CN104364240A - 一种用于预防或治疗分支杆菌疾病的药物 - Google Patents

一种用于预防或治疗分支杆菌疾病的药物 Download PDF

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CN104364240A
CN104364240A CN201380029863.5A CN201380029863A CN104364240A CN 104364240 A CN104364240 A CN 104364240A CN 201380029863 A CN201380029863 A CN 201380029863A CN 104364240 A CN104364240 A CN 104364240A
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oxo
phenyl
compound
fluoro
alkyl
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CN104364240B (zh
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阙峰
王莹
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Sichuan Beilike Biotechnology LLC
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Sichuan Beilike Biotechnology LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

本发明公开了一种用于预防或治疗分支杆菌疾病的药物。具体来说，公开了一种下列通式I表示的化合物或其药学上可接受的盐、水合物、溶剂化物、配合物或前药在制备用于预防或治疗分支杆菌疾病的药物中的应用，为结核病等的防治提供给了新的途径。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201380029863.5A 2012-06-08 2013-06-06 一种用于预防或治疗分支杆菌疾病的药物 Expired - Fee Related CN104364240B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201380029863.5A CN104364240B (zh) 2012-06-08 2013-06-06 一种用于预防或治疗分支杆菌疾病的药物

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201210187947.9 2012-06-08
CN2012101879479 2012-06-08
CN201210187947 2012-06-08
CN201380029863.5A CN104364240B (zh) 2012-06-08 2013-06-06 一种用于预防或治疗分支杆菌疾病的药物
PCT/CN2013/076872 WO2013182070A1 (zh) 2012-06-08 2013-06-06 一种用于预防或治疗分支杆菌疾病的药物

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CN104364240A true CN104364240A (zh) 2015-02-18
CN104364240B CN104364240B (zh) 2017-02-22

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WO (1) WO2013182070A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017066964A1 (en) * 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
CN107286111B (zh) * 2016-03-30 2020-06-19 广东赛法洛药业有限公司 一种噁唑烷酮化合物的制备方法
CN107400126A (zh) * 2016-05-19 2017-11-28 陕西合成药业股份有限公司 新型噁唑烷酮类化合物及其制备方法和在医学上的应用
JP2021534215A (ja) * 2018-08-24 2021-12-09 ゼニオプロ ゲーエムベーハー 病的症状の治療における使用のための芳香族分子
CN111925343B (zh) * 2020-08-12 2021-11-23 石家庄四药有限公司 一种利奈唑胺降解杂质的合成方法

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CN1130379A (zh) * 1993-09-09 1996-09-04 厄普约翰公司 取代的噁嗪和噻嗪噁唑烷酮抗微生物剂
CN1143961A (zh) * 1994-03-15 1997-02-26 法玛西雅厄普约翰公司 噁唑烷酮衍生物和含有它们的药物组合物
CN1161333A (zh) * 1996-02-06 1997-10-08 拜尔公司 新的杂芳基噁唑烷酮类化合物
CN1172484A (zh) * 1995-02-03 1998-02-04 法玛西雅厄普约翰美国公司 杂芳环取代的苯基噁唑烷酮抗菌剂
CN1261889A (zh) * 1997-07-11 2000-08-02 法玛西雅厄普约翰美国公司 噻二唑基和噁二唑基苯基噁唑烷酮抗菌剂
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CN1668308A (zh) * 2002-07-29 2005-09-14 兰贝克赛实验室有限公司 作为抗菌剂的噁唑烷酮衍生物
WO2006035283A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
CN1816545A (zh) * 2003-07-02 2006-08-09 默克制药公司 环丙基取代的噁唑烷酮抗生素及其衍生物
WO2007023507A2 (en) * 2005-06-20 2007-03-01 Wockhardt Limited Oxazolidinones bearing antimicrobial activity composition and methods of preparation
CN101720325A (zh) * 2007-08-06 2010-06-02 盟科医药技术公司 用于治疗细菌感染的抗菌邻-氟苯基噁唑烷酮
CN101993448A (zh) * 2009-08-24 2011-03-30 上海柯盟医药技术有限公司 可用于治疗传染病的抗分枝杆菌的噁唑烷酮
CN102256951A (zh) * 2009-11-04 2011-11-23 四川贝力克生物技术有限责任公司 结晶水合物、药物组合物及其制备方法和用途
WO2012061360A2 (en) * 2010-11-01 2012-05-10 Rib-X Pharmaceuticals, Inc. Pharmaceutical compositions

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1130379A (zh) * 1993-09-09 1996-09-04 厄普约翰公司 取代的噁嗪和噻嗪噁唑烷酮抗微生物剂
CN1143961A (zh) * 1994-03-15 1997-02-26 法玛西雅厄普约翰公司 噁唑烷酮衍生物和含有它们的药物组合物
CN1121919A (zh) * 1994-07-20 1996-05-08 拜尔公司 五元杂芳基-噁唑烷酮
CN1172484A (zh) * 1995-02-03 1998-02-04 法玛西雅厄普约翰美国公司 杂芳环取代的苯基噁唑烷酮抗菌剂
CN1161333A (zh) * 1996-02-06 1997-10-08 拜尔公司 新的杂芳基噁唑烷酮类化合物
CN1261889A (zh) * 1997-07-11 2000-08-02 法玛西雅厄普约翰美国公司 噻二唑基和噁二唑基苯基噁唑烷酮抗菌剂
CN1304410A (zh) * 1998-06-05 2001-07-18 阿斯特拉曾尼卡有限公司 噁唑烷酮及其制备方法和含有它们的药物组合物
CN1322203A (zh) * 1998-10-09 2001-11-14 阿斯特拉曾尼卡有限公司 作为抗菌剂的杂环氨基甲基噁唑烷酮
CN1433413A (zh) * 2000-06-05 2003-07-30 东亚制药株式会社 新的噁唑烷酮衍生物及其制备方法
CN1668308A (zh) * 2002-07-29 2005-09-14 兰贝克赛实验室有限公司 作为抗菌剂的噁唑烷酮衍生物
CN1816545A (zh) * 2003-07-02 2006-08-09 默克制药公司 环丙基取代的噁唑烷酮抗生素及其衍生物
WO2006035283A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
WO2007023507A2 (en) * 2005-06-20 2007-03-01 Wockhardt Limited Oxazolidinones bearing antimicrobial activity composition and methods of preparation
CN101720325A (zh) * 2007-08-06 2010-06-02 盟科医药技术公司 用于治疗细菌感染的抗菌邻-氟苯基噁唑烷酮
CN101993448A (zh) * 2009-08-24 2011-03-30 上海柯盟医药技术有限公司 可用于治疗传染病的抗分枝杆菌的噁唑烷酮
CN102256951A (zh) * 2009-11-04 2011-11-23 四川贝力克生物技术有限责任公司 结晶水合物、药物组合物及其制备方法和用途
WO2012061360A2 (en) * 2010-11-01 2012-05-10 Rib-X Pharmaceuticals, Inc. Pharmaceutical compositions

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WO2013182070A1 (zh) 2013-12-12

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