CN104873606A - Traditional Chinese medicine external used agent for curing ulcerative gingivitis and preparation method thereof - Google Patents
Traditional Chinese medicine external used agent for curing ulcerative gingivitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine external used agent for curing ulcerative gingivitis. The traditional Chinese medicine external used agent for curing the ulcerative gingivitis is prepared from following crude medicines of, by weight part, 9-13 parts of concha arcae, 7-12 parts of exocarpium, 10-15 parts of white amaranth, 8-14 parts of emarginate stonecrop herbs, 9-13 parts of silkworm exuviae, 10-14 parts of gizzard pepsin, 11-15 parts of phyllanthus virgatus, 9-16 parts of finetooth holly, 7-14 parts of jujube pits, 11-17 parts of pubescent holly leaves, 10-16 parts of merremia hungaiensis and 8-13 parts of crab shells. The traditional Chinese medicine external used agent for curing the ulcerative gingivitis has the excellent effects of being composed by using a traditional Chinese medicine theory analysis prescription, and prepared through a reasonable and stable preparation method of active constituents, obtained through research according to research results of physicochemical properties and pharmacologic action of constituents in each medicine, using the crude medicines easy to obtain, being low in medicine material cost, and free of toxic and side effects, and preventing the ulcerative gingivitis after being cured from relapsing.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of Chinese medicine external agent for the treatment of ulcerative gingivitis and preparation method thereof.
Background technology
Ulcerative gingivitis, refers to red swelling of gingiva, and pain of festering, flows the diseases such as rancid pus and blood." Confucian's Duties to Their Parents " rolls up five: " ulcerative gingivitis person, dental caries also.Dental caries person, tooth Yan rots also." according to the cause of disease and feature thereof: ulcerative gingivitis due to pathogenic windheat, pyogingivitis with swollen legs, acute gangrenous stomatitis three kinds.Wherein comparatively common with ulcerative gingivitis due to pathogenic windheat; Pyogingivitis with swollen legs is shown in cyan lump and therefore named because its lower limb are double, acute gangrenous stomatitis mostly occurs children's.Hurried because falling ill, therefore namedly galloping along on horseback, is that more critical Acute oral is sick, how sends out because residual poison is after being ill clear.Ulcerative gingivitis due to pathogenic windheat, many Yin Yangming intrinsic heat is fought mutually with the heresy of wind heat, pathogenic heat upper punch, and visitor is caused by the gingiva.See gingivitis from the beginning of disease, heating or cold and heat are handed over and are done, and then gums is rotten to the corn, often easily hemorrhage, or constipation nausea and vomiting.Control suitable wind and heat dispersing, eliminating fire and detoxication.Pyogingivitis with swollen legs disease name.See " surgeon complete works of " volume 16: " ... the rotten blood person of all cacodontia infantile malnutritions, must pastiness lower limb under it, the thus life of the two phase." refer to suffer from ulcerative gingivitis and doublely see lower limb bruise.Disease is seen from the beginning of gingivitis, gradually causes gingiva corruption of bursting and goes out pus and blood, notably wear the cheek and break lip, two lower limb bruises, and shape is as cloud sheet, and color is black like eggplant, and muscles is firmly stupid, walks with difficulty, and doublely sees limbs pain, extremity edema.How because heresy of cold-damp stagnates passages through which vital energy circulates, QI and blood not freely, the strongly fragrant lower limb of the stasis of blood, and gastrointestinal hot and suffocating on attack caused by gums.Class is in vitamin C deficiency.Control suitable promoting flow of qi by warming channel, hold concurrently with removing toxic substances.
The Chinese traditional treatment principle of primary disease: based on clear positive bright gastric heat.Belong to wind heat person, suitable wind and heat dispersing, eliminating fire and detoxication; Belong to cold and stagnate person, suitable dispelling cold and eliminating dampness; Belong to residual poison and do not use up person, control and should detoxify, heat clearing away, putrefaction removing.Chen Bin treats acute gangrenous stomatitis, Be very effective with " acute gangrenous stomatitis falls apart " (being made up of Realgar, Alumen, Borax, Gypsum Fibrosum, Concha Haliotidis, Sal Nitri).Lijin's rank of nobility self-control Aloe disappear infantile malnutrition drink (being made up of raw Aloe, Rhizoma Picrorhizae, Gypsum Fibrosum, Fructus Gardeniae, Fructus Arctii, Radix Stellariae, Radix Platycodonis, Radix Et Rhizoma Rhei, Radix Scrophulariae, Herba Menthae, Radix Glycyrrhizae, running water Rhizoma Phragmitis, Folium Bambusae) treat 63 routine acute gangrenous stomatitis patients, effective percentage is 92.1%, determined curative effect.
Publication number CN 1748733A(application number 200510021299.X) Chinese invention patent document disclose a kind of throat powder formula for the treatment of throat and oral cavity diseases, be prepared from by the crude drug of following weight proportion: Indigo Naturalis 8-15g, drown white Yin 8-15g, Margarita 3-6g, Moschus 0.2-0.5g, Borneolum Syntheticum 2-6g, Sal Nitri 1-3g, Catechu 0.1-0.3g, Borax 0.1-0.3g.Application publication number CN 102423319 A(application number 201110350897.7) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of oral ulcer, following raw material: be that crude drug is prepared from by following weight portion: Gypsum Fibrosum Preparatum 5-34 weight portion, calamitas urinae hominis 2.5-9 weight portion, the yellow 0.33-4 weight portion of waist; Borneolum Syntheticum 1-3 weight portion.Application publication number CN 102743568 A(application number 201210235687.8) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of acute gangrenous stomatitis, formulated by the raw material of Chinese medicine of following weight parts: Cornu Saigae Tataricae 3, Rhizoma Coptidis 50, the Rhizoma Anemarrhenae 58, dried Alumen 10, Borax 6, Venenum Bufonis 3, Folium Hibisci Mutabilis 60, Herba Pouzolziae Zeylanicae 60, Herba Solani Lyrati 50, Radix Tinosporae 50, Borneolum Syntheticum 3, Radix Glycyrrhizae 30.
