CN105079394A - Pharmaceutic preparation for treating arrhythmia - Google Patents

Abstract

The invention belongs to the field of Chinese herbal preparations, and in particular relates to a pharmaceutic preparation for treating arrhythmia. The pharmaceutic preparation is prepared from the following raw materials in parts by weight: 22 parts of microsorium fortunei ching, 18 parts of nicandra physalodes, 21 parts of all-grass of vigleaf stonecrop, 17 parts of Swertia bimaculata (Sieb. et Zucc.) Hook. f. et Thoms., 25 parts of poria with hostwood, 28 parts of astragalus membranaceus, 25 parts of the root of red-rooted salvia, 15 parts of angelica sinensis, 20 parts of pseudo-ginseng, 25 parts of semen plantaginis, 20 parts of Chinese yam, 25 parts of dandelion, 15 parts of chrysanthemum flowers, 15 parts of schisandra chinensis, 15 parts of rhizoma acori graminei, 15 parts of ligusticum wallichii, and 5 parts of liquorice. The pharmaceutic preparation can treat arrhythmia.

Description

One is used for the treatment of ARR pharmaceutical preparation

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to one and be used for the treatment of ARR pharmaceutical preparation and its preparation method and application.

Background technology

Arrhythmia is because the exciting exception of sinuatrial node or excitement result from beyond sinuatrial node; exciting conduction slowly, retardance or through abnormal passage conduction, namely the origin of cardiomotility and (or) conductive impairment cause frequency and (or) the allorhythmia of heartbeat.Arrhythmia is one group of disease important in cardiovascular disease.It can be fallen ill separately and also can occur together with cardiovascular diseases.Can break out and cause sudden death, also sustainablely involve heart and cause its exhaustion.For this reason, be bursting to develop and manyly treat the needs that ARR medicine meets clinical treatment safely and effectively.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of arrhythmia disease.In order to reach this object, adopt following technical scheme:

Technical scheme: one is used for the treatment of ARR pharmaceutical preparation, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 22 parts, large thousand raw 18 parts, Herba Sebi drymarioidiss 21 parts, greatly Herba vallisneriae Spiralis 17 parts, Poria cum Radix Pini 25 parts, the Radix Astragali 28 parts, Radix Salviae Miltiorrhizae 25 parts, Radix Angelicae Sinensis 15 parts, Radix Notoginseng 20 parts, Semen Plantaginis 25 parts, Rhizoma Dioscoreae 20 parts, Herba Taraxaci 25 parts, Flos Chrysanthemi 20 parts, Fructus Schisandrae Chinensis 15 parts, Rhizoma Acori Graminei 15 parts, Rhizoma Chuanxiong 15 parts, 5 parts, Radix Glycyrrhizae.

Describedly be used for the treatment of ARR pharmaceutical preparation, dosage form is pharmaceutically acceptable granule, tablet, capsule.

Describedly be used for the treatment of ARR pharmaceutical preparation, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

Described be used for the treatment of ARR pharmaceutical preparation preparation treatment arrhythmic agent in application.

Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore is Polypodiaceae subfam. Microsoroideae Cyclosorus plant south of the River Microsorium Link Microsoriumfortune (Moore) Ching, is used as medicine with herb and root stock.The four seasons can adopt, and clean, using fresh herb or dry.Clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, reducing swelling and alleviating pain.For jaundice, dysentery, urinary tract infection, tuberculous lymphadenitis, leucorrhea, rheumatic arthritis, hemoptysis, spits blood, has blood in stool, epistaxis; Traumatic injury is controlled in external, fracture, venom, furuncle swelling toxin.The present invention is with all herbal medicine.

Large thousand raw Classification system Nicandraphysaloides, calm, eliminate the phlegm, heat-clearing and toxic substances removing.For rabies, psychosis, epilepsy, rheumatic arthritis, nasal sinusitis, flu, urinary tract infection, furuncle.The present invention is used as medicine with root.

Herba Sebi drymarioidis is the herb of crassulaceae plants great Ye flame grass.Clearing away heat and cooling blood, subduing swelling and detoxicating.Control haematemesis, hemoptysis.

Large Herba vallisneriae Spiralis is Gentianaceae Swertia plant two point Herba Swertiae bimaculatae Swertiabimaculata (Sieb.etZucc.) Hook.f.etThoms., with all herbal medicine.Xia Qiucai herb, dries.Heat-clearing and toxic substances removing, 'Shugan Lidan '.For acute, chronic hepatitis, cholecystitis, urinary tract infection, gastroenteritis, cold, fever, influenza, pharyngolaryngitis, toothache.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect: the traditional Chinese medical science is thought, arrhythmia belongs to the category such as the traditional Chinese medical science " cardiopalmus ", " palpitation with a distress feeling ", " thoracic obstruction ", " pained ", how because internal organs negative and positive of qi and blood is deficient, internal damage by the excessive seven emotions, qi depression to blood stasis reciprocal action cause become homeless foster, heart arteries and veins of the heart and lose smooth and cause.Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore of the present invention, large thousand lifes, Herba Sebi drymarioidis, large Herba vallisneriae Spiralis, Poria cum Radix Pini, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Radix Notoginseng heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, benefiting qi and nourishing blood are monarch drug, Semen Plantaginis, Rhizoma Dioscoreae, Herba Taraxaci, Flos Chrysanthemi, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei, Rhizoma Chuanxiong vital energy regualting and blood circulation-promoting, promote blood circulation and calm the nerves as ministerial drug, Radix Glycyrrhizae is adjuvant, the mutual compatibility of full side, treatment arrhythmia successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 22g, large thousand raw 18g, Herba Sebi drymarioidis 21g, large Herba vallisneriae Spiralis 17g, Poria cum Radix Pini 25g, Radix Astragali 28g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 15g, Radix Notoginseng 20g, Semen Plantaginis 25g, Rhizoma Dioscoreae 20g, Herba Taraxaci 25g, Flos Chrysanthemi 20g, Fructus Schisandrae Chinensis 15g, Rhizoma Acori Graminei 15g, Rhizoma Chuanxiong 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, and atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 22g, large thousand raw 18g, Herba Sebi drymarioidis 21g, large Herba vallisneriae Spiralis 17g, Poria cum Radix Pini 25g, Radix Astragali 28g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 15g, Radix Notoginseng 20g, Semen Plantaginis 25g, Rhizoma Dioscoreae 20g, Herba Taraxaci 25g, Flos Chrysanthemi 20g, Fructus Schisandrae Chinensis 15g, Rhizoma Acori Graminei 15g, Rhizoma Chuanxiong 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds dextrin 50g, granulates, tabletting, makes tablet.

