CN103330198A - Preparation method of health care capsule used for improving chemical liver injury - Google Patents
Preparation method of health care capsule used for improving chemical liver injury Download PDFInfo
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- CN103330198A CN103330198A CN2013102435624A CN201310243562A CN103330198A CN 103330198 A CN103330198 A CN 103330198A CN 2013102435624 A CN2013102435624 A CN 2013102435624A CN 201310243562 A CN201310243562 A CN 201310243562A CN 103330198 A CN103330198 A CN 103330198A
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Abstract
The invention relates to a preparation method of a health care capsule used for improving chemical liver injury. The formula of every 1000 health care capsules used for improving chemical liver injury comprises the following components: 300-600g of lotus seed pot, 200-500g of dandelion, 20-60g of schisandra chinensis and 60-200g of auxiliary materials. The health care capsule used for improving chemical liver injury, prepared by adopting a reflux extraction method, is a health care food capsule with the functionality of improving the chemical liver injury, and the health care capsule has multiple effects of protecting liver, diminishing inflammation and the like and is natural nutrition used for improving the chemical liver injury.
Description
Technical field
What the present invention relates to is a kind of health food that improves chemical damage in the field of health care products, and especially relating to a kind of is the method that the base stock preparation improves the chemical damage health-caring capsule with lotus pod, dandelion, the fruit of Chinese magnoliavine.
Background technology
Liver is glandula digestive maximum in the human body, is the central station of substance in vivo energetic supersession, is requisite vitals of the activity of earning a bare living.Common hepatopathy has hepatitis, cirrhosis, hepatapostema, primary carcinoma of liver etc.Hepatitis is mainly based on chronic hepatitis, and the whole world number of carrying hepatitis B surface antigen surpasses 2.8 hundred million according to statistics, and China is the district occurred frequently of hepatitis B, and about 3,000 ten thousand people of chronic hepatitis B of existing disease are arranged at present, annually domesticly dies from the liver cirrhosis due to hbv person has 400,000 people.Tobacco and wine too much become modern's liver killer's first weapon, and the modern supports protecting liver and becomes particularly important.
Lotus pod is the dry holder of nymphaeaceae plant lotus, and successive dynasties books on Chinese herbal medicine such as Compendium of Material Medica, supplement to the Herbal all record, and the Chinese medicine that lotus pod has been opened up as tradition is well known, is the medicine-food two-purpose kind.Lotus pod is rich in OPC, and OPC is free radical one of the most effective natural in the removing human body of generally acknowledging in the world at present, and its oxidation resistance is more than 50 times of vitamin E, is ascorbic more than 20 times.OPC is as anti-ageing, anti-cancer, control hepatic injury, anti-sudden change, the active ingredient of control cardiovascular disease medicine and the natural of safety non-toxic, obtained extensive use at health food, medicine and the cosmetic field of America and Europe and Japan and other countries.OPC can improve the hepatic pathology tissue damage, and acute chemical damage due to the carbon tetrachloride is had protective effect.
Also added dandelion in the prescription, dandelion is the composite family herbaceos perennial, contains protein, fat, carbohydrate, trace element and vitamin etc., and abundant nutritive value is arranged, and is the plant of dietotherapeutic.According to Compendium of Material Medica record, the flat sweet and slightly bitter taste of its property, clearing heat and detoxicating, dispersing swelling and dissipating binds and galgctogogue action are arranged, very effective to the treatment mastitis.In addition, dandelion also has effects such as diuresis, laxative, removing jaundice subcutaneous ulcer, cholagogic, is widely used in clinical.Studies show that inject with dandelion decoction filling stomach or with Dandelion Injectable Solution, the glutamic-pyruvic transaminase rising that carbon tetrachloride is caused has obvious inhibitory action; Can significantly alleviate the Histological change that the carbon tetrachloride liver damage causes.
The schizandrin that contains in the fruit of Chinese magnoliavine in the side, can excitating organism hepatocellular protective reaction, reduce the hepatotoxicity wind agitation that mercuric chloride, carbon tetrachloride cause, and can improve the state of oxidation and the HSR of liver.
