CN105106684A - Pharmaceutical preparation for treating liver-yang hyperactivity type hypertension - Google Patents

Abstract

The invention belongs to the field of Chinese herba preparations, and particularly provides a pharmaceutical preparation for treating liver-yang hyperactivity type hypertension. The pharmaceutical preparation is prepared from the following raw materials: 25 parts of salsola ruthenica, 18 parts of dracocephalum rupestre hance, 24 parts of evodia lepta, 18 parts of Desmos cochinchinensis Lour., 20 parts of Cymbopogon distans (Nees)A. Camus, 15 parts of earthworm, 20 parts of gastrodin, 20 parts of semen cassiae, 25 parts of snakegourd fruit, 25 parts of semen plantaginis, 18 parts of achyranthes bidentata, 15 parts of uncaria, 15 parts of prunella vulgaris, 20 parts of radix rehmanniae and 5 parts of radix glycyrrhizae. The pharmaceutical preparation can be used for treating liver-yang hyperactivity type hypertension.

Description

One is used for the treatment of the hypertensive pharmaceutical preparation of liver-Yang sthenia type

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to one and be used for the treatment of hypertensive pharmaceutical preparation of liver-Yang sthenia type and its preparation method and application.

Background technology

The clinical manifestation of syndrome of upper hyperactivity of liver yang, with vertigo and tinnitus, distending pain of the head and eyes, flushing conjunctival congestion, being irritable and getting angry easily, nose heave foot is light, and red tongue, wiry forceful pulse is main.Doublely can see dry mouth and tougue, palpitation and amnesia, the diseases such as insomnia and dreamful sleep.If hyperpietic has these to show, liver-Yang sthenia type hypertension can be diagnosed as.For this reason, be bursting to develop and manyly treat the needs that liver-Yang sthenia type hypertensive medicine meets clinical treatment safely and effectively.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of liver-Yang sthenia type high blood pressure disease.In order to reach this object, adopt following technical scheme:

Technical scheme: one is used for the treatment of the hypertensive pharmaceutical preparation of liver-Yang sthenia type, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Salsolae Ruthenicae 25 parts, Herba Dracocephali Rupestris 18 parts, Foliumet Ramulus Evodiae 24 parts, curled paralysis 18 parts, Cymbopogon distans (Nees)A. Camus 20 parts, Pheretima 15 parts, 20 parts, Rhizoma Gastrodiae, Semen Cassiae 20 parts, Fructus Trichosanthis 25 parts, Semen Plantaginis 25 parts, Radix Achyranthis Bidentatae 18 parts, Ramulus Uncariae Cum Uncis 15 parts, Spica Prunellae 15 parts, Radix Rehmanniae 20 parts, 5 parts, Radix Glycyrrhizae.

Describedly be used for the treatment of the hypertensive pharmaceutical preparation of liver-Yang sthenia type, dosage form is pharmaceutically acceptable granule, tablet, capsule.

Describedly be used for the treatment of the hypertensive pharmaceutical preparation of liver-Yang sthenia type, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

Describedly be used for the treatment of the application of the hypertensive pharmaceutical preparation of liver-Yang sthenia type in preparation treatment liver-Yang sthenia type hypertension drug.

Herba Salsolae Ruthenicae, Latin is called Salsolaruthenica, is the plant of Amaranthaceae Salsola.Be distributed in the ground such as North China, northeast, northwest, Jiangsu, Tibet, Shandong of Russia, Mongolia and China's Mainland, be grown on the area of height above sea level 100 meters to 4,600 meters, be grown on conglomerate re servoir, river valley sandy ground and seashore more, cure mainly hypertension; Headache; Dizzy.The present invention is with all herbal medicine.

Herba Dracocephali Rupestris, Classification system is DracocephalumrupestreHance, is the herb of labiate Herba Dracocephali Rupestris.Heat clearing and inflammation relieving, cooling blood for hemostasis.Control affection due to external wind and heat, headache cold and heat, laryngalgia, cough, icterohepatitis, spits blood, epistaxis, dysentery.

