CN104800497A - Traditional Chinese medicine composition for treating irregular menstruation of gynecology - Google Patents
Traditional Chinese medicine composition for treating irregular menstruation of gynecology Download PDFInfo
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- CN104800497A CN104800497A CN201510246891.3A CN201510246891A CN104800497A CN 104800497 A CN104800497 A CN 104800497A CN 201510246891 A CN201510246891 A CN 201510246891A CN 104800497 A CN104800497 A CN 104800497A
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Abstract
The invention provides a traditional Chinese medicine composition for treating irregular menstruation of gynecology, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared by the following raw materials: 12 parts of murraya euchrestifolia, 10 parts of short-stem ardisia crenata, 10 parts of rehmannia root, 10 parts of dogwood, 10 parts of Chinese angelica, 10 parts of tuckahoe, 10 parts of fruit of Chinese wolfberry, 10 parts of yam, 6 parts of cassia twig, 10 parts of teasel root, 10 parts of bark of eucommia, 6 parts of divaricate saposhnikovia root, 10 parts of snake slough, 10 parts of glossy privet fruit, 10 parts of yerbadetajo herb, and 5 parts of licorice root. The invention also discloses a preparation method. The traditional Chinese medicine composition is used for treating the irregular menstruation of gynecology.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind ofly be used for the treatment of Chinese medicine composition of gynecological's menoxenia and its preparation method and application.
Background technology
Menoxenia Xi Shi gynecological common disease, shows as the exception of menstrual cycle or amount of bleeding, can accompany that the moon is premenstrual, menstrual period time stomachache and General Symptoms.The cause of disease may be organic disease or malfunction.For this reason, be bursting to and develop the needs that more medicines for the treatment of menoxenia safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of gynecological's menoxenia disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of Chinese medicine composition being used for the treatment of gynecological's menoxenia, the active component contained by it is extracted by following weight crude drug and is prepared from: tetramerous jasminorange leaf 12 parts, Radix ardisiae brevicaulis 10 parts, Radix Rehmanniae 10 parts, Fructus Corni 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Poria, Fructus Lycii 10 parts, Rhizoma Dioscoreae 10 parts, Ramulus Cinnamomi 6 parts, Radix Dipsaci 10 parts, the Cortex Eucommiae 10 parts, Radix Saposhnikoviae 6 parts, Periostracum Serpentis 10 parts, Fructus Ligustri Lucidi 10 parts, Herba Ecliptae 10 parts, 5 parts, Radix Glycyrrhizae.
The described Chinese medicine composition being used for the treatment of gynecological's menoxenia, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described Chinese medicine composition being used for the treatment of gynecological's menoxenia, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of Chinese medicine composition in preparation treatment gynecological menoxenia medicine being used for the treatment of gynecological's menoxenia.
Above-mentioned tetramerous jasminorange leaf is Rutaceae Murraya plant tetramerous jasminorange leaf Murraya tetramera Huang, is used as medicine with Ye Hegen.The picking leaves of autumn in summer, autumn adopts root, cleans cutting, all can using fresh herb or dry in the shade for subsequent use.Expelling pathogenic wind from the body surface, promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis.For cold, fever, bronchitis, asthma, rheumatic numbness, bones and muscles pain, traumatic injury swelling and pain due to blood stasis, skin pruritus, eczema, venom, malaria, stomachache, edema etc.The present invention is used as medicine with leaf.
Radix ardisiae brevicaulis is Myrsinacea Ardisa plant Radix ardisiae brevicaulis Ardisia brevicaulis Diels, is used as medicine with root.Autumn and winter excavate, and clean and dry.Relieving sore-throat by clearing away heat, promoting blood circulation and detumescence.For laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore, venom, Fengshi Guanjie pain, traumatic injury.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: tetramerous jasminorange leaf of the present invention, Radix ardisiae brevicaulis, Radix Rehmanniae, Fructus Corni, Radix Angelicae Sinensis heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling is monarch drug, Poria, Fructus Lycii, Rhizoma Dioscoreae, Ramulus Cinnamomi, Radix Dipsaci, the Cortex Eucommiae, Radix Saposhnikoviae, Periostracum Serpentis, Fructus Ligustri Lucidi, Herba Ecliptae regulating menstruation, regulating QI to relieve pain, enriching yin and nourishing kidney are ministerial drug, and Radix Glycyrrhizae is adjuvant, mediation pig medicine, full side's compatibility, heat clearing away, regulating menstruation, blood circulation promoting and blood stasis dispelling, treatment menoxenia successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
1, the preparation of granule embodiment: get tetramerous jasminorange leaf 12g, Radix ardisiae brevicaulis 10g, Radix Rehmanniae 10g, Fructus Corni 10g, Radix Angelicae Sinensis 10g, Poria 10g, Fructus Lycii 10g, Rhizoma Dioscoreae 10g, Ramulus Cinnamomi 6g, Radix Dipsaci 10g, Cortex Eucommiae 10g, Radix Saposhnikoviae 6g, Periostracum Serpentis 10g, Fructus Ligustri Lucidi 10g, Herba Ecliptae 10g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
2, the preparation of Tablets Example: get tetramerous jasminorange leaf 12g, Radix ardisiae brevicaulis 10g, Radix Rehmanniae 10g, Fructus Corni 10g, Radix Angelicae Sinensis 10g, Poria 10g, Fructus Lycii 10g, Rhizoma Dioscoreae 10g, Ramulus Cinnamomi 6g, Radix Dipsaci 10g, Cortex Eucommiae 10g, Radix Saposhnikoviae 6g, Periostracum Serpentis 10g, Fructus Ligustri Lucidi 10g, Herba Ecliptae 10g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.
