CN103743916B - A kind of Full-automatic chemiluminescence immunoassay analysis meter - Google Patents
A kind of Full-automatic chemiluminescence immunoassay analysis meter Download PDFInfo
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- CN103743916B CN103743916B CN201310718774.3A CN201310718774A CN103743916B CN 103743916 B CN103743916 B CN 103743916B CN 201310718774 A CN201310718774 A CN 201310718774A CN 103743916 B CN103743916 B CN 103743916B
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Abstract
The present invention adopts a kind of Full-automatic chemiluminescence immunoassay analysis meter, comprise TIP tube module, reaction tube module, sample hose module, Reagent Tube module, TIP pipe fetching device, three-dimensional machinery arm module, wherein three-dimensional machinery arm module can drive the arbitrary motion on working face of TIP pipe fetching device, reaction tube TIP pipe in reaction tube module adds sample and reagent adding, and described reaction tube is picked and placeed by TIP pipe fetching device and moved.The invention has the beneficial effects as follows: the program uses TIP pipe replacement pin to come application of sample and reagent adding, avoids cross pollution, and use TIP head fetching device to carry out alternative mechanical arm simultaneously and pick and place and mobile response pipe, the error rate of this mode will be significantly less than mechanical arm scheme.
Description
Technical field
The invention belongs to luminesceence analysis field, be specifically related to a kind of scheme of Full-automatic chemiluminescence analyser, and a kind of novel reaction pipe being applied to the program.
Background technology:
Full-automatic chemiluminescence analysers most in the market all comprises mechanical arm or chain reaction pipe connecting gear, also has sample pin and these requisite comprising modules of reagent needles.This technical scheme decides according to chemiluminescent principle and reaction detection step, first to testing sample serum be joined in reaction tube by sample pin, then joined in reaction tube by reagent needles abstraction reaction reagent and react, need mechanical arm or chain conveyor that reaction tube is moved in reaction module afterwards and carry out temperature reaction, need after reaction to be done to continue to transfer to cleaning and the adsorption process that cleaning module carries out magnetic bead, finally detect.
Sample in whole reaction process in reaction tube and reagent all need to use pin to extract and application of sample, and the movement of reaction tube needs to have come by mechanical arm or chain type transmission mechanism.These two kinds of modes all also exist defect, and the former pin application of sample also exists a cleaning problem, needs the cleaning device of complete set, comprises pump, pipeline, service sink, devil liquor recovery etc., even if also there is the risk of cross pollution like this.And the defect of mechanical arm or linked transmission is complex structure, failure rate is high.
The present invention devises a kind of Full-automatic chemiluminescence immunoassay analysis meter scheme can evade above two kinds of defects.
Summary of the invention:
The present invention, in order to overcome the deficiencies in the prior art, provides a kind of Full-automatic chemiluminescence immunoassay analysis meter, and a kind of reaction tube being applied to the particular design of the program.
The present invention adopts a kind of Full-automatic chemiluminescence immunoassay analysis meter, comprise TIP tube module, reaction tube module, sample hose module, kit module, TIP pipe fetching device, three-dimensional machinery arm module, wherein three-dimensional machinery arm module can drive the arbitrary motion on working face of TIP pipe fetching device, reaction tube TIP pipe in reaction tube module adds sample and reagent adding, and described reaction tube is picked and placeed by TIP pipe fetching device and moved.
Further, the size of described reaction tube inside is consistent with standard TIP head inside dimension.
Further, the internal diameter of the upper orifice of reaction tube is managed consistent with standard TIP with the internal diameter of lower nozzle respectively.
Further, the external structure of described reaction tube and size meet the requirement that mechanical arm captures.
The invention has the beneficial effects as follows: the program uses TIP head (pipe) replacement pin to come application of sample and reagent adding, avoid cross pollution, use TIP head fetching device to carry out alternative mechanical arm to pick and place and mobile response pipe, the error rate of this mode will be significantly less than mechanical arm scheme simultaneously.
Accompanying drawing illustrates:
Fig. 1 is the schematic perspective view of the embodiment of the present invention;
Fig. 2 is the TIP tube module schematic perspective view of the embodiment of the present invention;
Fig. 3 is the sample hose module schematic perspective view of the embodiment of the present invention;
Fig. 4 is the kit module schematic perspective view of the embodiment of the present invention;
Fig. 5 is the reaction tube module schematic perspective view of the embodiment of the present invention;
Fig. 6 is the three-dimensional machinery arm module schematic perspective view of the embodiment of the present invention;
Fig. 7 is the reagent bottle frame module schematic perspective view of the embodiment of the present invention;
Fig. 8 is the reaction pipe support schematic perspective view of the embodiment of the present invention;
Fig. 9 is the reaction tube broken isometric schematic diagram of the embodiment of the present invention;
Figure 10 is the reaction tube of the embodiment of the present invention and the Profile Correlation figure of standard tip pipe.