Foliumet Ramulus Evodiae derives from Rutaceae Evodia plant Foliumet Ramulus Evodiae Evodialepta (Spreng.) Merr., is used as medicine with root and leaf.The whole year can adopt, and root is cleaned, and section is dried for subsequent use; Leaf dries in the shade for subsequent use.Heat-clearing and toxic substances removing, expelling wind and removing dampness.Control the diseases such as laryngopharynx swelling and pain, rheumatic ostalgia, malaria, jaundice, eczema, dermatitis, traumatic injury and worm venom.

Curled paralysis is annonaceae Desmos Lour Desmos chinensis DesmoscochinchinensisLour., is used as medicine with root and Herb.The whole year can adopt, and clean chopping is dried.Expelling wind and removing dampness, spleen invigorating is regulated the flow of vital energy, stasis-dispelling and pain-killing.For rheumatic arthritis, puerperal exposure to wind pain, puerperal abdonimal pain, bleed more than, dysmenorrhea, stomachache, stomachache, abdominal distention, dyspepsia, diarrhoea, oedema due to nephritis, traumatic injury.The present invention is used as medicine with root.

Cymbopogon distans (Nees)A. Camus is arbor section Cymbopogon plants, and for bronchitis, chronic bronchitis, rheumatic arthritis, neuralgia, enteritis, dyspepsia, has relieving cough and asthma, antiinflammatory, pain relieving, the effects such as expelling wind and removing dampness.Classification system is Cymbopogondistans (Nees) A.Camus, relieving cough and asthma, antiinflammatory, pain relieving, expelling wind and removing dampness.For bronchitis, chronic bronchitis, rheumatic arthritis, neuralgia, enteritis, dyspepsia.The present invention is with all herbal medicine.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect: the traditional Chinese medical science thinks that liver-Yang sthenia type hypertension is many because of the hepatic and renal YIN deficiency, the kidney failing to nourish the liver, liver-yang is high inverse without made, gas fire is disturbed, and Herba Salsolae Ruthenicae of the present invention, Herba Dracocephali Rupestris, Foliumet Ramulus Evodiae, curled paralysis, Cymbopogon distans (Nees)A. Camus, Pheretima heat-clearing and toxic substances removing, suppressing the hyperactive liver and subsiding YANG are monarch drug, and Rhizoma Gastrodiae, Semen Cassiae, Fructus Trichosanthis, Semen Plantaginis, Radix Achyranthis Bidentatae, Ramulus Uncariae Cum Uncis, Spica Prunellae, Radix Rehmanniae nourishing YIN to lower pathogenic fire are ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, suppressing the hyperactive liver and subsiding YANG, nourishing YIN to lower pathogenic fire treatment liver-Yang sthenia type antihypertensive effect is obvious.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get Herba Salsolae Ruthenicae 25g, Herba Dracocephali Rupestris 18g, Foliumet Ramulus Evodiae 24g, curled paralysis 18g, Cymbopogon distans (Nees)A. Camus 20g, Pheretima 15g, Rhizoma Gastrodiae 20g, Semen Cassiae 20g, Fructus Trichosanthis 25g, Semen Plantaginis 25g, Radix Achyranthis Bidentatae 18g, Ramulus Uncariae Cum Uncis 15g, Spica Prunellae 15g, Radix Rehmanniae 20g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get Herba Salsolae Ruthenicae 25g, Herba Dracocephali Rupestris 18g, Foliumet Ramulus Evodiae 24g, curled paralysis 18g, Cymbopogon distans (Nees)A. Camus 20g, Pheretima 15g, Rhizoma Gastrodiae 20g, Semen Cassiae 20g, Fructus Trichosanthis 25g, Semen Plantaginis 25g, Radix Achyranthis Bidentatae 18g, Ramulus Uncariae Cum Uncis 15g, Spica Prunellae 15g, Radix Rehmanniae 20g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.

3, the preparation of capsule embodiment: get Herba Salsolae Ruthenicae 25g, Herba Dracocephali Rupestris 18g, Foliumet Ramulus Evodiae 24g, curled paralysis 18g, Cymbopogon distans (Nees)A. Camus 20g, Pheretima 15g, Rhizoma Gastrodiae 20g, Semen Cassiae 20g, Fructus Trichosanthis 25g, Semen Plantaginis 25g, Radix Achyranthis Bidentatae 18g, Ramulus Uncariae Cum Uncis 15g, Spica Prunellae 15g, Radix Rehmanniae 20g, Radix Glycyrrhizae 5g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.

