CN104840687A

CN104840687A - Pharmaceutical preparation for treating pelvic inflammation

Info

Publication number: CN104840687A
Application number: CN201510309767.7A
Authority: CN
Inventors: 陈爱华
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-06-08
Filing date: 2015-06-08
Publication date: 2015-08-19

Abstract

The invention belongs to the field of traditional Chinese medicines and provides a pharmaceutical preparation for treating pelvic inflammation. The pharmaceutical preparation is prepared from the following raw materials: 20 parts of campsis grandiflora, 16 parts of Indian azalea leaves, 15 parts of rough knotweed herbs, 20 parts of lobedfruit tacca leaves, 20 parts of fragile blueberry roots, 15 parts of serrateleaf carallia herbs, 18 parts of chun spicebush roots, 20 parts of common oxyspora roots, 16 parts of Chinese shuteria roots and 20 parts of okubo dryoathyrium frond. The pharmaceutical preparation can be used for treating pelvic inflammation.

Description

A kind of pharmaceutical preparation being used for the treatment of pelvic inflammatory disease

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of pelvic inflammatory disease and its preparation method and application.

Background technology

Pelvic inflammatory disease is divided into acute pelvic inflammatory disease and chronic pelvic inflammatory disease.Chronic pelvic inflammatory disease refers to female internal genital organs and surrounding connective tissue, pelvic peritoneal chronic inflammatory disease.Often thoroughly do not treat for acute pelvic inflammatory disease, when patient's body constitution is poor, the course of disease of acute pelvic inflammatory disease can be delayed and recurrent exerbation, causes chronic pelvic inflammatory disease; But also can without acute pelvic inflammation medical history process, salpingitis caused by chlamydia trachomatis infection.The chronic pelvic inflammatory disease state of an illness is more obstinate, can cause menoxenia, leucorrhoea grow in quantity, waist abdomen pain and infertile etc.Because sickness rate is high, for this reason, be bursting to and develop the needs that more medicines for the treatment of pelvic inflammatory disease safely and effectively meet clinical treatment.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of pelvic inflammatory disease.In order to reach this object, adopt following technical scheme:

Technical scheme: a kind of pharmaceutical preparation being used for the treatment of pelvic inflammatory disease, the active component contained by it is extracted by following weight crude drug and is prepared from: Flos Campsis 20 parts, Floium Rhododendri Simsii 16 parts, Polygonum rude Meissn 15 parts, Folium Taccae plantagineae 20 parts, Folium Vaccinii Fragilis 20 parts, Radix caralliae diplopetalae 15 parts, Radix Linderae Chunii 18 parts, Radix oxysporae paniculatae 20 parts, Radix shuteriae sinensis 16 parts, Folium Dryoathyrii okuboanii 20 parts.

The described pharmaceutical preparation being used for the treatment of pelvic inflammatory disease, dosage form is pharmaceutically acceptable granule, tablet, capsule.

The described pharmaceutical preparation being used for the treatment of pelvic inflammatory disease, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make granule, tablet, capsule.

The described application of pharmaceutical preparation in preparation treatment pelvic inflammatory disease medicine being used for the treatment of pelvic inflammatory disease.

Described pelvic inflammatory disease is chronic pelvic inflammatory disease.

Flos Campsis is the flower of Bignoniaceae plant Radix campsis.Floium Rhododendri Simsii is the tender leaf of ericad Folium Rhododendri Simsii.Polygonum rude Meissn is the herb of the withered cattle of polygonaceae plant nine.Folium Taccae plantagineae is the leaf of Tacca chantrieri section Zhi Wu Rhizoma amorphophalli potato.Folium Vaccinii Fragilis is the root of ericad Corvus macrorhuchus fruit.Radix caralliae diplopetalae is the Herb of Rhizophoraceae plant Radix caralliae diplopetalae.Radix Linderae Chunii is the root of canella white glue wood.Radix oxysporae paniculatae is the Herb of Melastomateae plants ace wood.Radix shuteriae sinensis is the root of leguminous plant China place bud bean.Folium Dryoathyrii okuboanii is the leaf of Athyriaceae plant Central China Jie Herba pteridii latiusculi.

