CN101897733B - Drug for curing bladder stone and preparation method thereof - Google Patents

Abstract

The invention discloses a drug for curing bladder stone and a preparation method thereof, belonging to the field of Chinese herba preparation. The drug is a submerged fermentation product of Phellinus linteus mycelium mother strain, and the submerged fermentation medium is a water extract which is prepared from the following crude drugs of traditional Chinese medicine in parts by weight: 1-3 parts of immature bitter orange, 8-12 parts of Lygodium japonicum vine, 3-8 parts of Lygodium japonicum, 8-12 parts of plantain, 3-8 parts of plantain seed, 4-6 parts of talcum powder, 8-12 parts of chicken's gizzardskin, 8-12 parts of tuckahoe, 1-3 parts of Chinese waxgourd peel, 1-3 parts of ginger peel, 8-12 parts of crude hawthorn, 10 parts of fried hawthorn, 8-12 parts of green malt, 8-12 parts of fried malt, 8-12 parts of rice-grain sprout, 8-12 parts of fried rice sprout, 8-12 parts of medicated leaven and 8-12 parts of semen raphani. The submerged fermentation time is 72-114h and the inoculation amount of Phellinus linteus mycelium liquid in the water extract is 5-15% (W/W). The drug has rapid response and high cure rate, and is suitable for bladder stone patients with various symptom types.

Description

Cystolithic medicine of a kind of treatment and preparation method thereof

Technical field

The present invention relates to Chinese medicine preparation, cystolithic medicine of particularly a kind of treatment and preparation method thereof.

Background technology

Calculus is to be accumulated too much by the oxalic acid in the food; The purine composition is piled up; Calcium, oxalates, urate composition increase in the unnecessary urine, secondly are carbonate, cystine, sulfonamide, take and control the stomach Western medicine for a long time, and these crystallised components deposit in urine and form the in-house calculus of urinary system.

Cystolithic composition mainly contains: calcium oxalate, podolite, urate, ammonium magnesium phosphate, calcium phosphate, calcium carbonate, cystine etc.Can be divided into constitutional and Secondary cases and mainly betide the male for two kinds.The constitutional vesical calculus is many to be mainly in the infant except some outlying mountain areas by due to the malnutrition now, rare.The Secondary cases vesical calculus mainly is secondary to benign prostate hyperplasia, has occurred in urethral stricture, diverticulum of bladder, foreign body easily and comprises long-term drainage catheter and neurogenic bladder dysfunction etc. along with this disease of life-time dilatation also increases other calculus gradually.Mostly the constitutional vesical calculus is single property, is oval, and mostly the Secondary cases vesical calculus is the Combination of calcium oxalate, calcium phosphate and uric acid, for a plurality of than microlith.Vesical calculus is many to be formed at intravesical, and minority is divided a word with a hyphen at the end of a line from last urinary tract.Vesical calculus has provincialism, is more common in the boy below 10 years old, like relevant with nutrition.Along with improving constantly of Chinese people's living standard, cystolithic sickness rate has minimizing trend.Old people's vesical calculus often is the complication of hyperplasia of prostate.

But little calculus per urethra is discharged voluntarily, than the maximum size feasible intravesical lithotrity of discharge person voluntarily.Lithotripsy method has ESWL and liquid surge rubble, ultrasound wave stone and lithotrite rubble.Than the maximum size and the feasible suprapubic cystolithotomy of person that do not have the rock crushing plant, be combined bladder infection person, active treatment inflammation simultaneously.

Cystolithic western medical treatment method is more, but two types substantially, one type is surgical calculus removing, one type is non-operation rubble.Wherein surgical calculus removing is traditional suprapubic cystolithotomy, and another kind of non-operation rubble then can be divided into cystoscope mechanical lithotripsy (locking pliers rubble), electrohydraulic effect rubble, ultrasonic rubble, trajectory air pressure rubble etc. again.Mainly contain following four kinds of methods

Behind the ESWL bladder lithotripsy method patient emptying bladder, interior injection normal saline 100ml, but intravesical urine can not emptying person's reserve part urine, gets the ventricumbent position, removes fixture behind the rubble.It is movable to let about the patient, observes the pulverizing situation, and gravel particle＜0.5cm gets final product.Postoperative 3 days, intramuscular injection furosemide 20mg 2 times/day, increases amount of drinking water, 1 week of oral antibiotic.Cystoscope is lithotripsy method energetically: sacrum fiber crops successes back calculi position, and urethra injects liquid paraffin 5ml, calculus is pressed from both sides under the Forceps for breaking stone in bladder direct-view brokenly energetically at 24F, and repeatable operation is till can going out crushed stone with irrigator fully.