Embodiment:
Following content elaborates to the specific embodiment of the present invention in conjunction with Figure of description.
See Fig. 1, Full-automatic chemiluminescence immunoassay analysis meter of the present invention by TIP tube module 1, reaction tube module 2, sample hose module 3, kit module 4, waste material box 5, Y-axis mechanical arm 6, Z axis mechanical arm 7, TIP pipe fetching device 8, needle cleaning device 9, X-axis mechanical arm 10, detect aperture 11, external cleaning fluid and waste liquid barrel 12, and automatically controlled part and PC control end composition.
Fig. 2 is TIP tube module, this module by feet 13, bracing frame 16, standard TIP pipe support 17, and 200 microlitre TIP pipes, 14,1 milliliter of TIP pipe 15 forms.
Fig. 3 is sample hose module, and this module is by sample pipe support 21, and sample hose 20, sample pipe support box 19, photoelectric sensor 18 forms.Each when sample pipe support 21 inserts sample pipe support box 19 time, photoelectric sensor 18 can detect insertion signal, passes to PC control end, makes instrument grasp sample listings at any time.
Fig. 4, Fig. 7 are kit module, and it is by reagent carriage 22, kit pallet 23, mixing tooth bar 24, and mixing motor 25, power wheel 26 forms.Containing reagent bottle 44 in reagent carriage 22, damping fluid bottle 43 and magnetic bead bottle.Near inside circular reagent bottle be magnetic bead bottle, it needs ceaselessly to rotate to ensure that the magnetic bead in bottle does not precipitate in use, with gear 45 bottom magnetic bead bottle, coordinate with mixing tooth bar 24, drive mixing tooth bar 24 to do straight reciprocating motion by mixing motor 25 by power wheel 26 to keep magnetic bead bottle ceaselessly to rotate, reach the object of magnetic bead mixing.
Fig. 5, Fig. 8 are reaction tube modules.It is by reaction tray feet 28, reaction tray support 29, reaction pipe support 30, reaction disk body 31, and reaction tube 27 forms.Reaction tube 27 is regularly arranged on reaction pipe support 30, and then entirety is placed on reaction disk body 31, and reaction disk body 31 is with heating function, guarantees the temperature environment needed for reagent reacting.And reaction tube 27 adopts particular design, directly crawl can be inserted with TIP pipe fetching device 8, thus avoid the extra robot device of use to transport reaction tube, the size of reaction mouth of pipe inside 46 is consistent with standard TIP head inside dimension, reaction tube comprises top tube and down tube, standard TIP head comprises pipe, lower pipe and suction head portion, wherein the internal diameter of the upper orifice of reaction tube and the internal diameter of lower nozzle and standard TIP pipe is consistent, so just can as picking and placeing the first sample of TIP to pick and place reaction tube, and the size of reaction tube outside 47 still meets common mechanical hand (this area conventional mechanical hand) captures dimensional requirement, can one tube multipurpose.
As shown in Figure 10, the reaction mouth of pipe inside dimension of the present invention's design manage (head) inside dimension with standard Tip consistent, and like this with regard to energy compatibility standard Tip pipe rifle head, the device that can pick and place standard Tip pipe just can pick and place the reaction tube that the present invention designs.Profile and the common response pipe of simultaneous reactions pipe are basically identical, and common mechanical arm so also can be coordinated to use, and so a kind of reaction tube can compatible two kinds of fetching devices.
See Fig. 6, be three-dimensional machinery arm module, comprise X-axis mechanical arm, Y-axis mechanical arm and Z axis mechanical arm.Wherein X-axis mechanical arm is by X-axis circular shaft 32, X-axis base plate 33, X-axis motor 34, X-axis slide block 35, X-axis driving-belt 37 forms, Y-axis mechanical arm by y-axis motor 36, Y-axis circular shaft 40, Y-axis driving-belt 39 forms, Z axis arm is by Z axis motor 38, and Z axis guide rail 41, Z-axis transmission band 42 forms.
Principle of work: the three-dimensional motion arm be made up of x-axis y-axis z-axis can drive TIP pipe fetching device 8 arbitrary motion on working face.Such as to allow tip pipe fetching device 8 from reaction tube module 2 abstraction reaction pipe to detect aperture 11, then TIP pipe fetching device 8 first moves in reaction tube module 2 above one of them reaction tube position coordinate by x-axis and y-axis, and then Z axis drives and moves up and down.By mentioning in tip pipe fetching device 8 intercalation reaction pipe, detect aperture 11 coordinate is moved to again by x-axis y-axis, Z axis drives tip pipe fetching device 8 to move downward, put into detect aperture 11, then tip pipe fetching device 8 has an ejecting mechanism and is unloaded from above by reaction tube, completes wholely to pick and place action.
