, is expanded and cause by long-standing gingivitis to deep periodontal tissue.Clinically, gingivitis can be transited into periodontitis gradually, concealment, and therefore early discovery is very important with diagnosis periodontitis, because the consequence of periodontitis is serious more than gingivitis.Microorganism (antibacterial) is the initiation factor causing periodontitis.Be deposited in inflammation and swelling that bacterial plaque microorganism in the facing of tooth and gingiva intersection and gingival sulcus and product thereof cause gingiva, make local microecological environment be more conducive to some Periodontal Pathogens and grow, prolonging by expanding under gingivally on gingiva.Inflammation expanded range caused by them, to deep tissue, causes the destruction of periodontal tissue.Every factor that can increase the weight of bacterial plaque and be detained, as the exception etc. of tartar, ill fitting prosthesis, food impaction (getting stuck between the teeth), irregular tooth alignment, anatomic form, all can become the local promoting factor of periodontitis, increase the weight of and accelerate the progress of periodontitis.Periodontitis is multi-factor disease, and some systemic disease such as diabetes etc. also can have negative effect to periodontitis.Think the generation not having which kind of systemic disease or dysfunction directly can cause chronic periodontitis at present.In addition, some environmental factors and behavial factor such as smoking, stress etc. may be risk factors.Discovered in recent years genetic background also may be relevant with chronic periodontitis.For this reason, be bursting to and develop the needs that more medicines for the treatment of chronic periodontitis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of chronic periodontitis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of chronic periodontitis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Rubi parvifolii 25 parts, Ilex purpurea Hassk.[I.chinensis Sims 20 parts, large Herba Hyperici Japonici 25 parts, Herba Stenolomatis Chusani 18 parts, Flos Eriocauli 10 parts, 15 parts, the Radix Rehmanniae, Fructus Forsythiae 20 parts, Radix Ophiopogonis 20 parts, Radix Scutellariae 25 parts, Radix Achyranthis Bidentatae 25 parts, Rhizoma Smilacis Glabrae 20 parts, Fructus Lycii 15 parts, Semen Vaccariae 18 parts, Radix Paeoniae Rubra 15 parts, Flos Chrysanthemi 20 parts, Flos Lonicerae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of chronic periodontitis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of chronic periodontitis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment chronic periodontitis medicine being used for the treatment of chronic periodontitis.
Herba Rubi parvifolii, RubuscorchorifoliusL.f., leaf: antiinflammatory, synthetism.For severed finger.Root: dispelling, collateral-activating, heat clearing away is relieving convulsion.For infantile convulsion, bones and muscles pain due to rheumatism.The present invention uses leaf.
Ilex purpurea Hassk.[I.chinensis Sims is the plant of Aquifoliaceae.Be distributed in various places on the south China the Changjiang river, be often grown in sparse woods.Its root, leaf all can pharmacy, Classification system IlexpurpureaHassk., heat-clearing and toxic substances removing, promoting blood circulation and hemostasis.For upper respiratory tract hepatitis, chronic tracheitis, pyelonephritis, bacillary dysentery; Burn and scald is controlled in external, ulcer of the lower limb, leprelcosis, and extra earning is hemorrhage, cold injury, mastitis, chapped skin (ashing is adjusted outside oil and put on the skin).
Large Herba Hyperici Japonici is Primulaceae Lysimachia plant Arisaema balansae Engl. Herba lysimachiae capillipedis LysimachiafortuneiMaxim., with all herbal medicine.Summer, autumn gather, clean, dry, cutting or binding for subsequent use.Clearing away heat-damp and promoting diuresis, promoting blood flow to regulate menstruation.For flu, cough spitting of blood, enteritis, dysentery, hepatitis, infantile malnutrition, malaria, rheumatic arthritis, dysmenorrhea, amenorrhea, leucorrhea; Mastitis, conjunctivitis, venom, traumatic injury.
Herba Stenolomatis Chusani is Lindsaeaceae Folium Stenolomatis platymiscium Folium Stenolomatis Stenolomachusanum (L.) Ching, with all herbal medicine.The four seasons can adopt, and Xia Qiu is better.Clean, dry or using fresh herb.Hardship, cold.Heat-clearing and toxic substances removing, dampness removing.For cold, fever, cough, tonsillitis, parotitis, enteritis, dysentery, hepatitis, alimentary toxicosis, pesticide intoxication; Burn and scald is controlled in external, skin eczema.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: the traditional Chinese medical science thinks that periodontitis belongs to the category such as the traditional Chinese medical science " gingival atrophy ", " bleeding from the gum ".Li Dongheng thinks, various focusing depths represented, hemorrhage, red and swollen, pain and halitosis, how by steaming in stomach-fire, deficiency of kidney yin, burning hot evil poison is outer invade caused by.Herba Rubi parvifolii of the present invention, Ilex purpurea Hassk.[I.chinensis Sims, large Herba Hyperici Japonici, Herba Stenolomatis Chusani, Flos Eriocauli, the Radix Rehmanniae, Fructus Forsythiae, heat clearing away Radix Ophiopogonis internal organs pyretic toxicity are monarch drug, Radix Scutellariae, Radix Achyranthis Bidentatae, Rhizoma Smilacis Glabrae, Fructus Lycii, Semen Vaccariae, Radix Paeoniae Rubra, Flos Chrysanthemi, Flos Lonicerae liver and kidney tonifying, reinforcing Guyuan are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, reducing swelling and alleviating pain, treatment chronic periodontitis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get Herba Rubi parvifolii 25g, Ilex purpurea Hassk.