A kind of man's health food and preparation method thereof
Technical field
The present invention relates to a kind of man's health food and preparation method thereof, being specifically related to a kind of is the formulated man's health food of raw material by agate coffee, saline cistanche and Radix Glycyrrhizae, belongs to field of health care food.
Background technology
Agate coffee is the new resource food of health ministry approval in 2011, and saline cistanche and Radix Glycyrrhizae are the integration of drinking and medicinal herbs food that health ministry is announced.Agate coffee, make again agate card (Maca, Lepidium meyemii Walp), belong to a Plants of Cruciferae (Cruciferae) Lepidium, originate in the mountain area, Andean, South America of 3500~4500 meters of Peru's middle part height above sea level, locals is mainly used in as food, can be used as conventional medicament and use, successfully plant in places such as Yunnan Province of China province Lijing, river celebrating and TAXKORGAN counties, Xinjiang at present, belong to pure natural plant.Since nineteen eighty-two, plantation and edible agate coffee are recommended by FAO (Food and Agriculture Organization of the United Nation) to various countries, and point out that agate coffee is a kind of nutrient safe food, can solve the health problem that multiple nutrients deficiency causes.In agate coffee, containing the nutrition such as agate coffee acid amides (macamides), agate coffee alkene (macaenes), glucosinolate, sterol, steroids composition alive, is a kind of natural food resource that full nutrition material can be provided to human body.Agate coffee has antifatigue, improves sexual function, improves fecundity, regulates endocrine, reduces the effects such as hyperplasia of prostate.
The integration of drinking and medicinal herbs food that saline cistanche (Cistanche deserticola Y.C.Ma) is announced for health ministry, for orobanchaceae plant cistanche belongs to perennial parasitics plant, main product is being the ground such as Inner Mongol, Gansu and Xinjiang, and its chemical composition contains abundant alkaloid, amino acid, benzyl carbinol glycoside, polysaccharide, iridoid, lignin and galactitol etc.Chinese medicine thinks that saline cistanche returns kidney large intestine two warps, cures mainly impotence, infertile, soreness and weakness of waist and knees, and muscles and bones is unable etc.Modern pharmacology experimental study proves, saline cistanche have kidney-replenishing, benefiting essence-blood, anti-ageing, strengthen the multiple bioactive molecules such as body immunity and antifatigue.
Radix Glycyrrhizae (Glycyrrhiza uralensis), herbaceos perennial, is a kind of help Chinese herbal medicine, is the integration of drinking and medicinal herbs food of health ministry announcement.Gas is micro-, and taste is sweet and special, and function cures mainly clearing heat and detoxicating, moistens the lung and relieve the cough, and coordinating the drug actions of a prescription, invigorates the spleen and benefits qi.Main component: glycyrrhizic acid, its sugariness is 250 times of sucrose.
The health food that a kind of health food combination of alleviating physical fatigue and preparation method thereof (Chinese patent CN102907663) report adopts pueraria root powder, Cordyceps militaris, saline cistanche and L-R-gene to prepare, a kind of Chinese herbal compounds that improves immunity, antifatigue, change the original sentence to sexual function (Chinese patent CN102872206) report adopts agate coffee, excessive sheep's hay, Chinese medicine preparation prepared by the traditional Chinese medicine extraction compositions such as rhodiola root, saline cistanche and wilsonii, so far there are no by agate coffee, saline cistanche and Radix Glycyrrhizae is report and the application of the formulated man's health food of raw material.
Summary of the invention
Object: for solving the deficiencies in the prior art, the invention provides a kind of man's health food and preparation method thereof, adopt the Overall View of differential diagnosis in tcm opinion, male health-care bioactive molecule in agate coffee, saline cistanche and Radix Glycyrrhizae is developed into the man's health food containing agate coffee, saline cistanche and Radix Glycyrrhizae, on health-care efficacy, makes it have more science, validity, targeting; The health-care efficacy of this combination is except having separately efficacy exertion, and its specific proportioning and production technology, strengthening aspect immunity, can be used for treating burnout syndrome, improve sexual function, strengthening body and improve fecundity.
Technical scheme: for solving the problems of the technologies described above, the technical solution used in the present invention is:
A kind of man's health food, is made up of the raw material of following components by weight percent: agate coffee 20-60 part, saline cistanche 25-65 part, Radix Glycyrrhizae 5-20 part.
Described healthy product for beautifying face, the processing method of raw material is: above-mentioned raw materials is proportionally processed respectively, cleaned, dry or dry, pulverize, can obtain or further extract by alcohol extracting or water extraction.
As preferred version, described a kind of man's health food, it is characterized in that, the processing method of raw material is as follows: above-mentioned raw materials is proportionally processed respectively, agate coffee, saline cistanche, Radix Glycyrrhizae obtain agate coffee extract, cistanche extracts and licorice after extracting respectively, concentrate, being dried, then agate coffee extract, cistanche extracts and licorice are fully mixed, obtain traditional Chinese medicine extraction composition.