The foregoing is only preferred embodiment of the present invention, be not limited to the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included in protection scope of the present invention.
Claims (8)
1. a Full-automatic chemiluminescence immunoassay analysis meter, comprise TIP tube module, reaction tube module, sample hose module, kit module, TIP pipe fetching device, three-dimensional machinery arm module, wherein three-dimensional machinery arm module can drive the arbitrary motion on working face of TIP pipe fetching device, it is characterized in that, reaction tube TIP pipe in reaction tube module adds sample and reagent adding, and described reaction tube is picked and placeed by TIP pipe fetching device and moved;
The size of described reaction mouth of pipe inside is consistent with standard TIP head inside dimension, and reaction tube comprises top tube and down tube;
The external structure of described reaction tube and size meet the requirement that mechanical arm captures, and the mouth of pipe outside of described reaction tube is provided with ring groove.
2. analyser according to claim 1, is characterized in that, the internal diameter of the upper orifice of reaction tube is managed consistent with standard TIP with the internal diameter of lower nozzle respectively.
3. analyser according to claim 1, it is characterized in that, described three-dimensional machinery arm module comprises X-axis mechanical arm, Y-axis mechanical arm and Z axis mechanical arm, wherein X-axis mechanical arm comprises X-axis circular shaft, X-axis base plate, X-axis motor, X-axis slide block and X-axis driving-belt, Y-axis mechanical arm comprises y-axis motor, Y-axis circular shaft and Y-axis driving-belt, and Z axis mechanical arm comprises Z axis motor, Z axis guide rail and Z-axis transmission band.
4. analyser according to claim 1, is characterized in that, described analyser also comprises waste material box, needle cleaning device, external cleaning fluid and waste liquid barrel, automatically controlled part and PC control end.
5. analyser according to claim 1, is characterized in that, described TIP tube module comprises feet, bracing frame, standard TIP pipe support, 200 microlitre TIP manage and 1 milliliter of TIP manages.
6. analyser according to claim 1, is characterized in that, described sample hose module, comprises sample pipe support, sample hose, sample pipe support box and photoelectric sensor.
7. analyser according to claim 1, is characterized in that, kit module comprises reagent carriage, kit pallet, mixing tooth bar, mixing motor and power wheel, and wherein reagent carriage has included reagent bottle, damping fluid bottle and magnetic bead bottle.
8. analyser according to claim 1, is characterized in that, described reaction tube module comprises reaction tray feet, reaction tray support, reaction pipe support, reaction disk body and reaction tube.
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| CN201310718774.3A CN103743916B (en) | 2013-12-23 | 2013-12-23 | A kind of Full-automatic chemiluminescence immunoassay analysis meter |
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| CN201310718774.3A CN103743916B (en) | 2013-12-23 | 2013-12-23 | A kind of Full-automatic chemiluminescence immunoassay analysis meter |
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| CN103743916B true CN103743916B (en) | 2016-04-06 |
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| CN105242055B (en) * | 2014-05-21 | 2017-04-05 | 凯和生物科技(上海)有限公司 | Improved bar formula immunity fully-automatic analyzer |
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| CN107271701B (en) * | 2016-04-08 | 2019-06-11 | 北京德鲁伊医疗器材有限公司 | A kind of multi-purpose medical detector and detection system |
| CN107389407B (en) * | 2017-08-16 | 2023-06-06 | 威海福瑞机器人有限公司 | Liquid pretreatment device and control method thereof |
| CN107632106A (en) * | 2017-10-24 | 2018-01-26 | 上海北裕分析仪器股份有限公司 | A kind of robot permanganate index analyzer |
| CN110412303B (en) * | 2019-07-31 | 2023-11-03 | 深圳麦科田生物医疗技术股份有限公司 | Method for sample analysis |
| CN110404594B (en) * | 2019-07-31 | 2024-06-04 | 深圳麦科田生物医疗技术股份有限公司 | Sample analysis kit |
| CN111024968A (en) * | 2019-12-19 | 2020-04-17 | 江苏泽成生物技术有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN111913000A (en) * | 2020-06-22 | 2020-11-10 | 深圳天深医疗器械有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
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| JP5694813B2 (en) * | 2010-03-04 | 2015-04-01 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Method and system for isolating and analyzing an analyte in an automated analyzer |
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| EP0819942A2 (en) * | 1996-07-19 | 1998-01-21 | Hitachi, Ltd. | Apparatus for transferring liquid having liquid level sensing function |
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