4, pharmaceutical preparation treatment liver-Yang sthenia type hypertension of the present invention clinical research

4.1 general data: this pharmaceutical preparation is applied to clinical observation liver-Yang sthenia type hypertension case 50 example, wherein man 25 example, female 25 example, 48 ~ 70 years old age.The shortest person of the course of disease 1 year, most elder reaches 15 years.

4.2 diagnostic criterias: Western medicine diagnose: determine according to the new Treatment Guidelines for Hypertension that World Health Organization (WHO)/International Society of Hypertension (WHO/ISH) promulgates, namely do not taking under antihypertensive drugs, systolic pressure >=18.7kPa (140mmHg) and (or) diastolic pressure >=12.0kPa (90mmHg), unless blood pressure extremely raises and merges medical condition relevant (eventually last target organ damage) certainly, can not only according to a blood pressure measurement diagnosis primary disease.After pressure measurement first finds that blood pressure raises, should at least measure twice different occasion to determine whether blood pressure raises.

Get Western medicine diagnose be there is in hypertensive patient dizziness, headache, susceptible to lose temper due to restlessness, night sleep peaceful or nose heave limb fiber crops, micro-red, the white and thin fur of bitter taste xerostomia, tongue or slightly Huang, stringy pulse, are liver-Yang sthenia type hypertension case.

4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

4.4 criterions of therapeutical effect: recovery from illness: systolic pressure≤18.7kPa (140mmHg) and diastolic pressure≤12.0kPa (90mmHg), and the transference cures such as dizziness, headache.Effective: systolic pressure >=18.7kPa (140mmHg) and (or) diastolic pressure >=12.0kPa (90mmHg), but blood pressure decreases, and the symptoms such as dizziness, headache are greatly improved.Invalid: for blood pressure is unchanged, other severity of symptoms or unchanged.。

4.5 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Effectively	Invalid	Total effective rate (%)
						Treatment group	25	6	15	4	84
Blank group	25	1	1	23	8

Visible, the medicine that the present invention obtains can safe and effective treatment liver-Yang sthenia type hypertension, and have no side effect.

4.6 Lee, female, 67 years old, suffers from hypertension 2 years, shows as dizziness, headache, susceptible to lose temper due to restlessness, night sleep peaceful or nose heave limb fiber crops, micro-red, the white and thin fur of bitter taste xerostomia, tongue or slightly Huang, stringy pulse, is diagnosed as liver-Yang sthenia type hypertension.Give the Chinese medicine that granule embodiment of the present invention provides, after 2 courses for the treatment of, systolic pressure≤18.7kPa (140mmHg) and diastolic pressure≤12.0kPa (90mmHg), and the transference cures such as dizziness, headache.

Claims (4)

1. one kind is used for the treatment of the hypertensive pharmaceutical preparation of liver-Yang sthenia type, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Herba Salsolae Ruthenicae 25 parts, Herba Dracocephali Rupestris 18 parts, Foliumet Ramulus Evodiae 24 parts, curled paralysis 18 parts, Cymbopogon distans (Nees)A. Camus 20 parts, Pheretima 15 parts, 20 parts, Rhizoma Gastrodiae, Semen Cassiae 20 parts, Fructus Trichosanthis 25 parts, Semen Plantaginis 25 parts, Radix Achyranthis Bidentatae 18 parts, Ramulus Uncariae Cum Uncis 15 parts, Spica Prunellae 15 parts, Radix Rehmanniae 20 parts, 5 parts, Radix Glycyrrhizae.

2. be used for the treatment of the hypertensive pharmaceutical preparation of liver-Yang sthenia type as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of the hypertensive pharmaceutical preparation of liver-Yang sthenia type as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. be used for the treatment of the application of the hypertensive pharmaceutical preparation of liver-Yang sthenia type in treatment liver-Yang sthenia type hypertension drug according to claim 1.