Further, described agate coffee or saline cistanche raw material wash with water, dry or dry, pulverize, add 4-8 alcohol-aqueous acid doubly to carry out multi-stage counter current extraction 2-6 hour, after extracting liquid filtering under 30-60 ℃ of degree reduced pressure concentration, spray-dried agate coffee extract and cistanche extracts.
Described alcohol-aqueous acid is one or more in the Ethanol-Acetic Acid aqueous solution, ethanol-glycine solution, the Ethanol-Acetic Acid aqueous solution; And/or the pH value of described alcohol-aqueous acid is 3.0-6.5; And/or alcohol-water is long-pending than being 9:1-1:4 in described alcohol-aqueous acid; And/or it is 30-80 order that agate coffee or saline cistanche raw material are pulverized rear granularity.
Further, described licorice raw material washes with water, dries or dry, pulverizes, after while adding 4-10 times of alcohol-ammonia spirit to soak 10-24, carry out multi-stage counter current extraction, extract 2-8 hour heating and refluxing extraction, after extracting liquid filtering under 40-65 ℃ of degree reduced pressure concentration, spray-dried licorice.
Described alcohol-ammonia spirit is ethanol-ammonia spirit, and described ethanol-ammonia spirit pH value is 7.5-10.5; And/or,, alcohol-water is long-pending than being 4-10:1; And/or it is 30-80 order that licorice raw material is pulverized rear granularity.
As more preferably, described agate coffee and saline cistanche adopt alcohol extract, after gained extract is concentrated, and spray-dried agate coffee extract and cistanche extracts.Described Radix Glycyrrhizae adopts water extraction to get, after gained extract is concentrated, and the spray-dried licorice that obtains.
In addition, the formulation of described healthy product for beautifying face can be capsule, tablet, granule, pill or oral liquid.Respectively there is health-care efficacy spy according to agate coffee, saline cistanche and Radix Glycyrrhizae, the bioactive molecule of extraction is added to edible auxiliary materials and make capsule, tablet, granule, pill or oral liquid etc.
According to different formulations, add different edible auxiliary materials, wherein edible auxiliary materials is the auxiliary material using in the edible or medicine of national regulation, as starch, dextrin, white granulated sugar, cellulose and derivative thereof, dolomol etc.
Described a kind of man's health food, the preparation method of tablet is as follows:
Agate coffee, saline cistanche and traditional Chinese medicine of licorice root extract composition 25-60 part, add starch 30-50 part, carboxymethyl cellulose 5-15 part, dextrin 5-15 part, drop into mixing 10-30 minute in mixer, add ethanol as wetting agent, mix 5-10 minute, mixed material is granulated with 10-20 mesh sieve, puts into drying equipment inner drying, add the dolomol of 1-5 part of dried particles total amount, whole grain, compressing tablet, packing, to obtain final product.
Described a kind of man's health food, the preparation method of granule is as follows:
Agate coffee, saline cistanche and traditional Chinese medicine of licorice root extract composition 20-70 part, add starch 15-35 part, dextrin 10-35 part, white granulated sugar 5-10 part, drop in mixer and mix 10-30 minute, add ethanol as wetting agent, mix 5-10 minute, mixed material is granulated with 10-20 mesh sieve, put into drying equipment inner drying, 20-60 eye mesh screen screening for dried particles, removes coarse granule and fine powder, packing, to obtain final product.
Described a kind of man's health food, the preparation method of capsule is as follows:
Agate coffee, saline cistanche and traditional Chinese medicine of licorice root extract composition 10-50 part, starch 45-80 part, dextrin 5-10 part, drops into mixing 10-30 minute in mixer, add ethanol as wetting agent, mix 5-10 minute, mixed material is granulated with 10-20 mesh sieve, the hard fatty acids magnesium that adds dry material total amount 1-5 part, whole grain, capsule charge, packing, to obtain final product.
Described a kind of man's health food, the preparation method of oral liquid is as follows:
It is quantitative that agate coffee, saline cistanche and traditional Chinese medicine of licorice root extract composition, adds 6-40 doubly to measure purified water and dissolve to obtain liquid, adds the potassium sorbate of amount of liquid 0.05-1.0 part, and filtration, packing, sterilizing, packing, to obtain final product.
Beneficial effect: a kind of man's health food provided by the invention and preparation method thereof, adopt the Overall View of differential diagnosis in tcm opinion, male health-care bioactive molecule in agate coffee, saline cistanche and Radix Glycyrrhizae is developed into the man's health food containing agate coffee, saline cistanche and Radix Glycyrrhizae, on health-care efficacy, makes it have more science, validity, targeting; The health-care efficacy of this combination is except having separately efficacy exertion, its specific proportioning and production technology, between each component, have synergy, agate coffee, saline cistanche and Radix Glycyrrhizae are improved bioactive molecule bioavilability by nanometer technology, are prepared into man's health food by fine finishining; Edible safety is effective, nontoxic; There is synergy for improving sexual function, improve fecundity, regulate endocrine, reduce prostatic disorders and improving body's immunity.
