CN103923122B - 含有噁唑烷酮的二聚体化合物、组合物以及制备方法和用途 - Google Patents
含有噁唑烷酮的二聚体化合物、组合物以及制备方法和用途 Download PDFInfo
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- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229940006486 zinc cation Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
时间(分钟) | 流速(mL/分钟) | %A | %B |
0.0 | 1.0 | 98.0 | 2.0 |
15.0 | 1.0 | 5.0 | 95.0 |
25.0 | 1.0 | 5.0 | 95.0 |
27.0 | 1.0 | 98.0 | 2.0 |
30.0 | 1.0 | 98.0 | 2.0 |
组 | 治疗 | 浓度(mg/kg) | 浓度(mg/m2) | 48小时存活率 |
1 | 式Ⅲ | 10 | 0.2 | 1/10 |
2 | 式Ⅲ | 5 | 0.1 | 1/10 |
3 | 式Ⅲ | 2.5 | 0.05 | 0/10 |
4 | 式Ⅲ | 1.25 | 0.025 | 1/10 |
5 | 感染对照 | - | 1/10 |
组 | 治疗 | 浓度(mg/kg) | 浓度(mg/m2) | 24小时存活率 | 48小时存活率 |
1 | 式Ⅳ | 10 | 0.2 | 10/10 | 10/10 |
2 | 式Ⅳ | 5 | 0.1 | 10/10 | 10/10 |
3 | 式Ⅳ | 2.5 | 0.05 | 8/10 | 7/10 |
4 | 式Ⅳ | 1.25 | 0.025 | 5/10 | 2/10 |
5 | 感染对照 | - | 2/10 | 1/10 |
Claims (11)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18195509P | 2009-05-28 | 2009-05-28 | |
US61/181,955 | 2009-05-28 | ||
US12/787,293 US8580767B2 (en) | 2009-05-28 | 2010-05-25 | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
US12/787,293 | 2010-05-25 | ||
CN201080032447.7A CN102497866B (zh) | 2009-05-28 | 2010-05-27 | 含有噁唑烷酮的二聚体化合物、组合物以及制备方法和用途 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201080032447.7A Division CN102497866B (zh) | 2009-05-28 | 2010-05-27 | 含有噁唑烷酮的二聚体化合物、组合物以及制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103923122A CN103923122A (zh) | 2014-07-16 |
CN103923122B true CN103923122B (zh) | 2016-08-24 |
Family
ID=42333294
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410101354.5A Expired - Fee Related CN103923122B (zh) | 2009-05-28 | 2010-05-27 | 含有噁唑烷酮的二聚体化合物、组合物以及制备方法和用途 |
CN201080032447.7A Expired - Fee Related CN102497866B (zh) | 2009-05-28 | 2010-05-27 | 含有噁唑烷酮的二聚体化合物、组合物以及制备方法和用途 |
Family Applications After (1)
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CN201080032447.7A Expired - Fee Related CN102497866B (zh) | 2009-05-28 | 2010-05-27 | 含有噁唑烷酮的二聚体化合物、组合物以及制备方法和用途 |
Country Status (13)
Country | Link |
---|---|
US (2) | US8580767B2 (zh) |
EP (1) | EP2435051A1 (zh) |
JP (2) | JP5785939B2 (zh) |
KR (1) | KR101745511B1 (zh) |
CN (2) | CN103923122B (zh) |
AU (1) | AU2010254039B2 (zh) |
BR (1) | BRPI1012047A2 (zh) |
CA (1) | CA2769769A1 (zh) |
IL (2) | IL216547A0 (zh) |
MX (2) | MX2011012544A (zh) |
NZ (2) | NZ596602A (zh) |
RU (2) | RU2557910C2 (zh) |
WO (1) | WO2010138649A1 (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
KR101674146B1 (ko) | 2008-10-10 | 2016-11-08 | 머크 샤프 앤드 돔 코포레이션 | 옥사졸리디논 및 이를 포함하는 조성물을 제조하는 방법 |
PE20120585A1 (es) | 2009-02-03 | 2012-06-13 | Trius Therapeutics | Forma cristalina del fosfato de dihidrogeno r)-3-(4-(2-(2-metiltetrazol-5-il) piridin-5-il)-3-fluorofensil)-5-hidroximetil oxazolidin-2-ona |
US8580767B2 (en) | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
CN105229001B (zh) * | 2014-04-18 | 2017-04-26 | 杭州普晒医药科技有限公司 | 一种噁唑烷酮类抗生素的晶型及制备方法、组合物和用途 |