Cystoscope electrohydraulic effect lithotripsy method method is with the locking pliers rubble, guarantees when just operating more than the electrode distance cystoscope 2cm, and guarantees that the electrode spacing calculus is lower than 0.5cm, and appearance is effective rubble both, can avoid damaging cystoscope again.Suprapubic cystolithotomy successively cuts after bladder is got clean calculus after the epidural anesthesia success, merges severe infections, patient's suprapubic cystotomy.Cystolithic Chinese traditional treatment, cystolithiasis can be different because of the position that calculus exists, and the branch of renal calculus, ureteral calculus, vesical calculus and calculus of urethra is arranged, and are referred to as " stranguria caused by urinary stone " or " sand Stranguria " in the Chinese medicine.For urinary system calculus sick formation and prevention, the conditioning of diet and compatibility and incompatibility of drugs have crucial positive effect.Common dialectical dispenser: lower warmer wetness-heat type: disease is seen waist or hypogastric region constant pain, and is not well with heating, nausea and vomiting, frequent micturition, urgent micturition, dysurea, stool, or hematuria, pyuria, yellow and greasy fur, slippery and rapid pulse are arranged.Control suitable: clearing away heat-damp and promoting diuresis, Tonglin Paishi.Can obey: lithagogue infusion, Herba Lysimachiae granule, FENQINGWULIN WAN, Pill for Replenishing the Kidney-yin etc.Qi stagnation and blood stasis type: disease is seen patient's waist or hypogastric region paroxysm angor, or hematuria is arranged, or rarely seen waist or distention and pain in the lower abdomen, urinates the puckery sound of rain pattering not to the utmost, and is light when heavy during symptom, dimly red tongue or petechia is arranged, white and thin fur, stringy and hesitant pulse.Control suitable: promoting flow of QI and blood, Tonglin Paishi.Can obey: Niaosaitong, Shao Fu Zu Yu Wan, drench electuary etc. clearly.Spleen kidney both deficiency type: with the passing of time disease sees calculus, lumbago, and the lower limb knees soreness is unable, tired mind, diet is not good enough, and big loose stool is thin, and it is not smooth to urinate, pale tongue with white fur, deep,thready and forceless pulse.Control suitable: training spleen reinforcing kidney, treating stranguria fossil.Can obey: JINGUI SHENQI WAN, LIUJUNZI WAN, lithagogue infusion etc.Control suitable invigorate the spleen and warm the kidney, tonifying YANG fossil, eliminating damp-heat, blood stasis dispelling calculus.

Comprehensive, with respect to the misery that the physical method rubble brings to the patient, the therapeutic process comfort level of traditional Chinese medicine lithagogue is higher.Do not see at present medicament in the vesical calculus calculus that is fit to multiple symptom type as yet.The applicant has kept grain surplus the big microlith 80 that the people discharges surplus the patient 60.

Summary of the invention

The present invention is directed to the demand and the defective in above-mentioned field, cystolithic medicine of a kind of treatment and preparation method thereof is provided.This medicine effect instant effect, cure rate height, the vesical calculus patient of suitable multiple symptom type.

The cystolithic medicine of a kind of treatment; Be the female submerged fermentation product of planting of phellinus liteus, the culture medium of said submerged fermentation is the water extract of following component and parts by weight of Chinese traditional medicine crude drug: 1～3 part of Fructus Aurantii Immaturus, 8～12 parts of Herba lygodiis, 3～8 parts of Spora Lygodii, 8～12 parts of Herba Plantaginiss, 3～8 parts of Semen Plantaginiss, 4～6 parts of Pulvis Talci, 8～12 parts of Endothelium Corneum Gigeriae Galli, 8～12 parts in Poria, 1～3 part of Exocarpium Benincasae, 1～3 part of CORTEX ZINGIBERIS RHIZOMAE, 8～12 parts of Fructus Crataegi, 10 parts of Fructus Crataegi (parched), 8～12 parts of Fructus Hordei Germinatus, 8～12 parts of Fructus Hordei Germinatus (parched)s, 8～12 parts of living Fructus Setariae Germinatuss, 8～12 parts of Fructus Setariae Germinatus (parched), 8～12 parts of Massa Medicata Fermentata, 8～12 parts of Semen Raphanis; The said submerged fermentation time is 72～114 hours, and the inoculum concentration of said phellinus liteus liquid in water extract is 5～15% (W/W).

Said component and parts by weight of Chinese traditional medicine crude drug are: 2 parts of Fructus Aurantii Immaturuss, 10 parts of Herba lygodiis, 5 parts of Spora Lygodii, 10 parts of Herba Plantaginiss, 5 parts of Semen Plantaginiss, 5 parts of Pulvis Talci, 10 parts of Endothelium Corneum Gigeriae Galli, 10 parts in Poria, 2 parts of Exocarpium Benincasaes, 2 parts of CORTEX ZINGIBERIS RHIZOMAEs, 10 parts of Fructus Crataegi, 10 parts of Fructus Crataegi (parched), 10 parts of Fructus Hordei Germinatus, 10 parts of Fructus Hordei Germinatus (parched)s, 10 parts of living Fructus Setariae Germinatuss, 10 parts of Fructus Setariae Germinatus (parched), 10 parts of Massa Medicata Fermentata, 10 parts of Semen Raphanis.

The inoculum concentration of said phellinus liteus liquid in water extract is 10% (W/W).