Summary of the invention
The object of the present invention is to provide a kind of is that primary raw material is prepared into a kind of functional health capsule that improves chemical damage that has with lotus pod, dandelion, the fruit of Chinese magnoliavine.
Of the present invention is that the method that base stock preparation improves the chemical damage capsule may further comprise the steps with lotus pod, dandelion, the fruit of Chinese magnoliavine:
1, takes by weighing supplementary material by following prescription
To make 1000 capsules
Lotus pod 300～600g
Dandelion 200～500g
The fruit of Chinese magnoliavine 20～60g
Auxiliary material 60～200g;
Described auxiliary material can be one or more in microcrystalline cellulose, PVPP, carboxyrnethyl starch sodium, 30 POVIDONE K 30 BP/USP 30, superfine silica gel powder, lactose, low-substituted hydroxypropyl cellulose, starch, dextrin, the dolomol;
2, prepare the chemical damage health-caring capsule with above-mentioned supplementary material
Method one cleans three raw materials respectively, removes impurity, and lotus pod, dandelion are pulverized, mix with the fruit of Chinese magnoliavine, boiling 1～3 time, each 1～3 hour, solid-liquid ratio was 1:10～30, amount of water is 6～15 times of amounts of dose for the first time, second and third time is 4～10 times of amounts of dose, and collecting decoction filters, filtrate is concentrated into the thick paste shape, drying is pulverized, and adds appropriate amount of auxiliary materials, put abrasive dust in the efficient flour mill, make the mixed powder fineness be not less than 120 orders, with the ethanol of 60～95% concentration to this fine powder particle processed, 60 ℃ of dry 4h, use the whole grain of 40 mesh sieves again, encapsulated;
Method two cleans three raw materials respectively, remove impurity, lotus pod, dandelion are pulverized, mix with the fruit of Chinese magnoliavine, add the ethanolic solution refluxing extraction 1～3 time of 30～70% concentration, add the ethanolic solution flow control and once be 6～15 times of amounts of dose, second and third time is 4～10 times of amounts of dose, return time is 1～3 hour for the first time, and second and third time is 0.5～3 hour; Merge extract, filter, filtrate recycling ethanol is concentrated into the thick paste shape, drying, pulverize, add appropriate amount of auxiliary materials, put abrasive dust in the efficient flour mill, make the mixed powder fineness be not less than 120 orders, to this fine powder particle processed, 60 ℃ of dry 4h use the whole grain of 40 mesh sieves again, and are encapsulated with the ethanol of 60～95% concentration;
Method three cleans three raw materials respectively, removes impurity, and lotus pod, dandelion are pulverized, mix with the fruit of Chinese magnoliavine, add the ethanolic solution diacolation of 30～70% concentration to colourless, get percolate, filter, filtrate recycling ethanol is concentrated into the thick paste shape, drying is pulverized, and adds appropriate amount of auxiliary materials, put abrasive dust in the efficient flour mill, make the mixed powder fineness be not less than 120 orders, with the ethanol of 60～95% concentration to this fine powder particle processed, 60 ℃ of dry 4h use the whole grain of 40 mesh sieves again, and are encapsulated;
Concentrate in the technology and can adopt decompression to concentrate or film concentrates;
The filtration of extract also can be adopted centrifugation method in the technology;
Drying can adopt drying under reduced pressure or spray-drying in the technology, the control of drying under reduced pressure temperature is at 50-90 ℃, the best is 60 ℃, spray-drying is for to be condensed into the concentrate that relative density is 1.05-1.15 (60 ℃) with extract, spray-drying, EAT are 100-200 ℃, and leaving air temp is 50-150 ℃, EAT is 160 ℃, and leaving air temp is 100 ℃.Particle drying adopts drying under reduced pressure.
Beneficial effect of the present invention: the prepared capsule of this method can improve the hepatic pathology tissue damage, and acute chemical damage due to the carbon tetrachloride is had protective effect; Can significantly alleviate the Histological change that the carbon tetrachloride liver damage causes.Have protect the liver, multiple efficacies such as anti-inflammatory, be the natural nutriment that improves chemical damage.This method technology is simple, can guarantee product quality.Has the functional health-care food capsule that improves chemical damage.