The specific embodiment
Below in conjunction with example, the present invention is illustrated:
Embodiment 1: a kind of man's health food, comprise traditional Chinese medicinal components, made by the raw material of following components by weight percent: agate coffee 20-60 part, saline cistanche 25-65 part, Radix Glycyrrhizae 5-20 part.
Above-mentioned raw materials is proportionally processed respectively, cleaned, dry or dry, pulverize, can obtain or further extract by alcohol extracting or water extraction.
As preferred version, described a kind of man's health food, it is characterized in that, the processing method of raw material is as follows: above-mentioned raw materials is proportionally processed respectively, agate coffee, saline cistanche, Radix Glycyrrhizae obtain agate coffee extract, cistanche extracts and licorice after extracting respectively, concentrate, being dried, then agate coffee extract, cistanche extracts and licorice are fully mixed, obtain traditional Chinese medicine extraction composition.Below introduce concrete extracting method:
Agate coffee or saline cistanche are broken into agate coffee or saline cistanche powder, add the alcohol-aqueous acid of 4-8 20%-90% volumetric concentration doubly, carry out multi-stage counter current extraction and extract 2-6 hour, after extracting liquid filtering, under 30-60 ℃ of degree, reduced pressure concentration obtains agate coffee or saline cistanche activity extract;
Wherein, agate coffee saline cistanche Powder Particle Size can pass through 30-80 mesh sieve.Preferably 40-60 mesh sieve.
Described alcohol-aqueous acid is one or more in the Ethanol-Acetic Acid aqueous solution, ethanol-glycine solution, the Ethanol-Acetic Acid aqueous solution; The pH value of described alcohol-aqueous acid is 3.0-6.5; The pH value of preferred described alcohol-aqueous acid is 4.5-5.5.Alcohol-water is long-pending than being 9:1-1:4, preferably than being 5:1-1:2.
Embodiment: agate coffee raw meal is broken into 40-50 order pueraria root powder, take 200 grams of pueraria root powders, pack in multi-stage counter current extraction device, add again ethanol-phosphate aqueous solution of 50% of 2000ml to carry out counter-current extraction 5 hours, after extraction, filter, lower concentrated in vacuum (0.05-0.1MPa), 50 ℃ of left and right reduced pressure concentrations obtain 13.5 grams of agate coffee activity extracts.
Licorice raw material washes with water, dries or dry, pulverizes, after while adding the alcohol of 4-10 times of volume 1-15% concentration-ammonia spirit to soak 10-24, carry out multi-stage counter current extraction, extract 2-8 hour heating and refluxing extraction, after extracting liquid filtering, under 40-65 ℃ of degree, reduced pressure concentration obtains Radix Glycyrrhizae activity extract.
Licorice powder granularity can be passed through 30-80 mesh sieve; More preferably cross 40-60 mesh sieve.
Described alcohol-ammonia spirit is ethanol-ammonia spirit, and described ethanol-ammonia spirit pH value is 7.5-10.5; Preferred described ethanol-ammonia spirit pH value is 8.5-10.0.Alcohol-water is long-pending than being 4-10:1, more preferably than being 5-8:1.
Embodiment: licorice raw material is ground into 40-50 order licorice powder, take 200 grams of licorice powders, pack in multi-stage counter current extraction device, add again ethanol-ammonia spirit of 10% of 1600ml to carry out counter-current extraction 6 hours, after extraction, filter, lower concentrated in vacuum (0.05-0.1MPa), 50 ℃ of left and right reduced pressure concentrations obtain 9.8 grams of Radix Glycyrrhizae activity extracts.
When concrete use, agate coffee, saline cistanche and Radix Glycyrrhizae can be to be all crude drug material, can be also all the composition of extract, and extract is to extract and obtain with crude drug.
Embodiment 1: 20 parts of agate coffees, 55 parts of saline cistanches, 25 parts, Radix Glycyrrhizae, clean, dry or dry, pulverize, after mixing, obtain the traditional Chinese medicine extraction composition 1 of agate coffee, saline cistanche and Radix Glycyrrhizae.
Embodiment 2: 60 parts of agate coffees, 25 parts of saline cistanches, 15 parts, Radix Glycyrrhizae, agate coffee and saline cistanche adopt alcohol extracting, after concentrated, dry agate coffee extract and cistanche extracts; Radix Glycyrrhizae obtains licorice after adopting water extraction to get, concentrate, be dried, and then agate coffee extract, cistanche extracts and licorice is fully mixed, and obtains traditional Chinese medicine extraction composition 2.