Manufacturing method for above mentioned medicine comprises that step is following:

(1) preparation water extract: after said component and bulk drugs mixing, each amount of water is 5～10 times of crude drug gross weight, decocts 2～3 times, and each 1～2 hour, merge each time medicinal liquid, abandon medicinal residues, get water extract;

(2) inoculation: water extract is carried out the normal pressure deactivation, to be cooled to room temperature, insert phellinus liteus liquid;

(3) submerged fermentation: fermentation time is 72～114 hours.

Said submerged fermentation is after 72～114 hours, and to tunning last the powder of putting jar, concentrate, dry, sieve, refined honey becomes ball.

Said normal pressure deactivation refers to that water steamed 12 hours under the normal pressure.

Said phellinus liteus liquid is the female turbid solution that in the 400ml fluid medium, ferments and obtained in 72～96 hours of planting of test tube phellinus liteus; Said fluid medium is said water extract; In said water extract, also added the aid nutrition material of 11～15% (W/W), said aid nutrition material is made up of following components in part by weight: 5 parts of dipotassium hydrogen phosphates, 5 parts of potassium dihydrogen phosphates, 2 parts in zinc sulfate, 2 parts of aspartic acids, 2 parts in mannitol, 50 parts of white sugar, 20 parts of yeast extracts, 100 parts of nutrient agars.

The present invention according to the vesical calculus patient be mostly to have damp-heat in lower-JIAO, the characteristics of symptom such as qi depression to blood stasis or asthenia of both the spleen and kidney, impose clearing away heat-damp and promoting diuresis, promoting flow of QI and blood; The symptomatic drugs of training spleen reinforcing kidney, Tonglin Paishi, the various glandular secretion characteristics of facilitating digestion road and urinary tract, and can assist these secretions in layer to dissolve calculus; The lubricated pipeline of urinating is discharged calculus, also contains several mineral materials in these medicines; Can produce chemical reaction to calculus, impel calculus to strip off, fragmentation; With the physics rubble means in the western medical treatment play the same tune on different musical instruments wonderful arranged; These medicines make calculus not have the formation of calculus composition for a long time and lose pillar, the surface floating layer is disappeared gradually fall to diminish, and help down to drain through narrow mouthful.Add muchly in these medicines have a treating stranguria effect, the function of expansion tube wall is arranged again, can get rid of the calculus that diminishes external.Outpatient service receives observes 40 routine patients, and cure rate is 80%

Medicine among the present invention is main with the Phellinus igniarius (L. ex Fr.) Quel. tunning; Be aided with multiple clearing away heat-damp and promoting diuresis; Promoting flow of QI and blood; The crude drug of training spleen reinforcing kidney or Tonglin Paishi: Fructus Aurantii Immaturus, Herba lygodii, Spora Lygodii, Herba Plantaginis, Semen Plantaginis, Pulvis Talci, Endothelium Corneum Gigeriae Galli, Poria, Exocarpium Benincasae, CORTEX ZINGIBERIS RHIZOMAE, Fructus Crataegi, Fructus Crataegi (parched), Fructus Hordei Germinatus, Fructus Hordei Germinatus (parched), living Fructus Setariae Germinatus, Fructus Setariae Germinatus (parched), Massa Medicata Fermentata, Semen Raphani.Medicine of the present invention is not only the simple compatibility mixing of various medicines; But the product that various medical herbs get with the Phellinus igniarius (L. ex Fr.) Quel. submerged fermentation behind meticulous compatibility; Various crude drug are as the fermentation medium of Phellinus igniarius (L. ex Fr.) Quel.; Effective ingredient is transferred in the phellinus liteus mixed, make between the composition and produce synergism with the phellinus liteus fermentating metabolism product is organic.The nature and flavor of the crude drug of medicine of the present invention, cure mainly symptom and the source as follows:

Phellinus igniarius (L. ex Fr.) Quel., Mycophyta Basidiomycetes Aphyllophorales Polyporaceae Phellinus igniarius (L. ex Fr.) Quel. Phellinus igniarius (L.ex Fr.) Quel. [Fomes igniarius L.ex Fr.] is used as medicine with sporophore.Have another name called: phellinus igniarius. be born on the trunks such as poplar, willow, birch, oak.Ground such as distribution northeast, North China, northwest and Sichuan, Yunnan.Another name monkey eye, Mulberry, phellinus; Meridian distribution of property and flavor: little hardship, cold.Function cures mainly: sharp the five internal organs, and softening the hard mass, toxin expelling, stomach function regulating antidiarrheal is invigorated blood circulation in hemostasis.Cure mainly gonorrhea, bleeding not during menses, lump in the abdomen, addiction drink, diarrhea due to hypofunction of the spleen " national Chinese herbal medicine compilation ".

Fructus Aurantii Immaturus: for Rutaceae kind of plant Citrus aurantium Linn. and variety or Fructus Citri sinensis young fruit.Hardship is slightly cold.Return spleen, stomach, large intestine channel.Circulation of qi promoting removes distension, the numbness of reducing phlegm out, consumer product dredge stasis.These article can be regulated the flow of vital energy, and can reduce phlegm again, and phlegm-damp is held back resistance breast sun, hypofunction of YANG QI in chest, thoracic obstruction pain, can join Fructus Trichosanthis, and article such as Bulbus Allii Macrostemonis, Ramulus Cinnamomi are with using; With control combination of phlegm and heat, the feeling of stuffiness in chest by pain, can join Rhizoma Coptidis, Fructus Trichosanthis is equal to usefulness; Can join Pericarpium Citri Reticulatae, the Rhizoma Pinelliae, Rhizoma Gastrodiae for abundant expectoration cough, dizziness due to wind-phlegm etc. and be equal to usefulness.Be used for diseases such as food stagnation stagnation, constipation stomachache and dysentery are smooth, tenesmus.