Doctor trained in Western medicine is mainly by sulfonamides or penicillin treatment acute gangrenous stomatitis, although can obtain certain effect, wholistic therapy poor effect, has and cure slowly, cure low shortcoming; Chinese medicine is played a role by different link, different mechanisms, eliminates focus, in clinical, obtain good therapeutic effect.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare Chinese medicine external agent for the treatment of ulcerative gingivitis simple, evident in efficacy and preparation method thereof.This Chinese medicine external agent determined curative effect and more after do not recur.
Technical scheme of the present invention is:
The Chinese medicine external agent for the treatment of ulcerative gingivitis, is prepared from by following bulk drugs, is weight portion: Concha Arcae 9-13; Exocarpium Citri Grandis 7-12; Herba Amaranthi Viridis 10-15; Herba Sedi Emarginati 8-14; Periostachum bombycis 9-13; Endothelium Corneum Gigeriae Galli 10-14; Phyllanthus simplex Retz． 11-15; Folium ilicis serratae 9-16; Semen Jujubae 7-14; Folium Ilicis Pubescentis 11-17; Ipomoea hungaiensis Lingelsh. Et Borza. 10-16; Carapax Eriocheir sinensis 8-13.
In preferred scheme, Concha Arcae 10-12; Exocarpium Citri Grandis 8-11; Herba Amaranthi Viridis 11-14; Herba Sedi Emarginati 10-12; Periostachum bombycis 10-12; Endothelium Corneum Gigeriae Galli 11-13; Phyllanthus simplex Retz． 12-14; Folium ilicis serratae 11-14; Semen Jujubae 9-12; Folium Ilicis Pubescentis 13-15; Ipomoea hungaiensis Lingelsh. Et Borza. 12-14; Carapax Eriocheir sinensis 9-12.
Be more preferably, Concha Arcae 11; Exocarpium Citri Grandis 9.5; Herba Amaranthi Viridis 12.5; Herba Sedi Emarginati 11; Periostachum bombycis 11; Endothelium Corneum Gigeriae Galli 12; Phyllanthus simplex Retz． 13; Folium ilicis serratae 12.5; Semen Jujubae 10.5; Folium Ilicis Pubescentis 14; Ipomoea hungaiensis Lingelsh. Et Borza. 13; Carapax Eriocheir sinensis 10.5.
The preparation method of the Chinese medicine external agent for the treatment of ulcerative gingivitis, step is as follows:
(1) Carapax Eriocheir sinensis is cleaned, and is placed in marmite, and moderate heat heating baked coke, takes out slightly cool, be ground into fine powder, for subsequent use; Endothelium Corneum Gigeriae Galli is cleaned, and is placed in warm water and soaks 1-2 hour (being preferably placed in warm water to soak 1.5 hours), is then placed in ethanol and soaks 5-15 minute (being preferably placed in ethanol to soak 10 minutes), after taking-up is dried, be placed in thermostatic drying chamber dry, grind to form fine powder, for subsequent use; Semen Jujubae is placed on smokeless intense fire and is fired to charcoal sustainability, cools, porphyrize, for subsequent use;
(2) Exocarpium Citri Grandis is smashed to pieces, is placed in the Mel (Exocarpium Citri Grandis: Mel=5:1) refined, mixes thoroughly, and slow fire is fried to micro-yellow, cools, porphyrize, for subsequent use; To get Concha Arcae and be placed in smokeless intense fire, and be calcined to and be popular in, and pour in white vinegar while hot, and stir a moment, cotton cloth filters, and dries, is ground into fine powder, for subsequent use; Periostachum bombycis charred medicinal herb with its property retained, cools, and porphyrize is for subsequent use;
(3) by Herba Amaranthi Viridis, Herba Sedi Emarginati, Phyllanthus simplex Retz．, Folium Ilicis Pubescentis, Folium ilicis serratae and Ipomoea hungaiensis Lingelsh. Et Borza. are together placed in Chinese medicine pan, add clear water to soak under room temperature, then intense fire heated and boiled 10-16 minute (preferred intense fire heated and boiled 13 minutes), turn slow fire boiling twice, first time decocts 40-60 minute (preferred first time decocts 50 minutes), second time decocts 25-35 minute (preferably second time decocts 30 minutes), merge twice decocting liquid, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.15-1.20, coldly go to room temperature, add ethanol, the content of ethanol is made to be that 45%-65%(preferably makes the content of ethanol be 55%) stir along clockwise direction once, leave standstill, filter, distilling under reduced pressure is extremely without alcohol taste, vacuum drying gets dry extract powder, porphyrize, for subsequent use,
(4) the raw material medicated powder after being processed step (1)-(3), mixing, sieves, adds Borneolum Syntheticum, stir, to obtain final product.
The preparation method of the Chinese medicine external agent of above-mentioned treatment ulcerative gingivitis, preferred scheme is, the temperature of warm water described in step (1) is 45-65 DEG C (temperature of preferred warm water is 50-60 DEG C, and the temperature of the warm water be more preferably is 55 DEG C).
The preparation method of the Chinese medicine external agent of above-mentioned treatment ulcerative gingivitis, preferred scheme is, in step (3), the amount of clear water is the 6-12 of material quantity doubly (amount of preferred clear water is 8-10 times of material quantity, and the amount of the clear water be more preferably is 9 times of material quantity).
The preparation method of the Chinese medicine external agent of above-mentioned treatment ulcerative gingivitis, preferred scheme is, the time of soaking in step (3) is 1.6-3.0 hour (the preferred time of soaking is 2.0-2.6 hour, and the time of the immersion be more preferably is 2.3 hours).
The preparation method of the Chinese medicine external agent of above-mentioned treatment ulcerative gingivitis, preferred scheme is, in step (3), the mass concentration of added ethanol is the mass concentration of the preferred added ethanol of 60%-80%(is 65%-75%, and the mass concentration of the added ethanol be more preferably is 70%).
The preparation method of the Chinese medicine external agent of above-mentioned treatment ulcerative gingivitis, preferred scheme is, in step (4), the amount of Borneolum Syntheticum is the amount of the preferred Borneolum Syntheticum of 9%-13%(of material quantity is the 10%-12% of material quantity, and the amount of the Borneolum Syntheticum be more preferably is 11% of material quantity).
