CN105250552A - Pharmaceutical preparation used for treating acute gastroenteritis - Google Patents
Pharmaceutical preparation used for treating acute gastroenteritis Download PDFInfo
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- CN105250552A CN105250552A CN201510646240.3A CN201510646240A CN105250552A CN 105250552 A CN105250552 A CN 105250552A CN 201510646240 A CN201510646240 A CN 201510646240A CN 105250552 A CN105250552 A CN 105250552A
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Abstract
The invention belongs to the field of Chinese herbal preparations and particularly provides a pharmaceutical preparation used for treating acute gastroenteritis. The pharmaceutical preparation is prepared from 20 parts of awned goosefeet, 25 parts of herbal tripterospermi, 28 parts of piper kadsura, 22 parts of the roots of cinnamomum burmanni, 26 parts of agastache rugosus, 18 parts of pinellia ternate, 20 parts of codonopsis pilosula, 25 parts of rhizoma atractylodis macrocephalae, 20 parts of portulaca oleracea, 20 parts of folium artemisiae argyi, 20 parts of mangnolia officinalis, 20 parts of semen plantaginis, 20 parts of poria cocos, 20 parts of dandelion, 25 parts of houttuynia cordata, 15 parts of hairyvein agrimonia and 5 parts of licorice. The pharmaceutical preparation can treat acute gastroenteritis.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of acute gastroenteritis and its preparation method and application.
Background technology
Acute gastroenteritis is the acute inflammation of gastrointestinal mucosa, and clinical manifestation is mainly Nausea and vomiting, stomachache, diarrhoea, heating etc.Primary disease is common in summer and autumn, and it occurs many due to improper diet, eating and drinking too much at one meal; Or eat rotten sour, the foul unclean food of raw food.Often infect the most common with Salmonella and halophilic bacteria (vibrio parahaemolytious), toxin is common with staphylococcus aureus, and virus also can be seen.The situation of the morbidity of Chang You collective or familial prevalence.As eaten contaminated poultry, the meat of domestic animal, fish; Or eaten the marine product such as Eriocheir sinensis, spiral shell of halophilic bacteria growth and eaten by the polluted leftovers of staphylococcus aureus, leftovers etc. and brought out primary disease.Take food raw and cold food or some drugs as salicylic acid salt, sulfanilamide, some antibiotic etc.; Or wrongly take strong acid, highly basic and pesticide etc. and all can cause primary disease.For this reason, be bursting to and develop the needs that more medicines for the treatment of acute gastroenteritis safely and effectively meet clinical treatment.
Summary of the invention
In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of acute gastroenteritis disease.In order to reach this object, adopt following technical scheme:
Technical scheme: a kind of pharmaceutical preparation being used for the treatment of acute gastroenteritis, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Chenopodii Aristati 20 parts, Herba Tripterospermi 25 parts, Radix seu Caulis fici Martinii 28 parts, Radix Cinnamomi Burmanni 22 parts, Herba Pogostemonis 26 parts, the Rhizoma Pinelliae 18 parts, Radix Codonopsis 20 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Herba Portulacae 20 parts, Folium Artemisiae Argyi 20 parts, Cortex Magnoliae Officinalis 20 parts, Semen Plantaginis 20 parts, 20 parts, Poria, Herba Taraxaci 20 parts, Herba Houttuyniae 25 parts, Herba Agrimoniae 15 parts, 5 parts, Radix Glycyrrhizae.
The described pharmaceutical preparation being used for the treatment of acute gastroenteritis, dosage form is pharmaceutically acceptable granule, tablet, capsule.
The described pharmaceutical preparation being used for the treatment of acute gastroenteritis, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
The described application of pharmaceutical preparation in preparation treatment acute gastroenteritis medicine being used for the treatment of acute gastroenteritis.
Herba Chenopodii Aristati is Chenopodiaceae genus Chenopodium Herba Chenopodii Aristati ChenopodiumaristatumL., with all herbal medicine.Xia Qiu gathers, and cleans cutting, dries.Dispelling wind for relieving itching.Allergic dermatitis is controlled in external, urticaria.