The specific embodiment
Embodiment one:
(1) takes by weighing each supplementary material by following prescription
Improve the chemical damage health-caring capsule to make 1000:
Lotus pod 450g
Dandelion 375g
Fruit of Chinese magnoliavine 40g
Superfine silica gel powder 80g
Lactose 50g
30 POVIDONE K 30 BP/USP 30 5g
(2) lotus pod, dandelion, the fruit of Chinese magnoliavine are cleaned respectively, remove impurity, it is standby to be up to the standards; Lotus pod, dandelion are pulverized, and with fruit of Chinese magnoliavine boiling 2 times, each 1 hour, amount of water was 15 times of amounts of dose for the first time, be 10 times of amounts of dose for the second time, collecting decoction filters, and filtrate is concentrated into the thick paste shape, drying was pulverized 65 mesh sieves, got medicinal substances extract.
(3) medicinal substances extract in the above-mentioned prescription, auxiliary material are mixed, put abrasive dust in the efficient flour mill, make the mixed powder fineness be not less than 120 orders, to this fine powder particle processed, 60 ℃ of dry 4h use whole of 40 mesh sieves again, and are encapsulated with the ethanol of 70% concentration.
Embodiment two:
(1) takes by weighing each supplementary material by following prescription
Improve the chemical damage health-caring capsule to make 1000:
Lotus pod 450g
Dandelion 375g
Fruit of Chinese magnoliavine 40g
Starch 80g
Lactose 50g
Dolomol 5g
(2) lotus pod, dandelion, the fruit of Chinese magnoliavine are cleaned respectively, remove impurity, it is standby to be up to the standards; Lotus pod, dandelion are pulverized, and add 40% ethanolic solution refluxing extraction 3 times with the fruit of Chinese magnoliavine, and adding the ethanolic solution flow control and once be 12 times of amounts of dose, second and third time is 8 times of amounts of dose, time is 1 hour for first and second time, be 0.5 hour for the third time, merge extract, filter, filtrate is concentrated into the thick paste shape, drying was pulverized 65 mesh sieves, got medicinal substances extract.
(3) medicinal substances extract in the above-mentioned prescription, auxiliary material are mixed, put abrasive dust in the efficient flour mill, make the mixed powder fineness be not less than 120 orders, to this fine powder particle processed, 60 ℃ of dry 4h use whole of 40 mesh sieves again, and are encapsulated with the ethanol of 80% concentration.
Embodiment three:
(1) takes by weighing each supplementary material by following prescription
Improve the chemical damage health-caring capsule to make 1000:
Lotus pod 450g
Dandelion 375g
Fruit of Chinese magnoliavine 40g
Microcrystalline cellulose 80g
Dextrin 30g
(2) three raw materials are cleaned respectively, remove impurity, it is standby to be up to the standards; Lotus pod, dandelion are pulverized, and add 40% ethanolic solution diacolation to colourless with the fruit of Chinese magnoliavine, get percolate, filter, filtrate recycling ethanol is concentrated into the thick paste shape, and drying was pulverized 65 mesh sieves, got medicinal substances extract.
(3) medicinal substances extract in the above-mentioned prescription, auxiliary material are fully mixed, excessively direct filled capsules behind 80 mesh sieves.