The preparation method of the Chinese medicine external agent of above-mentioned treatment ulcerative gingivitis, preferred scheme is, the middle 80-140 mesh sieve excessively of step (4) (preferred 100-120 mesh sieve excessively, mistake 110 mesh sieve be more preferably).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Concha Arcae: base is former: be the shell of Carnis Arca inflata section animal Scapharca broughtonii, Tegillarca granosa or Scapharca subcrenata.Character: shell is fan-shaped or triangle, left and right two hull shape shape is identical, or left shell is a bit larger tham right shell.Long 2.5 ~ 8 centimetres, wide 2 ~ 6 centimetres.The back side is swelled, and have tens of directly stupefiedly to be radiated towards periphery by top as row of tiles on a roof shape, stupefied stricture of vagina obviously, forms by taupe is alternate with white.Nature and flavor: Gan Xian are flat.Gui Jing: enter liver, spleen channel.Function cures mainly: reduce phlegm, softening the hard mass, dissipating blood stasis, removing food stagnancy.Control accumulation of phlegm, stomachache, noisy, acid regurgitation, lump in the abdomen, scrofula, ulcerative gingivitis.
Exocarpium Citri Grandis: base is former: be immaturity or the maturescent outside rind of Rutaceae citrus plant Citrus grandis or Fructus Citri grandis.Composition: 1. contain flavone compound in Huajuhong (Citrus grandis) peel: naringin, Poncirus glycosides, Radix seu Folium Tosicodendri Delavayi glucoside and volatile oil.2. Fructus Citri grandis outer peel volatile oil main constituent, comprises citral; , linalool, methyl 2-aminobenzoate, limonene, australene, Flos Caryophylli olefinic oxide, linalool list oxide, cis-3-enol, cinene, γ-Du Songxi etc.The property of medicine: bitter, pungent, temperature.Return lung, spleen channel.Effect: drying dampness to eliminate phlegm, regulates the flow of vital energy, and helps digestion.Cure mainly wind and cold cough with asthma abundant expectoration, vomiting singultus, accumulation of food in the stomach and intes tine due to indigestion, abdominal distention.Pharmacology: the 1. effect of pair respiratory system: limonene and pinene have the effect of eliminating the phlegm, and limonene also has antitussive effect.2. sedation: linalool has sedation.3. anti-microbial effect: limonene has very strong inhibitory action to streptococcus pneumoniae, alpha streptococcus, micrococcus catarrhalis and staphylococcus aureus in vitro.
Herba Amaranthi Viridis: base is former: be herb or the root of amaranthaceous plant wrinkle fruit Herba Amaranthi tricoloris.Chemical analysis: herb is containing 24-ethyl-5 α-cholestane-7, anti-glycoside-22-diene-3 β-ol, chondrillasterol, 24-methyl-7-cholestenol, 24-methyl-22-dehydrogenation-7-cholestenol, the acid of 24-ethyl-7-cholestene, 24-ethyl cholesterol, 24-ethyl-22-aphyllidine, carotenoid, beta-carotene, vitamin.Containing violaxanthin, neoxathin, beta-carotene, α-kryptoxanthin, phylloxanthin, vitamin C, lipoid and the fatty acid based on Palmic acid [4] in leaf.Amaranthus mangostanus L. sterol is got from root.Nature and flavor: sweet; Light; Cold in nature.Gui Jing: large intestine; Small intestine meridian.Function cures mainly: heat clearing away; Dampness removing; Removing toxic substances.Main dysentery; Have loose bowels; Hot urination; Skin ulcer swells; Snakeworm sting; Ulcerative gingivitis.
Herba Sedi Emarginati: base is former: be the herb of crassulaceae plants Herba hylotelephii erythrosticti.Nature and flavor: bitter; Acid; Cool.Gui Jing: the heart; Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Cooling blood for hemostasis; Dampness removing.Main carbuncle furuncle; Furuncle; Herpes zoster; Scrofula; Spitting of blood; Spit blood; Epistaxis; Have blood in stool; Dysentery; Gonorrhea; Jaundice; Metrorrhagia; Leukorrhagia.
Periostachum bombycis: base is former: be casting off a skin of Bombycidae insecticide bombyx mori larva.Nature and flavor: sweet in the mouth; Property is put down.Gui Jing: the heart; Liver Channel.Function cures mainly: hemostasis of dispeling the wind; Removing nebula to improve visual acuity.Main metrorrhagia; Leukorrhagia; Dysentery; Discharging fresh blood stool; Hematemesis and epistaxis; Ulcerative gingivitis; Aphtha; Acute throat trouble; Corneal nebula.
Endothelium Corneum Gigeriae Galli: base is former: be the dry gizzard tunica intima of Phasianidae animal man chicken.Chemical analysis: containing gastric hormone, keratin etc.Nature and flavor: sweet are flat.Gui Jing: enter spleen, stomach warp.Function cures mainly: removing food stagnancy is stagnant, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.
Phyllanthus simplex Retz．: base is former: be herb or the root of euphorbia plant Phyllanthus simplex Retz．.Nature and flavor: 1. " Nanning City's medicine will ": " sweetness and bitterness." 2. " Guangxi Chinese medicinal herbal ": " sweet, flat." function cures mainly: 1. " Nanning City's medicine will ": " herb: help digestion, nebula removing.Control infantile malnutrition and infantile malnutrition is pleasing to the eye." 2. " register planted by Guangxi medicine ": " herb: tonifying the spleen and stomach, controls gonorrhea, and bone is choked larynx, infantile malnutrition.Root: control galactapostema.”
Folium ilicis serratae: base is former: be the leaf of holly plant Ilex hirsuta C. J. Tseng.Chemical analysis: containing forming stricture of vagina India element-3-primaverose in fruit.Nature and flavor: sweet; Bitter; Cool.Gui Jing: the heart; Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main scald; Ulcerative gingivitis; Skin infection festers; Traumatic hemorrhage.
Semen Jujubae: base is former: be the pit of Rhamnaceae plant Fructus Jujubae.Nature and flavor: bitter; Flat.Gui Jing: liver; Kidney channel.Function cures mainly: removing toxic substances; Sore.Main ecthyma; Ulcerative gingivitis.