Herba Tripterospermi is the herb of Gentianaceae Tripterospermum plant Tripterospermum affine Tripterospermumaffine (Wall.) H.Smith.The four seasons can adopt.Clean, dry.Heat-clearing and toxic substances removing, cough-relieving is stopped blooding.For bronchitis, hemoptysis of pulmonary tuberculosis, pneumonia, lung abscess, nephritis, urinary system infection; Furuncle furuncle and phyma is controlled in external, mastitis, traumatic hemorrhage.
Radix seu Caulis fici Martinii is root, the stem of moraceae plants Martin fig.
Radix Cinnamomi Burmanni is the cloudy fragrant root of canella.All the other Chinese medicines are pharmacopeia kind.
Beneficial effect: acute gastroenteritis belongs to vomiting in the traditional Chinese medical science, scope of having loose bowels, the traditional Chinese medical science thinks the generation of primary disease, is that eating cold and uncooked food excessively is rich, so that impairing the spleen and stomach by the heresy of heat-damp in summer or greedy cool feeling by cold-damp, dysfunction of the spleen in transportation and transformation and causing a disease.Herba Chenopodii Aristati of the present invention, Herba Tripterospermi, Radix seu Caulis fici Martinii, Radix Cinnamomi Burmanni, Herba Pogostemonis heat-clearing and toxic substances removing, air making-up and spleen enlivening are monarch drug, the Rhizoma Pinelliae, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Herba Portulacae, Folium Artemisiae Argyi, Cortex Magnoliae Officinalis, Semen Plantaginis, Poria, Herba Taraxaci, Herba Houttuyniae, Herba Agrimoniae dampness diuretic, promoting digestion and removing stagnation is ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment acute gastroenteritis successful.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1, the preparation of granule embodiment: get Herba Chenopodii Aristati 20g, Herba Tripterospermi 25g, Radix seu Caulis fici Martinii 28g, Radix Cinnamomi Burmanni 22g, Herba Pogostemonis 26g, Rhizoma Pinelliae 18g, Radix Codonopsis 20g, Rhizoma Atractylodis Macrocephalae 25g, Herba Portulacae 20g, Folium Artemisiae Argyi 20g, Cortex Magnoliae Officinalis 20g, Semen Plantaginis 20g, Poria 20g, Herba Taraxaci 20g, Herba Houttuyniae 25g, Herba Agrimoniae 15g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.
Embodiment 2, the preparation of Tablets Example: get Herba Chenopodii Aristati 20g, Herba Tripterospermi 25g, Radix seu Caulis fici Martinii 28g, Radix Cinnamomi Burmanni 22g, Herba Pogostemonis 26g, Rhizoma Pinelliae 18g, Radix Codonopsis 20g, Rhizoma Atractylodis Macrocephalae 25g, Herba Portulacae 20g, Folium Artemisiae Argyi 20g, Cortex Magnoliae Officinalis 20g, Semen Plantaginis 20g, Poria 20g, Herba Taraxaci 20g, Herba Houttuyniae 25g, Herba Agrimoniae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.
Embodiment 3, the preparation of capsule embodiment: get Herba Chenopodii Aristati 20g, Herba Tripterospermi 25g, Radix seu Caulis fici Martinii 28g, Radix Cinnamomi Burmanni 22g, Herba Pogostemonis 26g, Rhizoma Pinelliae 18g, Radix Codonopsis 20g, Rhizoma Atractylodis Macrocephalae 25g, Herba Portulacae 20g, Folium Artemisiae Argyi 20g, Cortex Magnoliae Officinalis 20g, Semen Plantaginis 20g, Poria 20g, Herba Taraxaci 20g, Herba Houttuyniae 25g, Herba Agrimoniae 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.
4, pharmaceutical preparation treatment acute gastroenteritis of the present invention clinical research
4.1 general data: this pharmaceutical preparation is applied to clinical observation acute gastroenteritis 80 cases, 16 ~ 48 years old age.The shortest person of the course of disease 1 day, most elder reaches 2 weeks.