Claims (1)
1. preparation method who improves the chemical damage health-caring capsule is characterized in that:
(1) takes by weighing supplementary material by following prescription
To make 1000 capsules
Lotus pod 300～600g
Dandelion 200～500g
The fruit of Chinese magnoliavine 20～60g
Auxiliary material 60～200g;
Described auxiliary material can be one or more in microcrystalline cellulose, PVPP, carboxyrnethyl starch sodium, 30 POVIDONE K 30 BP/USP 30, superfine silica gel powder, lactose, low-substituted hydroxypropyl cellulose, starch, dextrin, the dolomol;
(2) prepare the chemical damage health-caring capsule with above-mentioned supplementary material
Method one cleans three raw materials respectively, removes impurity, and lotus pod, dandelion are pulverized, mix with the fruit of Chinese magnoliavine, boiling 1～3 time, each 1～3 hour, solid-liquid ratio was 1:10～30, amount of water is 6～15 times of amounts of dose for the first time, second and third time is 4～10 times of amounts of dose, and collecting decoction filters, filtrate is concentrated into the thick paste shape, drying is pulverized, and adds appropriate amount of auxiliary materials, put abrasive dust in the efficient flour mill, make the mixed powder fineness be not less than 120 orders, with the ethanol of 60～95% concentration to this fine powder particle processed, 60 ℃ of dry 4h, use the whole grain of 40 mesh sieves again, encapsulated;
Method two cleans three raw materials respectively, remove impurity, lotus pod, dandelion are pulverized, mix with the fruit of Chinese magnoliavine, add the ethanolic solution refluxing extraction 1～3 time of 30～70% concentration, add the ethanolic solution flow control and once be 6～15 times of amounts of dose, second and third time is 4～10 times of amounts of dose, return time is 1～3 hour for the first time, and second and third time is 0.5～3 hour; Merge extract, filter, filtrate recycling ethanol is concentrated into the thick paste shape, drying, pulverize, add appropriate amount of auxiliary materials, put abrasive dust in the efficient flour mill, make the mixed powder fineness be not less than 120 orders, to this fine powder particle processed, 60 ℃ of dry 4h use the whole grain of 40 mesh sieves again, and are encapsulated with the ethanol of 60～95% concentration;
Method three cleans three raw materials respectively, removes impurity, and lotus pod, dandelion are pulverized, mix with the fruit of Chinese magnoliavine, add the ethanolic solution diacolation of 30～70% concentration to colourless, get percolate, filter, filtrate recycling ethanol is concentrated into the thick paste shape, drying is pulverized, and adds appropriate amount of auxiliary materials, put abrasive dust in the efficient flour mill, make the mixed powder fineness be not less than 120 orders, with the ethanol of 60～95% concentration to this fine powder particle processed, 60 ℃ of dry 4h use the whole grain of 40 mesh sieves again, and are encapsulated;
Drying can adopt drying under reduced pressure or spray-drying in the technology, the control of drying under reduced pressure temperature is at 50-90 ℃, spray-drying is the concentrate at 60 ℃ of following 1.05-1.15 for extract being condensed into relative density, during spray-drying, EAT is 100-200 ℃, leaving air temp is 50-150 ℃, and particle drying adopts drying under reduced pressure.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768149A (en) * | 2014-01-15 | 2014-05-07 | 李海涛 | Lotus seedpod procyanidins soft capsule health care product for controlling gastric ulcer |
| CN106561899A (en) * | 2016-10-24 | 2017-04-19 | 湖北省农业科学院果树茶叶研究所 | Tea buccal tablet capable of protecting liver, and preparation method thereof |
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| CN102670763A (en) * | 2012-06-01 | 2012-09-19 | 广州市奥海生物科技有限公司 | Composition with auxiliary protection effect on chemical liver injury and preparation method of composition |
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| CN101607063A (en) * | 2008-06-20 | 2009-12-23 | 天科仁祥技术（北京）有限责任公司 | Drug regimen of a kind of fat-reducing liver-protecting and preparation method thereof |
| CN102670763A (en) * | 2012-06-01 | 2012-09-19 | 广州市奥海生物科技有限公司 | Composition with auxiliary protection effect on chemical liver injury and preparation method of composition |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768149A (en) * | 2014-01-15 | 2014-05-07 | 李海涛 | Lotus seedpod procyanidins soft capsule health care product for controlling gastric ulcer |
| CN106561899A (en) * | 2016-10-24 | 2017-04-19 | 湖北省农业科学院果树茶叶研究所 | Tea buccal tablet capable of protecting liver, and preparation method thereof |
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Application publication date: 20131002 |