Folium Ilicis Pubescentis: base is former: medical material Ji Yuan: be the leaf of holly plant Radix Ilicis Pubescentis.Chemical analysis: Ilex pubescens var. glabra Chang leaf contains DHAP, hydroquinone, scopoletin, aesculetin, 4-hydroxy-3-methoxy-.alpha.-toluic acid., vomiofliol, Ilex pubescens var. glabra Chang A prime, Radix Ilicis Pubescentis Triterpene Glycosides.Nature and flavor: bitter; Puckery; Cool.Gui Jing: stomach; Lung meridian.Function cures mainly: clearing away heat and cooling blood; Removing toxic substances and promoting subsidence of swelling.Main scald; Traumatic hemorrhage; Carbuncle furuncle; Acute gangrenous stomatitis.
Ipomoea hungaiensis Lingelsh. Et Borza.: base is former: be the tuber of dicotyledon scammonia section plant Ipomoea hungaiensis Lingelsh. Et Borza..Nature and flavor: sweet light; Flat return through liver; Spleen; Lung meridian.Function cures mainly: heat clearing away; Dehumidifying; Cough-relieving; Spleen invigorating.Main jaundice; Chronic hepatitis; Cough due to lung-heat; Hematochezia; Breast is few; Leukorrhagia; Infantile malnutrition; Burn due to hot liquid or fire.
Carapax Eriocheir sinensis: base is former: be the carapace of Grapsidae animal Eriocheir sinensis.Chemical analysis: about 3/4 is calcium carbonate, remaining in 1/4 and about have half to be chitin, remaining half is mainly protein.Chitin system is polysaccharide formed by N-acetic acid glucosamine, is insoluble to rare acid, alkali, as boiled altogether with acid, is hydrolyzed and raw acetic acid and D-Glucose amine.Chitin is the special composition of the shell such as Eriocheir sinensis, shrimp, but is also contained in the shell of some insecticide, mycelia, spore.Nature and flavor: salty in the mouth; Cold in nature.Gui Jing: liver; Spleen channel.Function cures mainly: scattered silt is stopped blooding; Removing toxic substances and promoting subsidence of swelling.Main jaundice due to accumulation of stagnant blood; Hemostagnant metrorrhagia; Carbuncle pyogenic infections from tumour or sore; Acute gangrenous stomatitis; Insect bite.
Chinese medicine external agent scientific formula provided by the invention, preparation method is simple, and products obtained therefrom is evident in efficacy.In addition, excellent results of the present invention also shows:
1,the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of taste medicine ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component;
2,the present invention adopts kinds of traditional Chinese medicines to prepare, and collocation rationally, has and has heat-clearing and toxic substances removing, reducing swelling and alleviating pain, effect of putrefaction-removing granulation-promoting, fundamentally can eliminate focus, reach strengthening the body resistance, the object of thoroughly curing;
3,medicine source of the present invention is easy to get, and medical material is with low cost, treating both the principal and secondary aspects of a disease, instant effect, has no side effect, and does not recur after recovery from illness.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the Chinese medicine external agent for the treatment of ulcerative gingivitis, is prepared from by following bulk drugs, is weight portion (60g/ part): Concha Arcae 9 parts; Exocarpium Citri Grandis 7 parts; Herba Amaranthi Viridis 10 parts; Herba Sedi Emarginati 8 parts; Periostachum bombycis 9 parts; Endothelium Corneum Gigeriae Galli 10 parts; Phyllanthus simplex Retz． 11 parts; Folium ilicis serratae 9 parts; Semen Jujubae 7 parts; Folium Ilicis Pubescentis 11 parts; Ipomoea hungaiensis Lingelsh. Et Borza. 10 parts; Carapax Eriocheir sinensis 8 parts.
The preparation method of the Chinese medicine external agent of above-mentioned treatment ulcerative gingivitis is:
(1) Carapax Eriocheir sinensis is cleaned, and is placed in marmite, and moderate heat heating baked coke, takes out slightly cool, be ground into fine powder, for subsequent use; Endothelium Corneum Gigeriae Galli is cleaned, and is placed in 45 DEG C of warm water and soaks 1 hour, is then placed in ethanol and soaks 5 minutes, take out after drying, be placed in thermostatic drying chamber dry, grind to form fine powder, for subsequent use; Semen Jujubae is placed on smokeless intense fire and is fired to charcoal sustainability, cools, porphyrize, for subsequent use;
(2) Exocarpium Citri Grandis is smashed to pieces, is placed in the Mel (Exocarpium Citri Grandis: Mel=5:1) refined, mixes thoroughly, and slow fire is fried to micro-yellow, cools, porphyrize, for subsequent use; To get Concha Arcae and be placed in smokeless intense fire, and be calcined to and be popular in, and pour in white vinegar while hot, and stir a moment, cotton cloth filters, and dries, is ground into fine powder, for subsequent use; Periostachum bombycis charred medicinal herb with its property retained, cools, and porphyrize is for subsequent use;
(3) by Herba Amaranthi Viridis, Herba Sedi Emarginati, Phyllanthus simplex Retz．, Folium Ilicis Pubescentis, Folium ilicis serratae and Ipomoea hungaiensis Lingelsh. Et Borza. are together placed in Chinese medicine pan, the clear water adding 6 times of material quantities soaks 1.6 hours under room temperature, then intense fire heated and boiled 10 minutes, turn slow fire boiling twice, first time decocts 40 minutes, second time decocts 25 minutes, merge twice decocting liquid, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.15-1.20, coldly go to room temperature, add the ethanol that mass concentration is 60%, the content of ethanol is made to be 45% to stir along clockwise direction once, leave standstill, filter, distilling under reduced pressure is extremely without alcohol taste, vacuum drying gets dry extract powder, porphyrize, for subsequent use,
(4) the raw material medicated powder after being processed step (1)-(3), mixing, crosses 80 mesh sieves, adds the Borneolum Syntheticum of 9% material quantity, stir, to obtain final product.
The using method of gained Chinese medicine external of the present invention agent is: first carried out disinfection in affected part, then gets appropriate this product uniform application in affected part, one day 4-6 time, 5 days courses for the treatment of.
embodiment 2the Chinese medicine external agent for the treatment of ulcerative gingivitis, is prepared from by following bulk drugs, is weight portion (20g/ part): Concha Arcae 13 parts; Exocarpium Citri Grandis 12 parts; Herba Amaranthi Viridis 15 parts; Herba Sedi Emarginati 14 parts; Periostachum bombycis 13 parts; Endothelium Corneum Gigeriae Galli 14 parts; Phyllanthus simplex Retz． 15 parts; Folium ilicis serratae 16 parts; Semen Jujubae 14 parts; Folium Ilicis Pubescentis 17 parts; Ipomoea hungaiensis Lingelsh. Et Borza. 16 parts; Carapax Eriocheir sinensis 13 parts.