WO2016063246A1 (en) * | 2014-10-22 | 2016-04-28 | Sun Pharmaceutical Industries Limited | Crystalline form r of tedizolid phosphate |
EP3723758A4 (en) | 2017-12-13 | 2021-06-23 | Merck Sharp & Dohme Corp. | PHARMACEUTICAL COMPOSITIONS OF TEDIZOLID PHOSPHATE |
CN111825666B (zh) * | 2019-04-23 | 2024-03-08 | 上海仕谱生物科技有限公司 | 二聚或多聚体形式的突变型idh抑制剂 |
KR20230052873A (ko) | 2020-06-18 | 2023-04-20 | 아카제라 메디신즈, 인크. | 옥사졸리디논 화합물, 옥사졸리디논 화합물을 포함하는 리포좀 조성물 및 이의 사용 방법 |
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US8580767B2 (en) | 2009-05-28 | 2013-11-12 | Trius Therapeutics, Inc. | Oxazolidinone containing dimer compounds, compositions and methods to make and use |
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2010
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- 2010-05-27 NZ NZ596602A patent/NZ596602A/en not_active IP Right Cessation
- 2010-05-27 JP JP2012513234A patent/JP5785939B2/ja not_active Expired - Fee Related
- 2010-05-27 AU AU2010254039A patent/AU2010254039B2/en not_active Ceased
- 2010-05-27 RU RU2011151861/15A patent/RU2557910C2/ru not_active IP Right Cessation
- 2010-05-27 RU RU2015122032/04A patent/RU2015122032A/ru not_active Application Discontinuation
- 2010-05-27 CN CN201410101354.5A patent/CN103923122B/zh not_active Expired - Fee Related
- 2010-05-27 NZ NZ620552A patent/NZ620552A/en not_active IP Right Cessation
- 2010-05-27 CN CN201080032447.7A patent/CN102497866B/zh not_active Expired - Fee Related
- 2010-05-27 KR KR1020117031076A patent/KR101745511B1/ko active IP Right Grant
- 2010-05-27 CA CA2769769A patent/CA2769769A1/en not_active Abandoned
- 2010-05-27 WO PCT/US2010/036283 patent/WO2010138649A1/en active Application Filing
- 2010-05-27 BR BRPI1012047A patent/BRPI1012047A2/pt not_active IP Right Cessation
- 2010-05-27 EP EP10721903A patent/EP2435051A1/en not_active Withdrawn
- 2010-05-27 MX MX2011012544A patent/MX2011012544A/es active IP Right Grant
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2011
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Also Published As
Publication number | Publication date |
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JP5785939B2 (ja) | 2015-09-30 |
KR101745511B1 (ko) | 2017-06-20 |
AU2010254039A1 (en) | 2011-12-15 |
CN103923122A (zh) | 2014-07-16 |
RU2015122032A (ru) | 2015-12-10 |
CA2769769A1 (en) | 2010-12-02 |
RU2557910C2 (ru) | 2015-07-27 |
US20100305069A1 (en) | 2010-12-02 |
KR20120026568A (ko) | 2012-03-19 |
US20140057874A1 (en) | 2014-02-27 |
US8580767B2 (en) | 2013-11-12 |
JP2012528182A (ja) | 2012-11-12 |
IL239049A0 (en) | 2015-07-30 |
JP2016026145A (ja) | 2016-02-12 |
BRPI1012047A2 (pt) | 2019-09-24 |
IL216547A0 (en) | 2012-02-29 |
NZ596602A (en) | 2014-02-28 |
MX2014001282A (es) | 2014-06-10 |
MX2011012544A (es) | 2012-02-28 |
WO2010138649A1 (en) | 2010-12-02 |
AU2010254039B2 (en) | 2016-03-03 |
JP6010196B2 (ja) | 2016-10-19 |
NZ620552A (en) | 2015-08-28 |
IL239049A (en) | 2017-07-31 |
EP2435051A1 (en) | 2012-04-04 |
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