3, the preparation of capsule embodiment: get tetramerous jasminorange leaf 12g, Radix ardisiae brevicaulis 10g, Radix Rehmanniae 10g, Fructus Corni 10g, Radix Angelicae Sinensis 10g, Poria 10g, Fructus Lycii 10g, Rhizoma Dioscoreae 10g, Ramulus Cinnamomi 6g, Radix Dipsaci 10g, Cortex Eucommiae 10g, Radix Saposhnikoviae 6g, Periostracum Serpentis 10g, Fructus Ligustri Lucidi 10g, Herba Ecliptae 10g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.
4, traditional Chinese medicine composition for treating gynecological of the present invention menoxenia clinical research
4.1 general data: this Chinese medicine composition is applied to clinical observation gynecological menoxenia 80 cases, 17 ~ 32 years old age.The shortest person of the course of disease 3 months, most elder reaches 2 years, average 1.1 years.
4.2 diagnostic criterias:
4.2.1 infrequent menstruation a: menstrual blood loss is less than 10 milliliters or few and all wets to two layers of paper not saturating, even if hypomenorrhea.
4.2.2 change in menstrual cycle: repeatedly change in menstrual cycle more than 7 days persons.
4.2.3 menorrhagia: be that in continuous several menstrual cycle, BTB amount is many, but menstruation interval time and bleeding time are all regular, without the unexpected increase of intermenstrual bleeding, postcoital bleeding or menses.There is the class in ovulation type dysfunctional uterine bleeding in system.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: clinical recovery: menstrual cycle recovers normal, and menstrual blood volume is normal, maintains more than 3 months.Take a turn for the better: menstrual cycle recovers normal, and menstrual blood volume is normal, but can not maintain more than 3 months.Invalid: menstrual cycle and menstrual blood volume have no improvement.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Take a turn for the better | Invalid | Total effective rate (%) |
| Treatment group | 40 | 13 | 23 | 4 | 90 |
| Blank group | 40 | 4 | 3 | 33 | 17.5 |
Visible the present invention has good therapeutic effect to gynecological's menoxenia, and toxic and side effects does not occur treatments period.
Claims (4)
1. one kind is used for the treatment of the Chinese medicine composition of gynecological's menoxenia, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: tetramerous jasminorange leaf 12 parts, Radix ardisiae brevicaulis 10 parts, Radix Rehmanniae 10 parts, Fructus Corni 10 parts, Radix Angelicae Sinensis 10 parts, 10 parts, Poria, Fructus Lycii 10 parts, Rhizoma Dioscoreae 10 parts, Ramulus Cinnamomi 6 parts, Radix Dipsaci 10 parts, the Cortex Eucommiae 10 parts, Radix Saposhnikoviae 6 parts, Periostracum Serpentis 10 parts, Fructus Ligustri Lucidi 10 parts, Herba Ecliptae 10 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the Chinese medicine composition of gynecological's menoxenia as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the Chinese medicine composition of gynecological's menoxenia as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of Chinese medicine composition in treatment gynecological menoxenia medicine of gynecological's menoxenia according to claim 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412582A (en) * | 2015-12-02 | 2016-03-23 | 苏州枫灵医药科技有限公司 | Traditional Chinese medicine composition for treating abnormal menstruation |
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| CN101049400A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Composition of Chinese traditional medicine for treating barrenness caused by hypoplasia of uterus |
| CN104491315A (en) * | 2015-01-09 | 2015-04-08 | 卞毓平 | Traditional Chinese medicine composition for treating irregular menstrual period |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049400A (en) * | 2007-05-16 | 2007-10-10 | 北京艺信堂医药研究所 | Composition of Chinese traditional medicine for treating barrenness caused by hypoplasia of uterus |
| CN104491315A (en) * | 2015-01-09 | 2015-04-08 | 卞毓平 | Traditional Chinese medicine composition for treating irregular menstrual period |
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| 云南省食品药品监督管理局: "《云南省中药材标准》", 31 December 2005, 云南美术出版社 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412582A (en) * | 2015-12-02 | 2016-03-23 | 苏州枫灵医药科技有限公司 | Traditional Chinese medicine composition for treating abnormal menstruation |
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