The preparation method of the Chinese medicine external agent for the treatment of ulcerative gingivitis is:
(1) Carapax Eriocheir sinensis is cleaned, and is placed in marmite, and moderate heat heating baked coke, takes out slightly cool, be ground into fine powder, for subsequent use; Endothelium Corneum Gigeriae Galli is cleaned, and is placed in 65 DEG C of warm water and soaks 2 hours, is then placed in ethanol and soaks 15 minutes, take out after drying, be placed in thermostatic drying chamber dry, grind to form fine powder, for subsequent use; Semen Jujubae is placed on smokeless intense fire and is fired to charcoal sustainability, cools, porphyrize, for subsequent use;
(2) Exocarpium Citri Grandis is smashed to pieces, is placed in the Mel (Exocarpium Citri Grandis: Mel=5:1) refined, mixes thoroughly, and slow fire is fried to micro-yellow, cools, porphyrize, for subsequent use; To get Concha Arcae and be placed in smokeless intense fire, and be calcined to and be popular in, and pour in white vinegar while hot, and stir a moment, cotton cloth filters, and dries, is ground into fine powder, for subsequent use; Periostachum bombycis charred medicinal herb with its property retained, cools, and porphyrize is for subsequent use;
(3) by Herba Amaranthi Viridis, Herba Sedi Emarginati, Phyllanthus simplex Retz．, Folium Ilicis Pubescentis, Folium ilicis serratae and Ipomoea hungaiensis Lingelsh. Et Borza. are together placed in Chinese medicine pan, the clear water adding 12 times of material quantities soaks 3.0 hours under room temperature, then intense fire heated and boiled 16 minutes, turn slow fire boiling twice, first time decocts 60 minutes, second time decocts 35 minutes, merge twice decocting liquid, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.15-1.20, coldly go to room temperature, add the ethanol that mass concentration is 80%, the content of ethanol is made to be 65% to stir along clockwise direction once, leave standstill, filter, distilling under reduced pressure is extremely without alcohol taste, vacuum drying gets dry extract powder, porphyrize, for subsequent use,
(4) the raw material medicated powder after being processed step (1)-(3), mixing, crosses 140 mesh sieves, adds the Borneolum Syntheticum of 13% material quantity, stir, to obtain final product.
The using method of gained Chinese medicine external of the present invention agent is: first carried out disinfection in affected part, then gets appropriate this product uniform application in affected part, one day 4-6 time, 5 days courses for the treatment of.
Model case: grandson XX, man, 7 years old half.Its female Dai Shu: the symptoms such as patient occurred fever and irritability without obvious inducement before month, lower gingivitis.At community examination in hospital, give the treatment of antibacterial analgesic, DeGrain, patient is exacerbation of symptoms before one week, and symptom of rotting appears in gums, and foul smelling blood and slime flows out, and recommends through neighbours, comes my institute check treatment on June 22nd, 2010.Checking: patient's oral cavity pain, there is downright bad, bleeding in gingiva, and gums many places are rotten to the corn, and oral cavity is with strong stink, and lab testing peripheral white blood cell obviously increases.Be diagnosed as ulcerative gingivitis.
Use the Chinese medicine external agent of the present embodiment gained treatment ulcerative gingivitis, using method: first carried out disinfection in affected part, then gets appropriate this product uniform application in affected part, one day 4-6 time, 5 days courses for the treatment of.After treating a course for the treatment of, infant oral cavity pain obviously alleviates, bleeding is alleviated, and other symptom is also obviously improved, after treating two courses for the treatment of, patient oral cavity is without pain, normal color is recovered at erosion place, gums many places gradually, and exhort that continuing medication is consolidated a course for the treatment of, patient fully recovers, within after drug withdrawal three months, pay a return visit, without recurrence.
embodiment 3the Chinese medicine external agent for the treatment of ulcerative gingivitis, is prepared from by following bulk drugs, is weight portion (50g/ part): Concha Arcae 12 parts; Exocarpium Citri Grandis 11 parts; Herba Amaranthi Viridis 14 parts; Herba Sedi Emarginati 12 parts; Periostachum bombycis 12 parts; Endothelium Corneum Gigeriae Galli 13 parts; Phyllanthus simplex Retz． 14 parts; Folium ilicis serratae 14 parts; Semen Jujubae 12 parts; Folium Ilicis Pubescentis 15 parts; Ipomoea hungaiensis Lingelsh. Et Borza. 14 parts; Carapax Eriocheir sinensis 12 parts.
The preparation method of the Chinese medicine external agent for the treatment of ulcerative gingivitis is:
(1) Carapax Eriocheir sinensis is cleaned, and is placed in marmite, and moderate heat heating baked coke, takes out slightly cool, be ground into fine powder, for subsequent use; Endothelium Corneum Gigeriae Galli is cleaned, and is placed in warm water and soaks 1.2 hours, is then placed in ethanol and soaks 8 minutes, take out after drying, be placed in thermostatic drying chamber dry, grind to form fine powder, for subsequent use; Semen Jujubae is placed on smokeless intense fire and is fired to charcoal sustainability, cools, porphyrize, for subsequent use;
(2) Exocarpium Citri Grandis is smashed to pieces, is placed in the Mel (Exocarpium Citri Grandis: Mel=5:1) refined, mixes thoroughly, and slow fire is fried to micro-yellow, cools, porphyrize, for subsequent use; To get Concha Arcae and be placed in smokeless intense fire, and be calcined to and be popular in, and pour in white vinegar while hot, and stir a moment, cotton cloth filters, and dries, is ground into fine powder, for subsequent use; Periostachum bombycis charred medicinal herb with its property retained, cools, and porphyrize is for subsequent use;
(3) by Herba Amaranthi Viridis, Herba Sedi Emarginati, Phyllanthus simplex Retz．, Folium Ilicis Pubescentis, Folium ilicis serratae and Ipomoea hungaiensis Lingelsh. Et Borza. are together placed in Chinese medicine pan, the clear water adding 8 times of material quantities soaks 2.0 hours under room temperature, then intense fire heated and boiled 12 minutes, turn slow fire boiling twice, first time decocts 45 minutes, second time decocts 28 minutes, merge twice decocting liquid, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.15-1.20, coldly go to room temperature, add the ethanol that mass concentration is 65%, the content of ethanol is made to be 50% to stir along clockwise direction once, leave standstill, filter, distilling under reduced pressure is extremely without alcohol taste, vacuum drying gets dry extract powder, porphyrize, for subsequent use,
(4) the raw material medicated powder after being processed step (1)-(3), mixing, crosses 100 mesh sieves, adds the Borneolum Syntheticum of 10% material quantity, stir, to obtain final product.