Herba lygodii: another name: Zhen Dongmao, bitter rattan (Taiwan), Spora Lygodii, left-hand rotation rattan, Oviductus Ranae rattan, net rattan, wire plant, the grass of weaving silk, ancient cooking vessel are wiped rattan, violent ancient rattan.Climb up by holding on to for Lygodiaceae is perennial pteridophyta Spora Lygodii Lygodium japonicum (Thunb.) Sw. herb.Sweet, cold.Return bladder, small intestine meridian.Inducing diuresis for treating stranguria syndrome.Heat-clearing and toxic substances removing, relieving stranguria by diuresis.Control urinary tract infection, lithangiuria, the nebulousurine leukorrhagia, dysuria, oedema due to nephritis, jaundice due to damp-heat, cold, fever, cough, laryngopharynx swelling and pain, enteritis, dysentery are scalded erysipelas.① "Lu crags Materia Medica": "cure gonorrhea by heat pain and dysuria." 2. " the SHENGCAO property of medicine is wanted fully ": " specially managed traumatic injury." 3. " classification medical herbs property ": " annealing.Control stranguria, cough, bones and muscles pain." 4. " Tian Bao book on Chinese herbal medicine ": " suppressing the hyperactive liver Ji fire.Control children's's Scarabaeiform infantile malnutrition, the red pouring drop that collapses." 5. " south of the Five Ridges gather medicinal herbs record ": " is treating stranguria, sharp small intestinal, analgesic poison.It is cold fanatic to cure the wound, damp and hot generalized edema with distention of the chest and abdomen, and pain in the penis is treated the variola blackening.6. " Guangzhou flora ": " can apply the stagnation of the blood, can go up spitting of blood again." 7. " Guizhou side's medicine among the people collection ": " controlled five types of stranguria nebulousurine, consumer edema." 8. " Sichuan Chinese medicinal herbal ": " controlled the consumptive disease cough caused by pathogenic fire of coughing." 9. " the temmoku Rhizoma Dioscoreae is planted will in Zhejiang ": " harnesses the river swollen, jaundice due to damp-heat, laryngopharynx swelling and pain, conjunctival congestion and swelling pain, toothache due to stomach-fire, blister skin ulcer.10. Guangzhou army " Chinese herbal medicine handbook commonly used: " heat clearing away, diuretic, treating stranguria.Control urinary tract infection, lithangiuria, oedema due to nephritis, cold, fever, oliguria with reddish urine, enteritis and dysentery." (11) " Guangxi Chinese herbal medicine ": " controlled burn." (12) Chengdu " herbtherapy handbook commonly used: " promoting blood circulation to remove obstruction in the collateral is controlled pertussis.″

Spora Lygodii Spora Lygodii, (English) Japanese Climbing Fern Spore, another name ferrum Scolopendra, gold sand cut, net rattan, wire plant, clam call out rattan, left-hand rotation rattan.Spore for Lygodiaceae plant Spora Lygodii Lygodium japonicum (Thunb.) Sw..Eliminating damp-heat, treating stranguria pain relieving.Be used for pyretic stranguria, sand Stranguria, stranguria with blood, stranguria marked by chyluria, Urethra astringent pain.

Herba Plantaginis has another name called the wheel dish, is the Plantaginaceae perennial herb.Nature and flavor and function are sweet, and be cold, returns the hands sun, Yangming Channel.Diuretic, heat clearing away makes eye bright, and eliminates the phlegm, and is used for urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, jaundice, edema, hematodiarrhoea is had loose bowels, epistaxis, conjunctival congestion and swelling pain, laryngalgia, cough, skin ulcer.

Semen Plantaginis, Semen Plantaginis (Ch ē Qi á n Z ǐ) has another name called Herba Plantaginis reality, Rana limnocharis clothing, pig ear tassel, phoenix eyes Semen Plantaginis, and these article are the dry mature seed of Plantaginaceae plant Herba Plantaginis.Nature and flavor are sweet; Light; Cold nature.Gui Jing: return lung; Liver; Kidney; Urinary bladder channel.Function cures mainly: clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Make eye bright; Eliminate the phlegm.Main dysuria; The stranguria with turbid discharge leukorrhagia; The edema distension; The heat-damp in summer dysentery; Conjunctival congestion is hidden from view; The expectorant heat syndrome cough is breathed heavily.

