CN104840703A

CN104840703A - Medicine preparation for treating breast cancer

Info

Publication number: CN104840703A
Application number: CN201510310011.4A
Authority: CN
Inventors: 徐艳
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-06-08
Filing date: 2015-06-08
Publication date: 2015-08-19

Abstract

The invention belongs to the field of medicines, and provides a medicine preparation for treating breast cancer. The medicine preparation is prepared from the following raw materials: 20 parts of small diuranthera root, 15 parts of Hongkong kumquat leaves, 18 parts of martin fig root and stem, 20 parts of devil rush rhizome, 16 parts of kaleniczenk euphorbia herb, 20 parts of pampanin shuteria herb, 18 parts of common yellow oxalis herb, 15 parts of puberulous glochidion root, 16 parts of common floweringquince seeds, 18 parts of Chinese holly roots, 20 parts of fernleaf dichocarpum roots, 15 parts of androsace umbellate, 16 parts of Chinese photinia fruit, 18 parts of common alocasia fruit and 20 parts of apricot-leaved adenophora leaves. The medicine preparation provided by the invention is capable of treating breast cancer.

Description

A kind of pharmaceutical preparation being used for the treatment of breast carcinoma

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of pharmaceutical preparation being used for the treatment of breast carcinoma and its preparation method and application.

Background technology

Current breast carcinoma has become the able-bodied kinds of tumor of threat women.Whole world breast cancer incidence starts always in rising trend from late 1970s.The U.S. 8 women just have 1 people in life and suffer from breast cancer.China is not the country occurred frequently of breast carcinoma, but unsuitable optimistic, and the growth rate of China's breast cancer incidence but exceeds national 1 ~ 2 percentage point occurred frequently in recent years.Because sickness rate is high, for this reason, be bursting to and develop the needs that more medicines for the treatment of breast carcinoma safely and effectively meet clinical treatment.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of breast cancer disease.In order to reach this object, adopt following technical scheme:

Technical scheme: a kind of pharmaceutical preparation being used for the treatment of breast carcinoma, the active component contained by it is extracted by following weight crude drug and is prepared from: Radix Diurantherae Minoris 20 parts, Folium Fortunellae Hindsii 15 parts, Radix seu Caulis fici Martinii 18 parts, Rhizoma Juci setchuensis 20 parts, Euphorbia kaleniczenkii Czerniaev 16 parts, Shuteria pampaniniana Hand.-Mazz. 20 parts, Herba Oxalidis Strictae 18 parts, Radix glochidionis puberi 15 parts, Semen Chaenomelis 16 parts, Radix Ilicis Cornutae 18 parts, Radix Dichocarpi Dalzielii 20 parts, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 15 parts, Chinese photinia fruit 16 parts, Fructus Alocasiae macrorrhizae 18 parts of, Folium Adenophorae Trachelioidis 20 parts.

The described pharmaceutical preparation being used for the treatment of breast carcinoma, dosage form is pharmaceutically acceptable granule, tablet, capsule.

The described pharmaceutical preparation being used for the treatment of breast carcinoma, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make granule, tablet, capsule.

The described application of pharmaceutical preparation in preparation treatment breast cancer medicines being used for the treatment of breast carcinoma.

Radix Diurantherae Minoris is the root of the little Radix diurantherae majoris of liliaceous plant.Folium Fortunellae Hindsii is the leaf of rutaceae mountain Fructus Citri tangerinae.Radix seu Caulis fici Martinii is root, the stem of moraceae plants Martin fig.Rhizoma Juci setchuensis is the rhizome that rush family plant intends Medulla Junci.Euphorbia kaleniczenkii Czerniaev is the herb of euphorbia plant Euphorbia kaleniczenkii Czerniaev.Shuteria pampaniniana Hand.-Mazz. is the herb of leguminous plant hair place bud bean.Herba Oxalidis Strictae is the tight oxalic herb of Oxalidaceae plant.Radix glochidionis puberi is the root of euphorbia plant Fructus glochidionis puberi(Herba Glochidii Puberi).Semen Chaenomelis is the seed of rosaceous plant chaenomeles lagenaria.Radix Ilicis Cornutae is the root of holly plant Ilex cornuta Lindl..Radix Dichocarpi Dalzielii is the root of ranunculaceae plant fern leaf herringbone fruit.Herba Androsaces Umbellatae (Herba Androsaces Coccineae) is the herb of Ofthe Primulaceae Caulis et folium clerodendri bungei Herba Androsaces Umbellatae (Herba Androsaces Coccineae).Chinese photinia fruit is the fruit of rosaceous plant Chinese photinia.Fructus Alocasiae macrorrhizae is the fruit of aroid Rhizoma alcasiae odorae.Folium Adenophorae Trachelioidis is the Seedling leaf of Campanulaceae Radix Adenophorae Trachelioidis.