The using method of gained Chinese medicine external of the present invention agent is: first carried out disinfection in affected part, then gets appropriate this product uniform application in affected part, one day 4-6 time, 5 days courses for the treatment of.
Model case: Zheng XX, female, 13 years old, patient was to our hospital on October 11st, 2013.There is high heat without obvious inducement before 10 days in patient, oral cavity pain symptom, once took antibiotic medicine treatment, and had no improvement, exacerbation of symptoms before 3 days, upper gingival hemorrhage, excessive saliva.It is to our hospital under friend introduces.Check: there is special and strong stink in patient oral cavity, excessive saliva, sticky as thick silk, lymph core enlargement under jaw, tenderness is obvious; Red tongue, yellow fur, wiry and frequent pulse.Lab testing peripheral white blood cell obviously increases.Be diagnosed as ulcerative gingivitis.
Use the Chinese medicine external agent of the present embodiment gained treatment ulcerative gingivitis, using method: first carried out disinfection in affected part, then gets appropriate this product uniform application in affected part, one day 4-6 time, 5 days courses for the treatment of.After treating two courses for the treatment of, patient oral cavity is without pain, and only, without tenderness, other symptom obviously alleviates oral hemorrhage, and after treating three courses for the treatment of, patient fully recovers.Drug withdrawal was paid a return visit after three months, without recurrence.
embodiment 4the Chinese medicine external agent for the treatment of ulcerative gingivitis, is prepared from by following bulk drugs, is weight portion (30g/ part): Concha Arcae 12 parts; Exocarpium Citri Grandis 11 parts; Herba Amaranthi Viridis 14 parts; Herba Sedi Emarginati 12 parts; Periostachum bombycis 12 parts; Endothelium Corneum Gigeriae Galli 13 parts; Phyllanthus simplex Retz． 14 parts; Folium ilicis serratae 14 parts; Semen Jujubae 12 parts; Folium Ilicis Pubescentis 15 parts; Ipomoea hungaiensis Lingelsh. Et Borza. 14 parts; Carapax Eriocheir sinensis 12 parts.
The preparation method of the Chinese medicine external agent for the treatment of ulcerative gingivitis is:
(1) Carapax Eriocheir sinensis is cleaned, and is placed in marmite, and moderate heat heating baked coke, takes out slightly cool, be ground into fine powder, for subsequent use; Endothelium Corneum Gigeriae Galli is cleaned, and is placed in 60 DEG C of warm water and soaks 1.8 hours, is then placed in ethanol and soaks 12 minutes, take out after drying, be placed in thermostatic drying chamber dry, grind to form fine powder, for subsequent use; Semen Jujubae is placed on smokeless intense fire and is fired to charcoal sustainability, cools, porphyrize, for subsequent use;
(2) Exocarpium Citri Grandis is smashed to pieces, is placed in the Mel (Exocarpium Citri Grandis: Mel=5:1) refined, mixes thoroughly, and slow fire is fried to micro-yellow, cools, porphyrize, for subsequent use; To get Concha Arcae and be placed in smokeless intense fire, and be calcined to and be popular in, and pour in white vinegar while hot, and stir a moment, cotton cloth filters, and dries, is ground into fine powder, for subsequent use; Periostachum bombycis charred medicinal herb with its property retained, cools, and porphyrize is for subsequent use;
(3) by Herba Amaranthi Viridis, Herba Sedi Emarginati, Phyllanthus simplex Retz．, Folium Ilicis Pubescentis, Folium ilicis serratae and Ipomoea hungaiensis Lingelsh. Et Borza. are together placed in Chinese medicine pan, the clear water adding 10 times of material quantities soaks 2.6 hours under room temperature, then intense fire heated and boiled 14 minutes, turn slow fire boiling twice, first time decocts 55 minutes, second time decocts 32 minutes, merge twice decocting liquid, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.15-1.20, coldly go to room temperature, add the ethanol that mass concentration is 75%, the content of ethanol is made to be 60% to stir along clockwise direction once, leave standstill, filter, distilling under reduced pressure is extremely without alcohol taste, vacuum drying gets dry extract powder, porphyrize, for subsequent use,
(4) the raw material medicated powder after being processed step (1)-(3), mixing, crosses 120 mesh sieves, adds the Borneolum Syntheticum of 12% material quantity, stir, to obtain final product.
The using method of gained Chinese medicine external of the present invention agent is: first carried out disinfection in affected part, then gets appropriate this product uniform application in affected part, one day 4-6 time, 5 days courses for the treatment of.
embodiment 5the Chinese medicine external agent for the treatment of ulcerative gingivitis, is prepared from by following bulk drugs, is weight portion (40g/ part): Concha Arcae 11; Exocarpium Citri Grandis 9.5 parts; Herba Amaranthi Viridis 12.5 parts; Herba Sedi Emarginati 11 parts; Periostachum bombycis 11 parts; Endothelium Corneum Gigeriae Galli 12 parts; Phyllanthus simplex Retz． 13 parts; Folium ilicis serratae 12.5 parts; Semen Jujubae 10.5 parts; Folium Ilicis Pubescentis 14 parts; Ipomoea hungaiensis Lingelsh. Et Borza. 13 parts; Carapax Eriocheir sinensis 10.5 parts.