Pulvis Talci, these article are magnesium silicate salt mineral talc family Talcum, and main component is a hydrous magnesium silicate, after crushed, use the salt acid treatment, washing, and drying forms.Sweet, light, cold.Return bladder, lung, stomach warp.Cure mainly inducing diuresis for treating stranguria syndrome, clearing away summer-heat, skin ulcer is held back in damp eliminating.Be used for pyretic stranguria, stranguria caused by urinary stone is urinated hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea; External treatment eczema, eczema, miliaria.

Endothelium Corneum Gigeriae Galli, the gizzard inwall of Phasianidae animal man chicken (Gallus gallus domesticus Brisson).Another name: ENDOTHELIUM CORNEUM GIGERIAE GALLI, chicken yellow skin, chicken gizzard, stomach of chicken; Property is hidden and to be returned through sweet, and is cold.Return spleen, stomach, small intestinal, urinary bladder channel.Promoting digestion and invigorating the stomach, arresting seminal emission.In addition, these article still can treating stranguria fossil, available sandstone stranguria and gallbladder, the renal calculus etc. controlled, and many and Herba Lysimachiae are with usefulness.

Poria, English name, Indian Buead, Tuckahoe, Latin plant animal mineral name Wolfiporia cocos (Schw.) Ryv.&Gibn is under the jurisdiction of Aphyllophorales Aphyllophorales, Polyporaceae Polyporaceae, Poria belongs to Wolfiporia.Be commonly called as Poria, Song Ling, Poria, for colonizing in PinasterFungi plant on the root, shape be as Rhizoma Dioscoreae esculentae, crust pitchy, the inside white or pink.Poria, GUIXIN, lung, spleen, kidney channel.Materia Medica of Decoction: " it is big cloudy to start with, the big sun of foot, shaoyang channel." " book on Chinese herbal medicine covers bamboo fish trap ": " go into bladder, kidney, lung." " Thunder God is concocted the property of medicine and is separated ": " go into lung, spleen, small intestinal three warps." " Bencao Jingshu ": " it is few cloudy to go into brothers, the hands sun, lunar, the Yangming Channel of foot." effect cures mainly: eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.

Exocarpium Benincasae, these article are the dry outer peel of cucurbitaceous plant Fructus Benincasae Benincasa hispida (THunb.) Cogn..When eating Fructus Benincasae, clean, cut and get outer peel, dry.Sweet, cold.Return spleen, small intestine meridian.Cure mainly: inducing diuresis to remove edema, be used for the edema distension, dysuria, summer-heat is thirsty, oliguria with reddish urine.

CORTEX ZINGIBERIS RHIZOMAE, the i.e. crust of Rhizoma Zingiberis Recens.Pungent in flavor and cool in property.The effect of inducing diuresis to remove edema is arranged, is applicable to dysuria, EdemaDeng disease, can cooperate Exocarpium Benincasae, Cortex MoriBe equal to usefulness.

Fructus Crataegi is Rosaceae, the dry mature fruit of Fructus Mali pumilae subfamily plant Fructus Pyri Pashiae or Fructus Crataegi.Meridian distribution of property and flavor: sour in the mouth, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.Cure mainly appetite-stimulating indigestion-relieving, change stagnate removing food stagnancy, promoting blood circulation to remove blood stasis, the circulation of qi promoting of reducing phlegm.Be used for carnivorous stagnate long-pending, lump in the abdomen, abdominal distention feeling of fullness, the stasis of blood resistance stomachache, phlegm retention, have loose bowels, discharging fresh blood stool etc.

Fructus Crataegi (parched) is Rosaceae, the dry mature fruit of Fructus Mali pumilae subfamily plant Fructus Pyri Pashiae or Fructus Crataegi, and to use coddle to decoction after decocting in water is opened instead dense thick and make through adding, and has.Blood circulation promoting and blood stasis dispelling, convergence analgesia, the effect of invigorating the spleen and replenishing QI

Fructus Hordei Germinatus, these article get through the drying of germinateing for the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L..After wheat grain is soaked in water, keep suitable temperature, humidity, when treating that plumelet grows to about 0.5cm, drying.Sweet, flat.Return spleen, stomach warp.Cure mainly promote qi circulation digestion promoting, insufficiency of the spleen lack of appetite, newborn antiperspirant smoulders.

Fructus Hordei Germinatus (parched) is used for circulation of qi promoting, helps digestion, abdominal distention.

Fructus Setariae Germinatus, another name tiller rice (" not Lu "), paddy tiller (" quiet small house side "), rice tiller (" detailed outline "), Fructus Oryzae Germinatus (" the Chinese crude drug handbook).Latin medicine name Fructus Oryzae Germinatus, former plant (1) " China's book on Chinese herbal medicine ": " Chinese pharmacopoeia: the fruit of Setaria italica (L.) Beauv. medicinal part plant forms sweet Oryza sativa L. (2) through germination, and is flat, warm.Return spleen, stomach warp.Cure mainly (1) promoting digestion and removing stagnation; Spleen benefiting and stimulating the appetite.Being used for food stagnation stagnates; Distension is had loose bowels; Insufficiency of the spleen few food; Beriberi edema.Help digestion with in, spleen benefiting and stimulating the appetite.Be used for food stagnation and do not disappear, abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite.

Fructus Setariae Germinatus (parched): relatively help digestion, be used for not hungry lack of appetite.