4.2 diagnostic criterias: (1). parasitic infection: Peripheral blood eosinophilia is found in ancylostome, schistosomicide, cestode, parasitic disease caused by capsule quasi-colubriformis, respectively has its clinical manifestation.(2) gastrointestinal tract cancerous protuberance and malignant lymphoma: Peripheral blood eosinophilic granulocyte also can be had to increase, but belong to Secondary cases, cancerous protuberance and lymphadenomatous other should be had to show.(3) eosinophilic granuloma: mainly betide harmonization of the stomach large intestine, small intestinal is localized mass, and pathologic diagnosis is mixed in connective tissue matrix for eosinophilic granuloma, and allergies are rare, and in Peripheral blood, leukocyte count and eosinophilic granulocyte often do not increase.(4) eosinophilia: except Peripheral blood eosinophilic granulocyte increases, pathological changes not only involves intestinal, also extensively involves other organa parenchymatosums, and as brain, the heart, lung, kidney etc., its course of disease is short, poor prognosis, is everlasting dead in a short time.
4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule one month is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.
4.4 criterions of therapeutical effect: recovery from illness: clinical symptom disappearance, result of laboratory test is normal, and ordinary circumstance is good; Effective: clinical symptom disappearance is fast, chemical examination is close to normal; Effective: clinical symptoms reduces gradually, result of laboratory test alleviates; Invalid: clinical symptoms and stool without changing, and use other medicine instead.
4.5 therapeutic effect: in table 1.
Table 1 liang group comparitive study
| Group | n | Recovery from illness | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 40 | 8 | 10 | 18 | 4 | 90 |
| Blank group | 40 | 1 | 1 | 1 | 37 | 7.5 |
Visible, the medicine that the present invention obtains can safe and effective treatment acute gastroenteritis, and has no side effect.
Claims (4)
1. one kind is used for the treatment of the pharmaceutical preparation of acute gastroenteritis, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Chenopodii Aristati 20 parts, Herba Tripterospermi 25 parts, Radix seu Caulis fici Martinii 28 parts, Radix Cinnamomi Burmanni 22 parts, Herba Pogostemonis 26 parts, the Rhizoma Pinelliae 18 parts, Radix Codonopsis 20 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Herba Portulacae 20 parts, Folium Artemisiae Argyi 20 parts, Cortex Magnoliae Officinalis 20 parts, Semen Plantaginis 20 parts, 20 parts, Poria, Herba Taraxaci 20 parts, Herba Houttuyniae 25 parts, Herba Agrimoniae 15 parts, 5 parts, Radix Glycyrrhizae.
2. be used for the treatment of the pharmaceutical preparation of acute gastroenteritis as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.
3. be used for the treatment of the pharmaceutical preparation of acute gastroenteritis as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.
4. be used for the treatment of the application of pharmaceutical preparation in treatment acute gastroenteritis medicine of acute gastroenteritis according to claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510646240.3A CN105250552A (en) | 2015-10-09 | 2015-10-09 | Pharmaceutical preparation used for treating acute gastroenteritis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510646240.3A CN105250552A (en) | 2015-10-09 | 2015-10-09 | Pharmaceutical preparation used for treating acute gastroenteritis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233074A (en) * | 2015-11-21 | 2016-01-13 | 王亚鹤 | Medicinal preparation used for promoting appetite and application thereof |
| CN106421604A (en) * | 2016-11-03 | 2017-02-22 | 杨均初 | Traditional Chinese medicinal composition for treating acute gastroenteritis and preparation method of traditional Chinese medicinal composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1733180A (en) * | 2005-08-01 | 2006-02-15 | 颜怀玮 | Medicine, food used article for preventing and curing acute gastroenteritis and method for producing the same |
| CN103495148A (en) * | 2013-10-08 | 2014-01-08 | 张淳珂 | Traditional Chinese medicine for treating acute gastroenteritis |
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2015
- 2015-10-09 CN CN201510646240.3A patent/CN105250552A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1733180A (en) * | 2005-08-01 | 2006-02-15 | 颜怀玮 | Medicine, food used article for preventing and curing acute gastroenteritis and method for producing the same |
| CN103495148A (en) * | 2013-10-08 | 2014-01-08 | 张淳珂 | Traditional Chinese medicine for treating acute gastroenteritis |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233074A (en) * | 2015-11-21 | 2016-01-13 | 王亚鹤 | Medicinal preparation used for promoting appetite and application thereof |
| CN106421604A (en) * | 2016-11-03 | 2017-02-22 | 杨均初 | Traditional Chinese medicinal composition for treating acute gastroenteritis and preparation method of traditional Chinese medicinal composition |
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Application publication date: 20160120 |