The preparation method of the Chinese medicine external agent for the treatment of ulcerative gingivitis is:
(1) Carapax Eriocheir sinensis is cleaned, and is placed in marmite, and moderate heat heating baked coke, takes out slightly cool, be ground into fine powder, for subsequent use; Endothelium Corneum Gigeriae Galli is cleaned, and is placed in 55 DEG C of warm water and soaks 1.5 hours, is then placed in ethanol and soaks 10 minutes, take out after drying, be placed in thermostatic drying chamber dry, grind to form fine powder, for subsequent use; Semen Jujubae is placed on smokeless intense fire and is fired to charcoal sustainability, cools, porphyrize, for subsequent use;
(2) Exocarpium Citri Grandis is smashed to pieces, is placed in the Mel (Exocarpium Citri Grandis: Mel=5:1) refined, mixes thoroughly, and slow fire is fried to micro-yellow, cools, porphyrize, for subsequent use; To get Concha Arcae and be placed in smokeless intense fire, and be calcined to and be popular in, and pour in white vinegar while hot, and stir a moment, cotton cloth filters, and dries, is ground into fine powder, for subsequent use; Periostachum bombycis charred medicinal herb with its property retained, cools, and porphyrize is for subsequent use;
(3) by Herba Amaranthi Viridis, Herba Sedi Emarginati, Phyllanthus simplex Retz．, Folium Ilicis Pubescentis, Folium ilicis serratae and Ipomoea hungaiensis Lingelsh. Et Borza. are together placed in Chinese medicine pan, the clear water adding 9 times of material quantities soaks 2.3 hours under room temperature, then intense fire heated and boiled 13 minutes, turn slow fire boiling twice, first time decocts 50 minutes, second time decocts 30 minutes, merge twice decocting liquid, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.15-1.20, coldly go to room temperature, add the ethanol that mass concentration is 70%, the content of ethanol is made to be 55% to stir along clockwise direction once, leave standstill, filter, distilling under reduced pressure is extremely without alcohol taste, vacuum drying gets dry extract powder, porphyrize, for subsequent use,
(4) the raw material medicated powder after being processed step (1)-(3), mixing, crosses 110 mesh sieves, adds the Borneolum Syntheticum of 11% material quantity, stir, to obtain final product.
The using method of gained Chinese medicine external of the present invention agent is: first carried out disinfection in affected part, then gets appropriate this product uniform application in affected part, one day 4-6 time, 5 days courses for the treatment of.
test example 1the clinical practice of the Chinese medicine external agent (embodiment 5) of gained treatment ulcerative gingivitis of the present invention:
1 data and method
1.1 physical data
In April ,-2013 in August, 2010, screen 275 routine acute gangrenous stomatitis patients at 4 department of stomatology, Hospital.Wherein male 138 example, women 137 example, minimum 4 years old of age, oldest 11 years old.
1.2 clinical manifestation
(1) acute gangrenous stomatitis from the beginning of time be everlasting on one-sided cheek mucosa and occur that aubergine is hardened, rapid blackening comes off and leaves over the ulcer surface of edge micro-protuberance, expands to deep layer, and have a large amount of slough to depart from, meanwhile, skin of cheek swelling is shinny, rot to come off, eventually to inside and outside through, " wearing the cheek grinningly ".
(2) disease damage mostly occurs between gingival edge or gingival papilla, and the state of an illness often spreads very soon, and destroys gingival soft tissue or sclerotin.Location of necrosis covers the yellow-white pseudomembrane formed by slough, and has intractable pain and Repeated Hemorrhage.Course of disease length is indefinite.Symptom has gently to be had heavily, and the severe one heat that can occur together waits General Symptoms, can be diffused into other position of oral mucosa during an acute stage nearly step development.
(3) there is the symptom of necrotic gingivostomatitis in the early stage overwhelming majority of acute gangrenous stomatitis.
1.3 Therapeutic Method
All infants are divided into two groups at random, experimental group and matched group.Experimental group takes products obtained therefrom of the present invention, and instructions of taking is: every day three times, each 15-30ml, 5 days courses for the treatment of.Matched group takes other medicine conventional medication such as () as loose in ulcerative gingivitis, penicillin, match-maker are loose.Observe two courses for the treatment of of treatment altogether.
1.4 efficacy assessment standard
Cure: clinical symptoms and sign all disappear; Effective: clinical symptoms and sign partial disappearance or obviously alleviate; Effective: clinical symptoms and sign take a turn for the better to some extent; Invalid: symptom and sign have no significant change.(total effective rate=cure rate+obvious effective rate+effective percentage)
1.5 therapeutic effect
Result is as shown in table 1.
Table 1: the therapeutic outcome of experimental group and matched group two groups of patients
Therapeutic effect: experimental group cures 111 examples (65.3%), effective 33 examples (19.4%), effective 23 examples (13.5%); Invalid 3 examples (1.8%), total effective rate 98.2%.Successful is better than matched group.
The present invention select Concha Arcae, Exocarpium Citri Grandis, Herba Amaranthi Viridis, Herba Sedi Emarginati, Periostachum bombycis, Endothelium Corneum Gigeriae Galli, Phyllanthus simplex Retz．, Folium ilicis serratae, Semen Jujubae, Folium Ilicis Pubescentis, Ipomoea hungaiensis Lingelsh. Et Borza. and Carapax Eriocheir sinensis totally 14 taste primary raw material medicines be prepared from.Fang Zhong, Concha Arcae has and reduces phlegm, softening the hard mass, dissipating blood stasis, effect of removing food stagnancy; Exocarpium Citri Grandis drying dampness to eliminate phlegm, regulates the flow of vital energy; Herba Amaranthi Viridis heat clearing away; Dampness removing; Removing toxic substances; Herba Sedi Emarginati heat-clearing and toxic substances removing; Cooling blood for hemostasis; Periostachum bombycis dispels the wind hemostasis; Removing nebula to improve visual acuity; Endothelium Corneum Gigeriae Galli removing food stagnancy is stagnant, strengthening the spleen and stomach; Folium ilicis serratae heat-clearing and toxic substances removing; Cooling blood for hemostasis; Folium Ilicis Pubescentis clearing away heat and cooling blood; Removing toxic substances and promoting subsidence of swelling; Carapax Eriocheir sinensis scattered silt is stopped blooding; Removing toxic substances and promoting subsidence of swelling.Full side's compatibility, has played heat-clearing and toxic substances removing, reducing swelling and alleviating pain altogether, effect of putrefaction-removing granulation-promoting.After treating two courses for the treatment of, experimental group total effective rate is 98.2%, and matched group is only 79.0%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the Chinese medicine external agent of ulcerative gingivitis, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Concha Arcae 9-13; Exocarpium Citri Grandis 7-12; Herba Amaranthi Viridis 10-15; Herba Sedi Emarginati 8-14; Periostachum bombycis 9-13; Endothelium Corneum Gigeriae Galli 10-14; Phyllanthus simplex Retz． 11-15; Folium ilicis serratae 9-16; Semen Jujubae 7-14; Folium Ilicis Pubescentis 11-17; Ipomoea hungaiensis Lingelsh. Et Borza. 10-16; Carapax Eriocheir sinensis 8-13.