Beneficial effect: Radix Diurantherae Minoris of the present invention, Folium Fortunellae Hindsii, Radix seu Caulis fici Martinii, Rhizoma Juci setchuensis heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling is monarch drug, Euphorbia kaleniczenkii Czerniaev, Shuteria pampaniniana Hand.-Mazz., Herba Oxalidis Strictae, Radix glochidionis puberi supplementing QI for promoting the production of body fluid are ministerial drug, Semen Chaenomelis, Radix Ilicis Cornutae, Radix Dichocarpi Dalzielii, Herba Androsaces Umbellatae (Herba Androsaces Coccineae), Chinese photinia fruit, Fructus Alocasiae macrorrhizae, Folium Adenophorae Trachelioidis are adjuvant, full side's treatment breast carcinoma successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get Radix Diurantherae Minoris 20g, Folium Fortunellae Hindsii 15g, Radix seu Caulis fici Martinii 18g, Rhizoma Juci setchuensis 20g, Euphorbia kaleniczenkii Czerniaev 16g, Shuteria pampaniniana Hand.-Mazz. 20g, Herba Oxalidis Strictae 18g, Radix glochidionis puberi 15g, Semen Chaenomelis 16g, Radix Ilicis Cornutae 18g, Radix Dichocarpi Dalzielii 20g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 15g, Chinese photinia fruit 16g, Fructus Alocasiae macrorrhizae 18g, Folium Adenophorae Trachelioidis 20g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get Radix Diurantherae Minoris 20g, Folium Fortunellae Hindsii 15g, Radix seu Caulis fici Martinii 18g, Rhizoma Juci setchuensis 20g, Euphorbia kaleniczenkii Czerniaev 16g, Shuteria pampaniniana Hand.-Mazz. 20g, Herba Oxalidis Strictae 18g, Radix glochidionis puberi 15g, Semen Chaenomelis 16g, Radix Ilicis Cornutae 18g, Radix Dichocarpi Dalzielii 20g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 15g, Chinese photinia fruit 16g, Fructus Alocasiae macrorrhizae 18g, Folium Adenophorae Trachelioidis 20g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.

3, the preparation of capsule embodiment: get Radix Diurantherae Minoris 20g, Folium Fortunellae Hindsii 15g, Radix seu Caulis fici Martinii 18g, Rhizoma Juci setchuensis 20g, Euphorbia kaleniczenkii Czerniaev 16g, Shuteria pampaniniana Hand.-Mazz. 20g, Herba Oxalidis Strictae 18g, Radix glochidionis puberi 15g, Semen Chaenomelis 16g, Radix Ilicis Cornutae 18g, Radix Dichocarpi Dalzielii 20g, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 15g, Chinese photinia fruit 16g, Fructus Alocasiae macrorrhizae 18g, Folium Adenophorae Trachelioidis 20g, adds the water of medical material 10 times of weight, soaks 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, and merges twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adds ethanol and makes the percent by volume of alcohol content reach 75%, stirs, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, and leaving air temp is 90 DEG C, and temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, adds starch 50g, granulates, fill, makes capsule.

4, pharmaceutical preparation treatment breast carcinoma of the present invention clinical research

Case selection: as the medicine for the treatment of breast carcinoma, select the routine clinical observation of patient with breast cancer 80 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group women 40 example, 35 ~ 61 years old age, 47.8 years old mean age, the course of disease 1 ~ 2 year; Matched group women 40 example, 34 ~ 64 years old age, 49.5 years old mean age, the course of disease 1 ~ 2 year; The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.

Medicament selection: the preparation method that treatment group takes above-mentioned granule embodiment prepares medicine of the present invention, oral, every day 3 times, each 1 time sooner or later, each 10g, after meal warm water delivery service; Within 12 days, be 1 course for the treatment of, 2 ~ 4 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.

Matched group takes medroxyprogesterone acetate tablets, oral, a 100mg (50), 3 times on the one, or oral 500mg (250), and every day 1 ~ 2 time, as the maintenance dose after intramuscular injection.

Efficacy determination: (1) cures: lump disappears, and physical recovery is normal.(2) effective: lump obviously reduces, health takes a turn for the better to some extent.(3) effective: lump reduces to some extent, and health is clearly better.(4) invalid: by treating rear lump without reducing or expanding.Therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Cure	Effective	Effectively	Invalid	Total effective rate (%)
							Treatment group	40	14	18	5	3	92.5
Blank group	40	7	8	12	13	67.5

Visible the present invention has good therapeutic effect to breast carcinoma, and toxic and side effects does not occur treatments period.

Claims

1. one kind is used for the treatment of the pharmaceutical preparation of breast carcinoma, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Radix Diurantherae Minoris 20 parts, Folium Fortunellae Hindsii 15 parts, Radix seu Caulis fici Martinii 18 parts, Rhizoma Juci setchuensis 20 parts, Euphorbia kaleniczenkii Czerniaev 16 parts, Shuteria pampaniniana Hand.-Mazz. 20 parts, Herba Oxalidis Strictae 18 parts, Radix glochidionis puberi 15 parts, Semen Chaenomelis 16 parts, Radix Ilicis Cornutae 18 parts, Radix Dichocarpi Dalzielii 20 parts, Herba Androsaces Umbellatae (Herba Androsaces Coccineae) 15 parts, Chinese photinia fruit 16 parts, Fructus Alocasiae macrorrhizae 18 parts of, Folium Adenophorae Trachelioidis 20 parts.

2. be used for the treatment of the application of pharmaceutical preparation in treatment breast cancer medicines of breast carcinoma according to claim 1.