Massa Medicata Fermentata, Chinese medicine name: Massa Medicata Fermentata, another name QuanzhouMassa Medicata Fermentata, model will is bent, and BAICAO is bent, latin name: medical material Massa Medicata Fermentata MassaMedicata Fermentat is bitter, temperature.1. " property of medicine is examined ": " little bitter fragrant sweet." 2. " detailed outline is picked up any lost article from the road ": " and sweet light, delicate fragrance.Title textual criticism Massa Medicata Fermentata (" detailed outline is picked up any lost article from the road "), Quanzhou Massa Medicata Fermentata (" property of medicine is examined "), bent, the BAICAO bent (" detailed outline is picked up any lost article from the road ") of model will; Go into spleen, stomach, large intestine channel.After flour, wheat bran and multiple medicine are mixed, through the herbal leaven that ferments and form.Effect cures mainly: strengthening the spleen to promote digestion, regulating QI to expel dampness induces sweat.Control Get ill from overeatingThe feeling of stuffiness in chest, stomachache is vomited and diarrhoea, dysentery, headache due to common cold, children's hinders hungry the mistake and satisfies.Concocting method: 1. get 1.5 jin of Fructus Aurantiis, 1 jin of Fructus Aurantii Immaturus (parched with bran), Rhizoma CyperiSon 1 (parched with bran), 1.5 jin of Radix Paeoniae Alba (wine stir-fry), 1 jin of Rhizoma Curcumae (wine stir-fry), 1 jin of Radix Polygoni Multiflori tablet (little stir-fry) is white Seem Lablab Album2 jin (stir-fry), 1 jin of corydalis tuber (vinegar stir-fry), 1 jin of Semen Arecae (stir-fry), 1 jin of Rhizoma Alpiniae Officinarum (red parching with earth), 1 jin on Pericarpium Citri Reticulatae Viride (vinegar stir-fry), 2.5 jin of Yellow Fructus Gardeniaes (stir-fry), 1 jin of RHIZOMA SPARGANII (vinegar stir-fry), 12 liang of Pericarpium Zanthoxylis (stir-fry), 1 jin of Radix Et Rhizoma Rhei (1 jin of infusing drugs in wine), 1 jin of Rhizoma Alismatis (the husky stir-fry), Fructus Amomi1 jin (Sucus Zingberis stir-fry), Cortex Magnoliae Officinalis 1.5 jin of (Sucus Zingberis stir-fry), 4 jin in Semen Armeniacae Amarums, Radix Scutellariae 1 jin (wine stir-fry), Fructus Hordei Germinatus1 jin (stir-fry), Cortex Phellodendri 1 jin of (stir-fry), 0.5 jin in Rhizoma Curcumae Longae, windproof 1 jin (go clean hair), The Radix Aucklandiae1 jin, 0.5 jin of Rhizoma Et Radix Notopterygii, 1.5 jin of Semen Plantaginiss, 1.5 jin of Semen Euryaless, Fructus Crataegi1 jin of skin, 1.5 jin of Pericarpium Citri Reticulataes, 2 jin of Herba Menthaes, Poria1 jin of skin, Radix Glycyrrhizae1 jin, white lead cut 1 jin, white bent 10 liang of method, Fructus Quisqualis 2.5 jin of (band shell), 1 jin of Herba Pogostemonis, complete 1 jin of Folium Perillae, 1 jin of Semen Sinapis Albae, 1.5 jin of Herba Moslaes, 1.5 jin of Herba Lycopi, 1 jin of Herba Schizonepetae, Rhizoma Atractylodis 1 jin (rice candy stir-fry), Radix Bupleuri1 jin (wine stir-fry).Medicine-feeding merges, and wears into smalls, sieves, and adds each 2 jin of Semen Phaseoli, each 8 jin of Semen Tritici aestivis (must soak into and pulverize) and Testa Tritici, flours, and mixing is mixed thoroughly.Other gets each 2 jin of Herba Artemisiae Annuae grass, Stanley grass, Herba Xanthii grass, and soup (being called three flavor soup) is fried in shallow oil in chopping, and is mixed with medicine-feeding; Knead repeatedly, go into to be pressed into fritter in the die, cool slightly back covers with Caulis et Folium Oryzae; Make and fully ferment when appearance grows yellow mycelia, taking-up is dried, and then toasts with suitable firepower (being controlled at 36 ℃); Store after 4 months, take out again and shine, brush away mould hair.Come from " Compendium of Materia MedicaPick up any lost article from the road ".

Semen Raphani, medical material formal name used at school Semen Raphani another name Semen Raphani, trailing plants white chessman, Semen Raphani.These article are the mature seed of crucifer Radix Raphani Raphanus sativus L..Nature and flavor: property is flat, acrid in the mouth, sweet.Gui Jing: return lung, spleen, stomach warp.Function cures mainly: help digestion to remove and expand lowering the adverse-rising QI to resolve phlegm.Being used for retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant stops up and breathes with cough.Go into spleen, stomach, lung meridian, can help digestion and remove expand, effect is remarkable, and the title of " falling wall towards wall " is arranged.Clinical commonly using in treatment real (food, wet, stagnant) disease.