2. the Chinese medicine external agent for the treatment of ulcerative gingivitis as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Concha Arcae 10-12; Exocarpium Citri Grandis 8-11; Herba Amaranthi Viridis 11-14; Herba Sedi Emarginati 10-12; Periostachum bombycis 10-12; Endothelium Corneum Gigeriae Galli 11-13; Phyllanthus simplex Retz． 12-14; Folium ilicis serratae 11-14; Semen Jujubae 9-12; Folium Ilicis Pubescentis 13-15; Ipomoea hungaiensis Lingelsh. Et Borza. 12-14; Carapax Eriocheir sinensis 9-12.
3. the Chinese medicine external agent for the treatment of ulcerative gingivitis as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Concha Arcae 11; Exocarpium Citri Grandis 9.5; Herba Amaranthi Viridis 12.5; Herba Sedi Emarginati 11; Periostachum bombycis 11; Endothelium Corneum Gigeriae Galli 12; Phyllanthus simplex Retz． 13; Folium ilicis serratae 12.5; Semen Jujubae 10.5; Folium Ilicis Pubescentis 14; Ipomoea hungaiensis Lingelsh. Et Borza. 13; Carapax Eriocheir sinensis 10.5.
4. the preparation method of the Chinese medicine external agent of the treatment ulcerative gingivitis as described in claim 1-3, it is characterized in that, step is as follows:
(1) Carapax Eriocheir sinensis is cleaned, and is placed in marmite, and moderate heat heating baked coke, takes out slightly cool, be ground into fine powder, for subsequent use; Endothelium Corneum Gigeriae Galli is cleaned, and is placed in warm water and soaks 1-2 hour (being preferably placed in warm water to soak 1.5 hours), is then placed in ethanol and soaks 5-15 minute (being preferably placed in ethanol to soak 10 minutes), after taking-up is dried, be placed in thermostatic drying chamber dry, grind to form fine powder, for subsequent use; Semen Jujubae is placed on smokeless intense fire and is fired to charcoal sustainability, cools, porphyrize, for subsequent use;
(2) Exocarpium Citri Grandis is smashed to pieces, is placed in the Mel (Exocarpium Citri Grandis: Mel=5:1) refined, mixes thoroughly, and slow fire is fried to micro-yellow, cools, porphyrize, for subsequent use; To get Concha Arcae and be placed in smokeless intense fire, and be calcined to and be popular in, and pour in white vinegar while hot, and stir a moment, cotton cloth filters, and dries, is ground into fine powder, for subsequent use; Periostachum bombycis charred medicinal herb with its property retained, cools, and porphyrize is for subsequent use;
(3) by Herba Amaranthi Viridis, Herba Sedi Emarginati, Phyllanthus simplex Retz．, Folium Ilicis Pubescentis, Folium ilicis serratae and Ipomoea hungaiensis Lingelsh. Et Borza. are together placed in Chinese medicine pan, add clear water to soak under room temperature, then intense fire heated and boiled 10-16 minute (preferred intense fire heated and boiled 13 minutes), turn slow fire boiling twice, first time decocts 40-60 minute (preferred first time decocts 50 minutes), second time decocts 25-35 minute (preferably second time decocts 30 minutes), merge twice decocting liquid, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.15-1.20, coldly go to room temperature, add ethanol, the content of ethanol is made to be that 45%-65%(preferably makes the content of ethanol be 55%) stir along clockwise direction once, leave standstill, filter, distilling under reduced pressure is extremely without alcohol taste, vacuum drying gets dry extract powder, porphyrize, for subsequent use,
(4) the raw material medicated powder after being processed step (1)-(3), mixing, sieves, adds Borneolum Syntheticum, stir, to obtain final product.
5. the preparation method of the Chinese medicine external agent for the treatment of ulcerative gingivitis according to claim 4, is characterized in that, the temperature of warm water described in step (1) is 45-65 DEG C (temperature of preferred warm water is 50-60 DEG C, and the temperature of the warm water be more preferably is 55 DEG C).
6. the preparation method of the Chinese medicine external agent for the treatment of ulcerative gingivitis according to claim 4, it is characterized in that, in step (3), the amount of clear water is the 6-12 of material quantity doubly (amount of preferred clear water is 8-10 times of material quantity, and the amount of the clear water be more preferably is 9 times of material quantity).
7. the preparation method of the Chinese medicine external agent for the treatment of ulcerative gingivitis according to claim 4, it is characterized in that, the time of soaking in step (3) is 1.6-3.0 hour (the preferred time of soaking is 2.0-2.6 hour, and the time of the immersion be more preferably is 2.3 hours).
8. the preparation method of the Chinese medicine external agent for the treatment of ulcerative gingivitis according to claim 4, it is characterized in that, in step (3), the mass concentration of added ethanol is the mass concentration of the preferred added ethanol of 60%-80%(is 65%-75%, and the mass concentration of the added ethanol be more preferably is 70%).
9. the preparation method of the Chinese medicine external agent for the treatment of ulcerative gingivitis according to claim 4, it is characterized in that, in step (4), the amount of Borneolum Syntheticum is the amount of the preferred Borneolum Syntheticum of 9%-13%(of material quantity is the 10%-12% of material quantity, and the amount of the Borneolum Syntheticum be more preferably is 11% of material quantity).
10. the preparation method of the Chinese medicine external agent for the treatment of ulcerative gingivitis according to claim 4, is characterized in that, the middle 80-140 mesh sieve excessively of step (4) (preferred 100-120 mesh sieve excessively, mistake 110 mesh sieve be more preferably).
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| CN103263615A (en) * | 2013-06-09 | 2013-08-28 | 张玉华 | Traditional Chinese medicine preparation for treating stomach illness, enteritis and cholecystitis and preparation method thereof |
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