[I.chinensis Sims 20g, large Herba Hyperici Japonici 25g, Herba Stenolomatis Chusani 18g, Flos Eriocauli 10g, Radix Rehmanniae 15g, Fructus Forsythiae 20g, Radix Ophiopogonis 20g, Radix Scutellariae 25g, Radix Achyranthis Bidentatae 25g, Rhizoma Smilacis Glabrae 20g, Fructus Lycii 15g, Semen Vaccariae 18g, Radix Paeoniae Rubra 15g, Flos Chrysanthemi 20g, Flos Lonicerae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get Herba Rubi parvifolii 25g, Ilex purpurea Hassk.[I.chinensis Sims 20g, large Herba Hyperici Japonici 25g, Herba Stenolomatis Chusani 18g, Flos Eriocauli 10g, Radix Rehmanniae 15g, Fructus Forsythiae 20g, Radix Ophiopogonis 20g, Radix Scutellariae 25g, Radix Achyranthis Bidentatae 25g, Rhizoma Smilacis Glabrae 20g, Fructus Lycii 15g, Semen Vaccariae 18g, Radix Paeoniae Rubra 15g, Flos Chrysanthemi 20g, Flos Lonicerae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
3, the preparation of capsule embodiment: get Herba Rubi parvifolii 25g, Ilex purpurea Hassk.[I.chinensis Sims 20g, large Herba Hyperici Japonici 25g, Herba Stenolomatis Chusani 18g, Flos Eriocauli 10g, Radix Rehmanniae 15g, Fructus Forsythiae 20g, Radix Ophiopogonis 20g, Radix Scutellariae 25g, Radix Achyranthis Bidentatae 25g, Rhizoma Smilacis Glabrae 20g, Fructus Lycii 15g, Semen Vaccariae 18g, Radix Paeoniae Rubra 15g, Flos Chrysanthemi 20g, Flos Lonicerae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment chronic periodontitis of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation chronic periodontitis case 60 example, 19 ~ 48 years old age.The shortest person of the course of disease 6 months, most elder reaches 2 years.
4.2 diagnostic criterias: (1) mostly is adult, also show in child or teenager.(2) have obvious bacterial plaque, tartar and local excitation factor, and with the inflammation of periodontal tissue and destructiveness more consistent.(3) prevalence and the state of an illness increase with the age and increase the weight of, and the state of an illness generally slow progress and increasing the weight of, also can have the active stage of rapid progress.(4) whole body general health, also can have some risk factor, as smoking, stress, osteoporosis etc.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: the attachment level of periodontal tissue and the reconstruction situation of alveolar bone recover normal substantially; Effective: the attachment level of periodontal tissue and the reconstruction of alveolar bone obviously improve before comparatively treating; Invalid: the attachment level of periodontal tissue and the reconstruction of alveolar bone unchanged.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 30 | 14 | 12 | 4 | 86.6 |
| Blank group | 30 | 1 | 1 | 28 | 6.7 |
Visible, the medicine that the present invention obtains can safe and effective treatment chronic periodontitis, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of chronic periodontitis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Rubi parvifolii 25 parts, Ilex purpurea Hassk.[I.chinensis Sims 20 parts, large Herba Hyperici Japonici 25 parts, Herba Stenolomatis Chusani 18 parts, Flos Eriocauli 10 parts, 15 parts, the Radix Rehmanniae, Fructus Forsythiae 20 parts, Radix Ophiopogonis 20 parts, Radix Scutellariae 25 parts, Radix Achyranthis Bidentatae 25 parts, Rhizoma Smilacis Glabrae 20 parts, Fructus Lycii 15 parts, Semen Vaccariae 18 parts, Radix Paeoniae Rubra 15 parts, Flos Chrysanthemi 20 parts, Flos Lonicerae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of chronic periodontitis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of chronic periodontitis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment chronic periodontitis medicine of chronic periodontitis according to claim 1.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107050337A (en) * | 2017-05-17 | 2017-08-18 | 黄小艳 | A kind of pharmaceutical composition for being used to treat periodontitis |
| CN111135233A (en) * | 2020-01-14 | 2020-05-12 | 南京医科大学附属口腔医院 | Immunoregulation preparation for treating chronic periodontitis and preparation method thereof |
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| CN101181416A (en) * | 2007-11-26 | 2008-05-21 | 胡玉翠 | Chinese medicine decoction for curing periodontitis |
| CN102488849A (en) * | 2011-12-28 | 2012-06-13 | 张君 | Traditional Chinese medicine composition used for treating periodontitis |
| CN103656127A (en) * | 2013-12-19 | 2014-03-26 | 王星月 | Traditional Chinese medicine for treating periodontitis |
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- 2015-09-12 CN CN201510578695.6A patent/CN105031439A/en active Pending
Patent Citations (4)
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| CN101181416A (en) * | 2007-11-26 | 2008-05-21 | 胡玉翠 | Chinese medicine decoction for curing periodontitis |
| CN102488849A (en) * | 2011-12-28 | 2012-06-13 | 张君 | Traditional Chinese medicine composition used for treating periodontitis |
| CN103656127A (en) * | 2013-12-19 | 2014-03-26 | 王星月 | Traditional Chinese medicine for treating periodontitis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107050337A (en) * | 2017-05-17 | 2017-08-18 | 黄小艳 | A kind of pharmaceutical composition for being used to treat periodontitis |
| CN111135233A (en) * | 2020-01-14 | 2020-05-12 | 南京医科大学附属口腔医院 | Immunoregulation preparation for treating chronic periodontitis and preparation method thereof |
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Application publication date: 20151111 |