The present invention also provides manufacturing method for above mentioned medicine, and key step is through extracting the Chinese medicine water extract, in water extract, inoculate the female liquid of planting of phellinus liteus then, carrying out submerged fermentation.In the preferred version of method for preparing of the present invention; Fluid medium used when the female kind of test tube phellinus liteus expanding propagation becomes mycelia liquid is the good Chinese medicine aqueous extract of compatibility among the present invention; It is the expanding propagation environment of culture medium that the Phellinus igniarius (L. ex Fr.) Quel. bacterium is adapted to the Chinese medicine extraction liquid in advance; Show all that the liquid mycelia is female preferably plants so that select in the Chinese medicine water extract vigor and reproductive capacity, thereby guarantee the tunning that can carry out and obtain better quality smoothly of next step extensive submerged fermentation.

The specific embodiment

Embodiment 1. medication preparation

The preparation of step 1. Chinese medicine water extract

Raw material of Chinese medicine and weight portion thereof: 2 parts of Fructus Aurantii Immaturuss, 10 parts of Herba lygodiis, 5 parts of Spora Lygodii, 10 parts of Herba Plantaginiss, 5 parts of Semen Plantaginiss, 5 parts of Pulvis Talci, 10 parts of Endothelium Corneum Gigeriae Galli, 10 parts in Poria, 2 parts of Exocarpium Benincasaes, 2 parts of CORTEX ZINGIBERIS RHIZOMAEs, 10 parts of Fructus Crataegi, 10 parts of Fructus Crataegi (parched), 10 parts of Fructus Hordei Germinatus, 10 parts of Fructus Hordei Germinatus (parched)s, 10 parts of living Fructus Setariae Germinatuss, 10 parts of Fructus Setariae Germinatus (parched), 10 parts of Massa Medicata Fermentata, 10 parts of Semen Raphanis

Take by weighing 25kg altogether by above-mentioned raw materials medicine component, as for placing the 130kg drinking water, big fire is boiled; And boil again with little fire and to endure two hours, filter extracting juice and obtain 65～80kg approximately, stay medicinal residues; And the 130kg drinking water that reinjects, little fire boiled and endures three hours after big fire was boiled, and filtered extracting juice and obtained 65～80kg approximately; Waste merges twice medicine juice, amounts to the about 160kg medicine of weight aqueous extract.

The female liquid of planting of step 2. preparation phellinus liteus

Material: Phellinus igniarius (L. ex Fr.) Quel. (Phellinus gniarius); The mycelia test tube is female plants; Chinese agriculture microorganism fungus kind preservation administrative center (Agricultural Culture Collection ofChina english abbreviation ACCC); Deposit number 51328, applicant's laboratory also has preservation, can provide to the public from 20 years applyings date to be used for experimentation.Being used for female kind of phellinus liteus of the present invention also can be to be purchased approach to obtain, and does not have special demands.

Utensil:

1.500ml vial;

2. portable pressure cooker, electric coal double-purpose; (Shen, Shanghai appearance three factories)

3. shaking table: D4-900; (Jiangsu Tai Lunshi experimental facilities factory)

4. superclean bench;

5. alcohol burner;

6. collude, rake, pin, cutter;

7. match;

The sterilization Cotton Gossypii;

9.75% ethanol; 10. rubber band.

Method:

1. add 50g dipotassium hydrogen phosphate, 50g potassium dihydrogen phosphate, 20g zinc sulfate, 20g aspartic acid, 20g mannitol, 500g white sugar, 200g yeast extract in the drug extract that 10kg step 1 obtains respectively; Stirring is also heated to 100 ℃; Put into the 1000g nutrient agar, the medicine aqueous extract that reinjects after dissolving is processed the muddy liquid of 15kg.

2. muddy liquid is injected in the 500ml vial, every bottle of 400ml inserts the inherent 0.012MP/cm of portable pressure cooker ², 30min takes out postcooling to 28 ℃-34 ℃, puts into superclean bench.

3. the culture medium after instrument and utensil and the deactivation is put into superclean bench, inserts with 30g potassium permanganate in the vessel that fill 50% formalin 30ml, and inoculation the colluding of usefulness, rake, pin, cutter are put into these vessel 30min that sterilizes.In the muddy liquid of every part of 400ml/ bottle, insert the female truffle 1.5cm that plants of Phellinus igniarius (L. ex Fr.) Quel. test tube ², 120min～150min rests.

4. vibration promptly obtained the phellinus liteus mother and plants liquid with 20 times/min in 72～96 hours on shaking table.

Step 3. submerged fermentation

The water extract that step 1 is obtained places that to be entitled as " cover of edible fungi liquid strain culture tank and culture tank " patent No. be that the fermentation tank of ZL03270560.3 is as fermentation substrate.And fermentation tank pushed " saturated vapor pressure-less boiler " patent No. be ZL200320126611.8 boiler in water at atmospheric pressure steam deactivation 12 hours.When treating that a jar interior substrate is cooled to 28～34 ℃, being called " edible fungus liquid injection rod and comprise the syringe of this injection rod " patent No. with name is the inoculation syringe of ZL200320126960.X, and the female liquid of planting of phellinus liteus that step 2 is prepared is injected in the substrate; Inoculum concentration: phellinus liteus female kind liquid and substrate solution mass ratio are 1: 10, and submerged fermentation is 72～144 hours under 26～28 degrees centigrade of room environmentals, puts jar.