Embodiment 3
Agate coffee, saline cistanche and Radix Glycyrrhizae components by weight percent are: 50 parts of agate coffees, 40 parts of saline cistanches, 10 parts of extracts of Radix Glycyrrhizae obtain traditional Chinese medicine extraction composition 3 after mixing, and all the other conditions are identical with example 2.
Embodiment 4
Agate coffee, saline cistanche and Radix Glycyrrhizae components by weight percent are: 50 parts of agate coffees, 40 parts of saline cistanches, 10 parts of extracts of Radix Glycyrrhizae obtain traditional Chinese medicine extraction composition 4 after mixing, and all the other conditions are identical with example 2.
Embodiment 2 to embodiment 4:
The preparation method who carries out traditional Chinese medicinal components in EXPERIMENTAL EXAMPLE 1 to embodiment 4 by the raw material components content of specifying in following table 1, obtains respectively the traditional Chinese medicine extraction composition 1 of different component content to traditional Chinese medicine extraction composition 4.
Table 1
Embodiment 5
Man's health food, the preparation of tablet: get 60 parts of traditional Chinese medicine extraction compositions 2, add 30 parts of starch, 5 parts of carboxymethyl celluloses, 5 parts, dextrin, drop in mixer and mix 10-30 minute, add ethanol as wetting agent, mix 5-10 minute, mixed material is granulated with 10-20 mesh sieve, put into drying equipment inner drying, add the dolomol of 1 part of dried particles total amount, whole grain, compressing tablet, packing, make tablet of the present invention.
Embodiment 6
The preparation of tablet: get 20 parts of traditional Chinese medicine extraction compositions 3, add 50 parts of starch, 15 parts of carboxymethyl celluloses, 15 parts, dextrin, following steps are with example 5.
Embodiment 7
Man's health food, the preparation of capsule: get 50 parts of traditional Chinese medicine extraction compositions 4,45 parts of starch, 5 parts, dextrin, drop in mixer and mix 10-30 minute, add ethanol as wetting agent, mix 5-10 minute, mixed material is granulated with 10-20 mesh sieve, add the hard fatty acids magnesium of 1 part of dry material total amount, whole grain, capsule charge, packing, makes capsule of the present invention.
Embodiment 8
Man's health food, the preparation of capsule: get 10 parts of traditional Chinese medicine extraction compositions 2,80 parts of starch, 10 parts, dextrin, following steps are with example 7.
Embodiment 9
Man's health food, the preparation of oral liquid: get a certain amount of traditional Chinese medicine extraction composition 3, add 6 times of amount purified water to obtain oral liquid, add the potassium sorbate of 0.1 part of oral liquid measure, filtration, packing, sterilizing, packing, make oral liquid of the present invention.
Embodiment 10
The preparation of oral liquid: get a certain amount of traditional Chinese medicine extraction composition 4, add 20 times of amount purified water to obtain oral liquid, add the potassium sorbate of 0.1 part of oral liquid measure, following steps are with example 9.
Embodiment 11
The preparation of oral liquid: get a certain amount of traditional Chinese medicine extraction composition 2, add 40 times of amount purified water to obtain oral liquid, add the potassium sorbate of 0.15 part of oral liquid measure, the white granulated sugar of 5 parts, dissolves, and filtration, packing, sterilizing, packing, make oral liquid of the present invention.
Embodiment 12
Man's health food of the present invention is tested mice burden swimming:
If physiological saline negative control group and 3 traditional Chinese medicine extraction composition various dose groups of the present invention, every group of 12 male ICR mouses, little, in, large three dosage groups, gavage every day health food of the present invention respectively, dosage is respectively, 15g/Kg, 30g/Kg, 60g/Kg successive administration 21 days, before test, training once, last gavage is carried out mouse heavy burden test after 30 minutes, group's afterbody is born a heavy burden 5 parts, put into water tank, water temperature, sinking to underwater 10s with mouse can not float and be judged to power and exhaust, the time that record exhausts from entering water to power.Realization shows, the effect that 15g/Kg, 30g/Kg, 60g/Kg can obviously extend the mice burden swimming time, relatively has conspicuousness <0.01 with feminine gender group).The results are shown in Table 2.
The experiment of table 2 mice burden swimming
Group |
Dosage (g/Kg) |
Swimming time (S) |
Negative control group |
Physiological saline |
406±98 |
Small dose group |
15g/Kg |
491±136 |
Middle dosage group |
30g/Kg |
521±179 |
Large three dosage groups |
60g/Kg |
592±208 |
Below disclose the present invention with preferred embodiment, so it is not intended to limiting the invention, and all employings are equal to replaces or the technical scheme that obtains of equivalent transformation mode, within all dropping on protection scope of the present invention.