3, the preparation of capsule embodiment: get Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 22g, large thousand raw 18g, Herba Sebi drymarioidis 21g, large Herba vallisneriae Spiralis 17g, Poria cum Radix Pini 25g, Radix Astragali 28g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 15g, Radix Notoginseng 20g, Semen Plantaginis 25g, Rhizoma Dioscoreae 20g, Herba Taraxaci 25g, Flos Chrysanthemi 20g, Fructus Schisandrae Chinensis 15g, Rhizoma Acori Graminei 15g, Rhizoma Chuanxiong 15g, Radix Glycyrrhizae 5g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.

4, pharmaceutical preparation treatment arrhythmia of the present invention clinical research

Case selection: diagnostic criteria: 1. sinus P ripple, I, II, aVF, V3-V6 be upright, aVR is inverted.2. during air-breathing, sinus rate is accelerated, and during expiration, sinus rate slows down, P-P cycle difference >=120 millisecond, and heart rate speed generating period becomes.The ARR phenomenon of the recording ecg that temporarily ceases breathing disappears.3. average sinus rhythm is between 60-100pm, for normal sinus rhythm is uneven; Heart rate is at more than 100pm, and for sinus tachycardia, companion is uneven; Heart rate <60pm, for sinus bradycardia, companion is uneven.

As the ARR medicine for the treatment of, select the routine clinical observation of arrhythmia patient 40 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 20 example, each half of men and women, 42 ~ 65 years old age, 53.7 years old mean age, the course of disease 1 ~ 2 year; Matched group 20 example, each half of men and women, 53 ~ 66 years old age, 57.3 years old mean age, the course of disease 1 ~ 2 year; The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.

Medicament selection: the preparation method that treatment group takes above-mentioned granule embodiment prepares medicine of the present invention, oral, every day 2 times, each 1 time sooner or later, each 10g, after meal warm water delivery service; Within 12 days, be 1 course for the treatment of, 2 ~ 4 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.

Matched group takes Diclofenac Potassium Capsules, oral, bfore meals.Adult: 100 ~ 150mg (4 ~ 6) on the one; Patients whose symptoms were less severe 75 ~ 100mg (3 ~ 4) on the one, divides and takes for 2 ~ 3 times.

Efficacy determination: (1) cures: clinical symptoms all disappears, lab testing is normal, and electrocardiogram recovers normal.(2) effective: clinical symptoms obviously alleviates, lab testing obviously improves, and electrocardiogram takes a turn for the better.(3) effective: clinical symptoms alleviates to some extent, and lab testing makes moderate progress, electrocardiogram takes a turn for the better.(4) invalid: by treating rear above-mentioned symptom without alleviating or increasing the weight of.Therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Cure	Effective	Effectively	Invalid	Total effective rate (%)
							Treatment group	20	4	12	2	2	90
Blank group	20	3	4	5	8	60

Visible the present invention has good therapeutic effect to arrhythmia, and toxic and side effects does not occur treatments period.

Claims (4)

1. one kind is used for the treatment of ARR pharmaceutical preparation, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 22 parts, large thousand raw 18 parts, Herba Sebi drymarioidiss 21 parts, greatly Herba vallisneriae Spiralis 17 parts, Poria cum Radix Pini 25 parts, the Radix Astragali 28 parts, Radix Salviae Miltiorrhizae 25 parts, Radix Angelicae Sinensis 15 parts, Radix Notoginseng 20 parts, Semen Plantaginis 25 parts, Rhizoma Dioscoreae 20 parts, Herba Taraxaci 25 parts, Flos Chrysanthemi 20 parts, Fructus Schisandrae Chinensis 15 parts, Rhizoma Acori Graminei 15 parts, Rhizoma Chuanxiong 15 parts, 5 parts, Radix Glycyrrhizae.

2. be used for the treatment of ARR pharmaceutical preparation as claimed in claim 1, it is characterized in that, dosage form is pharmaceutically acceptable granule, tablet, capsule.

3. be used for the treatment of ARR pharmaceutical preparation as claimed in claim 1, it is characterized in that, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

4. be used for the treatment of the application of ARR pharmaceutical preparation in treatment arrhythmic agent according to claim 1.