Step 4. is produced medicine:

Put the submerged fermentation product that obtains behind the jar, concentrate, dry, sieve powder 12kg or making pellets by mixing medical powder with honey, every ball contains 10g powdery tunning.

Experimental example. clinical statistics

Case 40 examples are observed in outpatient service

Taking honeyed pill or the powder that embodiment 1 prepares, 2 times/day, 30g/ time (honeyed pill) or 10g/ time (powder), and cure rate reaches 80% when taking 30 times, and effective percentage is 98%, does not see uncomfortable person.

Model case:

Ye Li *: the man, Han nationality, 55 years old, Huang gang, Hubei teacher of TV university suffered from two renal calculuss, vesical calculus, ureteral calculus, cholelithiasis is taken medicine 30 times, recovery from illness.Clinical all condition of illness disappeared 2 years.

Grain surplus the big microlith 80 of discharging after the patient takes medicine surplus the area 60, reservation Pearl River Delta.

Claims (6)

1. treat cystolithic medicine for one kind; Be the female submerged fermentation product of planting of phellinus liteus, the culture medium of said submerged fermentation is the water extract of following parts by weight of Chinese traditional medicine crude drug: 1～3 part of Fructus Aurantii Immaturus, 8～12 parts of Herba lygodiis, 3～8 parts of Spora Lygodii, 8～12 parts of Herba Plantaginiss, 3～8 parts of Semen Plantaginiss, 4～6 parts of Pulvis Talci, 8～12 parts of Endothelium Corneum Gigeriae Galli, 8～12 parts in Poria, 1～3 part of Exocarpium Benincasae, 1～3 part of CORTEX ZINGIBERIS RHIZOMAE, 8～12 parts of Fructus Crataegi, 10 parts of Fructus Crataegi (parched), 8～12 parts of Fructus Hordei Germinatus, 8～12 parts of Fructus Hordei Germinatus (parched)s, 8～12 parts of living Fructus Setariae Germinatuss, 8～12 parts of Fructus Setariae Germinatus (parched), 8～12 parts of Massa Medicata Fermentata, 8～12 parts of Semen Raphanis; The said submerged fermentation time is 72～114 hours, and the inoculum concentration of said phellinus liteus liquid in water extract is 5～15% by mass ratio, and said phellinus liteus liquid is the female turbid solution that ferments and obtained in 72～96 hours in the liquid medium within of planting of test tube phellinus liteus; Said fluid medium is for also added the water extract by mass ratio 11～15% aid nutrition materials therein, and said aid nutrition material is made up of following components in part by weight: 5 parts of dipotassium hydrogen phosphates, 5 parts of potassium dihydrogen phosphates, 2 parts in zinc sulfate, 2 parts of aspartic acids, 2 parts in mannitol, 50 parts of white sugar, 20 parts of yeast extracts, 100 parts of nutrient agars.

2. medicine according to claim 1, said parts by weight of Chinese traditional medicine crude drug is: 2 parts of Fructus Aurantii Immaturuss, 10 parts of Herba lygodiis, 5 parts of Spora Lygodii, 10 parts of Herba Plantaginiss, 5 parts of Semen Plantaginiss, 5 parts of Pulvis Talci, 10 parts of Endothelium Corneum Gigeriae Galli, 10 parts in Poria, 2 parts of Exocarpium Benincasaes, 2 parts of CORTEX ZINGIBERIS RHIZOMAEs, 10 parts of Fructus Crataegi, 10 parts of Fructus Crataegi (parched), 10 parts of Fructus Hordei Germinatus, 10 parts of Fructus Hordei Germinatus (parched)s, 10 parts of living Fructus Setariae Germinatuss, 10 parts of Fructus Setariae Germinatus (parched), 10 parts of Massa Medicata Fermentata, 10 parts of Semen Raphanis.

3. medicine according to claim 1 and 2, the inoculum concentration of said phellinus liteus liquid in water extract is 10% by mass ratio.

4. the method for preparing of claim 1 or 2 or 3 said medicines comprises that step is following:

(1) preparation water extract: after said parts by weight of Chinese traditional medicine crude drug mixing, each amount of water is 5～10 times of crude drug gross weight, decocts 2～3 times, and each 1～2 hour, merge each time medicinal liquid, abandon medicinal residues, get water extract;

(2) inoculation: water extract is carried out the normal pressure deactivation, to be cooled to room temperature, insert phellinus liteus liquid;

(3) submerged fermentation: fermentation time is 72～114 hours.

5. method for preparing according to claim 4, step (3) become ball to tunning put jar, concentrate, dry, sieve last powder packing or refined honey afterwards.

6. method for preparing according to claim 4, said normal pressure deactivation refer to that water steamed 12 hours under the normal pressure.