Beneficial effect: heat-clearing and toxic substances removing of the present invention, blood circulation promoting and blood stasis dispelling, invigorating the spleen and replenishing QI, eliminating blood stasis to promote regeneration of blood, full side's treatment pelvic inflammatory disease successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get Flos Campsis 20g, Floium Rhododendri Simsii 16g, Polygonum rude Meissn 15g, Folium Taccae plantagineae 20g, Folium Vaccinii Fragilis 20g, Radix caralliae diplopetalae 15g, Radix Linderae Chunii 18g, Radix oxysporae paniculatae 20g, Radix shuteriae sinensis 16g, Folium Dryoathyrii okuboanii 20g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get Flos Campsis 20g, Floium Rhododendri Simsii 16g, Polygonum rude Meissn 15g, Folium Taccae plantagineae 20g, Folium Vaccinii Fragilis 20g, Radix caralliae diplopetalae 15g, Radix Linderae Chunii 18g, Radix oxysporae paniculatae 20g, Radix shuteriae sinensis 16g, Folium Dryoathyrii okuboanii 20g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.

3, the preparation of capsule embodiment: get Flos Campsis 20g, Floium Rhododendri Simsii 16g, Polygonum rude Meissn 15g, Folium Taccae plantagineae 20g, Folium Vaccinii Fragilis 20g, Radix caralliae diplopetalae 15g, Radix Linderae Chunii 18g, Radix oxysporae paniculatae 20g, Radix shuteriae sinensis 16g, Folium Dryoathyrii okuboanii 20g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.

4, pharmaceutical preparation treatment pelvic inflammatory disease of the present invention clinical research

Case selection: as the medicine for the treatment of pelvic inflammatory disease, select the routine clinical observation of Patients with Pelvic Inflammatory Disease 80 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 40 example, 25 ~ 48 years old age, 35.8 years old mean age, the course of disease 1 ~ 2 year; Matched group women 40 example, 24 ~ 50 years old age, 39.8 years old mean age, the course of disease 1 ~ 2 year; The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.

Diagnostic criteria: 1. once had acute pelvic inflammatory disease medical history or pulmonary tuberculosis medical history.2. clinical manifestation can have Irregular uterine bleeding, lower abdomen falling inflation, and lumbosacral region is uncomfortable, sexual anhedonia.3. checking has the other tissue in palace to thicken and tenderness maybe can be laid one's hand on and enclosed mass.4. routine blood test and erythrocyte sedimentation rate may be higher.5. diagnostic curettage prompting endometrial tuberculosis or chronic endometritis.The enclosed mass that 6.B type ultrasound investigation visible pelvic cavity form is irregular, capsule is uneven in fact or hydrops.7. can find adhesion around internal genitalia under peritoneoscope, tissue thickens, enclosed mass is formed; Get tissue in art to make pathologic finding and can make a definite diagnosis further.

Medicament selection: the preparation method that treatment group takes above-mentioned granule embodiment prepares medicine of the present invention, oral, every day 3 times, each 1 time sooner or later, each 10g, after meal warm water delivery service; Within 15 days, be 1 course for the treatment of, 2 ~ 4 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.Matched group takes Noroxin, oral, and be grown up a 0.1 ~ 0.2g, 3 ~ 4 times on the one; Serious symptom takes the circumstances into consideration dosage, 1.6g on the one, divides and takes for 4 times.

Efficacy determination: (1) cures: transference cure such as pelvic cavity pendant pain, high hot headache, menoxenia, inappetence etc.; Appetite strengthens, and health is fully recovered.(2) effective: above-mentioned symptom is alleviated to some extent, appetite strengthens, and health is fully recovered.(3) invalid: disease is unchanged.Therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Cure	Effectively	Invalid	Total effective rate (%)
						Treatment group	40	21	16	3	92.5
Blank group	40	2	1	37	7.5

Visible the present invention has good therapeutic effect to pelvic inflammatory disease, and toxic and side effects does not occur treatments period.

Claims

1. one kind is used for the treatment of the pharmaceutical preparation of pelvic inflammatory disease, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Flos Campsis 20 parts, Floium Rhododendri Simsii 16 parts, Polygonum rude Meissn 15 parts, Folium Taccae plantagineae 20 parts, Folium Vaccinii Fragilis 20 parts, Radix caralliae diplopetalae 15 parts, Radix Linderae Chunii 18 parts, Radix oxysporae paniculatae 20 parts, Radix shuteriae sinensis 16 parts, Folium Dryoathyrii okuboanii 20 parts.

2. be used for the treatment of the application of pharmaceutical preparation in treatment pelvic inflammatory disease medicine of pelvic inflammatory disease according to claim 1.